Herb & supplement monograph

Evodia Drug Interactions, Uses, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Evodia interacts with medications. The heart of this page is the interaction list — every drug Evodia is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Evodia is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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On this page

Evodia Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Evodia drug interaction appears low for most people, though the herb has not been well studied in humans. None of the listed interactions are rated major, and almost all of them come from animal or lab research rather than human studies.

Interactions deserving the most attention

The best-documented concern is with theophylline, a narrow-margin asthma medicine: in animal studies, evodia sped up its breakdown and cut its levels by about 70 percent, which could weaken its effect. The same enzyme effect applies to caffeine, which may not work as well when taken with evodia. There is also a theoretical bleeding concern with anticoagulant and antiplatelet drugs, and animal data suggest evodia could add to the heart-rhythm effects of medicines that prolong the QT interval, so these combinations deserve extra care even though human evidence is lacking.

What the rest of the list means

The long list of interacting medications does not mean every combination is harmful. Most entries are theoretical, based on how evodia may affect enzymes the body uses to clear many medications, and these predicted effects have not been confirmed in people.

Check your medications against Evodia

Based on HelloPharmacist’s Evodia interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Evodia

951 medications have a known interaction with Evodia, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
Ado-trastuzumab EmtansineKadcyla› AbametapirXeglyze› AbciximabReoPro› AbemaciclibVerzenio› Abiraterone› Abiraterone AcetateYonsa, Zytiga› AbrocitinibCibinqo› AcalabrutinibCalquence› AcenocoumarolSintrom› AcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength› Acetaminophen, AspirinGemnisyn› Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine› Acetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu› Acetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more› Acetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more› Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine› Acetaminophen, Butalbital, CodeineBancap w/ Codeine› Acetaminophen, Butalbital, Codeine PhosphatePhrenilin #3› Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound› Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more› Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3› Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS› Acetaminophen, Caffeine, IsomethepteneMigralam› Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual› Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief› Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex› Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu› Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu› Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief› Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength›
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Evodia combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Evodia affects

Every type of medication (drug category) Evodia is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 11 drug categories Evodia interacts with
Anticoagulant/antiplatelet DrugsCaffeineChlorzoxazone (parafon Forte, Paraflex)Cytochrome P450 1a2 (cyp1a2) InhibitorsCytochrome P450 1a2 (cyp1a2) SubstratesCytochrome P450 2e1 (cyp2e1) SubstratesCytochrome P450 3a4 (cyp3a4) InducersCytochrome P450 3a4 (cyp3a4) InhibitorsCytochrome P450 3a4 (cyp3a4) SubstratesQt Interval-prolonging DrugsTheophylline
Anticoagulant/Antiplatelet Drugs

Theoretically, taking evodia with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
In vitro and animal studies show that rutaecarpine, a constituent of evodia, inhibits platelet aggregation.

Likelihood Possible Evidence D
Caffeine

Theoretically, evodia might decrease the levels and clinical effects of caffeine.
In animal models, evodia extract decreases caffeine levels by up to 71%. Evodia extract induces hepatic cytochrome P450 1A2 (CYP1A2) enzyme, of which caffeine is a substrate.

Likelihood Probable Evidence D
Chlorzoxazone (Parafon Forte, Paraflex)

Theoretically, evodia might decrease the levels and clinical effects of chlorzoxazone.
Animal research shows that administration of rutaecarpine, a constituent of evodia, with chlorzoxazone reduces the area under the curve (AUC) of chlorzoxazone by 84% and increases its clearance by 646%. This interaction is likely due to induction of cytochrome P450 2E1 (CYP2E1) by rutaecarpine .

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Inhibitors

Theoretically, drugs that inhibit CYP1A2 might increase the levels and clinical effects of evodia.
The evodia constituent rutaecarpine is metabolized by CYP1A2.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Evodia might reduce the levels and clinical effects of CYP1A2 substrates through induction of CYP1A2.
Evodia extract and the evodia constituent rutaecarpine induce hepatic CYP1A2 enzyme activity. Evodia decreases levels of theophylline and caffeine, CYP1A2 substrates, by about 70% in animal models.

