Drug & supplement interaction

Wasabi + Roflumilast

Roflumilast brand names: Daliresp, Zoryve.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Wasabi and Roflumilast in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Wasabi and Roflumilast

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Roflumilast and Wasabi in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Wasabi safety at a glance

Wasabi overall Use caution Generally safe as a food, but supplement-strength doses are not well studied in people.
Pregnancy Use caution Food amounts are likely fine, but avoid concentrated supplements due to a lack of safety data.
Breastfeeding Use caution Food amounts are likely fine, but supplement doses have not been studied, so caution is best.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Roflumilast and Wasabi? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Roflumilast

Interactions in our licensed database are recorded against drug classes, not just single drug names. Roflumilast is filed under 3 classifications — topical drugs, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Wasabi has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Roflumilast’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Wasabi Does Interact With Other Medications

Wasabi has 122 moderate known drug interactions in our database — Roflumilast isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Roflumilast)
Taking anything else?

Check Another of Your Medications Against Wasabi

Covers the 2,830 medications we’ve checked against Wasabi. Pick one to open its full report.

What to actually watch for

What Wasabi Itself Has Been Linked To

This is not an interaction — nothing below involves Roflumilast. It is the side-effect record for Wasabi on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Wasabi, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Kidney problems Worth acting on Additional detail

    “A small clinical study in adults taking oral wasabi extract 1000 mg once daily for 4 weeks has found 2 cases of proteinuria.”

    Wasabi · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 112846. Nakajima R, Kanou M, Tokushima M, Iwama Y, Yamana K. Oral administration of 6-methylsulfinylhexyl isothiocyanate extracted from wasabi is safe and improves the fatigue and sleep of healthy volunteers. Biopsychosoc Med 2023;17(1):30. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Wasabi — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Roflumilast’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Roflumilast column appears here.

Everything else you take

See Every Supplement That Interacts With Roflumilast

This page covers Wasabi only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Roflumilast page lists 141 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 96 moderate · 42 minor.

From our pharmacist’s overview on the Roflumilast page

“Roflumilast (Daliresp for severe COPD, Zoryve as a cream for skin conditions) is cleared almost entirely by one liver enzyme, CYP3A4, which is why 121 of the 141 supplements on this page can push its level up or down, and why real caution is warranted here. Start with the three rated major: grapefruit blocks that enzyme and can raise r…”

Reviewed by 2 · Jul 18, 2026

Open the Roflumilast interaction page

How much people look this up

Where Wasabi and Roflumilast Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Wasabi
Steady interest

#838 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Roflumilast
Top half

#1,331 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Wasabi reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Wasabi and Roflumilast records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Wasabi

What is Wasabi?

Wasabi
  • Flavoring for sushi and other foods
  • Antimicrobial support
  • Anti-inflammatory support
  • Antioxidant support
  • General immune support

Wasabi is best known as the pungent green condiment served with sushi, made from a Japanese plant in the cabbage family. Its natural compounds (isothiocyanates) show antimicrobial and antioxidant activity in lab studies, but there is very little human research to support taking it as a supplement. As a food it is generally safe; as a concentrated supplement, talk with your pharmacist or doctor first.

Eutrema japonicum · Brassicaceae · Rhizome (root stem), and sometimes the leaves and stalks · Fresh paste, dried powder, capsules, extracts, and as a culinary condiment

An interaction check asks whether these two react with each other — it does not ask whether Wasabi is a good idea for someone in your situation. Here is what our Wasabi record says about it on its own.

Wasabi: dosing

There is no established standard dose for wasabi as a supplement. Research has not identified a safe and effective amount for any specific health purpose.If you choose to use a wasabi product, follow the directions on the label and do not exceed the recommended amount.

From our Wasabi monograph — the full record covers uses, side effects and every documented interaction.

Read the full Wasabi monograph & all interactions
Medication

About Roflumilast

What Is Roflumilast Used For?

Brand names: Daliresp, Zoryve

Daliresp and roflumilast tablets are used to reduce the risk of COPD (chronic obstructive pulmonary disease) flare-ups in adults with severe COPD linked to chronic bronchitis who have had flare-ups in the past. They are not rescue inhalers and will not relieve a sudden breathing attack.

Zoryve cream is used topically to treat plaque psoriasis (adults and children 2+) and mild to moderate atopic dermatitis (eczema) in adults and children as young as 2. Zoryve topical foam is used to treat seborrheic dermatitis (adults and children 9+) and plaque psoriasis of the scalp and body (adults and children 12+).

Most-Reported Side Effects for Roflumilast

From FAERS, the FDA’s public side-effect reporting system (6,927 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 1,054 reports
Chronic obstructive pulmonary disease 657 reports
Diarrhea 596 reports
Nausea 491 reports
Pneumonia 476 reports
See full Roflumilast drug information
Keep checking

Other Drugs & Wasabi

Browse every other medication we’ve checked against Wasabi — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Wasabi page.

No interaction 2,707 drugs checked — show the list

We also checked Wasabi against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Wasabi list.

See the full Wasabi interactions page
See every supplement checked against Roflumilast, ranked by severity
Evidence & sources

Wasabi References

The 2 references that drive our Wasabi monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Morimitsu, Y., Hayashi, K., Nakagawa, Y., Fujii, H., Horio, F., Uchida, K., and Osawa, T. Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, Wasabi. Mech Ageing Dev 2000;116(2-3):125-134. PubMed
  2. Nakajima R, Kanou M, Tokushima M, Iwama Y, Yamana K. Oral administration of 6-methylsulfinylhexyl isothiocyanate extracted from wasabi is safe and improves the fatigue and sleep of healthy volunteers. Biopsychosoc Med 2023;17(1):30. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Wasabi and Roflumilast Together: Common Questions

Is it safe to take Wasabi with Roflumilast?
We do not list a known interaction between Wasabi and Roflumilast. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Wasabi and Roflumilast combination checked?
Interactions in our licensed database are recorded against drug classes. Roflumilast is filed under 3 classifications, and Wasabi has documented interactions with 1 drug class — none of Roflumilast's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Wasabi interact with any other medications?
Yes. Wasabi has 122 documented drug interactions in our database — Roflumilast is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Roflumilast interact with any supplements?
Yes. Roflumilast has documented interactions with 141 supplements in our database — Wasabi is not one of them. The Roflumilast interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Wasabi monograph Uses, safety profile, and every drug interaction in one place Roflumilast drug information The full plain-English guide to this medication Roflumilast supplement interactions Every supplement checked against Roflumilast, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Roflumilast and Wasabi?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.