Drug & supplement interaction

Royal Jelly + Celecoxib

Celecoxib brand names: Celebrex, Elyxyb.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Royal Jelly and Celecoxib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Royal Jelly and Celecoxib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Celecoxib and Royal Jelly in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Royal Jelly safety at a glance

Royal Jelly overall Use caution Generally well tolerated, but it can trigger serious allergic reactions in sensitive people.
Pregnancy Avoid Not enough safety information; best to avoid during pregnancy.
Breastfeeding Avoid Not enough safety information; best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Celecoxib and Royal Jelly? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Celecoxib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Celecoxib is filed under 9 classifications — including nonsteroidal anti-inflammatory drugs (nsaids), cytochrome p450 2c9 (cyp2c9) substrates, cytochrome p450 2d6 (cyp2d6) inhibitors. Royal Jelly has documented interactions with 2 drug classes — the most serious being antihypertensive drugs (moderate) and warfarin (coumadin) (moderate) — and none of Celecoxib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Royal Jelly Does Interact With Other Medications

Royal Jelly has 174 moderate known drug interactions in our database — Celecoxib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 174 No known interaction 2,656 (incl. Celecoxib)
Taking anything else?

Check Another of Your Medications Against Royal Jelly

Covers the 2,830 medications we’ve checked against Royal Jelly. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Royal Jelly and Celecoxib May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 4 of them are worth acting on rather than waiting out — marked below.

  • Wheezing / Shortness of breath / Hives Worth acting on Additional detail

    Royal Jelly

    “In people with a history of atopy or asthma, royal jelly taken orally appears to cause a high rate of allergic symptoms including pruritus, urticaria, eczema, eyelid and facial edema, conjunctivitis, rhinorrhea, dyspnea, oral allergy syndrome, and asthma. In severe cases, royal jelly can cause status asthmaticus, anaphylaxis, and death.”

    Royal Jelly · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    6 sources cited
    1. 792. Bullock RJ, et al. Fatal royal jelly-induced asthma. Med J Aust 1994;160:44. DOI
    2. 7315. Harwood M, Harding S, Beasley R, Frankish PD. Asthma following royal jelly. N Z Med J 1996;109:325.
    3. 7316. Laporte JR, Ibaanez L, Vendrell L, Ballarin E. Bronchospasm induced by royal jelly. Allergy 1996;51:440. DOI
    4. 10623. Leung R, Thien FC, Baldo B, et al. Royal jelly-induced asthma and anaphylaxis: clinical characteristics and immunologic correlations. J Allergy Clin Immunol 1995;96:1004-7. PubMed
    5. 10624. Peacock S, Murray V, Turton C. Respiratory distress and royal jelly. BMJ 1995;311:1472. DOI
    6. 108511. Li JD, Cui L, Xu YY, Guan K. A case of anaphylaxis caused by major royal jelly protein 3 of royal jelly and its cross-reactivity with honeycomb. J Asthma Allergy 2021;14:1555-7. PubMed

    Celecoxib

    Listed in the ADVERSE REACTIONS section of the FDA label for Celecoxib. Read the label on DailyMed ›

  • An allergic reaction Worth acting on reported in 6.1% of FDA reports for Celecoxib Additional detail

    Royal Jelly

    Recorded for Royal Jelly in the same Natural Medicines adverse-effect record shown under Wheezing / Shortness of breath / Hives above.

    Celecoxib

    Listed in the ADVERSE REACTIONS section of the FDA label for Celecoxib, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Itching / A skin rash Additional detail

    Royal Jelly

    Recorded for Royal Jelly in the same Natural Medicines adverse-effect record shown under Wheezing / Shortness of breath / Hives above.

    Celecoxib

    Listed in the ADVERSE REACTIONS section of the FDA label for Celecoxib. Read the label on DailyMed ›

  • Swelling Additional detail

    Royal Jelly

    Recorded for Royal Jelly in the same Natural Medicines adverse-effect record shown under Wheezing / Shortness of breath / Hives above.

    Celecoxib

    Listed in the ADVERSE REACTIONS section of the FDA label for Celecoxib. Read the label on DailyMed ›

  • Stomach pain / Diarrhea reported in 5.8% of FDA reports for Celecoxib Additional detail

    Royal Jelly

    “There is one case report of hemorrhagic colitis with abdominal pain, bloody diarrhea with concomitant hemorrhagic and edematous mucosa of the sigmoid colon after ingestion of royal jelly. Symptoms resolved within 2 weeks following discontinuation of royal jelly and conservative treatment.”

