Drug & supplement interaction

Stevia + Duvelisib

Duvelisib brand name: Copiktra.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Stevia and Duvelisib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Stevia and Duvelisib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Duvelisib and Stevia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Stevia safety at a glance

Stevia overall Generally safe Purified stevia sweeteners are generally recognized as safe in typical food amounts.
Pregnancy Use caution Purified stevia in food amounts is likely acceptable, but whole-leaf or supplement doses are not well studied, so use caution.
Breastfeeding Use caution Food amounts of purified stevia are probably fine, but high-dose supplements lack safety data, so use caution.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Duvelisib and Stevia? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Duvelisib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Duvelisib is filed under 3 classifications — cytochrome p450 3a4 (cyp3a4) inhibitors, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Stevia has documented interactions with 3 drug classes — the most serious being lithium (moderate), antidiabetes drugs (minor) and antihypertensive drugs (minor) — and none of Duvelisib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Stevia Does Interact With Other Medications

Stevia has 1 moderate, 258 minor known drug interactions in our database — Duvelisib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1 Minor 258 No known interaction 2,571 (incl. Duvelisib)
Taking anything else?

Check Another of Your Medications Against Stevia

Covers the 2,830 medications we’ve checked against Stevia. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Stevia and Duvelisib May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Muscle pain Additional detail

    Stevia

    “Orally, stevia and steviol glycosides may cause myalgia, but this generally resolves after the first week of use.”

    Stevia · Natural Medicines adverse-effect record, reported in myalgia.

    2 sources cited
    1. 11809. Hsieh MH, Chan P, Sue YM, et al. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. Clin Ther 2003;25:2797-808. PubMed
    2. 11810. Chan P, Tomlinson B, Chen YJ, et al. A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin Pharmacol 2000;50:215-20. PubMed

    Duvelisib

    Listed in the ADVERSE REACTIONS section of the FDA label for Duvelisib. Read the label on DailyMed ›

  • Nausea reported in 6.4% of FDA reports for Duvelisib Additional detail

    Stevia

    “Orally, stevia and steviol glycosides such as stevioside, can cause gastrointestinal adverse effects such as abdominal fullness and nausea. However, these generally resolve after the first week of use.”

    Stevia · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    3 sources cited
    1. 11809. Hsieh MH, Chan P, Sue YM, et al. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. Clin Ther 2003;25:2797-808. PubMed
    2. 11810. Chan P, Tomlinson B, Chen YJ, et al. A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin Pharmacol 2000;50:215-20. PubMed
    3. 113005. Almiron-Roig E, Navas-Carretero S, Castelnuovo G, et al. Impact of acute consumption of beverages containing plant-based or alternative sweetener blends on postprandial appetite, food intake, metabolism, and gastro-intestinal symptoms: Results of the SWEE

    Duvelisib

    Listed in the ADVERSE REACTIONS section of the FDA label for Duvelisib, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Headache Additional detail

    Stevia

    “Orally, stevia and steviol glycosides may cause headache, dizziness, and numbness.”

    Stevia · Natural Medicines adverse-effect record, reported in cluster headache.

    2 sources cited
    1. 11809. Hsieh MH, Chan P, Sue YM, et al. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. Clin Ther 2003;25:2797-808. PubMed
    2. 11810. Chan P, Tomlinson B, Chen YJ, et al. A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin Pharmacol 2000;50:215-20. PubMed

    Duvelisib

    Listed in the ADVERSE REACTIONS section of the FDA label for Duvelisib. Read the label on DailyMed ›

Reported for Stevia but not commonly for Duvelisib: an allergic reaction, dizziness, bloating or gas and numbness or tingling.

Effects for Duvelisib come from the ADVERSE REACTIONS section of its FDA label; effects for Stevia come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 765 voluntary FDA FAERS reports for Duvelisib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Duvelisib

This page covers Stevia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Duvelisib page lists 143 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 100 moderate · 40 minor.

From our pharmacist’s overview on the Duvelisib page

“Duvelisib (Copiktra) treats certain blood cancers, and its supplement list deserves genuine care because the body clears it through a single enzyme, CYP3A4. Most of the 143 ingredients either block or speed up that enzyme, which can push duvelisib levels high enough to worsen side effects or low enough to weaken its grip on the cancer.”

Reviewed by 2 · Jul 18, 2026

Open the Duvelisib interaction page

One more smart check

Taking Stevia as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,899 real supplement products containing Stevia, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Stevia. Even though Stevia itself has no known interaction with Duvelisib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Stevia and Duvelisib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Stevia
Top 25%

#158 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Duvelisib
Steady interest

#1,474 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Stevia reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Stevia and Duvelisib records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Stevia

What is Stevia?

