Drug & supplement interaction

Tree Tobacco + Cefaclor

Cefaclor brand names: Ceclor CD, Ceclor.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Tree Tobacco and Cefaclor in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Cefaclor states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Tree Tobacco and Cefaclor

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cefaclor and Tree Tobacco in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Tree Tobacco at all — not against Cefaclor, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tree Tobacco safety at a glance

Tree Tobacco overall Avoid Tree tobacco is toxic and has caused serious poisonings and deaths when eaten.
Pregnancy Likely Unsafe When tree tobacco is used orally. Tree tobacco contains anabasine, which is poisonous and teratogenic. Read the full pregnancy detail
Breastfeeding Likely Unsafe When tree tobacco is used orally. Tree tobacco contains anabasine, which is poisonous and teratogenic. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cefaclor and Tree Tobacco? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Tree Tobacco and Cefaclor May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Confusion Worth acting on Additional detail

    Tree Tobacco

    “Orally, tree tobacco is generally regarded as unsafe for use. Any benefits of therapy may not outweigh the risk of toxicity. Tree tobacco can cause nausea, vomiting, diarrhea, abdominal pain, changes in blood pressure and heart rate, muscle weakness and paralysis, respiratory distress, and neurological symptoms including vertigo, confusion, fatigue, headache, hallucinations, spasms, weakness, and coma.”

    Tree Tobacco · Natural Medicines adverse-effect record, reported in acute respiratory distress syndrome (ards).

    6 sources cited
    1. 28735. Mizrachi, N., Levy, S., and Goren, Z. Q. Fatal poisoning from Nicotiana glauca leaves: identification of anabasine by gas-chromatography/mass spectrometry. J Forensic Sci 2000;45(3):736-741. DOI
    2. 28736. Mellick, L. B., Makowski, T., Mellick, G. A., and Borger, R. Neuromuscular blockade after ingestion of tree tobacco (Nicotiana glauca). Ann Emerg Med 1999;34(1):101-104. PubMed
    3. 28737. Sims, D. N., James, R., and Christensen, T. Another death due to ingestion of Nicotiana glauca. J Forensic Sci 1999;44(2):447-449.
    4. 28738. Castorena, J. L., Garriott, J. C., Barnhardt, F. E., and Shaw, R. F. A fatal poisoning from Nicotiana glauca. J Toxicol Clin Toxicol 1987;25(5):429-435.
    5. 28739. Manoguerra, A. S. and Freeman, D. Acute poisoning from the ingestion of Nicotiana glauca. J Toxicol Clin Toxicol 1982;19(8):861-864.
    6. 98622. Bardas SL. Short-term intubation after ingestion of Nicotiana glauca. Am J Health Syst Pharm. 2011;68(18):1678-9.

    “Orally, tree tobacco has been reported to cause vertigo, confusion, fatigue, headache, photophobia, spasms, tingling, severe sweating, progressively worsening aphasia, neuromuscular blockage, seizures, coma, and bulbar palsy. Dizziness and confusion tend to occur early, within 4 hours of consumption. Weakness, coma, and paralysis occur later.”

    Tree Tobacco · Natural Medicines adverse-effect record, reported in cluster headache.

    4 sources cited
    1. 28734. Steenkamp, P. A., van Heerden, F. R., and van Wyk, B. E. Accidental fatal poisoning by Nicotiana glauca: identification of anabasine by high performance liquid chromatography/photodiode array/mass spectrometry. Forensic Sci Int 2002;127(3):208-217. PubMed
    2. 98622. Bardas SL. Short-term intubation after ingestion of Nicotiana glauca. Am J Health Syst Pharm. 2011;68(18):1678-9.
    3. 98623. Sercan Y, Selahattin KG. Respiratory failure due to plant poisoning: Nicotiana glauca Graham. J Emerg Med. 2018;55(3):e61-e63. PubMed
    4. 106641. Kear BM, Lee RW, Church SB, Youssef FA, Arguija A. Ingestion of a common plant's leaves leads to acute respiratory arrest and paralysis: a case report. Clin Pract Cases Emerg Med 2020;4(3):371-4. PubMed

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

  • Sweating / Numbness or tingling Additional detail

    Tree Tobacco

    Recorded for Tree Tobacco in the same Natural Medicines adverse-effect record shown under Confusion above.

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

  • Low blood pressure Additional detail

    Tree Tobacco

    “Orally, tree tobacco has been reported to cause hypertension, hypotension, bradycardia, tachycardia, and asystole. Hypertension tends to occur early, within 4 hours of consumption.”

    Tree Tobacco · Natural Medicines adverse-effect record, reported in hypertension.

