Drug & supplement interaction

Scopolia + Lofepramine

Lofepramine brand names: Feprapax, Lomont, Gamanil, Tymelyt.

Major Interaction
Medically reviewed by · Updated September 2026
The bottom line Major

Lofepramine falls into 2 drug categories that Scopolia can interact with; the most serious is rated major. The alkaloid constituents of scopolia, including hyoscyamine, scopolamine, and atropine, could potentiate the effects and adverse effects of anticholinergic drugs.

Read the full interaction report
SeverityMajor
LikelihoodProbable
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Scopolia and Lofepramine

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Scopolia interacts with whole categories of medication. Lofepramine falls into 2 of those categories, so it can interact with Scopolia in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Major).

Major

ANTICHOLINERGIC DRUGS

1 of 2

Why this applies to Lofepramine

Lofepramine falls under ANTICHOLINERGIC DRUGS — the group Scopolia interacts with.

The alkaloid constituents of scopolia, including hyoscyamine, scopolamine, and atropine, could potentiate the effects and adverse effects of anticholinergic drugs.
Severity Major Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: Lofepramine is a tricyclic antidepressant, and like others in its family it already has some anticholinergic activity of its own. That means it can cause things like a dry mouth, blurred vision, constipation, trouble emptying the bladder, and a faster heartbeat. Scopolia is loaded with strong anticholinergic alkaloids (atropine, hyoscyamine, scopolamine), so stacking the two together can pile those effects on top of each other.

The concern here is mostly theoretical, based on how these compounds work rather than detailed studies, but it makes sense biologically and the plant itself is genuinely toxic. Combining them could mean more pronounced dryness, confusion (especially in older folks), or urinary and heart issues. Please don't add Scopolia to your routine without checking with your doctor or pharmacist first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
Major

TRICYCLIC ANTIDEPRESSANTS (TCAs)

2 of 2

Lofepramine also falls under TRICYCLIC ANTIDEPRESSANTS (TCAs).

Concomitant use of TCAs with scopolia can increase the risk for anticholinergic effects and adverse effects.
Severity Major Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to keep in mind: Lofepramine is a tricyclic antidepressant, and these medicines already have their own built-in anticholinergic effects. Scopolia is loaded with strong anticholinergic alkaloids (atropine, hyoscyamine, scopolamine). When you stack the two, you're essentially doubling up on the same kind of effect, and that's where trouble can start.

Realistically, you might notice more dry mouth, constipation, blurry vision, trouble urinating, a racing heartbeat, confusion, or feeling overheated. In older adults especially, that combination can tip into confusion or a dangerous heart rhythm. This warning is based on how these drugs work rather than hard human studies, but the logic is sound and the alkaloids in Scopolia are no joke. Please don't combine them without checking with your doctor or pharmacist first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Scopolia Also Interacts With Other Medications

Scopolia has 199 major, known drug interactions in our database — the Lofepramine one above is among them. If you take anything else, check it against the full list below.

Major 199 No known interaction 2,631 (incl. Lofepramine)
Taking anything else?

Check Another of Your Medications Against Scopolia

Covers the 2,830 medications we’ve checked against Scopolia. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Lofepramine

This page covers Scopolia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lofepramine page lists 244 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), American Hellebore (major), Arsenic (major) and Beer (major).

By severity: 15 major · 190 moderate · 39 minor.

Open the Lofepramine interaction page

How much people look this up

Where Scopolia and Lofepramine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Scopolia
Steady interest

#1,051 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lofepramine
Steady interest

#1,926 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Scopolia

What is Scopolia?

Scopolia
  • Stomach and intestinal cramps
  • Motion sickness
  • Spasms and colic
  • Excess saliva or secretions
  • Pain relief (traditional)

Scopolia is a poisonous plant in the nightshade family that contains powerful anticholinergic alkaloids like atropine, hyoscyamine, and scopolamine. While these compounds are used in carefully measured prescription medicines, the raw plant is dangerous for self-treatment and should never be used without a doctor's supervision.

Read the full Scopolia monograph & all interactions
Keep checking

Other Drugs & Scopolia

Browse every other medication we’ve checked against Scopolia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

199Major
0Moderate
0Minor
2,630No known interaction
199 Major 2,630 No interaction
Major

199 interactions

Showing 60 of 199 major interactions — see all 199 on the Scopolia page.

No interaction 2,630 drugs checked — show the list

We also checked Scopolia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,630 medications checked with no known interaction — see the full Scopolia list.

See the full Scopolia interactions page
See every supplement checked against Lofepramine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
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Pharmacist Counseling Corner

Taking Scopolia and Lofepramine Together: Common Questions

Can you take Scopolia with Lofepramine?
This is rated a major interaction, so the combination is best avoided unless your doctor or pharmacist has specifically told you otherwise. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Scopolia and Lofepramine?
Lofepramine belongs to more than one drug category, and Scopolia interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Scopolia and Lofepramine interaction?
We rate it Major. This is a clinically significant combination that is generally best avoided, or used only under the direct supervision of your physician or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.