Drug & supplement interaction

Tung Seed + Lapatinib

Lapatinib brand name: Tykerb.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Tung Seed and Lapatinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Tung Seed and Lapatinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lapatinib and Tung Seed in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Tung Seed at all — not against Lapatinib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tung Seed safety at a glance

Tung Seed overall Avoid Tung seeds and oil are poisonous if eaten and are not safe as a supplement.
Pregnancy Likely Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lapatinib and Tung Seed? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Tung Seed and Lapatinib May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea / Vomiting reported in 27.1% of FDA reports for Lapatinib Additional detail

    Tung Seed

    “Orally, candlenut can cause severe abdominal pain, violent vomiting, and diarrhea (6,4502,106671,111341).”

    Tung Seed · Natural Medicines adverse-effect record, reported in diarrhea.

    4 sources cited
    1. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
    2. 4502. Duke JA. CRC handbook of medicinal herbs. 1st ed. Boca Raton, FL: CRC Press, LLC, 1985.
    3. 106671. O'Brien DR, Szymczuk V, Albaro CA. Weight loss supplement causing acute heart block in a child. Cardiol Young 2020;30(1):131-133. PubMed
    4. 111341. Lawani O, Winter M. Heart Block Initiated by Candlenut Ingestion. Case Rep Cardiol 2022;2022:3679968. PubMed

    “A 16-year-old patient presented with acute onset abdominal pain, chest pain, and profuse and persistent vomiting following ingestion of both a tea made from boiling a whole candlenut and the boiled candlenut itself. The patient was also found to have first-degree heart block that later progressed to Mobitz type I second degree heart block with occasional 2:1 block, requiring ICU admission and monitoring.”

    Tung Seed · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 106671. O'Brien DR, Szymczuk V, Albaro CA. Weight loss supplement causing acute heart block in a child. Cardiol Young 2020;30(1):131-133. PubMed
    2. 111341. Lawani O, Winter M. Heart Block Initiated by Candlenut Ingestion. Case Rep Cardiol 2022;2022:3679968. PubMed
    3. 111343. Koons AL, Laubach LT, Katz KD, Beauchamp GA. Mobitz Type II Atrioventricular Heart Block After Candlenut Ingestion. J Am Osteopath Assoc. 2020;120(12):839-843. PubMed

    Lapatinib

    Listed in the ADVERSE REACTIONS section of the FDA label for Lapatinib, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Tiredness / Nausea reported in 10.5% of FDA reports for Lapatinib Additional detail

    Tung Seed

    Recorded for Tung Seed in the same Natural Medicines adverse-effect record shown under Diarrhea / Vomiting above.

    Lapatinib

    Listed in the ADVERSE REACTIONS section of the FDA label for Lapatinib, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • A skin rash reported in 6.9% of FDA reports for Lapatinib Additional detail

    Tung Seed

    “Topically, candlenut can cause acute dermatitis.”

    Tung Seed · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 4502. Duke JA. CRC handbook of medicinal herbs. 1st ed. Boca Raton, FL: CRC Press, LLC, 1985.

    Lapatinib

    Listed in the ADVERSE REACTIONS section of the FDA label for Lapatinib, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Tung Seed but not commonly for Lapatinib: confusion, a slow heartbeat, shortness of breath and chest pain.

Effects for Lapatinib come from the ADVERSE REACTIONS section of its FDA label; effects for Tung Seed come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 15,427 voluntary FDA FAERS reports for Lapatinib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Tung Seed in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Lapatinib

This page covers Tung Seed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lapatinib page lists 143 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 100 moderate · 40 minor.

From our pharmacist’s overview on the Lapatinib page

“Of the 143 supplements on file for lapatinib (Tykerb), nearly all press on the same point, the CYP3A4 enzyme that clears this HER2-targeted breast cancer drug. That deserves real caution, since lapatinib only works when its blood level stays in range.”

