Drug & supplement interaction

Superoxide Dismutase (sod) + Voriconazole

Voriconazole brand name: Vfend.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Superoxide Dismutase (sod) and Voriconazole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Superoxide Dismutase (sod) and Voriconazole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Voriconazole and Superoxide Dismutase (sod) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Superoxide Dismutase (sod) at all — not against Voriconazole, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Superoxide Dismutase (sod) safety at a glance

Superoxide Dismuta... overall Use caution Generally considered low-risk in short-term use, but long-term safety and effectiveness of supplements are not well established.
Pregnancy Avoid There is not enough reliable safety information, so it is best to avoid during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoiding it is the safer choice.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Voriconazole and Superoxide Dismutase (sod)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Superoxide Dismutase (sod) Itself Has Been Linked To

This is not an interaction — nothing below involves Voriconazole. It is the side-effect record for Superoxide Dismutase (sod) on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Superoxide Dismutase (sod), this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • A severe allergic reaction Worth acting on Additional detail

    “Orally and parenterally, superoxide dismutase seems to be well tolerated.

    Most Common Adverse Effects:

    Parenterally: Pain and injection site reactions.

    Serious Adverse Effects (Rare):

    Parenterally: Anaphylaxis, possibly related to impurities in parenteral formulations.”

    Superoxide Dismutase (sod) · Natural Medicines adverse-effect record, reported in pain.

Everything above comes from the Natural Medicines adverse-effect record for Superoxide Dismutase (sod) — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Voriconazole’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Voriconazole column appears here.

Everything else you take

See Every Supplement That Interacts With Voriconazole

This page covers Superoxide Dismutase (sod) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Voriconazole page lists 205 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 159 moderate · 40 minor.

From our pharmacist’s overview on the Voriconazole page

“Voriconazole (Vfend) is a heavy-hitter antifungal, usually prescribed for dangerous infections like invasive aspergillosis, and its list of 205 interacting supplements includes six rated major, enough that anyone on this drug should read those entries before touching a supplement bottle. Most interactions run through the liver enzymes…”

Reviewed by 2 · Jul 18, 2026

Open the Voriconazole interaction page

How much people look this up

Where Superoxide Dismutase (sod) and Voriconazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Superoxide Dismutase (sod)
Steady interest

#1,417 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Voriconazole
Steady interest

#1,890 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Superoxide Dismutase (sod) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Superoxide Dismutase (sod) and Voriconazole records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Superoxide Dismutase (sod)

What is Superoxide Dismutase (sod)?

  • Antioxidant support
  • Anti-aging and skin health
  • Joint pain and arthritis
  • Exercise recovery and oxidative stress
  • General inflammation

Superoxide dismutase (SOD) is a natural antioxidant enzyme your body makes to help neutralize harmful free radicals. While it has clear biological importance, oral supplements may be broken down during digestion, and strong human evidence that taking SOD supplements improves health is limited. Talk to your pharmacist or doctor before using it, especially if you are pregnant or have a health condition.

Enzyme sourced from plants (such as cantaloupe melon), bovine liver, or made by microbes; also produced naturally in the body · Capsules, tablets, topical creams, injectable forms (used in some research settings)

An interaction check asks whether these two react with each other — it does not ask whether Superoxide Dismutase (sod) is a good idea for someone in your situation. Here is what our Superoxide Dismutase (sod) record says about it on its own.

Superoxide Dismutase (sod): dosing

There is no well-established standard dose for superoxide dismutase supplements. Doses vary widely between products and forms.The best advice is to follow the directions on the product label and not exceed the recommended amount.

From our Superoxide Dismutase (sod) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Superoxide Dismutase (sod) monograph & all interactions
Medication

About Voriconazole

What Is Voriconazole Used For?

Brand name: Vfend

Voriconazole treats several serious fungal infections. Across all available forms — tablets, oral suspension, and intravenous (IV) injection — it is used for invasive aspergillosis (a dangerous mold infection), candidemia (Candida fungus in the bloodstream) in patients who are not neutropenic (not severely low on white blood cells), other deep-tissue Candida infections, and serious infections caused by Scedosporium apiospermum or Fusarium species in patients who cannot tolerate or have not responded to other antifungal treatments.

Esophageal candidiasis (a Candida infection of the esophagus, the swallowing tube) is also an approved use for most formulations. Note on the oral tablet form (generic voriconazole tablets): that specific tablet formulation is approved for patients aged 12 to 14 years weighing at least 50 kg, and all patients 15 years and older — not for younger or smaller children. The oral suspension and the IV injection are approved for patients 2 years and older for most of these conditions.

Most-Reported Side Effects for Voriconazole

From FAERS, the FDA’s public side-effect reporting system (30,194 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 1,441 reports
Pneumonia 1,347 reports
Bronchopulmonary aspergillosis 1,051 reports
Aspergillus infection 908 reports
See full Voriconazole drug information
Keep checking

Other Drugs & Superoxide Dismutase (sod)

Browse every other medication we’ve checked against Superoxide Dismutase (sod) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Superoxide Dismutase (sod) References

The 2 references that drive our Superoxide Dismutase (sod) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
  2. Nielsen OS, Overgaard J, Overgaard M, et al. Orgotein in radiation treatment of bladder cancer. A report on allergic reactions and lack of radioprotective effect. Acta Oncol 1987;26:101-4. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Superoxide Dismutase (sod) and Voriconazole Together: Common Questions

Is it safe to take Superoxide Dismutase (sod) with Voriconazole?
We do not list a known interaction between Superoxide Dismutase (sod) and Voriconazole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Voriconazole interact with any supplements?
Yes. Voriconazole has documented interactions with 205 supplements in our database — Superoxide Dismutase (sod) is not one of them. The Voriconazole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Voriconazole and Superoxide Dismutase (sod)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.