Drug & supplement interaction

Sea Buckthorn + Talazoparib

Talazoparib brand name: Talzenna.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Sea Buckthorn and Talazoparib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Sea Buckthorn and Talazoparib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Talazoparib and Sea Buckthorn in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sea Buckthorn safety at a glance

Sea Buckthorn overall Use caution Generally well tolerated as a food, but supplement safety has not been fully studied.

Pregnancy Use caution Food amounts are likely fine, but supplement doses are not well studied, so use caution and ask your doctor.

Breastfeeding Use caution Not enough reliable safety data on supplement use while breastfeeding; use caution.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Talazoparib and Sea Buckthorn? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Talazoparib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Talazoparib is filed under 2 classifications — p-glycoprotein substrates, oral drugs. Sea Buckthorn has documented interactions with 2 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate) and antihypertensive drugs (moderate) — and none of Talazoparib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Sea Buckthorn Does Interact With Other Medications

Sea Buckthorn has 289 moderate known drug interactions in our database — Talazoparib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 289 No known interaction 2,541 (incl. Talazoparib)

Taking anything else?

Check Another of Your Medications Against Sea Buckthorn

Covers the 2,830 medications we’ve checked against Sea Buckthorn. Pick one to open its full report.

What to actually watch for

What Sea Buckthorn Itself Has Been Linked To

This is not an interaction — nothing below involves Talazoparib. It is the side-effect record for Sea Buckthorn on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Sea Buckthorn, this list is the first place to look.

Itching / A skin rash Additional detail
“Orally, high doses of sea buckthorn may cause yellow staining of the skin. One case of generalized yellow skin has been reported for a patient who consumed sea buckthorn 100 grams daily for 6 months. Topically, sea buckthorn oil has been associated with dryness, irritation, redness, and rash. Rash occurred in 4% of patients in one clinical study.”

Sea Buckthorn · Natural Medicines adverse-effect record, reported in pruritus.
4 sources cited

74072. Grad, S. C., Muresan, I., and Dumitrascu, D. L. Generalized yellow skin caused by high intake of sea buckthorn. Forsch.Komplementmed. 2012;19(3):153-156. PubMed

74077. Vlasov, V. V. [Hippophae oil in the treatment of superficial skin burns]. Vestn.Dermatol Venerol. 1970;44(6):69-72.

102845. Larmo P, Järvinen R, Laihia J, et al. Effects of a sea buckthorn oil spray emulsion on dry eye. Cont Lens Anterior Eye. 2019;42(4):428-433. PubMed

106089. De Seta F, Caruso S, Di Lorenzo G, Romano F, Mirandola M, Nappi RE. Efficacy and safety of a new vaginal gel for the treatment of symptoms associated with vulvovaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled study. Ma PubMed

Everything above comes from the Natural Medicines adverse-effect record for Sea Buckthorn — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Talazoparib’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Talazoparib column appears here.

Overlapping uses

What Talazoparib Is Prescribed For, and What Sea Buckthorn Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Talazoparib is a prescription medicine with approved uses on its FDA label. Sea Buckthorn is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Talazoparib is prescribed for: Talzenna (talazoparib) is used as a single agent to treat adults with HER2-negative locally advanced or metastatic breast cancer who carry a germline BRCA mutation (an inherited change in a DNA-repair gene). Patients must be selected for this use based on an FDA-approved test. Talzenna is also used in combination with another medicine called enzalutamide to treat adults with metastatic castration-resistant prostate cancer (mCRPC — prostate cancer that has spread and no longer responds to standard hormone therapy) whose tumors have mutations in homologous recombination repair (HRR) genes involved in DNA repair.

Sea Buckthorn has been studied for:

Cancer studied, not established Sea Buckthorn has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Sea Buckthorn for cancer

Although there is interest in using oral sea buckthorn for reducing morbidity related to cancer and side effects related to chemotherapy, there is insufficient reliable information about the clinical effects of sea buckthorn for these uses.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Talazoparib on your own; if you are taking Sea Buckthorn for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Talazoparib

This page covers Sea Buckthorn only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Talazoparib page lists 54 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), St. John's Wort (major), Bitter Melon (moderate), Black Pepper (moderate) and Bulbine Natalensis (moderate).

By severity: 2 major · 35 moderate · 17 minor.

From our pharmacist’s overview on the Talazoparib page

“Talazoparib (Talzenna) treats certain BRCA-mutated cancers, and with a drug doing that job I want its blood level exactly where the oncologist set it. The 54 supplements on this list mostly threaten that in one of two ways.”

Reviewed by 2 · Jul 18, 2026

Open the Talazoparib interaction page

One more smart check

Taking Sea Buckthorn as Part of a Dietary Supplement Product? Check It for Interactions

We hold 253 real supplement products containing Sea Buckthorn, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sea Buckthorn. Even though Sea Buckthorn itself has no known interaction with Talazoparib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Sea Buckthorn and Talazoparib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sea Buckthorn

Top half

#470 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Talazoparib

Steady interest

#2,538 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sea Buckthorn reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Sea Buckthorn and Talazoparib records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Sea Buckthorn

What is Sea Buckthorn?

