Interactions on record — worth a quick check against your medications. Based on 6 of 10 ingredients. Check your meds →
Dietary supplement

Okra Pepsin E3 Ingredients & Drug Interactions

by SP Standard Process

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Okra Pepsin E3 is a dietary supplement by SP Standard Process with 10 active ingredients. Its ingredients are commonly taken for low testosterone or male vitality, sexual performance and libido support, athletic performance and muscle building.Based on those ingredients, 2,050 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Alginic Acid, Okra. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Okra Pepsin E3 by SP Standard Process

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 10 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (215 mg) without saying how much of each component you get.

Okra Pepsin E3 contains 10 ingredients, including a proprietary blend. The active components include bovine orchic extract (from cattle testes), pepsin (a digestive enzyme), alginic acid (derived from seaweed), and extracts or powders of carrot, buckwheat, and okra.

The product also contains Spanish Moss, Carbamide, and Pea vine. Inactive ingredients include gelatin, water, calcium stearate, cellulose, and vitamin E.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Vitamin A deficiency — rated "Possibly Effective" (Carrot) (Natural Medicines).

The evidence for this product's effectiveness isn't established in the data we hold. Carrot is possibly effective for vitamin A deficiency, but the other ingredients — orchic extract, pepsin, alginic acid, buckwheat, okra, and the remaining components — either have no established effectiveness ratings or show insufficient evidence for their claimed uses.

If you're considering this for a specific health concern, talk it over with your doctor or pharmacist.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bovine orchic extract carries significant concerns: it's derived from raw cattle testes from slaughterhouses, which may include diseased animals, and there's a theoretical risk of contamination with BSE (mad cow disease) if the cattle were from affected regions — though no human cases have been reported. The safety data for orchic extract is very limited, and it should be avoided during pregnancy and breastfeeding.

Pepsin is generally well tolerated for most adults but may cause digestive upset or allergic reactions, particularly in people with occupational exposure to proteases. Carrot as a food is safe, but concentrated supplements aren't well studied in pregnancy and breastfeeding.

Buckwheat and okra can trigger allergic reactions in some people, including skin reactions, respiratory symptoms, or anaphylaxis. Alginic acid is generally well tolerated in food amounts, but supplement-level safety is less established.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 6 matched ingredients can interact with medications — Ambrette, Algin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 2,051 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Okra Pepsin E3, check with your doctor or pharmacist if you're on antidiabetes drugs — okra may increase the risk of low blood sugar (hypoglycemia). Also flag any oral medications, since alginic acid can theoretically alter drug absorption.

We have no documented interactions for the remaining ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product is designed to support digestive function, but the effectiveness evidence is limited to what's in our data. Because okra may lower blood sugar, anyone taking diabetes medications should check with their doctor or pharmacist before starting.

The bovine orchic extract carries contamination concerns and lacks pregnancy and breastfeeding safety data. If you have allergies to plants in the carrot or buckwheat families, or occupational exposure to proteases, discuss this product with your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 19, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Okra Pepsin E3, straight from the product label.

Brand SP Standard Process
Barcode (UPC) 812122013574
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Nov 19, 2021
DSLD ID 256538
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Okra Pepsin E3 by SP Standard Process, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
812122013574
IngredientAmount% DV
Cholesterol5 mg2%
Proprietary Blend215 mg--
Bovine Orchic extract0 NP--
Alginic Acid0 NP--
Pepsin0 NP--
organic Carrot0 NP--
Spanish Moss0 NP--
Carbamide0 NP--
organic Buckwheat0 NP--
organic Pea vine0 NP--
Okra0 NP--
Fat Soluble extract0 NP--

Other ingredients: Gelatin, Water, Calcium Stearate, Cellulose, D-Alpha Tocopherol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: One capsule after each meal, or as directed.

Formulation

Non-Dairy formula Gluten free

General Statements

Whole Food Supplements Since 1929

Precautions

Caution: This product is processed in a facility that manufactures other products containing soy, milk, egg, wheat, peanut, tree nuts, fish, shellfish.

