Drug & supplement interaction

Silicon + Lonafarnib

Lonafarnib brand name: Zokinvy.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Silicon and Lonafarnib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Lonafarnib states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Silicon and Lonafarnib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lonafarnib and Silicon in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Silicon at all — not against Lonafarnib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Silicon safety at a glance

Silicon overall Use caution Generally well tolerated from food and most supplements, but high-dose or long-term safety is not well studied.
Pregnancy Likely Safe When used orally in amounts commonly found in foods. It is estimated that the average dietary intake of silicon is 20-50 mg daily. There is insufficient reliabl... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in amounts commonly found in foods. It is estimated that the average dietary intake of silicon is 20-50 mg daily. There is insufficient reliabl... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lonafarnib and Silicon? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Silicon and Lonafarnib May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Joint pain Additional detail

    Silicon

    “Orally, silicon in the amounts found in food and water is not associated with adverse effects.

    Serious Adverse Effects (Rare):

    Inhaled: Crystalline silicon dioxide in the form of quartz dust found in industrial and occupational settings is associated with an increased risk of diseases such as silicosis, tuberculosis, chronic bronchitis, chronic obstructive pulmonary disease (COPD), lung cancer, glomerulonephritis, va…”

    Silicon · Natural Medicines adverse-effect record, reported in acute bronchitis.

    “High silicon levels in patients undergoing chronic hemodialysis have been associated with bone disease. A meta-analysis suggests that the risk of rheumatoid arthritis is elevated with occupational exposure to silicon dioxide.”

    Silicon · Natural Medicines adverse-effect record, reported in rheumatoid arthritis (ra).

    2 sources cited
    1. 75089. Jugdaohsingh, R. Silicon and bone health. J Nutr Health Aging 2007;11(2):99-110.
    2. 75078. Khuder, S. A., Peshimam, A. Z., and Agraharam, S. Environmental risk factors for rheumatoid arthritis. Rev Environ Health 2002;17(4):307-315. PubMed

    Lonafarnib

    Listed in the ADVERSE REACTIONS section of the FDA label for Lonafarnib. Read the label on DailyMed ›

Reported for Silicon but not commonly for Lonafarnib: kidney stones.

Effects for Lonafarnib come from the ADVERSE REACTIONS section of its FDA label; effects for Silicon come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Silicon in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in amounts commonly found in foods. It is estimated that the average dietary intake of silicon is 20-50 mg daily. There is insufficient reliable information available about the safety of silicon when used in larger, medicinal amounts; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Lonafarnib Products Have a Food Rule — Silicon Should Not Break It

At least one FDA label for a product containing Lonafarnib says to take it with food. If you take Silicon on an empty stomach out of habit, keep them separate — and take Lonafarnib with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Lonafarnib products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

If a dose is missed, take the dose as soon as possible with food, up to 8 hours prior to the next scheduled dose.

From the Dosage and Administration section of the FDA label we read for Lonafarnib — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Lonafarnib

This page covers Silicon only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lonafarnib page lists 160 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 5 major · 115 moderate · 40 minor.

From our pharmacist’s overview on the Lonafarnib page

“If you or your child takes lonafarnib (Zokinvy) for progeria, treat supplements with real caution. Most of the 160 flagged ingredients cross paths with the CYP3A4 enzyme, the same one that handles lonafarnib, so the traffic runs both ways.”

Reviewed by 2 · Jul 18, 2026

Open the Lonafarnib interaction page

One more smart check

Taking Silicon as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3,151 real supplement products containing Silicon, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Silicon. Even though Silicon itself has no known interaction with Lonafarnib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Silicon and Lonafarnib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Silicon
Top 10%

#74 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lonafarnib
Steady interest

#1,546 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Silicon reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Silicon and Lonafarnib records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Silicon

What is Silicon?

Silicon
  • Hair, skin, and nail health
  • Bone health and osteoporosis
  • Joint and connective tissue support
  • General 'beauty from within' support

Silicon is a trace mineral found in the body and in foods like oats, barley, and certain fruits and vegetables, and it is popular in supplements for hair, skin, nail, and bone health. Some small studies suggest possible benefits for skin and bone, but the overall evidence is limited and not strong. For most healthy people a balanced diet supplies enough silicon, so talk with a pharmacist or doctor before taking a supplement.

Silicon is a mineral element, not a plant part; supplements use silica, silicic acid, or stabilized orthosilicic acid · Capsules, tablets, liquid drops (orthosilicic acid), powders; also found in horsetail and bamboo extracts and as silicon dioxide

An interaction check asks whether these two react with each other — it does not ask whether Silicon is a good idea for someone in your situation. Here is what our Silicon record says about it on its own.

Silicon: dosing

There is no official recommended dose for silicon as a supplement, and an established upper limit has not been clearly set. Doses used in studies have varied widely depending on the form (such as silica, silicic acid, or choline-stabilized orthosilicic acid).Because there is no standard dose, the best advice is to follow the directions on the product label and not exceed them.

From our Silicon monograph — the full record covers uses, side effects and every documented interaction.