Skin health and dryness
Dry eye symptoms
Digestive complaints
Heart and cholesterol support
General antioxidant and immune support

Sea buckthorn is a berry-bearing shrub rich in vitamins, carotenoids, and fatty acids that people use for skin, eye, digestive, and heart health. Early research is promising for a few uses like dry skin and dry eye, but most claims are not yet proven. It is generally well tolerated as a food, but talk to your pharmacist before using concentrated supplements.

Hippophae rhamnoides · Elaeagnaceae · Berries (fruit), seeds, seed and fruit oil, and sometimes leaves · Capsules, softgels, oil (seed or fruit), juice, powder, teas, topical creams and ointments

An interaction check asks whether these two react with each other — it does not ask whether Sea Buckthorn is a good idea for someone in your situation. Here is what our Sea Buckthorn record says about it on its own.

Sea Buckthorn: dosing

There is no official or standardized dose of sea buckthorn. The right amount depends on the product, its form (oil, capsule, juice, or powder), and how it is concentrated.The best approach is to follow the directions on the product label and not exceed the recommended amount.

From our Sea Buckthorn monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sea Buckthorn monograph & all interactions

Medication

About Talazoparib

What Is Talazoparib Used For?

Brand name: Talzenna

Talzenna (talazoparib) is used as a single agent to treat adults with HER2-negative locally advanced or metastatic breast cancer who carry a germline BRCA mutation (an inherited change in a DNA-repair gene). Patients must be selected for this use based on an FDA-approved test.

Talzenna is also used in combination with another medicine called enzalutamide to treat adults with metastatic castration-resistant prostate cancer (mCRPC — prostate cancer that has spread and no longer responds to standard hormone therapy) whose tumors have mutations in homologous recombination repair (HRR) genes involved in DNA repair.

Most-Reported Side Effects for Talazoparib

From FAERS, the FDA’s public side-effect reporting system (1,763 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Anemia 273 reports

Neoplasm progression 171 reports

Fatigue 123 reports

Thrombocytopenia 95 reports

Haemoglobin decreased 80 reports

See full Talazoparib drug information

Keep checking

Other Drugs & Sea Buckthorn

Browse every other medication we’ve checked against Sea Buckthorn — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

289Moderate

0Minor

2,540No known interaction

289 Moderate 2,540 No interaction

Moderate

289 interactions

Showing 60 of 289 moderate interactions — see all 289 on the Sea Buckthorn page.

No interaction 2,540 drugs checked — show the list

We also checked Sea Buckthorn against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,540 medications checked with no known interaction — see the full Sea Buckthorn list.

See the full Sea Buckthorn interactions page

See every supplement checked against Talazoparib, ranked by severity

Evidence & sources

Sea Buckthorn References

The 7 references that drive our Sea Buckthorn monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Johansson AK, Korte H, Yang B, et al. Sea buckthorn berry oil inhibits platelet aggregation. J Nutr Biochem 2000;11:491-5.. PubMed
Grad, S. C., Muresan, I., and Dumitrascu, D. L. Generalized yellow skin caused by high intake of sea buckthorn. Forsch.Komplementmed. 2012;19(3):153-156. PubMed
Vlasov, V. V. [Hippophae oil in the treatment of superficial skin burns]. Vestn.Dermatol Venerol. 1970;44(6):69-72.
Chang BB, Wang F Xu TY Zhang QQ He J Zhang XJ Li J. Total flavones of Hippophae rhamnoides L. for essential hypertension: a systematic review of randomized controlled trials. Chinese Journal of Evidence-Based Medicine. 2009;9(11):1207-1213. DOI
Olas B, Kontek B, Szczesna M, et al. Inhibition of blood platelet adhesion by phenolics rich fraction of Hippophae rhamnoides L. fruits. J Physiol Pharmacol. 2017;68(2):223-9.
Larmo P, Järvinen R, Laihia J, et al. Effects of a sea buckthorn oil spray emulsion on dry eye. Cont Lens Anterior Eye. 2019;42(4):428-433. PubMed
De Seta F, Caruso S, Di Lorenzo G, Romano F, Mirandola M, Nappi RE. Efficacy and safety of a new vaginal gel for the treatment of symptoms associated with vulvovaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled study. Ma PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Sea Buckthorn and Talazoparib Together: Common Questions

Is it safe to take Sea Buckthorn with Talazoparib?

We do not list a known interaction between Sea Buckthorn and Talazoparib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Are Sea Buckthorn and Talazoparib used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Sea Buckthorn in each. That is a conversation for your prescriber, especially if Talazoparib is being adjusted to a target.

How was the Sea Buckthorn and Talazoparib combination checked?

Interactions in our licensed database are recorded against drug classes. Talazoparib is filed under 2 classifications, and Sea Buckthorn has documented interactions with 2 drug classes — none of Talazoparib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Sea Buckthorn interact with any other medications?

Yes. Sea Buckthorn has 289 documented drug interactions in our database — Talazoparib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Talazoparib interact with any supplements?

Yes. Talazoparib has documented interactions with 54 supplements in our database — Sea Buckthorn is not one of them. The Talazoparib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Sea Buckthorn monograph Uses, safety profile, and every drug interaction in one place Talazoparib drug information The full plain-English guide to this medication Talazoparib supplement interactions Every supplement checked against Talazoparib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Talazoparib and Sea Buckthorn?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.