See for yourself

Okra Pepsin E3 by SP Standard Process label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Okra Pepsin E3 by SP Standard Process

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

215 mg per serving

Other (inactive) ingredients: Gelatin, Water, Calcium Stearate, Cellulose, D-Alpha Tocopherol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Okra Pepsin E3 by SP Standard Process Drug Interactions

Want to check YOUR meds against Okra Pepsin E3?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
2,050Drugs
86 Moderate 1,964 Minor

Ingredients driving the most interactions

Alginic Acid 2,022
Okra 86

Each ingredient & the kinds of drugs it affects

For each ingredient in Okra Pepsin E3 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Alginic Acid1 drug type · 2,022 drugs

Oral Drugs

Theoretically, algin can alter the absorption of oral drugs. Laboratory research shows that algin, when consumed as part of the diet or used as a thickening agent in infant formula, reduces the absorption of certain minerals. Also, algin has been used as a tablet binder and disintegrant to enhance drug bioavailability. To avoid changes in absorption, take algin 30-60 minutes after oral medications.

Likelihood Possible Evidence D

Okra1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, concomitant use of ambrette with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that myricetin, a constituent of ambrette, can lower blood glucose levels.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Okra Pepsin E3, from the product label.

SP Standard Process

See all SP Standard Process products
Name
Standard Process Inc.
Street Address
1200 West Royal Lee Drive
City
Palmyra
State
WI
ZipCode
53156
Pharmacist Counseling Corner

Okra Pepsin E3 by SP Standard Process: Common Questions

Does Okra Pepsin E3 by SP Standard Process interact with any medications?
Yes. Based on its ingredients, Okra Pepsin E3 has a known interaction with 2,050 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Okra Pepsin E3 contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have diabetes or take blood-sugar medication?
Not without checking first. Okra in this product contains a compound that may lower blood glucose, so combining it with antidiabetes drugs could raise your risk of low blood sugar (hypoglycemia). Talk to your doctor or pharmacist before starting.
Is it safe during pregnancy?
No. Bovine orchic extract should be avoided in pregnancy because there's no safety data. Okra and concentrated carrot supplements are also best avoided. Talk to your doctor if you're pregnant or planning to be.
Is it safe while breastfeeding?
Bovine orchic extract and okra should be avoided while breastfeeding due to lack of safety data. Pepsin and concentrated carrot supplements are also not recommended without medical guidance. Check with your doctor or pharmacist.
Can I take this with my other oral medications?
Alginic acid in this product may alter how your body absorbs oral medications. Use the search tool on this page to check your specific drugs, and confirm the combination with your pharmacist before starting.
What's bovine orchic extract, and why is it in here?
It's an extract from cattle testes, traditionally used in supplements marketed for male health. However, it's derived from slaughterhouse organs that may be contaminated or diseased, and the human safety data are very limited — it's one reason to talk with your doctor before taking this product.
I'm allergic to carrots (or buckwheat). Can I still take this?
No. This product contains both carrot and buckwheat, and allergic reactions to either — including skin reactions, swelling, asthma, or anaphylaxis — have been reported. Avoid it and talk to your pharmacist about alternatives.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Okra Pepsin E3 is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Okra Pepsin E3 label
Go deeper

The Full Monographs Behind Okra Pepsin E3’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Orchic Extract

Orchic extract is a glandular supplement made from the testicle tissue of animals, usually cattle. It is marketed for testosterone and male vitality, but there is essentially no reliable hum...

Read the full Orchic Extract monograph →
Herb & supplement monograph

Algin

Interacts with 2,022 drugs

Algin (alginate) is a fiber-like substance from brown seaweed that is widely used as a thickener, gel, and binder in foods and medicines. Its best-known medical use is in heartburn products,...

Read the full Algin monograph →
Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Herb & supplement monograph

Carrot

Carrot is a common food vegetable that is a rich source of beta-carotene (which the body turns into vitamin A) and other nutrients. Eating carrots is safe and nutritious for most people, but...

