Herb & supplement monograph

Buckwheat Drug Interactions, Uses, Effectiveness, Safety & More

Check Buckwheat against your medication

Add one medication
Buckwheat
+
Start typing any prescription or over-the-counter drug name.
Reviewed by licensed pharmacists Sourced from Natural Medicines
Interaction report

Drugs that interact with Buckwheat

0 medications have a known interaction with Buckwheat, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Buckwheat. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Buckwheat combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Buckwheat: Uses, Safety & Side Effects

The bottom line

Buckwheat is a nutritious, naturally gluten-free seed that is high in fiber, protein, and antioxidants like rutin. As a food it can be part of a heart-healthy diet, but evidence that buckwheat supplements treat specific conditions is limited. Talk to your pharmacist or doctor before using concentrated extracts.

Buckwheat
Scientific name
Fagopyrum esculentum
Family
Polygonaceae
Part used
Seeds (grain), and sometimes the herb (leaves and flowers)
Common forms
Flour, groats, whole seeds, tea, capsules/tablets, and extracts
People commonly use it for
  • Heart and circulation health
  • Blood sugar support
  • Source of fiber and protein
  • Antioxidant support
  • Varicose veins or leg swelling (traditional)

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallLikely safe

Buckwheat is generally safe as a food for most people, though allergic reactions can occur.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Buckwheat is a plant grown for its grain-like seeds. Even though its name includes "wheat," it is not related to wheat at all and contains no gluten. It actually belongs to the same plant family as sorrel and knotweed.

Buckwheat is grown in many parts of the world, including Asia, Europe, and North America. The seeds are ground into flour or cooked as groats and used in foods like noodles, pancakes, and porridge. There are different types, including common buckwheat and Tartary buckwheat.

Beyond food, buckwheat is sometimes taken as a supplement or tea, often for its high content of fiber, protein, and plant antioxidants such as rutin.

How it works

Buckwheat contains several compounds that may explain its possible benefits. It is rich in fiber, which can slow digestion, support healthy bowel movements, and help blunt rises in blood sugar after meals.

It is also a good source of rutin and other flavonoid antioxidants. In laboratory and animal studies, these compounds have been shown to fight oxidative stress and may help support blood vessels. Buckwheat also provides quality plant protein, magnesium, and other minerals.

It is important to know that many of these proposed effects come from lab or animal research, or from studies of buckwheat as part of the diet. That does not always translate into proven benefits from taking a supplement.

Effectiveness

Does Buckwheat work?

Evidence overview · 4 uses evaluated
4 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Buckwheat, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 4 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Cardiovascular disease (CVD)
Rating & evidence shown verbatim from Natural Medicines

A meta-analysis of clinical research shows that taking buckwheat seems to improve some, but not all, markers of CVD risk. Buckwheat was found to decrease total cholesterol by 19 mg/dL, triglycerides by 22 mg/dL, and blood glucose by 15 mg/dL, but had no effect on blood pressure, body weight, insulin, or low-density lipoprotein (LDL) cholesterol when compared with a control group. The patient populations included in this analysis ranged from healthy adults to those with diabetes or hyperlipidemia; it's unclear whether the results are consistent across patient groups or if the benefits are more pronounced in certain types of patients. The effects of buckwheat on cardiovascular events, such as myocardial infarction, stroke, or cardiovascular death, in patients with CVD, are unknown.

Sources Ref 100947
Insufficient Reliable Evidence To Rate Chronic venous insufficiency (CVI)
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research shows that drinking common buckwheat tea for 3 months attenuates leg swelling compared with placebo in patients with chronic venous insufficiency.

Sources Ref 37351
Insufficient Reliable Evidence To Rate Diabetes
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research shows that patients with type 2 diabetes who replace a portion of white rice or white flour with tartary buckwheat 50 grams three times daily for 4 weeks show a 3% reduction in fasting insulin and a 7% reduction in low-density lipoprotein (LDL) cholesterol compared to baseline. Patients who consume the standardized recipe containing white rice and/or white flour three times daily for 4 weeks show no significant changes in these measurements. Neither groups show improvement in fasting blood glucose or hemoglobin A1c levels.

