Drug & supplement interaction

Theaflavin + Lemborexant

Lemborexant brand name: Dayvigo.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Theaflavin and Lemborexant in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Theaflavin and Lemborexant

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lemborexant and Theaflavin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Theaflavin safety at a glance

Theaflavin overall Use caution Black tea is generally safe in normal amounts, but concentrated extracts are less studied.
Pregnancy Use caution Limit caffeine-containing tea and avoid high-dose extracts unless your doctor approves.
Breastfeeding Use caution Caffeine passes into breast milk, so limit intake and avoid concentrated extracts.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lemborexant and Theaflavin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Lemborexant

Interactions in our licensed database are recorded against drug classes, not just single drug names. Lemborexant is filed under 3 classifications — cns depressants, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Theaflavin has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and organic anion-transporting polypeptide substrates (oatp) (moderate) — and none of Lemborexant’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Theaflavin Does Interact With Other Medications

Theaflavin has 130 moderate known drug interactions in our database — Lemborexant isn’t one of them. If you take anything else, check it against the full list below.

Moderate 130 No known interaction 2,700 (incl. Lemborexant)
Taking anything else?

Check Another of Your Medications Against Theaflavin

Covers the 2,830 medications we’ve checked against Theaflavin. Pick one to open its full report.

What to actually watch for

What Lemborexant’s Own FDA Label Lists

This is not an interaction — none of it involves Theaflavin. These are the most notable effects listed in the ADVERSE REACTIONS section of Lemborexant’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 3 of them are worth acting on rather than waiting out — marked below.

  • Thoughts of self-harm Worth acting on mentioned in 10.1% of FDA reports for Lemborexant
  • Hallucinations Worth acting on
  • Low mood Worth acting on
  • Vivid dreams or nightmares
  • Drowsiness mentioned in 5.1% of FDA reports for Lemborexant
  • A fast or pounding heartbeat
  • Trouble sleeping
  • Tiredness
  • Headache mentioned in 3.4% of FDA reports for Lemborexant

From the ADVERSE REACTIONS section of the FDA label for Lemborexant. Read the label on DailyMed › Where a percentage is shown, it is the share of 2,745 voluntary FDA FAERS reports for Lemborexant that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Theaflavin’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Theaflavin side to compare — that is a limit of the record, not a statement that Theaflavin has no side effects.

Everything else you take

See Every Supplement That Interacts With Lemborexant

This page covers Theaflavin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lemborexant page lists 195 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 147 moderate · 39 minor.

From our pharmacist’s overview on the Lemborexant page

“Lemborexant (Dayvigo) works by quieting the brain's wake signals, so the biggest risks on this list come from anything else that sedates you. Alcohol sits at the top; a drink layered over a dose can deepen drowsiness into real impairment, and a few entries carry the added danger of slowed breathing.”

Reviewed by 2 · Jul 18, 2026

Open the Lemborexant interaction page

One more smart check

Taking Theaflavin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 11 real supplement products containing Theaflavin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Theaflavin. Even though Theaflavin itself has no known interaction with Lemborexant, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Theaflavin and Lemborexant Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Theaflavin
Steady interest

#886 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lemborexant
Steady interest

#1,792 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Theaflavin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Theaflavin and Lemborexant records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Theaflavin

What is Theaflavin?

  • Heart health and cholesterol support
  • Antioxidant support
  • Weight management
  • Blood sugar support
  • General wellness

Theaflavins are antioxidant compounds formed when tea leaves are oxidized to make black tea. Early research suggests they may help with cholesterol and provide antioxidant effects, but high-quality human evidence is limited and doses are not standardized. Drinking black tea is generally safe, but talk to your pharmacist or doctor before taking concentrated extracts.

Camellia sinensis · Theaceae · Leaves (fermented/oxidized, as in black tea) · Black tea, standardized black tea extract capsules, tablets, powders

An interaction check asks whether these two react with each other — it does not ask whether Theaflavin is a good idea for someone in your situation. Here is what our Theaflavin record says about it on its own.

Theaflavin: dosing

There is no established standard dose of theaflavin. Supplements vary widely in how much theaflavin they contain and how the black tea extract is standardized.If you choose to take a product, follow the directions on the label and do not exceed the recommended amount. Drinking black tea is a simpler, well-tolerated way to get theaflavins for most people.

From our Theaflavin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Theaflavin monograph & all interactions
Medication

About Lemborexant

What Is Lemborexant Used For?

Brand name: Dayvigo

Dayvigo (lemborexant) is used to treat insomnia in adults. It helps people who have trouble falling asleep, staying asleep, or both.

It is not approved for use in children. Only the oral tablet form is available under the brand name Dayvigo.

Most-Reported Side Effects for Lemborexant

From FAERS, the FDA’s public side-effect reporting system (2,745 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Suicide attempt 148 reports
Somnolence 140 reports
Suicidal ideation 130 reports
Fall 105 reports
Nausea 95 reports
See full Lemborexant drug information
Keep checking

Other Drugs & Theaflavin

Browse every other medication we’ve checked against Theaflavin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
130Moderate
0Minor
2,699No known interaction
130 Moderate 2,699 No interaction
Moderate

130 interactions

Showing 60 of 130 moderate interactions — see all 130 on the Theaflavin page.

No interaction 2,699 drugs checked — show the list

We also checked Theaflavin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,699 medications checked with no known interaction — see the full Theaflavin list.

See the full Theaflavin interactions page
See every supplement checked against Lemborexant, ranked by severity
Evidence & sources

Theaflavin References

The 4 references that drive our Theaflavin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Maron DJ, Lu GP, Cai NS, et al. Cholesterol-lowering effect of a theaflavin-enriched green tea extract: a randomized controlled trial. Arch Intern Med 2003;163:1448-53.. PubMed
  2. Takemoto M, Takemoto H, Kouno H, Soeda T, Moriya T. A simple, enzymatic biotransformation method using fresh green tea leaves efficiently generates theaflavin-containing fermentation water that has potent physiological functions in mice and humans. Biol P PubMed
  3. Kondo A, Narumi K, Okuhara K, et al. Black tea extract and theaflavin derivatives affect the pharmacokinetics of rosuvastatin by modulating organic anion transporting polypeptide (OATP) 2B1 activity. Biopharm Drug Dispos. 2019;40(8):302-306. PubMed
  4. Gothandam K, Ganesan VS, Ayyasamy T, Ramalingam S. Antioxidant potential of theaflavin ameliorates the activities of key enzymes of glucose metabolism in high fat diet and streptozotocin - induced diabetic rats. Redox Rep. 2019;24(1):41-50. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Theaflavin and Lemborexant Together: Common Questions

Is it safe to take Theaflavin with Lemborexant?
We do not list a known interaction between Theaflavin and Lemborexant. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Theaflavin and Lemborexant combination checked?
Interactions in our licensed database are recorded against drug classes. Lemborexant is filed under 3 classifications, and Theaflavin has documented interactions with 2 drug classes — none of Lemborexant's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Theaflavin interact with any other medications?
Yes. Theaflavin has 130 documented drug interactions in our database — Lemborexant is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Lemborexant interact with any supplements?
Yes. Lemborexant has documented interactions with 195 supplements in our database — Theaflavin is not one of them. The Lemborexant interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Theaflavin monograph Uses, safety profile, and every drug interaction in one place Lemborexant drug information The full plain-English guide to this medication Lemborexant supplement interactions Every supplement checked against Lemborexant, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lemborexant and Theaflavin?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.