Read the full Carrot monograph →
Herb & supplement monograph

Buckwheat

Buckwheat is a nutritious, naturally gluten-free seed that is high in fiber, protein, and antioxidants like rutin. As a food it can be part of a heart-healthy diet, but evidence that buckwhe...

Read the full Buckwheat monograph →
Herb & supplement monograph

Ambrette

Interacts with 86 drugs

Ambrette (Abelmoschus moschatus) is a fragrant plant best known for its musky seed oil used in perfumes and food flavoring. It has a long history in traditional medicine for digestion, breat...

Read the full Ambrette monograph →
Sources

Sources & How We Checked

Okra Pepsin E3's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 40 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Orchic Extract 2 references
  1. ORCHIC PMG (Protomorphogen). Natural Health Cod. www.nbizz.com/naturalhealthdoc/listings/184.html (Accessed 9 November 2000).
  2. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.

See these in context on the Orchic Extract monograph →

Algin 3 references
  1. Harmuth-Hoene, A. E. and Schelenz, R. Effect of dietary fiber on mineral absorption in growing rats. J Nutr 1980;110(9):1774-1784. PubMed
  2. Bosscher D, Van Caillie-Bertrand M, Deelstra H. Effect of thickening agents, based on soluble dietary fiber, on the availability of calcium, iron, and zinc from infant formulas. Nutrition. 2001;17(7-8):614-8. PubMed
  3. Beneke CE, Viljoen AM, Hamman JH. Polymeric plant-derived excipients in drug delivery. Molecules. 2009;14(7):2602-20. PubMed

See these in context on the Algin monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Carrot 14 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Wetzel WE, Lehn W, Grieb A. [Carotene jaundice in infants with "sugar nursing bottle syndrome"]. Monatsschr Kinderheilkd 1989;137(10):659-61.
  3. el-Arab AE, Khalil F, Hussein L. Vitamin A deficiency among preschool children in a rural area of Egypt: the results of dietary assessment and biochemical assay. Int J Food Sci Nutr 2002;53(6):465-74. PubMed
  4. Helbling A. [Food allergy]. Ther Umsch 1994;51(1):31-7.
  5. Kaplan R. Carrot addiction. Aust N Z J Psychiatry 1996;30(5):698-700.
  6. Ncube, T. N., Greiner, T., Malaba, L. C., and Gebre-Medhin, M. Supplementing lactating women with puréed papaya and grated carrots improved vitamin A status in a placebo-controlled trial. J Nutr 2001;131(5):1497-1502. PubMed
  7. Mullins M, Froelke BR, Rivera MR. Effect of delayed activated charcoal on acetaminophen concentration after simulated overdose of oxycodone and acetaminophen. Clin Toxicol (Phila) 2009;47(2):112-5. PubMed
  8. Kawai M, Tamagawa-Mineoka R, Hagura A, Masuda K, Katoh N. Allergic contact dermatitis due to carrots. J Dermatol 2014;41(8):753-4. PubMed
  9. Xu X, Cheng Y, Li S, et al. Dietary carrot consumption and the risk of prostate cancer. Eur J Nutr 2014;53(8):1615-23. PubMed
  10. Donaldson MS, Speight N, Loomis S. Fibromyalgia syndrome improved using a mostly raw vegetarian diet: an observational study. BMC Complement Altern Med. 2001;1:7. PubMed
  11. Chen H, Shao F, Zhang F, Miao Q. Association between dietary carrot intake and breast cancer: A meta-analysis. Medicine (Baltimore). 2018;97(37):e12164. PubMed
  12. Bosanac SS, Clark AK, Sivamani RK. Phytophotodermatitis related to carrot extract-containing sunscreen. Dermatol Online J. 2018;24(1). pii: 13030/qt2nv2d1n0. DOI
  13. Deding U, Baatrup G, Christensen LP, Kobaek-Larsen M. Carrot Intake and Risk of Colorectal Cancer: A Prospective Cohort Study of 57,053 Danes. Nutrients 2020;12(2):332. PubMed
  14. Sánchez-Guerrero IM, Nieto A, Meseguer J, et al. Occupational Rhinoconjunctivitis Induced by Unusual Allergens of Carrot. J Investig Allergol Clin Immunol 2020;30(3):204-206. PubMed

