Slippery Elm - Sunosi (Solriamfetol) Interaction
Herbal: Slippery Elm
Also Known As: Indian Elm, Moose Elm, Olmo Americano, Orme, Orme Gras, Orme Rouge, Orme Roux, Red Elm, Sweet Elm, Ulmus rubra
Drug: Solriamfetol
Brand names:
Sunosi
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
Solriamfetol is classified as belonging to the following category: Oral Drugs
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Slippery elm inner bark contains mucilage, which may interfere with the absorption of orally administered drugs.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Slippery Elm Overview
Slippery elm is a type of tree that is native to North America and member of the elm family. It is known for its rough, reddish-brown bark and its slippery inner bark. In traditional medicine, slippery elm has been used to treat a variety of conditions, including sore throats, stomach ulcers, and skin irritations. It is believed to work by forming a protective barrier on the mucous membranes of the digestive and respiratory tracts, which can help to soothe irritation and reduce inflammation.
Solriamfetol Overview
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Solriamfetol is used to treat excessive daytime sleepiness caused by narcolepsy (a condition that causes excessive daytime sleepiness). Solriamfetol is also used along with breathing devices or other treatments to prevent excessive daytime sleepiness caused by obstructive sleep apnea/hypopnea syndrome (OSAHS; a sleep disorder in which the patient briefly stops breathing or breathes shallowly many times during sleep and therefore doesn't get enough restful sleep). Solriamfetol is in a class of medications called wakefulness promoting agents. It works by increasing the amounts of certain natural substances in the brain that controls sleep and wakefulness.
Slippery Elm - More Interactions
Slippery Elm interacts with 1987 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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