Sources Ref 96063
Insufficient Reliable Evidence To Rate Diabetic retinopathy
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research shows that taking common buckwheat 1 gram three times daily for 3 months does not significantly improve visual acuity compared with baseline in patients with diabetic retinopathy.

Sources Ref 37358

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

As a food, buckwheat is generally safe and is a useful gluten-free option for people who cannot eat wheat. The main concern is allergy. Buckwheat allergy is well documented and can sometimes be serious, including anaphylaxis. People with known buckwheat allergy should avoid it completely.

If you have asthma or other food allergies, be cautious, since allergic reactions to buckwheat appear more common in these groups.

Pregnancy: Eating buckwheat as a normal food is generally considered fine, but concentrated supplements or extracts have not been well studied in pregnancy, so it is safest to avoid them unless your doctor approves.

Breastfeeding: Buckwheat foods are likely fine in normal amounts, but the safety of supplement doses while breastfeeding is unknown. Use caution and check with your pharmacist or doctor.

Side effects

For most people, buckwheat eaten as food causes few problems. Because it is high in fiber, eating large amounts may cause gas, bloating, or stomach upset, especially if you are not used to it.

The most important risk is an allergic reaction. Signs can include hives, itching, swelling, trouble breathing, or, rarely, a severe whole-body reaction (anaphylaxis). If you have any of these symptoms after eating buckwheat, get medical help right away.

Some buckwheat products, like buckwheat hull pillows, can also trigger allergy symptoms in sensitive people.

Buckwheat: Reported Adverse Effects

Documented safety reports on Buckwheat from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Allergic rhinitis (hay fever) Immunologic

Orally, buckwheat seems to be well tolerated. However, allergic reactions to buckwheat can occur in some adults and children. Symptoms can include skin sensitization, allergic rhinitis, asthma, conjunctivitis, nausea, vomiting, and anaphylaxis.

Occupational exposure to buckwheat, or household exposure through sleeping on a buckwheat husk stuffed-pillow can cause sensitization, of which symptoms include allergic rhinitis and asthma.

  1. Skrabanja V, Liljeberg Elmstahl HG, Kreft I, Bjorck IM. Nutritional properties of starch in buckwheat products: studies in vitro and in vivo. J Agric Food Chem 2001;49:490-6.
  2. Bijlani RL, Gandhi BM, Gupta MC, et al. Effect of whole buckwheat (Fagopyrum esculentum) flour supplementation on lipid profile & glucose tolerance. Indian J Med Res 1985;81:162-8.
  3. Schiffner R, Przybilla B, Burgdorff T, et al. Anaphylaxis to buckwheat. Allergy 2001;56:1020-1.
  4. Lee SY, Lee KS, Hong CH, Lee KY. Three cases of childhood nocturnal asthma due to buckwheat allergy. Allergy 2001;56:763-6.
  5. Wieslander G, Norback D. Buckwheat allergy. Allergy 2001;56:703-4.
  6. Cifuentes L, Mistrello G, Amato S, et al. Identification of cross-reactivity between buckwheat and coconut. Ann Allergy Asthma Immunol. 2015 Dec;115(6):530-2.
  7. De Maat-Bleeker F, Stapel SO. Cross-reactivity between buckwheat and latex. Allergy. 1998 May;53(5):538-9.
  8. Fritz SB, Gold BL. Buckwheat pillow-induced asthma and allergic rhinitis. Ann Allergy Asthma Immunol 2003;90:355-8.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official standardized supplement dose of buckwheat. As a food, it can simply be eaten as part of a balanced diet, similar to other whole grains and seeds.

