Herb & supplement monograph

Rice Bran Drug Interactions, Uses, Effectiveness, Safety & More

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Interaction report

Drugs that interact with Rice Bran

0 medications have a known interaction with Rice Bran, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Rice Bran. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Rice Bran combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Rice Bran: Uses, Safety & Side Effects

The bottom line

Rice bran is the nutrient-rich outer layer of the rice grain and is a good source of fiber, healthy fats, and plant compounds. It is most studied for helping lower cholesterol, but for most other uses the evidence is limited. It is generally considered safe as a food, but talk with your pharmacist or doctor before using concentrated supplements.

Scientific name
Oryza sativa
Family
Poaceae
Part used
Bran (the outer layer of the rice grain) and rice bran oil
Common forms
Powder, capsules, tablets, rice bran oil, and as a fiber food additive
People commonly use it for
  • High cholesterol
  • Digestive health and fiber
  • Heart health support
  • Blood sugar support
  • Skin care (topical oil)

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally safe as food, but concentrated supplements have less safety data and may cause digestive effects.

PregnancyLikely Safe

When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of rice bran when used for...

Read the full pregnancy detail
BreastfeedingLikely Safe

When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of rice bran when used for...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Rice bran is the brown, outer layer of the rice grain that is removed when white rice is milled and polished. It comes from the rice plant (Oryza sativa), one of the most widely grown grains in the world, especially in Asia. The bran is rich in fiber, healthy oils, vitamins, minerals, and natural plant compounds.

People use rice bran in several ways. It can be eaten as a food (for example, in whole grain or brown rice), added to foods as a fiber source, or taken as a supplement in powder or capsule form. Rice bran oil is also pressed from the bran and used both in cooking and in skin care products.

How it works

Rice bran contains several compounds that may explain its possible effects. It is high in soluble and insoluble fiber, which can help with digestion and may bind some cholesterol in the gut. It also contains healthy fats, plant sterols, and antioxidants such as oryzanol (gamma-oryzanol) and tocotrienols (a form of vitamin E).

These plant sterols and other compounds are thought to reduce how much cholesterol the body absorbs. Many of the proposed effects, especially for blood sugar and antioxidant activity, are based on laboratory and animal research, so it is not certain they work the same way in people.

Effectiveness

Does Rice Bran work?

Evidence overview · 16 uses evaluated
1 Possibly effective 1 Leans ineffective 14 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Effective Dyslipidemia
Rating & evidence shown verbatim from Natural Medicines

Taking full-fat rice bran, reduced-fat rice bran, or rice bran oil daily appears to modestly reduce lipoprotein (LDL) cholesterol levels. The effects of rice bran on other types of cholesterol are unclear.

Possibly Ineffective Colorectal cancer
Rating & evidence shown verbatim from Natural Medicines

Clinical and population research suggest that consuming dietary cereal fiber, including rice bran, doesn't seem to reduce the risk of colorectal cancer.

Also studied for 14 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Alcohol use disorder
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral rice bran for alcohol use disorder, there is insufficient reliable information about the clinical effects of rice bran for this purpose.

Insufficient Reliable Evidence To Rate Androgenic alopecia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical rice bran is beneficial in patients with androgenic alopecia.

Insufficient Reliable Evidence To Rate Athletic performance
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral rice bran for athletic performance, there is insufficient reliable information about the clinical effects of rice bran for this purpose.

Insufficient Reliable Evidence To Rate Atopic dermatitis (eczema)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical rice bran is beneficial in patients with atopic dermatitis.

Insufficient Reliable Evidence To Rate Cardiovascular disease (CVD)
Rating & evidence shown verbatim from Natural Medicines

There is limited evidence on the oral use of rice bran oil in coronary artery disease (CAD).

Insufficient Reliable Evidence To Rate Diabetes
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral rice bran is beneficial in patients with type 2 diabetes.

Insufficient Reliable Evidence To Rate Gastric cancer
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral rice bran to prevent gastric cancer, there is insufficient reliable information about the clinical effects of rice bran for this purpose.

