Myrtle Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Myrtle interacts with medications. The heart of this page is the interaction list — every drug Myrtle is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Myrtle is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Myrtle against your medication
Add one medicationDrugs that interact with Myrtle
0 medications have a known interaction with Myrtle, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Myrtle. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Myrtle combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Myrtle: Uses, Safety & Side Effects
Myrtle (Myrtus communis) is a Mediterranean shrub used traditionally for respiratory, digestive, and skin complaints. Modern research is mostly limited to laboratory and small studies, so its benefits in people are not well proven. Use cautiously, follow product labels, and talk to your pharmacist or doctor first—especially since the essential oil should never be swallowed.
- Scientific name
- Myrtus communis
- Family
- Myrtaceae
- Part used
- Leaves, berries, flowers, and essential oil
- Common forms
- Tea, capsules, extracts, essential oil, topical preparations
- Coughs and respiratory congestion
- Digestive upset
- Antimicrobial and wound care
- Skin conditions
- Urinary complaints
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Likely safe in small amounts as food or tea, but concentrated extracts and oils need caution.
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Myrtle is an evergreen shrub with the botanical name Myrtus communis. It grows wild across the Mediterranean region and parts of the Middle East and is also planted as an ornamental garden plant. People have used its fragrant leaves, dark berries, and flowers for hundreds of years.
The plant has a long history in traditional medicine. The leaves and berries are used to make teas, extracts, and capsules, while the leaves and twigs are steam-distilled to make an aromatic essential oil. In some regions the berries are also used to flavor foods and liqueurs.
Today myrtle is marketed as a dietary supplement and aromatherapy product, often promoted for breathing problems, digestion, and skin care.
How it works
Myrtle contains several natural compounds that researchers think may be responsible for its effects. These include essential oil components such as 1,8-cineole (eucalyptol), myrtenol, and alpha-pinene, along with tannins and flavonoids like myricetin.
In laboratory tests, these compounds have shown antioxidant, anti-inflammatory, and germ-fighting activity. Cineole, for example, is also found in eucalyptus and is studied for its effect on mucus and airways.
It is important to understand that most of this evidence comes from test-tube and animal research. Showing that a compound works in a lab does not mean it will work the same way—or be safe—in the human body.
Does Myrtle work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Myrtle, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 12 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Acne
It is unclear if topical myrtle is beneficial in patients with acne.
Insufficient Reliable Evidence To Rate Bacterial vaginosis
Although there has been interest in using topical myrtle for bacterial vaginosis, there is insufficient reliable information about the clinical effects of myrtle for this purpose.
Insufficient Reliable Evidence To Rate Canker sores
It is unclear if topical myrtle is beneficial in patients with canker sores.
Insufficient Reliable Evidence To Rate Diarrhea
Although there has been interest in using oral myrtle for diarrhea, there is insufficient reliable information about the clinical effects of myrtle for this purpose.
Insufficient Reliable Evidence To Rate Gastroesophageal reflux disease (GERD)
It is unclear if oral myrtle is beneficial in patients with GERD.
Insufficient Reliable Evidence To Rate Gingivitis
It is unclear if topical myrtle is beneficial in patients with gingivitis.
Insufficient Reliable Evidence To Rate Human papillomavirus (HPV)
It is unclear if intravaginal myrtle is beneficial in patients with HPV.
Insufficient Reliable Evidence To Rate Intestinal parasite infection
Although there has been interest in using oral myrtle for intestinal parasite infection, there is insufficient reliable information about the clinical effects of myrtle for this purpose.
Insufficient Reliable Evidence To Rate Menorrhagia
It is unclear if oral myrtle is beneficial in patients with menorrhagia.
Insufficient Reliable Evidence To Rate Oropharyngeal candidiasis
Although there has been interest in using topical myrtle for oropharyngeal candidiasis, there is insufficient reliable information about the clinical effects of myrtle for this purpose.
Insufficient Reliable Evidence To Rate Respiratory tract infections
Although there has been interest in using oral myrtle for respiratory tract infections, there is insufficient reliable information about the clinical effects of myrtle for this purpose.
Insufficient Reliable Evidence To Rate Vaginitis
It is unclear if intravaginal myrtle is beneficial in patients with vaginitis.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
Small amounts of myrtle used as a food, spice, or tea are generally considered to have a low risk for most healthy adults. Concentrated extracts and the essential oil carry more risk and should be used carefully.