For buckwheat capsules, teas, or extracts, the right amount depends on the specific product. Because doses are not well established, the best approach is to follow the directions on the product label and not exceed the recommended amount.

Always check with your pharmacist or doctor before starting a buckwheat supplement, especially if you are pregnant, breastfeeding, have a medical condition, or take other medicines.

Pregnancy & Breastfeeding

Buckwheat & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Buckwheat & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 12 references that drive our Buckwheat monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Schiffner R, Przybilla B, Burgdorff T, et al. Anaphylaxis to buckwheat. Allergy 2001;56:1020-1. PubMed
  2. Lee SY, Lee KS, Hong CH, Lee KY. Three cases of childhood nocturnal asthma due to buckwheat allergy. Allergy 2001;56:763-6. PubMed
  3. Wieslander G, Norback D. Buckwheat allergy. Allergy 2001;56:703-4.
  4. Skrabanja V, Liljeberg Elmstahl HG, Kreft I, Bjorck IM. Nutritional properties of starch in buckwheat products: studies in vitro and in vivo. J Agric Food Chem 2001;49:490-6. PubMed
  5. Bijlani RL, Gandhi BM, Gupta MC, et al. Effect of whole buckwheat (Fagopyrum esculentum) flour supplementation on lipid profile & glucose tolerance. Indian J Med Res 1985;81:162-8.
  6. Fritz SB, Gold BL. Buckwheat pillow-induced asthma and allergic rhinitis. Ann Allergy Asthma Immunol 2003;90:355-8. PubMed
  7. Ihme, N., Kiesewetter, H., Jung, F., Hoffmann, K. H., Birk, A., Muller, A., and Grutzner, K. I. Leg oedema protection from a buckwheat herb tea in patients with chronic venous insufficiency: a single-centre, randomised, double-blind, placebo-controlled c
  8. Archimowicz-Cyrylowska B and et al. Clinical effect of buckwheat herb, Ruscus extract and troxerutin on retinopathy and lipids in diabetic patients. Phytother Res 1996;10(659):62. DOI
  9. Cifuentes L, Mistrello G, Amato S, et al. Identification of cross-reactivity between buckwheat and coconut. Ann Allergy Asthma Immunol. 2015 Dec;115(6):530-2. PubMed
  10. De Maat-Bleeker F, Stapel SO. Cross-reactivity between buckwheat and latex. Allergy. 1998 May;53(5):538-9. PubMed
  11. Qiu J, Liu Y, Yue Y, Qin Y, Li Z. Dietary tartary buckwheat intake attenuates insulin resistance and improves lipid profiles in patients with type 2 diabetes: a randomized controlled trial. Nutr Res. 2016 Dec;36(12):1392-1401. PubMed
  12. Li L, Lietz G, Seal C. Buckwheat and CVD risk markers: a systematic review and meta-analysis. Nutrients. 2018;10(5). pii: E619. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Product directory

Supplement products with Buckwheat

406 products in our database contain Buckwheat. Open any to see its full ingredient list and every drug interaction we check.

