Drug & supplement interaction

Wild Yam + Buspirone

Buspirone brand name: BuSpar.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Wild Yam and Buspirone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Wild Yam and Buspirone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Buspirone and Wild Yam in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Wild Yam safety at a glance

Wild Yam overall Use caution Likely fine for short-term use in healthy adults, but long-term safety is not well studied.
Pregnancy Avoid Not enough safety data; avoid during pregnancy.
Breastfeeding Avoid Not enough safety data; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Buspirone and Wild Yam? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Buspirone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Buspirone is filed under 5 classifications — including serotonergic drugs, serotonergic drugs, cytochrome p450 3a4 (cyp3a4) substrates. Wild Yam has documented interactions with 1 drug class — the most serious being estrogens (moderate) — and none of Buspirone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Wild Yam Does Interact With Other Medications

Wild Yam has 41 moderate known drug interactions in our database — Buspirone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 41 No known interaction 2,789 (incl. Buspirone)
Taking anything else?

Check Another of Your Medications Against Wild Yam

Covers the 2,830 medications we’ve checked against Wild Yam. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Wild Yam and Buspirone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • A severe allergic reaction Worth acting on Additional detail

    Wild Yam

    “Orally, wild yam is generally well tolerated.

    Most Common Adverse Effects:

    Orally: Fever, headache, upset stomach, and vomiting.

    Serious Adverse Effects (Rare):

    Orally: Anaphylaxis.”

    Wild Yam · Natural Medicines adverse-effect record, reported in cluster headache.

    Buspirone

    Listed in the ADVERSE REACTIONS section of the FDA label for Buspirone. Read the label on DailyMed ›

  • Stomach upset / Vomiting Additional detail

    Wild Yam

    “Orally, wild yam can cause upset stomach and vomiting, especially at higher doses (12,86450).”

    Wild Yam · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    2 sources cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    2. 86450. Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.

    Buspirone

    Listed in the ADVERSE REACTIONS section of the FDA label for Buspirone. Read the label on DailyMed ›

  • Fever / Headache Additional detail

    Wild Yam

    “Orally, wild yam can cause headache and fever, especially at higher doses.”

    Wild Yam · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 86450. Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.

    Buspirone

    Listed in the ADVERSE REACTIONS section of the FDA label for Buspirone. Read the label on DailyMed ›

Reported for Wild Yam but not commonly for Buspirone: loss of vision and blood clots.

Effects for Buspirone come from the ADVERSE REACTIONS section of its FDA label; effects for Wild Yam come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Wild Yam or Buspirone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Wild Yam or Buspirone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Buspirone

This page covers Wild Yam only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Buspirone page lists 155 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 5-htp (moderate).

By severity: 4 major · 108 moderate · 43 minor.

From our pharmacist’s overview on the Buspirone page

“I counsel genuine caution when supplements meet buspirone (BuSpar), the anxiety medication, because four of its 155 documented interactions are rated major. The bulk of the list, 121 ingredients, changes how your liver clears buspirone through the CYP3A4 enzyme, pushing its level up toward dizziness and drowsiness or down until the anx…”

Reviewed by 2 · Jul 18, 2026

Open the Buspirone interaction page

One more smart check

Taking Wild Yam as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,014 real supplement products containing Wild Yam, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Wild Yam. Even though Wild Yam itself has no known interaction with Buspirone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Wild Yam and Buspirone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Wild Yam
Top 25%

#211 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Buspirone
Top 5%

#54 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Wild Yam reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Wild Yam and Buspirone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Wild Yam

What is Wild Yam?

  • Menopausal symptoms
  • Menstrual cramps
  • Hormone balance (popular belief)
  • Digestive cramps
  • Joint and muscle discomfort

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular claims, your body cannot convert its compounds into hormones like progesterone, so creams marketed that way usually don't work as advertised. Talk with a pharmacist or doctor before using it.

Dioscorea villosa · Dioscoreaceae · Root and rhizome (underground stem) · Capsules, tablets, dried root, tinctures, topical creams, tea

An interaction check asks whether these two react with each other — it does not ask whether Wild Yam is a good idea for someone in your situation. Here is what our Wild Yam record says about it on its own.

Wild Yam: dosing

There is no well-established standard dose for wild yam. The amount can vary widely between products and forms (capsules, tinctures, teas, or creams).The safest approach is to follow the directions on the product label and not exceed the recommended amount.

From our Wild Yam monograph — the full record covers uses, side effects and every documented interaction.

Read the full Wild Yam monograph & all interactions
Medication

About Buspirone

What Is Buspirone Used For?

Brand name: BuSpar

Buspirone tablets and capsules are used to manage anxiety disorders or to relieve anxiety symptoms in the short term. Its effectiveness has been shown in clinical trials focused on Generalized Anxiety Disorder (GAD) — a condition marked by persistent, hard-to-control worry along with physical symptoms like muscle tension, restlessness, difficulty concentrating, and sleep problems.

Buspirone has also been shown to relieve anxiety in people who have mild depressive symptoms alongside their anxiety. Everyday stress and tension, on their own, generally do not require treatment with a medicine like buspirone.

See full Buspirone drug information
Keep checking

Other Drugs & Wild Yam

Browse every other medication we’ve checked against Wild Yam — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
41Moderate
0Minor
2,788No known interaction
41 Moderate 2,788 No interaction
Moderate

41 interactions

No interaction 2,788 drugs checked — show the list

We also checked Wild Yam against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,788 medications checked with no known interaction — see the full Wild Yam list.

See the full Wild Yam interactions page
See every supplement checked against Buspirone, ranked by severity
Evidence & sources

Wild Yam References

The 7 references that drive our Wild Yam monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
  3. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  4. Rosenberg Zand, R. S., Jenkins, D. J., and Diamandis, E. P. Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim.Acta 2001;312(1-2):213-219. PubMed
  5. Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.
  6. Zeng M, Zhang L, Li M, et al. Estrogenic effects of the extracts from the Chinese Yam (Dioscorea opposite Thunb.) and its effective compounds in vitro and in vivo. Molecules. 2018 Jan 23;23(2). Pii: E11. PubMed
  7. Lu J, Wong RN, Zhang L, et al. Comparative analysis of proteins with stimulating activity on ovarian estradiol biosynthesis from four different Dioscorea species in vitro using both phenotypic and target-based approaches: implication for treating menopaus

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Wild Yam and Buspirone Together: Common Questions

Is it safe to take Wild Yam with Buspirone?
We do not list a known interaction between Wild Yam and Buspirone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Wild Yam and Buspirone have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Wild Yam and Buspirone combination checked?
Interactions in our licensed database are recorded against drug classes. Buspirone is filed under 5 classifications, and Wild Yam has documented interactions with 1 drug class — none of Buspirone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Wild Yam interact with any other medications?
Yes. Wild Yam has 41 documented drug interactions in our database — Buspirone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Buspirone interact with any supplements?
Yes. Buspirone has documented interactions with 155 supplements in our database — Wild Yam is not one of them. The Buspirone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Wild Yam monograph Uses, safety profile, and every drug interaction in one place Buspirone drug information The full plain-English guide to this medication Buspirone supplement interactions Every supplement checked against Buspirone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Buspirone and Wild Yam?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.