Likelihood Probable Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, evodia might reduce the levels and clinical effects of CYP2E1 substrates through induction of CYP2E1.
Animal research suggests that rutaecarpine, a constituent of evodia, induces CYP2E1 activity. In rats, rutaecarpine increases markers of CYP2E1 activity, and administration of rutaecarpine with chlorzoxazone, a known CYP2E1 substrate, reduces the area under the curve (AUC) of chlorzoxazone by 84% and increases its clearance by 646%.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Inducers

Theoretically, taking CYP3A4 inducers might decrease the levels and clinical effects of evodia.
Animal research shows that concomitant administration of dexamethasone, a known CYP3A4 inducer, with the alkaloid constituents of evodia significantly reduces the area under the curve (AUC), maximum concentration (Cmax), and half-life of these constituents.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Inhibitors

Theoretically, CYP3A4 inhibitors might increase the levels and clinical effects of evodia.
Animal research shows that concomitant administration of ketoconazole, a known CYP3A4 inhibitor, with the alkaloid constituents of evodia significantly increases the area under the curve (AUC), maximum concentration (Cmax), and half-life of these constituents.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, evodia might increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that evodia extract inhibits hepatic CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Qt Interval-Prolonging Drugs

Theoretically, evodia might have an additive effect with drugs that prolong the QT interval, potentially increasing the risk of ventricular arrhythmias.
Evodia has demonstrated dose-dependent activity as a proarrhythmic agent in animal and in vitro studies. Evodia infusion in animals extends the action duration potential and induces prolongation of the QT interval and Torsade de pointes.

Likelihood Possible Evidence D
Theophylline

Theoretically, evodia might decrease the levels and clinical effects of theophylline.
The evodia constituent rutaecarpine decreases theophylline levels and half-life by about 70% in animal models. This constituent appears to induce hepatic cytochrome P450 1A2 (CYP1A2) enzyme activity, of which theophylline is a substrate. Rutaecarpine is the primary active constituent of evodia; however, it is not known if the whole crude extract of evodia also causes this interaction.

Likelihood Probable Evidence D
Monograph

Evodia: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Evodia is a fruit used in traditional Chinese medicine, most often for digestive complaints, headaches, and menstrual pain. Human evidence for these uses is very limited, and it is mostly studied in laboratory and animal research. Talk with a pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Scientific name
Tetradium ruticarpum
Family
Rutaceae
Part used
Dried unripe fruit
Common forms
Dried fruit, powder, capsules, tablets, teas, and traditional herbal formulas
People commonly use it for
  • Digestive upset and nausea
  • Headaches
  • Menstrual cramps
  • Abdominal pain
  • Diarrhea

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Limited human safety data exist, so use carefully and under professional guidance.

PregnancyPossibly Unsafe

When used orally. Active constituents in evodia have uterine stimulant activity in animal models. Evodia might also decrease litter size in animal mod...

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Evodia is an herbal remedy made from the dried, unripe fruit of Tetradium ruticarpum, a small tree in the citrus family that grows in China and other parts of East Asia. It has been used in traditional Chinese medicine for hundreds of years.

In traditional practice, evodia is described as a "warming" herb and is often combined with other herbs in formulas rather than used alone. People commonly take it for stomach and digestive complaints, headaches, and menstrual pain. Today it is sold as dried fruit, powders, capsules, teas, and as part of combination products.

Uses & effectiveness

Evodia is popularly used for digestive problems such as nausea, abdominal pain, and diarrhea, as well as for headaches and menstrual cramps. These uses come mainly from traditional medicine and not from strong modern research.

Most of what we know about evodia comes from laboratory and animal studies. These early studies have looked at possible effects on inflammation, pain, blood vessels, and the digestive tract. While interesting, these findings do not prove that evodia works in people for any specific condition.

Overall, there is not enough good-quality human research to confirm that evodia is effective for any health problem. If you are considering it, view it as unproven and discuss it with a healthcare professional first.

How it works

Evodia contains several natural compounds, including evodiamine and rutaecarpine, which are thought to be its main active ingredients. Researchers have studied these compounds in test tubes and animals.

Proposed actions include effects on inflammation, pain signaling, body temperature, and the activity of certain enzymes in the liver. Some compounds may also affect blood vessels and the heart in laboratory settings.

It is important to understand that these mechanisms are mostly based on laboratory and animal research. How evodia behaves in the human body, and at what doses, is not well understood.

Safety & precautions

There is limited modern safety information about evodia, so it should be used with caution. People with existing health conditions, those taking prescription medicines, and anyone with liver or heart problems should speak with a pharmacist or doctor before using it.

Pregnancy: Evodia has traditionally been avoided during pregnancy, and there is not enough safety data to consider it safe. Avoid use if you are pregnant or trying to become pregnant.

Breastfeeding: There is not enough reliable information about evodia while breastfeeding. To be safe, avoid it during this time.

Children, older adults, and people with chronic illnesses should be especially careful and seek professional advice first.

Side effects

Because evodia has not been well studied in people, its full side effect profile is not known. Some users may experience digestive upset, such as stomach discomfort, nausea, or diarrhea.

