Drug & supplement interaction

Yellow Loosestrife + Phenobarbital

Phenobarbital brand names: Phenobarbital, Solfoton, Luminal.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Yellow Loosestrife and Phenobarbital in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Yellow Loosestrife and Phenobarbital

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Phenobarbital and Yellow Loosestrife in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Yellow Loosestrife at all — not against Phenobarbital, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Yellow Loosestrife safety at a glance

Yellow Loosestrife overall Not established Human safety data are very limited, so use cautiously and talk to a healthcare provider first.
Pregnancy Avoid Not enough safety information exists, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid it to be safe.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Phenobarbital and Yellow Loosestrife? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Phenobarbital’s Own FDA Label Lists

This is not an interaction — none of it involves Yellow Loosestrife. These are the most notable effects listed in the ADVERSE REACTIONS section of Phenobarbital’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Dependence or withdrawal symptoms Worth acting on
  • Low sodium Worth acting on
  • A slow heartbeat Worth acting on
  • An irregular heartbeat Worth acting on
  • A severe skin reaction Worth acting on
  • Seizures Worth acting on
  • Kidney problems Worth acting on
  • Liver problems Worth acting on
  • A higher chance of infection Worth acting on
  • An allergic reaction Worth acting on

Showing the 10 most notable of 12 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Phenobarbital. Read the label on DailyMed › Yellow Loosestrife’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Yellow Loosestrife side to compare — that is a limit of the record, not a statement that Yellow Loosestrife has no side effects.

From our Q&A

Questions About Yellow Loosestrife or Phenobarbital

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Yellow Loosestrife or Phenobarbital, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Phenobarbital

This page covers Yellow Loosestrife only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Phenobarbital page lists 174 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Henbane (major).

By severity: 10 major · 143 moderate · 21 minor.

Open the Phenobarbital interaction page

How much people look this up

Where Yellow Loosestrife and Phenobarbital Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Yellow Loosestrife
Steady interest

#1,449 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Phenobarbital
Steady interest

#1,542 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Yellow Loosestrife is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Yellow Loosestrife reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Yellow Loosestrife and Phenobarbital records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Yellow Loosestrife

What is Yellow Loosestrife?

  • Diarrhea and digestive upset
  • Minor wounds and bleeding
  • Mouth and throat irritation
  • Mild gastrointestinal complaints

Yellow loosestrife (Lysimachia vulgaris) is a traditional European herb used mostly for diarrhea, minor bleeding, and mouth or throat irritation. There is very little modern scientific evidence to confirm it works, and its safety has not been well studied, so it should be used cautiously and avoided in pregnancy and breastfeeding.

Lysimachia vulgaris · Primulaceae · Aerial parts (leaves, stems, and flowers) · Tea (infusion), tincture, dried herb, occasionally topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Yellow Loosestrife is a good idea for someone in your situation. Here is what our Yellow Loosestrife record says about it on its own.

Yellow Loosestrife: dosing

There is no established standard dose for yellow loosestrife. Modern science has not determined a safe or effective amount.If you choose to use a product, follow the directions on the label and do not exceed them.

From our Yellow Loosestrife monograph — the full record covers uses, side effects and every documented interaction.

Read the full Yellow Loosestrife monograph & all interactions
Medication

About Phenobarbital

What Is Phenobarbital Used For?

Brand names: Phenobarbital, Solfoton, Luminal

Phenobarbital tablets and oral solutions are used to treat generalized and partial seizures and as a sedative. Phenobarbital Sodium injection is used as a long-term anticonvulsant for generalized tonic-clonic and focal seizures, for emergency control of acute convulsive episodes (including status epilepticus), for sedation, short-term treatment of insomnia, and as a preanesthetic. It is also used in pediatric patients as an anticonvulsant and sedative, including before and after surgery.

Sezaby (phenobarbital injection, intravenous) is specifically indicated for the treatment of neonatal seizures in term and preterm infants. It is not approved for use in adolescents or adults.

Most-Reported Side Effects for Phenobarbital

From FAERS, the FDA’s public side-effect reporting system (15,690 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Seizure 1,669 reports
Toxicity to various agents 647 reports
Status epilepticus 532 reports
Somnolence 492 reports
Multiple-drug resistance 475 reports
See full Phenobarbital drug information
Keep checking

Other Drugs & Yellow Loosestrife

Browse every other medication we’ve checked against Yellow Loosestrife — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Yellow Loosestrife against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Yellow Loosestrife list.

See the full Yellow Loosestrife interactions page
See every supplement checked against Phenobarbital, ranked by severity
Evidence & sources

Yellow Loosestrife References

The 2 sources that drive our Yellow Loosestrife monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Yellow Loosestrife is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Herbs at a Glance — NIH National Center for Complementary and Integrative Health Source
  2. Herbs and Supplements — MedlinePlus (U.S. National Library of Medicine) Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Yellow Loosestrife and Phenobarbital Together: Common Questions

Is it safe to take Yellow Loosestrife with Phenobarbital?
We do not list a known interaction between Yellow Loosestrife and Phenobarbital. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Phenobarbital interact with any supplements?
Yes. Phenobarbital has documented interactions with 174 supplements in our database — Yellow Loosestrife is not one of them. The Phenobarbital interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Yellow Loosestrife monograph Uses, safety profile, and every drug interaction in one place Phenobarbital drug information The full plain-English guide to this medication Phenobarbital supplement interactions Every supplement checked against Phenobarbital, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Phenobarbital and Yellow Loosestrife?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.