Drug & supplement interaction

Rye Grass + Amoxapine

Amoxapine brand name: Asendin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Rye Grass and Amoxapine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Rye Grass and Amoxapine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Amoxapine and Rye Grass in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Rye Grass at all — not against Amoxapine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Rye Grass safety at a glance

Rye Grass overall Use caution Generally well tolerated in studies, but long-term safety is not well established.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Not enough safety information, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Amoxapine and Rye Grass? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Rye Grass and Amoxapine May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea Additional detail

    Rye Grass

    “Orally, rye grass pollen extract can cause abdominal distention, heartburn, and nausea.”

    Rye Grass · Natural Medicines adverse-effect record, reported in dyspepsia.

    1 source cited
    1. 5293. Rugendorff EW, Weidner W, Ebeling L, Buck AC. Results of treatment with pollen extract (Cernilton N) in chronic prostatitis and prostatodynia. Br J Urol 1993;71:433-8.

    Amoxapine

    Listed in the ADVERSE REACTIONS section of the FDA label for Amoxapine. Read the label on DailyMed ›

Reported for Rye Grass but not commonly for Amoxapine: heartburn.

Effects for Amoxapine come from the ADVERSE REACTIONS section of its FDA label; effects for Rye Grass come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Amoxapine

This page covers Rye Grass only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amoxapine page lists 68 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Lithium (major), Scopolia (major), 5-htp (moderate) and Acetyl-l-carnitine (moderate).

By severity: 3 major · 49 moderate · 16 minor.

From our pharmacist’s overview on the Amoxapine page

“Amoxapine (Asendin) is an older tricyclic antidepressant, and its supplement list deserves real care. Three of the 68 ingredients on file are rated major: activated charcoal can soak up the drug before your body gets it, lithium raises the risk of serotonin syndrome (a dangerous serotonin overload), and scopolia piles onto amoxapine's…”

Reviewed by 2 · Jul 18, 2026

Open the Amoxapine interaction page

How much people look this up

Where Rye Grass and Amoxapine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Rye Grass
Steady interest

#991 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amoxapine
Top half

#846 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Rye Grass reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Rye Grass and Amoxapine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Rye Grass

What is Rye Grass?

  • Prostate symptoms (BPH)
  • Chronic prostatitis
  • Urinary symptoms
  • General wellness/nutrition
  • Allergy desensitization (research only)

Rye grass pollen extract is most often used as a supplement for prostate-related urinary symptoms, where some small studies suggest a possible benefit, but the overall evidence is limited and not conclusive. It is generally well tolerated, but it is not a proven treatment, and you should talk to your doctor or pharmacist before using it, especially if you have prostate or urinary problems.

Secale cereale · Poaceae · Pollen extract, grass (leaves), and seeds/grain · Tablets, capsules, pollen extracts, and dried grass powders

An interaction check asks whether these two react with each other — it does not ask whether Rye Grass is a good idea for someone in your situation. Here is what our Rye Grass record says about it on its own.

Rye Grass: dosing

There is no official or standardized dose for rye grass pollen extract. They can help you decide whether it is appropriate for you and review it alongside your other medicines and conditions.

From our Rye Grass monograph — the full record covers uses, side effects and every documented interaction.

Read the full Rye Grass monograph & all interactions
Medication

About Amoxapine

What Is Amoxapine Used For?

Brand name: Asendin

Amoxapine is used to treat symptoms of depression. This includes neurotic or reactive depression (depression triggered by life events), as well as endogenous depression (depression that arises from within, without a clear external cause) and psychotic depression.

It is also indicated for depression that comes with significant anxiety or agitation.

See full Amoxapine drug information
Keep checking

Other Drugs & Rye Grass

Browse every other medication we’ve checked against Rye Grass — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Rye Grass against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Rye Grass list.

See the full Rye Grass interactions page
See every supplement checked against Amoxapine, ranked by severity
Evidence & sources

Rye Grass References

The 1 references that drive our Rye Grass monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Rugendorff EW, Weidner W, Ebeling L, Buck AC. Results of treatment with pollen extract (Cernilton N) in chronic prostatitis and prostatodynia. Br J Urol 1993;71:433-8.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Rye Grass and Amoxapine Together: Common Questions

Is it safe to take Rye Grass with Amoxapine?
We do not list a known interaction between Rye Grass and Amoxapine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Rye Grass and Amoxapine have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Amoxapine interact with any supplements?
Yes. Amoxapine has documented interactions with 68 supplements in our database — Rye Grass is not one of them. The Amoxapine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Rye Grass monograph Uses, safety profile, and every drug interaction in one place Amoxapine drug information The full plain-English guide to this medication Amoxapine supplement interactions Every supplement checked against Amoxapine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Amoxapine and Rye Grass?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.