Drug & supplement interaction

Scopolia + Paliperidone

Paliperidone brand name: Invega.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Scopolia and Paliperidone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Scopolia and Paliperidone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Paliperidone and Scopolia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Scopolia safety at a glance

Scopolia overall Avoid Scopolia is toxic and unsafe for self-medication because of its potent anticholinergic alkaloids.
Pregnancy Likely Unsafe When the root or rhizome is used orally as a medicine; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When the root or rhizome is used orally as a medicine; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Paliperidone and Scopolia? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Paliperidone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Paliperidone is filed under 5 classifications — including antipsychotic drugs, qt interval-prolonging drugs, photosensitizing drugs. Scopolia has documented interactions with 3 drug classes — the most serious being anticholinergic drugs (major), quinidine (major) and tricyclic antidepressants (tcas) (major) — and none of Paliperidone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Scopolia Does Interact With Other Medications

Scopolia has 200 major, known drug interactions in our database — Paliperidone isn’t one of them. If you take anything else, check it against the full list below.

Major 200 No known interaction 2,630 (incl. Paliperidone)
Taking anything else?

Check Another of Your Medications Against Scopolia

Covers the 2,830 medications we’ve checked against Scopolia. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Scopolia and Paliperidone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Hallucinations Worth acting on Additional detail

    Scopolia

    “Scopolia is generally regarded as unsafe for use. Any benefits of therapy may not outweigh the risk of toxicity. Orally, scopolia root acts on the central nervous system and can cause dry mouth, dry and reddened skin, hyperthermia, disturbance of ocular accommodation, tachycardia, difficulty urinating, glaucoma attacks (2), and constipation (18).”

    Scopolia · Natural Medicines adverse-effect record, reported in arrhythmia.

    2 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    “Orally, adverse effects of scopolia are generally related to the central nervous system. Scopolia root can cause dry mouth, dry and reddened skin, hyperthermia, disturbance of ocular accommodation, tachycardia, difficulty urinating, glaucoma attacks (2), and constipation (18). Early symptoms of scopolia poisoning include reddened skin, dry mouth, and tachycardic arrhythmias (18).”

    Scopolia · Natural Medicines adverse-effect record, reported in arrhythmia.

    2 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Paliperidone

    Listed in the ADVERSE REACTIONS section of the FDA label for Paliperidone. Read the label on DailyMed ›

  • A fast or pounding heartbeat / Anxiety or restlessness / Constipation Additional detail

    Scopolia

    Recorded for Scopolia in the same Natural Medicines adverse-effect record shown under Hallucinations above.

    Paliperidone

    Listed in the ADVERSE REACTIONS section of the FDA label for Paliperidone. Read the label on DailyMed ›

Reported for Scopolia but not commonly for Paliperidone: trouble passing urine, dry mouth and confusion.

Effects for Paliperidone come from the ADVERSE REACTIONS section of its FDA label; effects for Scopolia come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 52,996 voluntary FDA FAERS reports for Paliperidone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Scopolia in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When the root or rhizome is used orally as a medicine; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Scopolia or Paliperidone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Scopolia or Paliperidone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Paliperidone

This page covers Scopolia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Paliperidone page lists 64 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 9 major · 44 moderate · 11 minor.

From our pharmacist’s overview on the Paliperidone page

“Paliperidone (Invega) is an antipsychotic for schizophrenia and related conditions that can stretch the heart's QT interval on its own, so this list warrants real vigilance. Nine of the 64 ingredients on file carry a major rating, and most either prolong that QT interval further (grapefruit in large amounts is one of them) or intensify…”

Reviewed by 2 · Jul 18, 2026

Open the Paliperidone interaction page

How much people look this up

Where Scopolia and Paliperidone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Scopolia
Steady interest

#1,097 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Paliperidone
Steady interest

#1,930 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Scopolia reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Scopolia and Paliperidone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Scopolia

What is Scopolia?

Scopolia
  • Stomach and intestinal cramps
  • Motion sickness
  • Spasms and colic
  • Excess saliva or secretions
  • Pain relief (traditional)

Scopolia is a poisonous plant in the nightshade family that contains powerful anticholinergic alkaloids like atropine, hyoscyamine, and scopolamine. While these compounds are used in carefully measured prescription medicines, the raw plant is dangerous for self-treatment and should never be used without a doctor's supervision.

Scopolia carniolica · Solanaceae · Rhizome (root) and leaves · Standardized extracts, tinctures, and as a source for isolated alkaloid drugs (rarely sold as a stand-alone supplement)

An interaction check asks whether these two react with each other — it does not ask whether Scopolia is a good idea for someone in your situation. Here is what our Scopolia record says about it on its own.

Scopolia: dosing

There is no established safe over-the-counter dose of Scopolia for self-care. Because the plant contains powerful and toxic alkaloids, even small differences in amount can be the difference between an effect and a poisoning.The purified alkaloids found in Scopolia are dosed precisely in prescription products by trained professionals. When in doubt, do not use it.

From our Scopolia monograph — the full record covers uses, side effects and every documented interaction.

Read the full Scopolia monograph & all interactions
Medication

About Paliperidone

What Is Paliperidone Used For?

Brand name: Invega

Paliperidone treats schizophrenia and schizoaffective disorder. The extended-release tablets (Invega and generic paliperidone) are approved for schizophrenia in adults and adolescents ages 12–17, and for schizoaffective disorder in adults.

Several injectable formulations are also available, each with specific roles. Invega Sustenna and Erzofri extended-release are once-monthly injections approved for schizophrenia and schizoaffective disorder in adults. Invega Trinza is a once-every-3-month injection for schizophrenia in adults who have already been stabilized on a once-monthly paliperidone palmitate injection for at least four months. Invega Hafyera is a once-every-6-month injection for schizophrenia in adults already stabilized on a once-monthly or every-3-month paliperidone palmitate injection.

Most-Reported Side Effects for Paliperidone

From FAERS, the FDA’s public side-effect reporting system (52,996 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Injury 4,361 reports
Gynaecomastia 4,232 reports
Weight increased 2,843 reports
Hospitalisation 2,188 reports
Abnormal weight gain 1,828 reports
See full Paliperidone drug information
Keep checking

Other Drugs & Scopolia

Browse every other medication we’ve checked against Scopolia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

200Major
0Moderate
0Minor
2,629No known interaction
200 Major 2,629 No interaction
Major

200 interactions

Showing 60 of 200 major interactions — see all 200 on the Scopolia page.

No interaction 2,629 drugs checked — show the list

We also checked Scopolia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,629 medications checked with no known interaction — see the full Scopolia list.

See the full Scopolia interactions page
See every supplement checked against Paliperidone, ranked by severity
Evidence & sources

Scopolia References

The 4 references that drive our Scopolia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  4. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Scopolia and Paliperidone Together: Common Questions

Is it safe to take Scopolia with Paliperidone?
We do not list a known interaction between Scopolia and Paliperidone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Scopolia and Paliperidone have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Scopolia and Paliperidone combination checked?
Interactions in our licensed database are recorded against drug classes. Paliperidone is filed under 5 classifications, and Scopolia has documented interactions with 3 drug classes — none of Paliperidone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Scopolia interact with any other medications?
Yes. Scopolia has 200 documented drug interactions in our database — Paliperidone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Paliperidone interact with any supplements?
Yes. Paliperidone has documented interactions with 64 supplements in our database — Scopolia is not one of them. The Paliperidone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Scopolia monograph Uses, safety profile, and every drug interaction in one place Paliperidone drug information The full plain-English guide to this medication Paliperidone supplement interactions Every supplement checked against Paliperidone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Paliperidone and Scopolia?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.