Drug & supplement interaction

Yerba Santa + Verapamil

Verapamil brand names: Isoptin SR, Verelan, Isoptin, Calan SR, Verelan SR, and others.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Yerba Santa and Verapamil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Yerba Santa and Verapamil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Verapamil and Yerba Santa in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Yerba Santa safety at a glance

Yerba Santa overall Use caution Generally used in small amounts in foods and teas, but human safety data are limited.
Pregnancy Avoid Not enough safety information is available, so it is best to avoid medicinal amounts during pregnancy.
Breastfeeding Avoid Safety has not been studied in nursing mothers, so avoid medicinal use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Verapamil and Yerba Santa? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Verapamil

Interactions in our licensed database are recorded against drug classes, not just single drug names. Verapamil is filed under 11 classifications — including calcium channel blockers, cytochrome p450 2c8 (cyp2c8) substrates, cytochrome p450 3a4 (cyp3a4) inhibitors. Yerba Santa has documented interactions with 1 drug class — the most serious being lithium (moderate) — and none of Verapamil’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Yerba Santa Does Interact With Other Medications

Yerba Santa has 1 moderate known drug interaction in our database — Verapamil isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1 No known interaction 2,829 (incl. Verapamil)
Taking anything else?

Check Another of Your Medications Against Yerba Santa

Covers the 2,830 medications we’ve checked against Yerba Santa. Pick one to open its full report.

What to actually watch for

What Verapamil’s Own FDA Label Lists

This is not an interaction — none of it involves Yerba Santa. These are the most notable effects listed in the ADVERSE REACTIONS section of Verapamil’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 6 of them are worth acting on rather than waiting out — marked below.

  • A bowel blockage Worth acting on
  • A slow heartbeat Worth acting on
  • Heart failure Worth acting on
  • Raised blood pressure Worth acting on
  • Liver problems Worth acting on
  • A higher chance of infection Worth acting on
  • A stuffy or runny nose
  • Sore throat
  • Low blood pressure
  • Stomach upset

Showing the 10 most notable of 17 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Verapamil. Read the label on DailyMed › Yerba Santa’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Yerba Santa side to compare — that is a limit of the record, not a statement that Yerba Santa has no side effects.

From our Q&A

Questions About Yerba Santa or Verapamil

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Yerba Santa or Verapamil, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Verapamil

This page covers Yerba Santa only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Verapamil page lists 295 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Beer (major) and Coleus (major).

By severity: 10 major · 245 moderate · 40 minor.

From our pharmacist’s overview on the Verapamil page

“This is one of the longer interaction lists we publish, and with verapamil (Calan, Verelan) it warrants genuine care, starting with the ten major-rated entries. Verapamil lowers blood pressure and slows the heart, so most of the 295 ingredients on file either push that effect further than intended or change how much of the drug reaches…”

Reviewed by 2 · Jul 18, 2026

Open the Verapamil interaction page

One more smart check

Taking Yerba Santa as Part of a Dietary Supplement Product? Check It for Interactions

We hold 276 real supplement products containing Yerba Santa, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Yerba Santa. Even though Yerba Santa itself has no known interaction with Verapamil, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Yerba Santa and Verapamil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Yerba Santa
Top half

#716 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Verapamil
Top 10%

#204 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources.
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Yerba Santa and Verapamil records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Yerba Santa

What is Yerba Santa?

Yerba Santa
  • Coughs and colds
  • Chest congestion (expectorant)
  • Asthma and bronchitis
  • Sore throat
  • Masking bitter tastes in medicines

Yerba Santa is an aromatic shrub from the western United States and Mexico that has long been used in folk medicine for coughs, congestion, and other respiratory complaints. Modern scientific evidence supporting these uses is very limited, with most data coming from laboratory studies rather than human trials. It is best known today as a flavoring agent that helps mask the bitter taste of medicines; talk to a pharmacist or doctor before using it for health purposes.

Eriodictyon californicum · Boraginaceae · Leaves · Tea, tincture, capsules, syrup, dried leaf, throat lozenges, and as a flavoring agent

An interaction check asks whether these two react with each other — it does not ask whether Yerba Santa is a good idea for someone in your situation. Here is what our Yerba Santa record says about it on its own.

Yerba Santa: dosing

There is no established standardized dose for Yerba Santa, and the amount of active compounds can vary a lot from product to product. Because of this, it is hard to recommend a specific safe and effective dose.If you choose to use it, follow the directions on the product label and do not exceed the recommended amount. A pharmacist or doctor can help you decide whether it is appropriate for you, especially if you take other medicines or have a health condition. Do not use it as a replacement for proven treatments for asthma or infections.

From our Yerba Santa monograph — the full record covers uses, side effects and every documented interaction.

Read the full Yerba Santa monograph & all interactions
Medication

About Verapamil

What Is Verapamil Used For?

Brand names: Isoptin SR, Verelan, Isoptin, Calan SR, Verelan SR, Calan, Covera HS, Verap, Veramil

Verapamil tablets and film-coated tablets are used to treat angina — including vasospastic (Prinzmetal's) angina, unstable angina, and chronic stable angina — as well as certain abnormal heart rhythms (arrhythmias) and high blood pressure (essential hypertension). For arrhythmias, regular-release tablets are used alongside digoxin to control heart rate in atrial flutter or atrial fibrillation, and to help prevent episodes of paroxysmal supraventricular tachycardia (SVT), a type of rapid heartbeat.

Extended-release and sustained-release oral forms (tablets and capsules) are indicated specifically for high blood pressure. Verapamil hydrochloride injection is used in hospital settings for rapid conversion of SVT to normal rhythm and for temporary control of fast heart rates in atrial flutter or atrial fibrillation.

Most-Reported Side Effects for Verapamil

From FAERS, the FDA’s public side-effect reporting system (4,297 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 352 reports
Nausea 351 reports
Dizziness 295 reports
Hypotension 293 reports
Fatigue 275 reports
See full Verapamil drug information
Keep checking

Other Drugs & Yerba Santa

Browse every other medication we’ve checked against Yerba Santa — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1Moderate
0Minor
2,828No known interaction
1 Moderate 2,828 No interaction
Moderate

1 interaction

No interaction 2,828 drugs checked — show the list

We also checked Yerba Santa against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Yerba Santa list.

See the full Yerba Santa interactions page
See every supplement checked against Verapamil, ranked by severity
Sources

Sources & How We Checked

We checked Yerba Santa against Verapamil in the Natural Medicines interaction database and found no documented interaction on file. The medication overview comes from MedlinePlus, and supplement label details from the NIH Dietary Supplement Label Database.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Yerba Santa monograph › Uses, safety, and every drug interaction in one place Verapamil supplement interactions › Every supplement checked against Verapamil, ranked by severity Verapamil drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Yerba Santa and Verapamil Together: Common Questions

Is it safe to take Yerba Santa with Verapamil?
We do not list a known interaction between Yerba Santa and Verapamil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Yerba Santa and Verapamil combination checked?
Interactions in our licensed database are recorded against drug classes. Verapamil is filed under 11 classifications, and Yerba Santa has documented interactions with 1 drug class — none of Verapamil's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Yerba Santa interact with any other medications?
Yes. Yerba Santa has 1 documented drug interaction in our database — Verapamil is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Verapamil interact with any supplements?
Yes. Verapamil has documented interactions with 295 supplements in our database — Yerba Santa is not one of them. The Verapamil interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Verapamil and Yerba Santa?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.