  • Sugar substitute / sweetener
  • Blood sugar support in diabetes
  • Weight management
  • Blood pressure support
  • Reducing calorie intake

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regulators. Purified stevia extracts have a good safety record, but evidence for medicinal benefits like lowering blood sugar or blood pressure is limited. Talk to your pharmacist or doctor before using stevia supplements for any health condition.

Stevia rebaudiana · Asteraceae · Leaves · Powder, liquid drops, tablets, granules, tea, and purified extracts (such as rebaudioside A and stevioside)

An interaction check asks whether these two react with each other — it does not ask whether Stevia is a good idea for someone in your situation. Here is what our Stevia record says about it on its own.

Stevia: dosing

There is no standard medicinal dose of stevia. As a sweetener, the right amount is simply enough to reach the sweetness you like, and a little goes a long way because it is much sweeter than sugar.For tabletop and food products, follow the directions on the label and stay within the recommended daily intake.

From our Stevia monograph — the full record covers uses, side effects and every documented interaction.

Read the full Stevia monograph & all interactions
Medication

About Duvelisib

What Is Duvelisib Used For?

Brand name: Copiktra

Copiktra (duvelisib) is used in adults with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) — meaning the cancer has returned or stopped responding to treatment — after at least two prior therapies.

Copiktra is also used for relapsed or refractory follicular lymphoma (FL) after at least two prior systemic therapies. The follicular lymphoma approval is based on overall response rate and is considered an accelerated approval; continued approval may depend on results from confirmatory trials. Copiktra is not intended for use as a first- or second-line treatment for any of these cancers.

Most-Reported Side Effects for Duvelisib

From FAERS, the FDA’s public side-effect reporting system (765 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 107 reports
Fatigue 78 reports
Prescribed underdose 65 reports
Nausea 49 reports
Pneumonia 41 reports
See full Duvelisib drug information
Keep checking

Other Drugs & Stevia

Browse every other medication we’ve checked against Stevia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1Moderate
258Minor
2,570No known interaction
1 Moderate 258 Minor 2,570 No interaction
Moderate

1 interaction

Minor

258 interactions

Showing 60 of 258 minor interactions — see all 258 on the Stevia page.

No interaction 2,570 drugs checked — show the list

We also checked Stevia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,570 medications checked with no known interaction — see the full Stevia list.

See the full Stevia interactions page
See every supplement checked against Duvelisib, ranked by severity
Evidence & sources

Stevia References

The 10 references that drive our Stevia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Chan P, Xu DY, Liu JC, et al. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci 1998;63:1679-84. PubMed
  2. Melis MS. A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats. Braz J Med Biol Res 1996;29:669-75.
  3. Melis MS. Chronic administration of aqueous extract of Stevia rebaudiana in rats: renal effects. J Ethnopharmacol 1995;47:129-34. PubMed
  4. Melis MS, Sainati AR. Effect of calcium and verapamil on renal function of rats during treatment with stevioside. J Ethnopharmacol 1991;33:257-622. PubMed
  5. Hsieh MH, Chan P, Sue YM, et al. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. Clin Ther 2003;25:2797-808. PubMed
  6. Chan P, Tomlinson B, Chen YJ, et al. A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin Pharmacol 2000;50:215-20. PubMed
  7. Gregersen S, Jeppesen PB, Holst JJ, Hermansen K. Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism 2004;53:73-6. PubMed
  8. Barriocanal LA, Palacios M, Benitez G, et al. Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabeti
  9. Ferri LA, Alves-Do-Prado W, Yamada SS, et al. Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension. Phytother Res 2006;20:732-6. PubMed
  10. Almiron-Roig E, Navas-Carretero S, Castelnuovo G, et al. Impact of acute consumption of beverages containing plant-based or alternative sweetener blends on postprandial appetite, food intake, metabolism, and gastro-intestinal symptoms: Results of the SWEE

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Stevia and Duvelisib Together: Common Questions

Is it safe to take Stevia with Duvelisib?
We do not list a known interaction between Stevia and Duvelisib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Stevia and Duvelisib have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Stevia and Duvelisib combination checked?
Interactions in our licensed database are recorded against drug classes. Duvelisib is filed under 3 classifications, and Stevia has documented interactions with 3 drug classes — none of Duvelisib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Stevia interact with any other medications?
Yes. Stevia has 259 documented drug interactions in our database — Duvelisib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Duvelisib interact with any supplements?
Yes. Duvelisib has documented interactions with 143 supplements in our database — Stevia is not one of them. The Duvelisib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Stevia monograph Uses, safety profile, and every drug interaction in one place Duvelisib drug information The full plain-English guide to this medication Duvelisib supplement interactions Every supplement checked against Duvelisib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 10 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Duvelisib and Stevia?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.