    Royal Jelly · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 3516. Yonei Y, Shibagaki K, Tsukada N, et al. Case report: haemorrhagic colitis associated with royal jelly intake. J Gastroenterol Hepatol 1997;12:495-9.

    Celecoxib

    Listed in the ADVERSE REACTIONS section of the FDA label for Celecoxib, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Dizziness Additional detail

    Royal Jelly

    “There is one report of dizziness in a patient who took a combination product containing royal jelly, bee pollen extract, and a bee pollen plus pistil extract.”

    Royal Jelly · Natural Medicines adverse-effect record, reported in vertigo.

    1 source cited
    1. 12008. Winther K, Hedman C. Assessment of the Effects of the Herbal Remedy Femal on the Symptoms of Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study. Curr Ther Res Clin Exp 2002;63:344-53. DOI

    Celecoxib

    Listed in the ADVERSE REACTIONS section of the FDA label for Celecoxib. Read the label on DailyMed ›

Reported for Royal Jelly but not commonly for Celecoxib: a severe allergic reaction.

Effects for Celecoxib come from the ADVERSE REACTIONS section of its FDA label; effects for Royal Jelly come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 130,888 voluntary FDA FAERS reports for Celecoxib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Royal Jelly or Celecoxib

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Royal Jelly or Celecoxib, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Celecoxib

This page covers Royal Jelly only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Celecoxib page lists 117 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 84 moderate · 28 minor.

From our pharmacist’s overview on the Celecoxib page

“Alcohol tops my worry list here. Beer and wine both carry major ratings with celecoxib (Celebrex, Elyxyb) because mixing alcohol with an NSAID raises the odds of stomach and intestinal bleeding, the drug's best-known danger.”

Reviewed by 2 · Jul 18, 2026

Open the Celecoxib interaction page

One more smart check

Taking Royal Jelly as Part of a Dietary Supplement Product? Check It for Interactions

We hold 677 real supplement products containing Royal Jelly, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Royal Jelly. Even though Royal Jelly itself has no known interaction with Celecoxib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Royal Jelly and Celecoxib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Royal Jelly
Top 25%

#322 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Celecoxib
Top 25%

#536 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Royal Jelly reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Royal Jelly and Celecoxib records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Royal Jelly

What is Royal Jelly?

Royal Jelly
  • Menopausal symptoms
  • Skin health and wound care
  • Immune support
  • General energy and vitality
  • Cholesterol support
  • Eye dryness (eye drops)

Royal jelly is a nutrient-rich substance made by worker bees to feed the queen bee. People take it for menopause symptoms, energy, skin, and immune support, but solid human evidence is limited for most uses. It is generally well tolerated by most people, but it can cause serious allergic reactions, especially in those allergic to bees or with asthma.

Secretion from the glands of worker honey bees (Apis mellifera) · Capsules, softgels, fresh (frozen) jelly, liquid, powder, and skin creams

An interaction check asks whether these two react with each other — it does not ask whether Royal Jelly is a good idea for someone in your situation. Here is what our Royal Jelly record says about it on its own.

Royal Jelly: dosing

There is no official or standardized dose of royal jelly. The amounts used in studies have varied widely, and products differ in their strength and purity.Because there is no proven best dose, it is wise to follow the directions on the product label and not take more than recommended.

From our Royal Jelly monograph — the full record covers uses, side effects and every documented interaction.

Read the full Royal Jelly monograph & all interactions
Medication

About Celecoxib

What Is Celecoxib Used For?

Brand names: Celebrex, Elyxyb

Celecoxib capsules and the generic oral suspension treat the signs and symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis (AS), and juvenile rheumatoid arthritis (JRA) in children 2 years and older. Celecoxib capsules also treat acute pain and primary dysmenorrhea (painful periods) in adults.

ELYXYB (celecoxib oral liquid) is specifically approved for the acute treatment of migraine with or without aura in adults — but it is not used to prevent migraines. VYSCOXA (celecoxib oral suspension) is not indicated for acute pain or primary dysmenorrhea.