As with any herbal product, allergic reactions are possible. Stop using it and seek medical care if you have signs of an allergic reaction such as rash, swelling, or trouble breathing. Because quality and purity can vary between products, choose reputable brands and report any unusual symptoms to your doctor or pharmacist.

Evodia: Reported Adverse Effects

Documented safety reports on Evodia from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

There is no reliable evidence regarding the safety of evodia from clinical trials. In animal studies, evodia has induced QT prolongation and Torsade de pointes.

  1. Baburin I, Varkvisser R, Schramm A, et al. Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo. Pharmacol Res. 2018 May;131:150-163.
Reports by condition
Torsades de pointes Cardiovascular

In animal studies, evodia acts as a proarrhythmic agent with a dose-dependent effect. Evodia infusion has resulted in QT prolongation and Torsade de pointes. It is not clear what dose of evodia, if any, is required to produce a similar effect in humans.

  1. Baburin I, Varkvisser R, Schramm A, et al. Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo. Pharmacol Res. 2018 May;131:150-163.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no well-established standard dose for evodia. Traditional use often relies on combination formulas prepared by trained practitioners, and modern supplement products vary widely in strength and ingredients.

If you choose to use evodia, follow the directions on the product label and do not exceed the recommended amount. Because doses are not standardized and safety data are limited, it is best to check with a pharmacist or doctor before starting.

Pregnancy & Breastfeeding

Evodia & Pregnancy

Possibly Unsafe

When used orally. Active constituents in evodia have uterine stimulant activity in animal models. Evodia might also decrease litter size in animal models. Theoretically, taking evodia during pregnancy might adversely affect pregnancy outcome.

  1. King CL, Kong YC, Wong NS, et al. Uterotonic effect of Evodia rutaecarpa alkaloids. J Nat Prod 1980;43:577-82.

Evodia & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 13 references that drive our Evodia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Sheu JR, Kan YC, Hung WC, et al. The antiplatelet activity of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa, is mediated through inhibition of phospholipase C. Thromb Res 1998;92:53-64. PubMed
  2. Sheu JR, Hung WC, Lee YM, Yen MH. Mechanism of inhibition of platelet aggregation by rutaecarpine, an alkaloid isolated from Evodia rutaecarpa. Eur J Pharmacol 1996;318:469-75. PubMed
  3. Ueng YF, Tsai TH, Don MJ, et al. Alteration of the pharmacokinetics of theophylline by rutaecarpine, an alkaloid of the medicinal herb Evodia rutaecarpa, in rats. J Pharm Pharmacol 2005;57:227-32.
  4. King CL, Kong YC, Wong NS, et al. Uterotonic effect of Evodia rutaecarpa alkaloids. J Nat Prod 1980;43:577-82. PubMed
  5. Ueng YF, Jan WC, Lin LC, et al. The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes. Drug Metab Dispos 2002;30:349-53. PubMed
  6. Iwata H, Tezuka Y, Kadota S, et al. Mechanism-based inactivation of human liver microsomal CYP3A4 by rutaecarpine and limonin from Evodia fruit extract. Drug Metab Pharmacokinet 2005;20:34-45. PubMed
  7. Sheu JR, Hung WC, Wu CH, et al. Antithrombotic effect of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa, on platelet plug formation in in vivo experiments. Br J Haematol 2000;110:110-5.
  8. Tsai TH, Chang CH, Lin LC. Effects of Evodia rutaecarpa and rutaecarpine on the pharmacokinetics of caffeine in rats. Planta Med 2005;71:640-5.
  9. Lee SK, Kim NH, Lee J, et al. Induction of cytochrome P450s by rutaecarpine and metabolism of rutaecarpine by cytochrome P450s. Planta Med 2004;70:753-7. PubMed
  10. Baburin I, Varkvisser R, Schramm A, et al. Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo. Pharmacol Res. 2018 May;131:150-163. DOI
  11. Zhang W, Guo J, Wang D, et al. Effect of CYP3A inducer/inhibitor on pharmacokinetics of five alkaloids in Evodiae Fructus. Chem Biol Interact 2020;327:109146. PubMed
  12. Huang CJ, Huang WC, Lin WT, et al. Rutaecarpine, an alkaloid from Evodia rutaecarpa, can prevent platelet activation in humans and reduce microvascular thrombosis in mice: crucial role of the PI3K/Akt/GSK3ß signal axis through a cyclic nucleotides/VASP-in
  13. Bista SR, Lee SK, Thapa D, et al. Effects of oral rutaecarpine on the pharmacokinetics of intravenous chlorzoxazone in rats. Toxicol Res 2008;24(3):195-9. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Evodia

65 brands in our database make a supplement containing Evodia.

