Rice Bran Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Rice Bran interacts with medications. The heart of this page is the interaction list — every drug Rice Bran is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Rice Bran is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Rice Bran against your medication
Add one medicationDrugs that interact with Rice Bran
0 medications have a known interaction with Rice Bran, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Rice Bran. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Rice Bran combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Rice Bran: Uses, Safety & Side Effects
Rice bran is the nutrient-rich outer layer of the rice grain and is a good source of fiber, healthy fats, and plant compounds. It is most studied for helping lower cholesterol, but for most other uses the evidence is limited. It is generally considered safe as a food, but talk with your pharmacist or doctor before using concentrated supplements.
- Scientific name
- Oryza sativa
- Family
- Poaceae
- Part used
- Bran (the outer layer of the rice grain) and rice bran oil
- Common forms
- Powder, capsules, tablets, rice bran oil, and as a fiber food additive
- High cholesterol
- Digestive health and fiber
- Heart health support
- Blood sugar support
- Skin care (topical oil)
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally safe as food, but concentrated supplements have less safety data and may cause digestive effects.
When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of rice bran when used for...
Read the full pregnancy detailWhen used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of rice bran when used for...
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Rice bran is the brown, outer layer of the rice grain that is removed when white rice is milled and polished. It comes from the rice plant (Oryza sativa), one of the most widely grown grains in the world, especially in Asia. The bran is rich in fiber, healthy oils, vitamins, minerals, and natural plant compounds.
People use rice bran in several ways. It can be eaten as a food (for example, in whole grain or brown rice), added to foods as a fiber source, or taken as a supplement in powder or capsule form. Rice bran oil is also pressed from the bran and used both in cooking and in skin care products.
How it works
Rice bran contains several compounds that may explain its possible effects. It is high in soluble and insoluble fiber, which can help with digestion and may bind some cholesterol in the gut. It also contains healthy fats, plant sterols, and antioxidants such as oryzanol (gamma-oryzanol) and tocotrienols (a form of vitamin E).
These plant sterols and other compounds are thought to reduce how much cholesterol the body absorbs. Many of the proposed effects, especially for blood sugar and antioxidant activity, are based on laboratory and animal research, so it is not certain they work the same way in people.
Does Rice Bran work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
Possibly Effective Dyslipidemia
Taking full-fat rice bran, reduced-fat rice bran, or rice bran oil daily appears to modestly reduce lipoprotein (LDL) cholesterol levels. The effects of rice bran on other types of cholesterol are unclear.
Possibly Ineffective Colorectal cancer
Clinical and population research suggest that consuming dietary cereal fiber, including rice bran, doesn't seem to reduce the risk of colorectal cancer.
Also studied for 14 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Alcohol use disorder
Although there has been interest in using oral rice bran for alcohol use disorder, there is insufficient reliable information about the clinical effects of rice bran for this purpose.
Insufficient Reliable Evidence To Rate Androgenic alopecia
It is unclear if topical rice bran is beneficial in patients with androgenic alopecia.
Insufficient Reliable Evidence To Rate Athletic performance
Although there has been interest in using oral rice bran for athletic performance, there is insufficient reliable information about the clinical effects of rice bran for this purpose.
Insufficient Reliable Evidence To Rate Atopic dermatitis (eczema)
It is unclear if topical rice bran is beneficial in patients with atopic dermatitis.
Insufficient Reliable Evidence To Rate Cardiovascular disease (CVD)
There is limited evidence on the oral use of rice bran oil in coronary artery disease (CAD).
Insufficient Reliable Evidence To Rate Diabetes
It is unclear if oral rice bran is beneficial in patients with type 2 diabetes.
Insufficient Reliable Evidence To Rate Gastric cancer
Although there has been interest in using oral rice bran to prevent gastric cancer, there is insufficient reliable information about the clinical effects of rice bran for this purpose.
Insufficient Reliable Evidence To Rate Halitosis
It is unclear if oral rice bran is beneficial in patients with halitosis.
Insufficient Reliable Evidence To Rate HIV/AIDS
Although there has been interest in using oral rice bran for HIV/AIDS, there is insufficient reliable information about the clinical effects of rice bran for this purpose.
Insufficient Reliable Evidence To Rate Hypercalciuria
It is unclear if oral rice bran is beneficial in patients with hypercalciuria.
Insufficient Reliable Evidence To Rate Hypertension
Although there has been interest in using oral rice bran for hypertension, there is insufficient reliable information about the clinical effects of rice bran for this purpose.
Insufficient Reliable Evidence To Rate Insomnia
It is unclear if oral rice bran is beneficial in patients with insomnia.
Insufficient Reliable Evidence To Rate Metabolic syndrome
It is unclear if oral rice bran is beneficial in patients with metabolic syndrome.
Insufficient Reliable Evidence To Rate Obesity
Although there has been interest in using oral rice bran for obesity, there is insufficient reliable information about the clinical effects of rice bran for this purpose.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
As a normal part of food, rice bran is widely eaten and generally considered safe. Concentrated supplements and high doses have less safety data, so they call for more caution.
Because rice bran adds a lot of fiber, increasing your intake too quickly can cause gas or bloating. Drink plenty of water and increase the amount slowly. People with bowel narrowing or swallowing problems should be careful with high-fiber products.
One important note: rice and rice bran can contain trace amounts of arsenic from the environment. Eating a varied diet helps limit exposure. For pregnancy and breastfeeding, food amounts are likely fine, but there is not enough information on concentrated supplement doses, so it is best to be cautious and check with your doctor or pharmacist first.
Side effects
The most common side effects are digestive, including gas, bloating, stomach discomfort, or changes in bowel movements, especially when starting a higher-fiber product or taking it in large amounts.