Most-Reported Side Effects for Celecoxib

From FAERS, the FDA’s public side-effect reporting system (130,888 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Arthralgia 11,261 reports
Fatigue 10,100 reports
Nausea 9,771 reports
Drug hypersensitivity 7,939 reports
Diarrhea 7,598 reports
See full Celecoxib drug information
Keep checking

Other Drugs & Royal Jelly

Browse every other medication we’ve checked against Royal Jelly — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
174Moderate
0Minor
2,655No known interaction
174 Moderate 2,655 No interaction
Moderate

174 interactions

Showing 60 of 174 moderate interactions — see all 174 on the Royal Jelly page.

No interaction 2,655 drugs checked — show the list

We also checked Royal Jelly against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,655 medications checked with no known interaction — see the full Royal Jelly list.

See the full Royal Jelly interactions page
See every supplement checked against Celecoxib, ranked by severity
Evidence & sources

Royal Jelly References

The 14 references that drive our Royal Jelly monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Takahashi M, Matsuo I, Ohkido M. Contact dermatitis due to honeybee royal jelly. Contact Dermatitis 1983;9:452-5.
  2. Bullock RJ, et al. Fatal royal jelly-induced asthma. Med J Aust 1994;160:44. DOI
  3. Thien FC, Leung R, Baldo BA, et al. Asthma and anaphylaxis induced by royal jelly. Clin Exp Allergy 1996;26:216-22. PubMed
  4. Yonei Y, Shibagaki K, Tsukada N, et al. Case report: haemorrhagic colitis associated with royal jelly intake. J Gastroenterol Hepatol 1997;12:495-9.
  5. Harwood M, Harding S, Beasley R, Frankish PD. Asthma following royal jelly. N Z Med J 1996;109:325.
  6. Laporte JR, Ibaanez L, Vendrell L, Ballarin E. Bronchospasm induced by royal jelly. Allergy 1996;51:440. DOI
  7. Leung R, Thien FC, Baldo B, et al. Royal jelly-induced asthma and anaphylaxis: clinical characteristics and immunologic correlations. J Allergy Clin Immunol 1995;96:1004-7. PubMed
  8. Peacock S, Murray V, Turton C. Respiratory distress and royal jelly. BMJ 1995;311:1472. DOI
  9. Winther K, Hedman C. Assessment of the Effects of the Herbal Remedy Femal on the Symptoms of Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study. Curr Ther Res Clin Exp 2002;63:344-53. DOI
  10. Lee NJ, Fermo JD. Warfarin and royal jelly interaction. Pharmacotherapy 2006;26:583-6. PubMed
  11. Tokunaga, K. H., Yoshida, C., Suzuki, K. M., Maruyama, H., Futamura, Y., Araki, Y., and Mishima, S. Antihypertensive effect of peptides from royal jelly in spontaneously hypertensive rats. Biol.Pharm.Bull. 2004;27(2):189-192. PubMed
  12. Sultana, A., Nabi, A. H., Nasir, U. M., Maruyama, H., Suzuki, K. M., Mishima, S., and Suzuki, F. A dipeptide YY derived from royal jelly proteins inhibits renin activity. Int.J.Mol.Med. 2008;21(6):677-681. DOI
  13. Gómez Torrijos E, Méndez Diaz Y, Borja Segade JM, et al. Occupational allergic respiratory disease due to royal jelly. Ann Allergy Asthma Immunol. 2016;117(1):102-3. PubMed
  14. Li JD, Cui L, Xu YY, Guan K. A case of anaphylaxis caused by major royal jelly protein 3 of royal jelly and its cross-reactivity with honeycomb. J Asthma Allergy 2021;14:1555-7. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Royal Jelly and Celecoxib Together: Common Questions

Is it safe to take Royal Jelly with Celecoxib?
We do not list a known interaction between Royal Jelly and Celecoxib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Royal Jelly and Celecoxib have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Royal Jelly and Celecoxib combination checked?
Interactions in our licensed database are recorded against drug classes. Celecoxib is filed under 9 classifications, and Royal Jelly has documented interactions with 2 drug classes — none of Celecoxib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Royal Jelly interact with any other medications?
Yes. Royal Jelly has 174 documented drug interactions in our database — Celecoxib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Celecoxib interact with any supplements?
Yes. Celecoxib has documented interactions with 117 supplements in our database — Royal Jelly is not one of them. The Celecoxib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Royal Jelly monograph Uses, safety profile, and every drug interaction in one place Celecoxib drug information The full plain-English guide to this medication Celecoxib supplement interactions Every supplement checked against Celecoxib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 14 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Celecoxib and Royal Jelly?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.