The essential oil should never be swallowed, especially products containing cineole. Concentrated cineole oils can cause serious problems, including breathing trouble, in children. Keep all essential oils away from infants and young children.
People with asthma or other breathing conditions, and those with liver or kidney problems, should talk to a healthcare provider before using myrtle. Anyone allergic to plants in the myrtle family should avoid it.
Pregnancy and breastfeeding: There is not enough reliable safety information, so myrtle supplements, extracts, and essential oil should be avoided during pregnancy and while breastfeeding.
Side effects
When used in small food-like amounts, myrtle is usually well tolerated. Larger doses or concentrated products may cause side effects.
Possible side effects include stomach upset, nausea, or diarrhea. Applied to the skin, myrtle preparations may cause irritation or allergic reactions in some people.
The biggest concern is the essential oil. Swallowing it can be toxic and may cause vomiting, drowsiness, breathing problems, or seizures, particularly in children. If essential oil is swallowed, seek emergency medical care or contact poison control right away.
Myrtle: Reported Adverse Effects
Documented safety reports on Myrtle from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
There is currently a limited amount of information on the adverse effects of oral and intravaginal myrtle. A thorough evaluation of safety outcomes has not been conducted. Topically, myrtle leaf seems to be generally well tolerated in adults.
Most Common Adverse Effects:
Topically: Dry skin.
Intravaginally: Vaginal irritation and dryness.
Serious Adverse Effects (Rare):
Orally: Hypotension, respiratory failure.
Topically: Bronchial spasm and respiratory failure, most commonly in infants or children.
Asthma Pulmonary/Respiratory
Orally, consumption of very large amounts of undiluted myrtle leaf oil might lead to respiratory failure and collapse.
Topically, facial contact with myrtle oil preparations may cause glottal or bronchial spasm, asthma-like attacks, or respiratory failure in infants and children.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Constipation Gastrointestinal
Orally, myrtle berry extract has been reported to cause constipation in infants and young children.
Dry skin Dermatologic
Topically, myrtle leaf extract has been reported to cause dry skin.
Hypotension Cardiovascular
Orally, very large amounts of undiluted myrtle leaf oil might lead to low blood pressure and circulatory disorders due to the cineole constituent.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no well-established standard dose for myrtle. Amounts used in traditional practice and studies vary widely depending on the form—tea, extract, capsule, or oil.
Because products differ in strength and quality, the safest approach is to follow the directions on the product label and not exceed them. The essential oil is for external or aromatic use only and should never be taken by mouth.
Before starting myrtle, check with your pharmacist or doctor, especially if you take other medicines or have a health condition.
Myrtle & Pregnancy
Myrtle & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 3 references that drive our Myrtle monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Salmanian M, Shirbeigi L, Hashem-Dabaghian F, et al. The Effects of Myrtle (Myrtus communis) and Clindamycin Topical Solution in the Treatment of Mild to Moderate Acne Vulgaris: A Comparative Split-Face Study. J Pharmacopuncture 2020;23(4):220-229.
- Paknejad MS, Eftekhari K, Rahimi R, Vigeh M, Naghizadeh A, Karimi M. Myrtle (Myrtus communis L.) fruit syrup for gastroesophageal reflux disease in children: A double-blind randomized clinical trial. Phytother Res 2021;35(11):6369-6376.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Myrtle
8 brands in our database make a supplement containing Myrtle.
Supplement products with Myrtle
33 products in our database contain Myrtle. Open any to see its full ingredient list and every drug interaction we check.
Myrtle: Common Questions
What is Myrtle used for, and does it work?
Does Myrtle interact with prescription medications?
How are Myrtle interactions rated?
Is it safe to take Myrtle with my medications?
Where does this Myrtle interaction information come from?
What is Myrtle used for?
Is Myrtle safe to take?
Can I use Myrtle during pregnancy or breastfeeding?
Can I swallow Myrtle essential oil?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Myrtle
A rotating sample of real supplements in our database that list Myrtle — open any to see its full ingredients and every drug interaction we check.
- Sinutol Extra Strength by EuroMedica
- Oregulin by North American Herb & Spice
- Oregulin by North American Herb & Spice
- Myrtle Alcohol Free by Herbal Terra
- Oregulin by North American Herb & Spice
- Oil of Wild Myrtle by North American Herb & Spice
- Prostate Health by Young Living Essential Oils
- Viragen by Terry Naturally
- Fung-E Clenz by North American Herb & Spice
- Prostate Health by Young Living Essential Oils
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