Secretin + Rifapentine
Rifapentine brand name: Priftin.
We found no known interaction between Secretin and Rifapentine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Rifapentine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Secretin and Rifapentine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Rifapentine and Secretin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Secretin at all — not against Rifapentine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Secretin safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Rifapentine Products Have a Food Rule — Secretin Should Not Break It
At least one FDA label for a product containing Rifapentine says to take it with food. If you take Secretin on an empty stomach out of habit, keep them separate — and take Rifapentine with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Rifapentine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
( 2.2 ) Take with food.
From the Dosage and Administration section of the FDA label we read for Rifapentine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Rifapentine
This page covers Secretin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Rifapentine page lists 64 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Alkanna (moderate), Alpine Ragwort (moderate), Bacillus Coagulans (moderate) and Bacillus Subtilis (moderate).
By severity: 1 major · 53 moderate · 10 minor.
From our pharmacist’s overview on the Rifapentine page
“Rifapentine (Priftin) treats tuberculosis and is often dosed just once or twice a week, so a single blunted dose costs more than it would with a daily pill. That is why I read this list of 64 interacting supplements as a real warning rather than routine fine print.”
Reviewed by 2 · Jul 18, 2026
Where Secretin and Rifapentine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#833 of 1,452 supplements looked up here in the last 7 days
#2,107 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Secretin reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Secretin and Rifapentine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Secretin
What is Secretin?
- Diagnostic testing of pancreas function
- Diagnosing gastrinoma (Zollinger-Ellison syndrome)
- Aiding pancreatic imaging procedures
- Investigational use in autism (not proven)
Secretin is a natural digestive hormone, not a typical dietary supplement. As a medicine it is an FDA-approved injectable used mainly for diagnostic tests of the pancreas, and it must be given by a healthcare professional. Despite past interest, there is strong evidence that secretin does NOT help autism, and it should never be self-administered.
Hormone produced naturally in the small intestine; pharmaceutical versions are made synthetically or from animal sources · Injectable solution (prescription, used in medical settings)
An interaction check asks whether these two react with each other — it does not ask whether Secretin is a good idea for someone in your situation. Here is what our Secretin record says about it on its own.
Secretin: dosing
There is no general supplement dose for secretin because it is not used as a supplement. It is a prescription injectable, and the dose is calculated by your healthcare provider based on your body and the specific test being done.You should never try to obtain or self-administer secretin. Dosing, timing, and monitoring are all handled by trained medical staff during a procedure.
From our Secretin monograph — the full record covers uses, side effects and every documented interaction.
About Rifapentine
What Is Rifapentine Used For?
Brand name: Priftin
Rifapentine (brand name Priftin) is used to treat two forms of tuberculosis (TB) caused by Mycobacterium tuberculosis. For active pulmonary TB — an active infection in the lungs — it is approved for patients 12 years and older, always used alongside other TB medicines, never alone. For latent TB infection (LTBI) — where the bacteria are in the body but not causing active illness — it is approved for patients 2 years and older who are at high risk of the infection becoming active, always combined with isoniazid.
Priftin is not appropriate for every TB situation. It should not be used alone at any stage of active TB treatment, and it is not recommended as a once-weekly continuation regimen combined with isoniazid in people living with HIV who have active pulmonary TB, due to a higher risk of treatment failure or relapse.
Most-Reported Side Effects for Rifapentine
From FAERS, the FDA’s public side-effect reporting system (509 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Secretin
Browse every other medication we’ve checked against Secretin — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Secretin against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Abemaciclib ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Valacyclovir ›
- Ibuprofen ›
- Methamphetamine ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Bupropion ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Acyclovir ›
- Amitriptyline ›
- Methotrexate ›
- Doxycycline ›
- Fluoxetine ›
- Amphetamine ›
- Lamotrigine ›
- Acetaminophen, Codeine ›
- Pregabalin ›
- Gabapentin ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Methylene Blue ›
- Clonazepam ›
- Omeprazole ›
- Amlodipine Besylate ›
- Quetiapine ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Naproxen ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Secretin list.
Secretin References
The 14 references that drive our Secretin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Horvath K, Stefatos G, Sokolski KN. Improved social and language skills after secretin administration. J Assoc Acad Minor Phys 1998;9:9-15.
- Tympner F, Rosch W. The treatment of chronic recurrent pancreatitis with depot secretin-a preliminary report. Hepatogastroenterology 1986;33:159-62.
- Coniglio SJ, Lewis JD, Lang C, et al. A randomized, double-blind, placebo-controlled trial of single-dose intravenous secretin as treatment for children with autism. J Pediatr 2001;138:649-55. PubMed
- Secretin for the treatment of autism. Pharmacist's Letter/Prescriber's Letter 1998;14(12):141212.
- Sandler AD, Sutton KA, DeWeese J, et al. Lack of benefit of a single dose of synthetic human secretin in the treatment of autism and pervasive developmental disorder. N Engl J Med 1999;341(24):1801-6. PubMed
- Lightdale JR, Hayer C, Duer A, et al. Effects of intravenous secretin on language and behavior of children with autism and gastrointestinal symptoms: a single-blinded, open-label pilot study. Pediatrics 2001;108:90. PubMed
- Roberts W, Weaver L, Brian J, et al. Repeated doses of porcine secretin in the treatment of autism: A randomized, placebo-controlled trial. Pediatrics 2001;107:e71. PubMed
- Honomichl RD, Goodlin-Jones BL, Burnham MM, Hansen RL, Anders TF. Secretin and sleep in children with autism. Child Psychiatry Hum Dev. 2002;33(2):107-23. PubMed
- Law R, Vargo JJ, Stevens T. Acute pancreatitis and aspiration pneumonia after administration of synthetic human secretin (with video). Gastrointest Endosc. 2011;74(5):1166-8. PubMed
- Sheitman BB, Knable MB, Jarskog LF, et al. Secretin for refractory schizophrenia. Schizophr Res. 2004;66(2-3):177-81. PubMed
- Levenick JM, Andrews CL, Purich ED, Gordon SR, Gardner TB. A phase II trial of human secretin infusion for refractory type B pain in chronic pancreatitis. Pancreas. 2013;42(4):596-600. PubMed
- Williams K, Wray JA, Wheeler DM. Intravenous secretin for autism spectrum disorders (ASD). Cochrane Database Syst Rev. 2012;2012(4):CD003495. PubMed
- Brandler J, Miller LJ, Wang XJ, et al. Secretin effects on gastric functions, hormones and symptoms in functional dyspepsia and health: randomized crossover trial. Am J Physiol Gastrointest Liver Physiol 2020;318(4):G635-G645. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Rifapentine Is Linked to Lower Levels of 7 Nutrients
Natural Medicines records Rifapentine as a medicine that can lower these. This is not an interaction with Secretin — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Rifapentine nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Secretin and Rifapentine Together: Common Questions
Is it safe to take Secretin with Rifapentine?
Do Secretin and Rifapentine have any of the same side effects?
Should I take Secretin and Rifapentine at the same time of day?
Does Rifapentine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.