Read the full Silicon monograph & all interactions
Medication

About Lonafarnib

What Is Lonafarnib Used For?

Brand name: Zokinvy

Zokinvy (lonafarnib) is approved for patients 12 months of age and older who have a body surface area of 0.39 m² or above. It is used to reduce the risk of mortality in Hutchinson-Gilford Progeria Syndrome (HGPS) — a rare, severe premature-aging disorder.

Zokinvy is also used to treat processing-deficient Progeroid Laminopathies — a related group of rare genetic conditions — specifically those caused by a heterozygous LMNA mutation with progerin-like protein buildup, or by homozygous or compound heterozygous ZMPSTE24 mutations. It is not indicated for other Progeroid Syndromes or processing-proficient Progeroid Laminopathies.

Most-Reported Side Effects for Lonafarnib

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 16 reports
Vomiting 12 reports
Headache 4 reports
Abdominal pain upper 3 reports
Asthenia 3 reports
See full Lonafarnib drug information
Keep checking

Other Drugs & Silicon

Browse every other medication we’ve checked against Silicon — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Silicon against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Silicon list.

See the full Silicon interactions page
See every supplement checked against Lonafarnib, ranked by severity
Evidence & sources

Silicon References

The 19 references that drive our Silicon monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Jugdaohsingh R, Anderson SH, Tucker KL, et al. Dietary silicon intake and absorption. Am J Clin Nutr 2002;75:887-93. PubMed
  3. Ichiyanagi O, Sasagawa I, Adachi Y, et al. Silica urolithiasis without magnesium trisilicate intake. Urol Int 1998;61:39-42. PubMed
  4. Levison DA, Crocker PR, Banim S, Wallace DM. Silica stones in the urinary bladder. Lancet 1982;1:704-5. PubMed
  5. Lee MH, Lee YH, Hsu TH, et al. Silica stone--development due to long time oral trisilicate intake. Scand J Urol Nephrol 1993;27:267-9. PubMed
  6. Cruz Guerra, N. A., Gomez Garcia, M. A., Lovaco, Castellano F., Saez Garrido, J. C., Garcia, Cuerpo E., and Escudero, Barrilero A. [Silica urolithiasis: report of a new case]. Actas Urol.Esp 2000;24(2):202-204.
  7. Merget, R., Bauer, T., Kupper, H. U., Philippou, S., Bauer, H. D., Breitstadt, R., and Bruening, T. Health hazards due to the inhalation of amorphous silica. Arch Toxicol. 2002;75(11-12):625-634. PubMed
  8. Khuder, S. A., Peshimam, A. Z., and Agraharam, S. Environmental risk factors for rheumatoid arthritis. Rev Environ Health 2002;17(4):307-315. PubMed
  9. McLaughlin, J. K., Chow, W. H., and Levy, L. S. Amorphous silica: a review of health effects from inhalation exposure with particular reference to cancer. J Toxicol.Environ Health 4-25-1997;50(6):553-566. DOI
  10. Pelucchi, C., Pira, E., Piolatto, G., Coggiola, M., Carta, P., and La, Vecchia C. Occupational silica exposure and lung cancer risk: a review of epidemiological studies 1996-2005. Ann.Oncol. 2006;17(7):1039-1050. PubMed
  11. Gillissen, A., Gessner, C., Hammerschmidt, S., Hoheisel, G., and Wirtz, H. [Health significance of inhaled particles]. Dtsch.Med Wochenschr. 3-24-2006;131(12):639-644.
  12. Hu, J. F., Qu, H., and Wang, J. Z. [Meta analysis for relationship between exposure of free silicon dioxide and lung tumor]. Zhonghua Lao.Dong.Wei Sheng Zhi.Ye.Bing.Za Zhi. 2006;24(7):415-417.
  13. Jugdaohsingh, R. Silicon and bone health. J Nutr Health Aging 2007;11(2):99-110.
  14. Lacasse, Y., Martin, S., Gagne, D., and Lakhal, L. Dose-response meta-analysis of silica and lung cancer. Cancer Causes Control 2009;20(6):925-933. PubMed
  15. McCormic, Z. D., Khuder, S. S., Aryal, B. K., Ames, A. L., and Khuder, S. A. Occupational silica exposure as a risk factor for scleroderma: a meta-analysis. Int Arch Occup.Environ Health 2010;83(7):763-769. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Silicon and Lonafarnib Together: Common Questions

Is it safe to take Silicon with Lonafarnib?
We do not list a known interaction between Silicon and Lonafarnib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Silicon and Lonafarnib have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Silicon and Lonafarnib at the same time of day?
At least one FDA label for a product containing Lonafarnib says to take it with food. If you take Silicon on an empty stomach out of habit, keep them separate and take Lonafarnib with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Lonafarnib products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Lonafarnib interact with any supplements?
Yes. Lonafarnib has documented interactions with 160 supplements in our database — Silicon is not one of them. The Lonafarnib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Silicon monograph Uses, safety profile, and every drug interaction in one place Lonafarnib drug information The full plain-English guide to this medication Lonafarnib supplement interactions Every supplement checked against Lonafarnib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 19 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lonafarnib and Silicon?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.