Drug & supplement interaction

Sea Buckthorn + Trastuzumab

Trastuzumab brand name: Herceptin.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Sea Buckthorn and Trastuzumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Sea Buckthorn and Trastuzumab

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Trastuzumab and Sea Buckthorn in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sea Buckthorn safety at a glance

Sea Buckthorn overall Use caution Generally well tolerated as a food, but supplement safety has not been fully studied.

Pregnancy Use caution Food amounts are likely fine, but supplement doses are not well studied, so use caution and ask your doctor.

Breastfeeding Use caution Not enough reliable safety data on supplement use while breastfeeding; use caution.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Trastuzumab and Sea Buckthorn? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

Keep it in perspective

Sea Buckthorn Does Interact With Other Medications

Sea Buckthorn has 289 moderate known drug interactions in our database — Trastuzumab isn’t one of them. If you take anything else, check it against the full list below.

Moderate 289 No known interaction 2,541 (incl. Trastuzumab)

Taking anything else?

Check Another of Your Medications Against Sea Buckthorn

Covers the 2,830 medications we’ve checked against Sea Buckthorn. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Sea Buckthorn and Trastuzumab May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

Itching / A skin rash Additional detail
Sea Buckthorn
“Orally, high doses of sea buckthorn may cause yellow staining of the skin. One case of generalized yellow skin has been reported for a patient who consumed sea buckthorn 100 grams daily for 6 months. Topically, sea buckthorn oil has been associated with dryness, irritation, redness, and rash. Rash occurred in 4% of patients in one clinical study.”

Sea Buckthorn · Natural Medicines adverse-effect record, reported in pruritus.
4 sources cited

74072. Grad, S. C., Muresan, I., and Dumitrascu, D. L. Generalized yellow skin caused by high intake of sea buckthorn. Forsch.Komplementmed. 2012;19(3):153-156. PubMed

74077. Vlasov, V. V. [Hippophae oil in the treatment of superficial skin burns]. Vestn.Dermatol Venerol. 1970;44(6):69-72.

102845. Larmo P, Järvinen R, Laihia J, et al. Effects of a sea buckthorn oil spray emulsion on dry eye. Cont Lens Anterior Eye. 2019;42(4):428-433. PubMed

106089. De Seta F, Caruso S, Di Lorenzo G, Romano F, Mirandola M, Nappi RE. Efficacy and safety of a new vaginal gel for the treatment of symptoms associated with vulvovaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled study. Ma PubMed
Trastuzumab

Listed in the ADVERSE REACTIONS section of the FDA label for Trastuzumab. Read the label on DailyMed ›

Effects for Trastuzumab come from the ADVERSE REACTIONS section of its FDA label; effects for Sea Buckthorn come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 86,493 voluntary FDA FAERS reports for Trastuzumab that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Trastuzumab Is Prescribed For, and What Sea Buckthorn Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Trastuzumab is a prescription medicine with approved uses on its FDA label. Sea Buckthorn is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Trastuzumab is prescribed for: Trastuzumab injection is used in adults to treat certain cancers that overexpress the HER2 protein. For breast cancer, it is used as adjuvant (after-surgery) treatment for early-stage HER2-positive breast cancer, in combination with certain chemotherapy regimens, as well as for metastatic (spread) HER2-positive breast cancer — either with paclitaxel as a first-line treatment or as a single agent after prior chemotherapy. Ontruzant is also indicated in adults for treatment of HER2-overexpressing metastatic gastric or gastroesophageal junction adenocarcinoma (a type of stomach or esophageal junction cancer), in combination with cisplatin and capecitabine or 5-fluorouracil, for patients who have not received prior treatment for metastatic disease. Patients must be selected based on FDA-approved HER2 testing before starting therapy.

Sea Buckthorn has been studied for:

Cancer studied, not established Sea Buckthorn has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Sea Buckthorn for cancer

Although there is interest in using oral sea buckthorn for reducing morbidity related to cancer and side effects related to chemotherapy, there is insufficient reliable information about the clinical effects of sea buckthorn for these uses.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Trastuzumab on your own; if you are taking Sea Buckthorn for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

One more smart check

Taking Sea Buckthorn as Part of a Dietary Supplement Product? Check It for Interactions

We hold 253 real supplement products containing Sea Buckthorn, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Sea Buckthorn. Even though Sea Buckthorn itself has no known interaction with Trastuzumab, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Sea Buckthorn and Trastuzumab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sea Buckthorn

Top half

#375 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Trastuzumab

Top half

#890 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sea Buckthorn reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Sea Buckthorn and Trastuzumab records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Sea Buckthorn

What is Sea Buckthorn?

Skin health and dryness
Dry eye symptoms
Digestive complaints
Heart and cholesterol support
General antioxidant and immune support

Sea buckthorn is a berry-bearing shrub rich in vitamins, carotenoids, and fatty acids that people use for skin, eye, digestive, and heart health. Early research is promising for a few uses like dry skin and dry eye, but most claims are not yet proven. It is generally well tolerated as a food, but talk to your pharmacist before using concentrated supplements.