Mega Chewable Acerola Plus Natural Berry Flavor by American Health Tablet Or Pill 60 Chewable Tablet(s) View ingredients & interactions Microbiome Rejuvenate by Big Bold Health Capsule 120 Capsule(s) View ingredients & interactions Nature's Lab Fit Complete Delightful Vanilla Flavor by DrVita Labs Powder 614 Gram(s) View ingredients & interactions Nature's Lab Fit Complete Luxurious Chocolate Flavor by DrVita Labs Powder 714 Gram(s) View ingredients & interactions Okra Pepsin E3 by SP Standard Process Capsule 90 Capsule(s) View ingredients & interactions Okra Pepsin E3 by SP Standard Process Capsule 150 Capsule(s) View ingredients & interactions OPC Synergy by SP Standard Process Capsule 40 Capsule(s) View ingredients & interactions Optimized Quercetin 250 mg by Life Extension Capsule 60 Vegetarian Capsule(s) View ingredients & interactions Organic Fit Chocolate Flavor by Garden of Life Powder 16.01 Oz(s) · 1.81 lb(s) · 457 Gram(s) View ingredients & interactions Organic Fit Vanilla Flavor by Garden of Life Powder 16.04 Oz(s) · 1 lb(s) · 466 Gram(s) · 44 Ounce(s) View ingredients & interactions Organic Greens Unflavored by Purely Inspired Powder 8.54 Ounce(s) · 242 Gram(s) View ingredients & interactions Organic Greens Unflavored by Purely Inspired Powder 8.57 Ounce(s) · 243 Gram(s) View ingredients & interactions Organic Greens Unflavored by Purely Inspired Powder 8.57 Ounce(s) · 243 Gram(s) View ingredients & interactions Organic Miracle Whey Protein Powder Chocolate by Dr. Mercola Powder 20.6 Ounce(s) · 1.29 Pound(s) · 585 Gram(s) View ingredients & interactions Organic Miracle Whey Protein Powder Strawberry by Dr. Mercola Powder 20.6 Ounce(s) · 1.29 Pound(s) · 585 Gram(s) View ingredients & interactions Organic Miracle Whey Protein Powder Vanilla by Dr. Mercola Powder 20.6 Ounce(s) · 1.29 Pound(s) · 585 Gram(s) View ingredients & interactions Organic Sprouted Radiance Blend Chocolate by Health Ranger Select Powder 9 Ounce(s) · 255 Gram(s) View ingredients & interactions Organic Superveggies by Ancient Nutrition Capsule 60 Capsule(s) View ingredients & interactions Organic Whey Protein 20 g Chocolate by Pure Power Powder 20.6 Ounce(s) · 1.28 lb(s) · 585 Gram(s) View ingredients & interactions Organic Whey Protein 20 g Strawberry by Pure Power Powder 20.6 Ounce(s) · 1.29 lb(s) · 585 Gram(s) View ingredients & interactions Organic Whey Protein 20 g Vanilla by Pure Power Powder 20.6 Ounce(s) · 1 lb(s) · 4.6 Ounce(s) · 585 Gram(s) View ingredients & interactions Organic Whey Protein Chocolate by Pure Power Powder 20.6 Ounce(s) · 1.29 Pound(s) · 585 Gram(s) View ingredients & interactions Organic Whey Protein Strawberry by Pure Power Powder 20.6 Ounce(s) · 1.29 Pound(s) · 585 Gram(s) View ingredients & interactions Organic Whey Protein Vanilla by Pure Power Powder 20.6 Ounce(s) · 1.29 Pound(s) · 585 Gram(s) View ingredients & interactions
Pharmacist Counseling Corner

Buckwheat: Common Questions

What is Buckwheat used for, and does it work?
People use Buckwheat for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Buckwheat interact with prescription medications?
We do not currently list any known drug interactions for Buckwheat. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Buckwheat interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Buckwheat with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Buckwheat interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
Is Buckwheat gluten-free?
Yes. Despite its name, Buckwheat is not related to wheat and is naturally gluten-free, making it a useful grain alternative for people with celiac disease or gluten sensitivity. Just be sure the product is not cross-contaminated with wheat during processing.
Can Buckwheat help lower blood sugar?
Buckwheat is high in fiber and digests slowly, and some small studies suggest it may modestly help with blood sugar. The evidence is still early, so it should not replace your prescribed diabetes treatment.
Can I be allergic to Buckwheat?
Yes. Buckwheat allergy is well known and can sometimes cause severe reactions, including anaphylaxis. If you have had a reaction to Buckwheat, avoid it and any products that contain it.
Is Buckwheat safe to eat during pregnancy?
Buckwheat eaten as a normal food is generally considered fine, but concentrated supplements have not been well studied in pregnancy. It is safest to stick to food amounts and check with your doctor before using supplements.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Have a question about Buckwheat?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist