Drug & supplement interaction

Yellow Dock + Methazolamide

Methazolamide brand name: Neptazane.

Major Interaction
Medically reviewed by · Updated September 2026
The bottom line Major

Yellow Dock has a major interaction with Methazolamide. Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.

Read the full interaction report
SeverityMajor
LikelihoodProbable
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Yellow Dock and Methazolamide

Here is the interaction we found between these two, with the evidence behind it.

Major

DIURETIC DRUGS

Why this applies to Methazolamide

Methazolamide falls under DIURETIC DRUGS — the group Yellow Dock interacts with.

Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
When yellow dock is used chronically or in large amounts, hypokalemia may occur, and overuse of yellow dock might compound diuretic-induced potassium loss.
Severity Major Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the concern with pairing yellow dock and methazolamide. Methazolamide is a carbonic anhydrase inhibitor that lowers eye pressure, but it also acts like a mild diuretic and naturally pushes potassium out through your urine. Yellow dock, when used regularly or in big amounts, contains anthraquinones (the same laxative-type compounds in senna) that can also drain potassium when they get your bowels moving often. Stack those two together over time and your potassium could dip too low.

Low potassium can leave you feeling tired, crampy, weak, or give you an irregular heartbeat. This is a theoretical, pharmacology-based caution rather than something proven in studies, and an occasional dose of yellow dock isn't likely the issue. Still, please check with your pharmacist or doctor before using it long-term.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Yellow Dock Also Interacts With Other Medications

Yellow Dock has 75 major, 2 moderate known drug interactions in our database — the Methazolamide one above is one of them. If you take anything else, check it against the full list below.

Major 75 Moderate 2 No known interaction 2,753 (incl. Methazolamide)
Taking anything else?

Check Another of Your Medications Against Yellow Dock

Covers the 2,830 medications we’ve checked against Yellow Dock. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Methazolamide

This page covers Yellow Dock only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methazolamide page lists 218 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Lithium (major) and Oleander (major).

By severity: 7 major · 187 moderate · 24 minor.

From our pharmacist’s overview on the Methazolamide page

“Methazolamide (Neptazane) treats glaucoma by lowering pressure inside the eye, and because it also has mild water-pill effects it can nudge blood pressure and potassium on its own. That is exactly where most of the 218 supplements on this page press, and the list earns real caution.”

Reviewed by 2 · Jul 18, 2026

Open the Methazolamide interaction page

One more smart check

Taking Yellow Dock as Part of a Dietary Supplement Product? Check It for Interactions

We hold 753 real supplement products containing Yellow Dock, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Yellow Dock. Your product may carry other ingredients that interact with Methazolamide too, on top of Yellow Dock — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Yellow Dock and Methazolamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Yellow Dock
Top 25%

#267 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Methazolamide
Top 25%

#642 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Yellow Dock

What is Yellow Dock?

  • Constipation
  • Digestive support
  • Skin conditions
  • Iron-deficiency or 'blood-building' tonic
  • Liver and detox support

Yellow dock is a traditional herb used mostly as a mild laxative and a digestive and skin tonic. Good-quality human studies are lacking, so its benefits are largely unproven, and its naturally occurring oxalates and anthraquinones mean it should be used cautiously and not long-term.

Read the full Yellow Dock monograph & all interactions
Medication

About Methazolamide

What Is Methazolamide Used For?

Brand name: Neptazane

Methazolamide tablets are used to treat eye conditions where lowering intraocular pressure (pressure inside the eye) is expected to help. These include chronic open-angle glaucoma and secondary glaucoma.

Methazolamide tablets are also used before surgery in acute angle-closure glaucoma, when reducing eye pressure ahead of the procedure is needed. Note that long-term use in angle-closure glaucoma is not appropriate.

See full Methazolamide drug information
Keep checking

Other Drugs & Yellow Dock

Browse every other medication we’ve checked against Yellow Dock — both the ones with a known interaction and the ones without. Select any drug for the full detail.

75Major
2Moderate
0Minor
2,752No known interaction
75 Major 2 Moderate 2,752 No interaction
Major

75 interactions

Showing 60 of 75 major interactions — see all 75 on the Yellow Dock page.

Moderate

2 interactions

No interaction 2,752 drugs checked — show the list

We also checked Yellow Dock against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,752 medications checked with no known interaction — see the full Yellow Dock list.

See the full Yellow Dock interactions page
See every supplement checked against Methazolamide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Yellow Dock monograph › Uses, safety, and every drug interaction in one place Methazolamide supplement interactions › Every supplement checked against Methazolamide, ranked by severity Methazolamide drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Yellow Dock and Methazolamide Together: Common Questions

Can you take Yellow Dock with Methazolamide?
This is rated a major interaction, so the combination is best avoided unless your doctor or pharmacist has specifically told you otherwise. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Yellow Dock and Methazolamide interaction?
We rate it Major. This is a clinically significant combination that is generally best avoided, or used only under the direct supervision of your physician or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Methazolamide and Yellow Dock?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.