Hippophae rhamnoides · Elaeagnaceae · Berries (fruit), seeds, seed and fruit oil, and sometimes leaves · Capsules, softgels, oil (seed or fruit), juice, powder, teas, topical creams and ointments

An interaction check asks whether these two react with each other — it does not ask whether Sea Buckthorn is a good idea for someone in your situation. Here is what our Sea Buckthorn record says about it on its own.

Sea Buckthorn: dosing

There is no official or standardized dose of sea buckthorn. The right amount depends on the product, its form (oil, capsule, juice, or powder), and how it is concentrated.The best approach is to follow the directions on the product label and not exceed the recommended amount.

From our Sea Buckthorn monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sea Buckthorn monograph & all interactions

Medication

About Trastuzumab Injection

What Is Trastuzumab Injection Used For?

Brand name: Herceptin

Trastuzumab injection is used in adults to treat certain cancers that overexpress the HER2 protein. For breast cancer, it is used as adjuvant (after-surgery) treatment for early-stage HER2-positive breast cancer, in combination with certain chemotherapy regimens, as well as for metastatic (spread) HER2-positive breast cancer — either with paclitaxel as a first-line treatment or as a single agent after prior chemotherapy.

Ontruzant is also indicated in adults for treatment of HER2-overexpressing metastatic gastric or gastroesophageal junction adenocarcinoma (a type of stomach or esophageal junction cancer), in combination with cisplatin and capecitabine or 5-fluorouracil, for patients who have not received prior treatment for metastatic disease. Patients must be selected based on FDA-approved HER2 testing before starting therapy.

Most-Reported Side Effects for Trastuzumab

From FAERS, the FDA’s public side-effect reporting system (88,598 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 7,825 reports

Nausea 6,098 reports

Fatigue 5,551 reports

Alopecia 5,432 reports

Disease progression 4,960 reports

See full Trastuzumab Injection drug information

Keep checking

Other Drugs & Sea Buckthorn

Browse every other medication we’ve checked against Sea Buckthorn — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

289Moderate

0Minor

2,540No known interaction

289 Moderate 2,540 No interaction

Moderate

289 interactions

Showing 60 of 289 moderate interactions — see all 289 on the Sea Buckthorn page.

No interaction 2,540 drugs checked — show the list

We also checked Sea Buckthorn against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,540 medications checked with no known interaction — see the full Sea Buckthorn list.

See the full Sea Buckthorn interactions page

See every supplement checked against Trastuzumab, ranked by severity

Evidence & sources

Sea Buckthorn References

The 7 references that drive our Sea Buckthorn monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Johansson AK, Korte H, Yang B, et al. Sea buckthorn berry oil inhibits platelet aggregation. J Nutr Biochem 2000;11:491-5.. PubMed
Grad, S. C., Muresan, I., and Dumitrascu, D. L. Generalized yellow skin caused by high intake of sea buckthorn. Forsch.Komplementmed. 2012;19(3):153-156. PubMed
Vlasov, V. V. [Hippophae oil in the treatment of superficial skin burns]. Vestn.Dermatol Venerol. 1970;44(6):69-72.
Chang BB, Wang F Xu TY Zhang QQ He J Zhang XJ Li J. Total flavones of Hippophae rhamnoides L. for essential hypertension: a systematic review of randomized controlled trials. Chinese Journal of Evidence-Based Medicine. 2009;9(11):1207-1213. DOI
Olas B, Kontek B, Szczesna M, et al. Inhibition of blood platelet adhesion by phenolics rich fraction of Hippophae rhamnoides L. fruits. J Physiol Pharmacol. 2017;68(2):223-9.
Larmo P, Järvinen R, Laihia J, et al. Effects of a sea buckthorn oil spray emulsion on dry eye. Cont Lens Anterior Eye. 2019;42(4):428-433. PubMed
De Seta F, Caruso S, Di Lorenzo G, Romano F, Mirandola M, Nappi RE. Efficacy and safety of a new vaginal gel for the treatment of symptoms associated with vulvovaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled study. Ma PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Sea Buckthorn and Trastuzumab Together: Common Questions

Is it safe to take Sea Buckthorn with Trastuzumab?

We do not list a known interaction between Sea Buckthorn and Trastuzumab. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Sea Buckthorn and Trastuzumab have any of the same side effects?

Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

Are Sea Buckthorn and Trastuzumab used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Sea Buckthorn in each. That is a conversation for your prescriber, especially if Trastuzumab is being adjusted to a target.

Does Sea Buckthorn interact with any other medications?

Yes. Sea Buckthorn has 289 documented drug interactions in our database — Trastuzumab is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Sea Buckthorn monograph Uses, safety profile, and every drug interaction in one place Trastuzumab Injection drug information The full plain-English guide to this medication Trastuzumab supplement interactions Every supplement checked against Trastuzumab, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Trastuzumab and Sea Buckthorn?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.