Allergic reactions are uncommon but possible. Stop using rice bran and seek medical care if you notice signs of an allergy such as rash, itching, swelling, or trouble breathing.
Rice Bran: Reported Adverse Effects
Documented safety reports on Rice Bran from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally, rice bran is generally well tolerated. However, increasing the amount of bran in the diet can cause transient abdominal discomfort, flatulence, and erratic bowel habits.
Most Common Adverse Effects:
Orally: Abdominal discomfort, erratic bowel habits, flatulence.
Topically: Erythema, itching.
Serious Adverse Effects (Rare):
All ROAs: Anaphylactic reactions, including urticaria and angioedema.
Cough Immunologic
Orally and topically, rice bran can cause allergic reactions such as urticaria, angioedema, wheezing, itching, and cough. In a case report, a 5-year-old male presented with allergic eczema, urticaria, and cough due to rice bran ingestion. In another case report, a 14-year-old male developed food-dependent, exercise-induced anaphylaxis after consuming 150 grams of rice bran. The 52-kDa and 63-kDa globulin constituents in rice bran have both been implicated as the source of allergic reactions. These constituents are not typically present in cooked, polished rice.
- Togashi Y, Inomata N, Suzuki A, Hakuta A, Aihara M. Pediatric case with rice bran allergy induced by epicutaneous sensitization in a family rice shop. Allergol Int. 2019;68(1):117-118.
- Haneda Y, Kadowaki S, Furui M, Taketani T. A pediatric case of food-dependent exercise-induced anaphylaxis due to rice bran. Asia Pac Allergy 2021;11(1):e4.
- Satoh R, Tsuge I, Tokuda R, Teshima R. Analysis of the distribution of rice allergens in brown rice grains and of the allergenicity of products containing rice bran. Food Chem. 2019;276:761-767.
Flatulence Gastrointestinal
Orally, increasing the amount of bran in the diet can cause erratic bowel habits, flatulence, and abdominal discomfort during the first few weeks.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- So WKW, Chan JYW, Law BMH, et al. Effects of a Rice Bran Dietary Intervention on the Composition of the Intestinal Microbiota of Adults with a High Risk of Colorectal Cancer: A Pilot Randomised-Controlled Trial. Nutrients 2021;13(2):526.
Pruritus Dermatologic
Topically, rice bran broth baths can cause itching and skin redness. In rare cases, rash and itching from rice bran has been associated with contact infestation with Pyemotes tritici, an arthropod commonly called straw itch mite.
- Fujiwaki T, Furusho K. The effects of rice bran broth bathing in patients with atopic dermatitis. Acta Paediatr Jpn 1992;34:505-10.
- Uenotsuchi T, Satoh E, Kiryu H, Yano Y. Pyemotes dermatitis caused by indirect contact with husk rice. Br J Dermatol 2000;143:680-2.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no single official or standardized dose for rice bran supplements. The right amount depends on the product, the form (powder, capsule, or oil), and your reason for using it.
The best approach is to follow the directions on the product label and not exceed the recommended amount. If you are adding rice bran for fiber, start with a small amount and increase slowly while drinking plenty of water. Always check with your pharmacist or doctor before starting a supplement, especially if you have a health condition or take other medicines.
Rice Bran & Pregnancy
Rice Bran & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 7 references that drive our Rice Bran monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Fujiwaki T, Furusho K. The effects of rice bran broth bathing in patients with atopic dermatitis. Acta Paediatr Jpn 1992;34:505-10.
- Uenotsuchi T, Satoh E, Kiryu H, Yano Y. Pyemotes dermatitis caused by indirect contact with husk rice. Br J Dermatol 2000;143:680-2. DOI
- Satoh R, Tsuge I, Tokuda R, Teshima R. Analysis of the distribution of rice allergens in brown rice grains and of the allergenicity of products containing rice bran. Food Chem. 2019;276:761-767. PubMed
- Togashi Y, Inomata N, Suzuki A, Hakuta A, Aihara M. Pediatric case with rice bran allergy induced by epicutaneous sensitization in a family rice shop. Allergol Int. 2019;68(1):117-118. PubMed
- So WKW, Chan JYW, Law BMH, et al. Effects of a Rice Bran Dietary Intervention on the Composition of the Intestinal Microbiota of Adults with a High Risk of Colorectal Cancer: A Pilot Randomised-Controlled Trial. Nutrients 2021;13(2):526. PubMed
- Haneda Y, Kadowaki S, Furui M, Taketani T. A pediatric case of food-dependent exercise-induced anaphylaxis due to rice bran. Asia Pac Allergy 2021;11(1):e4. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Rice Bran
446 brands in our database make a supplement containing Rice Bran.
Supplement products with Rice Bran
3,347 products in our database contain Rice Bran. Open any to see its full ingredient list and every drug interaction we check.
Rice Bran: Common Questions
What is Rice Bran used for, and does it work?
Does Rice Bran interact with prescription medications?
How are Rice Bran interactions rated?
Is it safe to take Rice Bran with my medications?
Where does this Rice Bran interaction information come from?
What is Rice Bran used for?
Is Rice Bran safe to take?
Can I take Rice Bran while pregnant or breastfeeding?
Does Rice Bran really lower cholesterol?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Rice Bran
A rotating sample of real supplements in our database that list Rice Bran — open any to see its full ingredients and every drug interaction we check.
- Grape Seed Extract by 21st Century
- Energize Greens by Holistic Labs Ltd.
- Enzyme Probiotic Complex by American Health
- SAM-e 200 mg by SuperSmart
- Respiratory & Immune by BioSchwartz
- B-150 by Wonder Laboratories
- Resveratrol 250 mg by ResVitale
- Liver Support by LES Labs
- CoQ10 60 mg by NOW
- Co Q-10 100 mg by 21st Century
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