Product directory

Supplement products with Evodia

188 products in our database contain Evodia. Open any to see its full ingredient list and every drug interaction we check.

Joint Inflammation Teapills Guan Jie Yan Wan by Plum Flower Tablet Or Pill 1.2 oz. · 33 g · 200 Pill(s) Off market View ingredients & interactions Joint Obstruction Teapills by Plum Flower Brand Tablet Or Pill 1.2 Ounce(s) · 33 Gram(s) · 200 Pill(s) Off market View ingredients & interactions Joint Obstruction Teapills Guan Jie Yan Wan by Plum Flower Tablet Or Pill 200 Pill(s) · 1.2 oz. · 33 Gram(s) Off market View ingredients & interactions Lipo 6 Black Hers by Nutrex Research Capsule 120 Black-Cap(s)(TM) Off market View ingredients & interactions Liquid ClenButrx by VPX Liquid 8 fl. Oz. · 240 mL Off market View ingredients & interactions Maternal Herbal by Health Concerns Tablet Or Pill 90 Tablet(s) Off market View ingredients & interactions Metabolic Boost by Shaklee 180 Tablet Or Pill 90 Tablet(s) Off market View ingredients & interactions Metabolic Boost by Shaklee 180 Tablet Or Pill 90 Tablet(s) Off market View ingredients & interactions Mu Xiang Shun Qi Teapills (Mu Xiang Shun Qi Wan) by Plum Flower Brand Tablet Or Pill 1.2 oz. · 33 g · 200 Pill(s) Off market View ingredients & interactions Mu Xiang Shun Qi Wan by Min Shan Tablet Or Pill 200 Pill(s) · 1.2 oz. · 33 Gram(s) Off market View ingredients & interactions NaturaLean by Eat The Bear ETB Capsule 90 Capsule(s) Off market View ingredients & interactions Neuro Lean by SirenLabs Capsule 60 Capsule(s) Off market View ingredients & interactions Neuro Lean by SirenLabs Capsule 60 Capsule(s) Off market View ingredients & interactions Osteoherbal by Health Concerns Tablet Or Pill 90 Tablet(s) Off market View ingredients & interactions PreSurge Unleashed! Citrus Ice by Athletic Edge Nutrition Powder 0.59 lb · 271 g Off market View ingredients & interactions PreSurge Unleashed! Juicy Watermelon by Athletic Edge Nutrition Powder 0.64 lb · 294 g Off market View ingredients & interactions PreSurge Unleashed! Wild Berry Punch by Athletic Edge Nutrition Powder 0.59 lb · 271 g Off market View ingredients & interactions Pro Thermogenic Diablo Electric Lime by ANS Performance Powder Off market View ingredients & interactions Rabid Pre Workout Blue Cocount by Muscle House Powder 0.255 Gram(s) · 0.56 lbs Off market View ingredients & interactions Red Zone by Ultimate Nutrition Platinum Series Other (e.g. Tea Bag) 120 Caplet(s) Off market View ingredients & interactions Redline Extreme Water Melon by VPX Liquid Off market View ingredients & interactions Redline Princess Exotic Fruit by VPX Liquid 8 fl. Oz. · 240 mL Off market View ingredients & interactions Redline White Heat Strawberry by VPX Powder 5.78 oz. · 164 Gram(s) Off market View ingredients & interactions Redline Xtreme Grape by VPX Liquid 4 8-Ounce Bottle(S) · 32 fl. Oz. · 960 mL Off market View ingredients & interactions
Pharmacist Counseling Corner

Evodia: Common Questions

Does Evodia interact with prescription medications?
Yes. We list 951 medications with a known interaction with Evodia. Use the checker above to see how Evodia interacts with a specific drug.
How are Evodia interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Evodia with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Evodia interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Evodia used for?
It is traditionally used for digestive complaints like nausea and abdominal pain, as well as for headaches and menstrual cramps. However, strong human evidence for these uses is lacking.
Is Evodia safe to take?
There is limited modern safety information, so it should be used cautiously and ideally under the guidance of a pharmacist or doctor, especially if you have health conditions or take other medicines.
Can I take Evodia during pregnancy or while breastfeeding?
No. Evodia has traditionally been avoided in pregnancy and there is not enough safety data, so it is best to avoid it during pregnancy and breastfeeding.
How much Evodia should I take?
There is no established standard dose. Follow the product label and check with a pharmacist or doctor, since products vary in strength and purity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain Evodia

A rotating sample of real supplements in our database that list Evodia — open any to see its full ingredients and every drug interaction we check.

See all 188 products with Evodia →
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