Reviewed by 2 · Jul 18, 2026

Open the Lapatinib interaction page

How much people look this up

Where Tung Seed and Lapatinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tung Seed
Steady interest

#755 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lapatinib
Steady interest

#2,248 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tung Seed reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Tung Seed and Lapatinib records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Tung Seed

What is Tung Seed?

  • Wood finishing and varnish (industrial)
  • Traditional folk skin applications
  • Traditional laxative use (historical)
  • Traditional topical remedies

Tung seed comes from the tung tree (Vernicia fordii), and its main product is tung oil, which is used mostly as an industrial wood finish, not as a food or medicine. The raw seeds and oil are toxic if swallowed and there is no reliable evidence supporting any health benefit. We do not recommend taking tung seed as a supplement.

Vernicia fordii · Euphorbiaceae · Seeds and the oil pressed from them (tung oil) · Tung oil (industrial), rarely available as a dietary supplement

An interaction check asks whether these two react with each other — it does not ask whether Tung Seed is a good idea for someone in your situation. Here is what our Tung Seed record says about it on its own.

Tung Seed: dosing

There is no established or safe dose of tung seed for use in people. Because the seeds and oil are toxic, no medical dosing exists, and we do not recommend taking it in any amount.If you see a product that claims to contain tung seed for health purposes, do not use it without first checking with a pharmacist or doctor. In general, tung oil should be treated as an industrial product only.

From our Tung Seed monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tung Seed monograph & all interactions
Medication

About Lapatinib

What Is Lapatinib Used For?

Brand name: Tykerb

Lapatinib tablets — sold under the brand name Tykerb — are used to treat advanced or metastatic breast cancer in patients whose tumors overexpress the HER2 protein. They are always used in combination with another medicine, not alone.

Tykerb is approved in combination with capecitabine for HER2-positive advanced or metastatic breast cancer in patients who have already received prior treatment including an anthracycline, a taxane, and trastuzumab, and whose disease has progressed on trastuzumab. Tykerb is also approved in combination with letrozole for postmenopausal women with hormone receptor-positive, HER2-positive metastatic breast cancer when hormonal therapy is appropriate.

Most-Reported Side Effects for Lapatinib

From FAERS, the FDA’s public side-effect reporting system (15,427 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 4,174 reports
Nausea 1,615 reports
Fatigue 1,305 reports
Vomiting 1,209 reports
Rash 1,061 reports
See full Lapatinib drug information
Keep checking

Other Drugs & Tung Seed

Browse every other medication we’ve checked against Tung Seed — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Tung Seed against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Tung Seed list.

See the full Tung Seed interactions page
See every supplement checked against Lapatinib, ranked by severity
Evidence & sources

Tung Seed References

The 5 references that drive our Tung Seed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Duke JA. CRC handbook of medicinal herbs. 1st ed. Boca Raton, FL: CRC Press, LLC, 1985.
  3. O'Brien DR, Szymczuk V, Albaro CA. Weight loss supplement causing acute heart block in a child. Cardiol Young 2020;30(1):131-133. PubMed
  4. Lawani O, Winter M. Heart Block Initiated by Candlenut Ingestion. Case Rep Cardiol 2022;2022:3679968. PubMed
  5. Koons AL, Laubach LT, Katz KD, Beauchamp GA. Mobitz Type II Atrioventricular Heart Block After Candlenut Ingestion. J Am Osteopath Assoc. 2020;120(12):839-843. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tung Seed and Lapatinib Together: Common Questions

Is it safe to take Tung Seed with Lapatinib?
We do not list a known interaction between Tung Seed and Lapatinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Tung Seed and Lapatinib have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Lapatinib interact with any supplements?
Yes. Lapatinib has documented interactions with 143 supplements in our database — Tung Seed is not one of them. The Lapatinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Tung Seed monograph Uses, safety profile, and every drug interaction in one place Lapatinib drug information The full plain-English guide to this medication Lapatinib supplement interactions Every supplement checked against Lapatinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lapatinib and Tung Seed?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.