    3 sources cited
    1. 28735. Mizrachi, N., Levy, S., and Goren, Z. Q. Fatal poisoning from Nicotiana glauca leaves: identification of anabasine by gas-chromatography/mass spectrometry. J Forensic Sci 2000;45(3):736-741. DOI
    2. 98623. Sercan Y, Selahattin KG. Respiratory failure due to plant poisoning: Nicotiana glauca Graham. J Emerg Med. 2018;55(3):e61-e63. PubMed
    3. 106641. Kear BM, Lee RW, Church SB, Youssef FA, Arguija A. Ingestion of a common plant's leaves leads to acute respiratory arrest and paralysis: a case report. Clin Pract Cases Emerg Med 2020;4(3):371-4. PubMed

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

  • Stomach pain / Diarrhea / Vomiting Additional detail

    Tree Tobacco

    “Orally, tree tobacco has been reported to cause nausea, vomiting, diarrhea, dry mouth, salivation, and abdominal pain. Nausea and vomiting tend to occur early, within 4 hours of consumption.”

    Tree Tobacco · Natural Medicines adverse-effect record, reported in diarrhea.

    5 sources cited
    1. 28734. Steenkamp, P. A., van Heerden, F. R., and van Wyk, B. E. Accidental fatal poisoning by Nicotiana glauca: identification of anabasine by high performance liquid chromatography/photodiode array/mass spectrometry. Forensic Sci Int 2002;127(3):208-217. PubMed
    2. 28736. Mellick, L. B., Makowski, T., Mellick, G. A., and Borger, R. Neuromuscular blockade after ingestion of tree tobacco (Nicotiana glauca). Ann Emerg Med 1999;34(1):101-104. PubMed
    3. 98622. Bardas SL. Short-term intubation after ingestion of Nicotiana glauca. Am J Health Syst Pharm. 2011;68(18):1678-9.
    4. 98623. Sercan Y, Selahattin KG. Respiratory failure due to plant poisoning: Nicotiana glauca Graham. J Emerg Med. 2018;55(3):e61-e63. PubMed
    5. 106641. Kear BM, Lee RW, Church SB, Youssef FA, Arguija A. Ingestion of a common plant's leaves leads to acute respiratory arrest and paralysis: a case report. Clin Pract Cases Emerg Med 2020;4(3):371-4. PubMed

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

  • Tiredness / Dizziness / Headache Additional detail

    Tree Tobacco

    Recorded for Tree Tobacco in the same Natural Medicines adverse-effect record shown under Confusion above.

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

Showing the 10 most notable of 11 shared effects — ranked by how unusual each one is, not just whether both lists mention it.

Reported for Tree Tobacco but not commonly for Cefaclor: shortness of breath, muscle weakness, hallucinations and raised blood pressure.

Effects for Cefaclor come from the ADVERSE REACTIONS section of its FDA label; effects for Tree Tobacco come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Tree Tobacco in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When tree tobacco is used orally. Tree tobacco contains anabasine, which is poisonous and teratogenic.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Cefaclor Products Have a Food Rule — Tree Tobacco Should Not Break It

At least one FDA label for a product containing Cefaclor says to take it with food. If you take Tree Tobacco on an empty stomach out of habit, keep them separate — and take Cefaclor with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Cefaclor products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

DOSAGE AND ADMINISTRATION The absorption of cefaclor extended-release tablets is enhanced when it is administered with food.

From the Dosage and Administration section of the FDA label we read for Cefaclor — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Cefaclor

This page covers Tree Tobacco only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cefaclor page lists 60 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Siberian Cocklebur (major), African Wild Potato (moderate) and Aristolochia (moderate).

By severity: 3 major · 46 moderate · 11 minor.

From our pharmacist’s overview on the Cefaclor page

“The entries worth understanding before any others on this cefaclor (Ceclor) page are the kidney risks and charcoal. Cefaclor is a cephalosporin antibiotic, typically a short course for ear, sinus, throat, or skin infections, and two herbs here, Siberian cocklebur and asarabacca, can damage the kidneys on their own, so pairing either wi…”

Reviewed by 2 · Jul 18, 2026

Open the Cefaclor interaction page

How much people look this up

Where Tree Tobacco and Cefaclor Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tree Tobacco
Steady interest

#1,383 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cefaclor
Top 10%

#260 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tree Tobacco reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Tree Tobacco and Cefaclor records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Tree Tobacco

What is Tree Tobacco?

  • Topical use on wounds or sores (folk use)
  • Joint and muscle pain (folk use)
  • Headache relief (traditional poultice)
  • Insect or pest control

Tree tobacco is a poisonous shrub that contains the toxic alkaloid anabasine, and it is not a safe dietary supplement. There is no reliable evidence that it treats any condition, and swallowing it can cause severe poisoning or death. We strongly recommend avoiding internal use entirely.