See these in context on the Carrot monograph →

Buckwheat 12 references
  1. Schiffner R, Przybilla B, Burgdorff T, et al. Anaphylaxis to buckwheat. Allergy 2001;56:1020-1. PubMed
  2. Lee SY, Lee KS, Hong CH, Lee KY. Three cases of childhood nocturnal asthma due to buckwheat allergy. Allergy 2001;56:763-6. PubMed
  3. Wieslander G, Norback D. Buckwheat allergy. Allergy 2001;56:703-4.
  4. Skrabanja V, Liljeberg Elmstahl HG, Kreft I, Bjorck IM. Nutritional properties of starch in buckwheat products: studies in vitro and in vivo. J Agric Food Chem 2001;49:490-6. PubMed
  5. Bijlani RL, Gandhi BM, Gupta MC, et al. Effect of whole buckwheat (Fagopyrum esculentum) flour supplementation on lipid profile & glucose tolerance. Indian J Med Res 1985;81:162-8.
  6. Fritz SB, Gold BL. Buckwheat pillow-induced asthma and allergic rhinitis. Ann Allergy Asthma Immunol 2003;90:355-8. PubMed
  7. Ihme, N., Kiesewetter, H., Jung, F., Hoffmann, K. H., Birk, A., Muller, A., and Grutzner, K. I. Leg oedema protection from a buckwheat herb tea in patients with chronic venous insufficiency: a single-centre, randomised, double-blind, placebo-controlled c
  8. Archimowicz-Cyrylowska B and et al. Clinical effect of buckwheat herb, Ruscus extract and troxerutin on retinopathy and lipids in diabetic patients. Phytother Res 1996;10(659):62. DOI
  9. Cifuentes L, Mistrello G, Amato S, et al. Identification of cross-reactivity between buckwheat and coconut. Ann Allergy Asthma Immunol. 2015 Dec;115(6):530-2. PubMed
  10. De Maat-Bleeker F, Stapel SO. Cross-reactivity between buckwheat and latex. Allergy. 1998 May;53(5):538-9. PubMed
  11. Qiu J, Liu Y, Yue Y, Qin Y, Li Z. Dietary tartary buckwheat intake attenuates insulin resistance and improves lipid profiles in patients with type 2 diabetes: a randomized controlled trial. Nutr Res. 2016 Dec;36(12):1392-1401. PubMed
  12. Li L, Lietz G, Seal C. Buckwheat and CVD risk markers: a systematic review and meta-analysis. Nutrients. 2018;10(5). pii: E619. PubMed

See these in context on the Buckwheat monograph →

Ambrette 6 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Liu, I. M., Liou, S. S., Lan, T. W., Hsu, F. L., and Cheng, J. T. Myricetin as the active principle of Abelmoschus moschatus to lower plasma glucose in streptozotocin-induced diabetic rats. Planta Med. 2005;71(7):617-621.
  3. Liu, I. M., Liou, S. S., and Cheng, J. T. Mediation of beta-endorphin by myricetin to lower plasma glucose in streptozotocin-induced diabetic rats. J.Ethnopharmacol. 3-8-2006;104(1-2):199-206.
  4. Liu, I. M., Tzeng, T. F., Liou, S. S., and Lan, T. W. Improvement of insulin sensitivity in obese Zucker rats by myricetin extracted from Abelmoschus moschatus. Planta Med. 2007;73(10):1054-1060.
  5. Wojnarowska, F. and Calnan, C. D. Contact and photocontact allergy to musk ambrette. Br.J.Dermatol. 1986;114(6):667-675. PubMed
  6. Liu IM, Tzeng TF, Liou SS. Abelmoschus moschatus (Malvaceae), an aromatic plant, suitable for medical or food uses to improve insulin sensitivity. Phytother Res 2010;24(2):233-9.

See these in context on the Ambrette monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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