Drug & supplement interaction

Wallflower + Avapritinib

Avapritinib brand name: Ayvakit.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Wallflower and Avapritinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Avapritinib states a food rule worth keeping to.

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Interaction report

Wallflower and Avapritinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Avapritinib and Wallflower in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Wallflower safety at a glance

Wallflower overall Use caution The plant contains heart-active glycosides that can be toxic, and human safety data are very limited.
Pregnancy Possibly Unsafe When used orally due to its cardiac glycoside content and possible toxic effects; avoid using. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally due to its cardiac glycoside content and possible toxic effects; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Avapritinib and Wallflower? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Avapritinib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Avapritinib is filed under 2 classifications — cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Wallflower has documented interactions with 6 drug classes — the most serious being corticosteroids (moderate), digoxin (lanoxin) (moderate) and diuretic drugs (moderate) — and none of Avapritinib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Wallflower Does Interact With Other Medications

Wallflower has 123 moderate known drug interactions in our database — Avapritinib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 123 No known interaction 2,707 (incl. Avapritinib)
Taking anything else?

Check Another of Your Medications Against Wallflower

Covers the 2,830 medications we’ve checked against Wallflower. Pick one to open its full report.

What to actually watch for

What Avapritinib’s Own FDA Label Lists

This is not an interaction — none of it involves Wallflower. These are the most notable effects listed in the ADVERSE REACTIONS section of Avapritinib’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 8 of them are worth acting on rather than waiting out — marked below.

  • Thoughts of self-harm Worth acting on
  • A stroke or mini-stroke Worth acting on
  • Memory problems Worth acting on
  • Confusion Worth acting on
  • Low mood Worth acting on
  • Anemia Worth acting on
  • Shortness of breath Worth acting on
  • Bleeding or bruising Worth acting on
  • Trouble concentrating
  • A change in taste

Showing the 10 most notable of 31 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Avapritinib. Read the label on DailyMed › Where a percentage is shown, it is the share of 12,039 voluntary FDA FAERS reports for Avapritinib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wallflower’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Wallflower side to compare — that is a limit of the record, not a statement that Wallflower has no side effects.

Special populations

Wallflower in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally due to its cardiac glycoside content and possible toxic effects; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Avapritinib Products Have a Food Rule — Wallflower Should Not Break It

At least one FDA label for a product containing Avapritinib says to take it on an empty stomach. Most supplements — Wallflower included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Avapritinib on its own and move Wallflower to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Avapritinib products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.7 ) 2.1 Recommended Administration Administer AYVAKIT orally on an empty stomach, at least 1 hour before or 2 hours after a meal [see Clinical Pharmacology (12.3) ] .

From the Dosage and Administration section of the FDA label we read for Avapritinib — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Avapritinib

This page covers Wallflower only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Avapritinib page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

Open the Avapritinib interaction page

How much people look this up

Where Wallflower and Avapritinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Wallflower
Top half

#703 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Avapritinib
Top half

#1,190 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Wallflower reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Wallflower and Avapritinib records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Wallflower

What is Wallflower?

  • Heart-related folk tonic
  • Nervous tension
  • Joint and muscle aches (topical)
  • Menstrual complaints
  • As an ornamental and fragrance plant

Wallflower (Erysimum cheiri) is a fragrant garden plant with a long history in traditional medicine, but there is very little modern human research to support any health use. It contains cardiac glycoside-type compounds that can be toxic, so it should not be taken internally without professional guidance, and it should be avoided during pregnancy and breastfeeding.

Erysimum cheiri · Brassicaceae · Flowers, leaves, seeds, and aerial parts · Dried herb, tincture, infusion (tea), and topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Wallflower is a good idea for someone in your situation. Here is what our Wallflower record says about it on its own.

Wallflower: dosing

There is no established or standardized dose for wallflower. It is not a mainstream supplement, and reliable dosing information from clinical research does not exist.If you come across a product that contains wallflower, follow the label exactly and do not exceed the suggested amount.

From our Wallflower monograph — the full record covers uses, side effects and every documented interaction.

Read the full Wallflower monograph & all interactions
Medication

About Avapritinib

What Is Avapritinib Used For?

Brand name: Ayvakit

Ayvakit (avapritinib) is approved to treat adults with unresectable (cannot be surgically removed) or metastatic (spread to other parts of the body) gastrointestinal stromal tumors (GIST) that have a specific genetic mutation called a PDGFRA exon 18 mutation, including the D842V variant. Patients must be tested for this mutation before starting treatment.

Ayvakit is also approved to treat advanced systemic mastocytosis (AdvSM) — a serious condition where abnormal mast cells build up in organs — including aggressive systemic mastocytosis, systemic mastocytosis with an associated blood cancer, and mast cell leukemia. Additionally, Ayvakit treats indolent systemic mastocytosis (ISM), a less severe form of the disease. It is not recommended for either form of mastocytosis if platelet counts are too low (below 50 × 10⁹/L).

Most-Reported Side Effects for Avapritinib

From FAERS, the FDA’s public side-effect reporting system (12,039 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 1,735 reports
Nausea 1,218 reports
Diarrhea 1,007 reports
Headache 568 reports
Dizziness 537 reports
See full Avapritinib drug information
Keep checking

Other Drugs & Wallflower

Browse every other medication we’ve checked against Wallflower — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
123Moderate
0Minor
2,706No known interaction
123 Moderate 2,706 No interaction
Moderate

123 interactions

Showing 60 of 123 moderate interactions — see all 123 on the Wallflower page.

No interaction 2,706 drugs checked — show the list

We also checked Wallflower against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,706 medications checked with no known interaction — see the full Wallflower list.

See the full Wallflower interactions page
See every supplement checked against Avapritinib, ranked by severity
Evidence & sources

Wallflower References

The 4 references that drive our Wallflower monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Wallflower and Avapritinib Together: Common Questions

Is it safe to take Wallflower with Avapritinib?
We do not list a known interaction between Wallflower and Avapritinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Wallflower and Avapritinib at the same time of day?
At least one FDA label for a product containing Avapritinib says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Avapritinib on its own and move Wallflower to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Wallflower and Avapritinib combination checked?
Interactions in our licensed database are recorded against drug classes. Avapritinib is filed under 2 classifications, and Wallflower has documented interactions with 6 drug classes — none of Avapritinib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Wallflower interact with any other medications?
Yes. Wallflower has 123 documented drug interactions in our database — Avapritinib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Avapritinib interact with any supplements?
Yes. Avapritinib has documented interactions with 138 supplements in our database — Wallflower is not one of them. The Avapritinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Wallflower monograph Uses, safety profile, and every drug interaction in one place Avapritinib drug information The full plain-English guide to this medication Avapritinib supplement interactions Every supplement checked against Avapritinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Avapritinib and Wallflower?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.