Nicotiana glauca · Solanaceae · Leaves · Crushed leaves, poultices, traditional topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Tree Tobacco is a good idea for someone in your situation. Here is what our Tree Tobacco record says about it on its own.

Tree Tobacco: dosing

There is no safe or established dose for tree tobacco. It is not sold or recommended as a standardized dietary supplement, and no amount is known to be safe to swallow.Because of its toxicity, we recommend avoiding it entirely.

From our Tree Tobacco monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tree Tobacco monograph & all interactions
Medication

About Cefaclor

What Is Cefaclor Used For?

Brand names: Ceclor CD, Ceclor

Cefaclor treats a range of bacterial infections. The capsule and oral suspension forms are used for ear infections (otitis media), lower respiratory tract infections including pneumonia, strep throat and tonsillitis, urinary tract infections (including kidney infections and bladder infections), and skin and skin structure infections.

The extended-release tablet form of Cefaclor is approved for a narrower set of uses: acute bacterial flare-ups of chronic bronchitis, strep throat and tonsillitis, and uncomplicated skin infections. Not all infections approved for the capsule or suspension are approved for the extended-release tablet — your prescriber will choose the right form for your infection.

Most-Reported Side Effects for Cefaclor

From FAERS, the FDA’s public side-effect reporting system (1,535 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Drug hypersensitivity 252 reports
Nausea 159 reports
Vomiting 159 reports
Fatigue 137 reports
Fever 121 reports
See full Cefaclor drug information
Keep checking

Other Drugs & Tree Tobacco

Browse every other medication we’ve checked against Tree Tobacco — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Tree Tobacco against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Tree Tobacco list.

See the full Tree Tobacco interactions page
See every supplement checked against Cefaclor, ranked by severity
Evidence & sources

Tree Tobacco References

The 9 references that drive our Tree Tobacco monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Steenkamp, P. A., van Heerden, F. R., and van Wyk, B. E. Accidental fatal poisoning by Nicotiana glauca: identification of anabasine by high performance liquid chromatography/photodiode array/mass spectrometry. Forensic Sci Int 2002;127(3):208-217. PubMed
  2. Mizrachi, N., Levy, S., and Goren, Z. Q. Fatal poisoning from Nicotiana glauca leaves: identification of anabasine by gas-chromatography/mass spectrometry. J Forensic Sci 2000;45(3):736-741. DOI
  3. Mellick, L. B., Makowski, T., Mellick, G. A., and Borger, R. Neuromuscular blockade after ingestion of tree tobacco (Nicotiana glauca). Ann Emerg Med 1999;34(1):101-104. PubMed
  4. Sims, D. N., James, R., and Christensen, T. Another death due to ingestion of Nicotiana glauca. J Forensic Sci 1999;44(2):447-449.
  5. Castorena, J. L., Garriott, J. C., Barnhardt, F. E., and Shaw, R. F. A fatal poisoning from Nicotiana glauca. J Toxicol Clin Toxicol 1987;25(5):429-435.
  6. Manoguerra, A. S. and Freeman, D. Acute poisoning from the ingestion of Nicotiana glauca. J Toxicol Clin Toxicol 1982;19(8):861-864.
  7. Bardas SL. Short-term intubation after ingestion of Nicotiana glauca. Am J Health Syst Pharm. 2011;68(18):1678-9.
  8. Sercan Y, Selahattin KG. Respiratory failure due to plant poisoning: Nicotiana glauca Graham. J Emerg Med. 2018;55(3):e61-e63. PubMed
  9. Kear BM, Lee RW, Church SB, Youssef FA, Arguija A. Ingestion of a common plant's leaves leads to acute respiratory arrest and paralysis: a case report. Clin Pract Cases Emerg Med 2020;4(3):371-4. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tree Tobacco and Cefaclor Together: Common Questions

Is it safe to take Tree Tobacco with Cefaclor?
We do not list a known interaction between Tree Tobacco and Cefaclor. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Tree Tobacco and Cefaclor have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Tree Tobacco and Cefaclor at the same time of day?
At least one FDA label for a product containing Cefaclor says to take it with food. If you take Tree Tobacco on an empty stomach out of habit, keep them separate and take Cefaclor with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Cefaclor products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Cefaclor interact with any supplements?
Yes. Cefaclor has documented interactions with 60 supplements in our database — Tree Tobacco is not one of them. The Cefaclor interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Tree Tobacco monograph Uses, safety profile, and every drug interaction in one place Cefaclor drug information The full plain-English guide to this medication Cefaclor supplement interactions Every supplement checked against Cefaclor, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cefaclor and Tree Tobacco?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.