Insufficient Reliable Evidence To Rate Halitosis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral rice bran is beneficial in patients with halitosis.

Insufficient Reliable Evidence To Rate HIV/AIDS
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral rice bran for HIV/AIDS, there is insufficient reliable information about the clinical effects of rice bran for this purpose.

Insufficient Reliable Evidence To Rate Hypercalciuria
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral rice bran is beneficial in patients with hypercalciuria.

Insufficient Reliable Evidence To Rate Hypertension
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral rice bran for hypertension, there is insufficient reliable information about the clinical effects of rice bran for this purpose.

Insufficient Reliable Evidence To Rate Insomnia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral rice bran is beneficial in patients with insomnia.

Insufficient Reliable Evidence To Rate Metabolic syndrome
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral rice bran is beneficial in patients with metabolic syndrome.

Insufficient Reliable Evidence To Rate Obesity
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral rice bran for obesity, there is insufficient reliable information about the clinical effects of rice bran for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

As a normal part of food, rice bran is widely eaten and generally considered safe. Concentrated supplements and high doses have less safety data, so they call for more caution.

Because rice bran adds a lot of fiber, increasing your intake too quickly can cause gas or bloating. Drink plenty of water and increase the amount slowly. People with bowel narrowing or swallowing problems should be careful with high-fiber products.

One important note: rice and rice bran can contain trace amounts of arsenic from the environment. Eating a varied diet helps limit exposure. For pregnancy and breastfeeding, food amounts are likely fine, but there is not enough information on concentrated supplement doses, so it is best to be cautious and check with your doctor or pharmacist first.

Side effects

The most common side effects are digestive, including gas, bloating, stomach discomfort, or changes in bowel movements, especially when starting a higher-fiber product or taking it in large amounts.

Allergic reactions are uncommon but possible. Stop using rice bran and seek medical care if you notice signs of an allergy such as rash, itching, swelling, or trouble breathing.

Rice Bran: Reported Adverse Effects

Documented safety reports on Rice Bran from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, rice bran is generally well tolerated. However, increasing the amount of bran in the diet can cause transient abdominal discomfort, flatulence, and erratic bowel habits.

Most Common Adverse Effects:

Orally: Abdominal discomfort, erratic bowel habits, flatulence.

Topically: Erythema, itching.

Serious Adverse Effects (Rare):

All ROAs: Anaphylactic reactions, including urticaria and angioedema.

Reports by condition
Cough Immunologic

Orally and topically, rice bran can cause allergic reactions such as urticaria, angioedema, wheezing, itching, and cough. In a case report, a 5-year-old male presented with allergic eczema, urticaria, and cough due to rice bran ingestion. In another case report, a 14-year-old male developed food-dependent, exercise-induced anaphylaxis after consuming 150 grams of rice bran. The 52-kDa and 63-kDa globulin constituents in rice bran have both been implicated as the source of allergic reactions. These constituents are not typically present in cooked, polished rice.

  1. Togashi Y, Inomata N, Suzuki A, Hakuta A, Aihara M. Pediatric case with rice bran allergy induced by epicutaneous sensitization in a family rice shop. Allergol Int. 2019;68(1):117-118.
  2. Haneda Y, Kadowaki S, Furui M, Taketani T. A pediatric case of food-dependent exercise-induced anaphylaxis due to rice bran. Asia Pac Allergy 2021;11(1):e4.
  3. Satoh R, Tsuge I, Tokuda R, Teshima R. Analysis of the distribution of rice allergens in brown rice grains and of the allergenicity of products containing rice bran. Food Chem. 2019;276:761-767.
Flatulence Gastrointestinal

Orally, increasing the amount of bran in the diet can cause erratic bowel habits, flatulence, and abdominal discomfort during the first few weeks.

  1. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  2. So WKW, Chan JYW, Law BMH, et al. Effects of a Rice Bran Dietary Intervention on the Composition of the Intestinal Microbiota of Adults with a High Risk of Colorectal Cancer: A Pilot Randomised-Controlled Trial. Nutrients 2021;13(2):526.
Pruritus Dermatologic

Topically, rice bran broth baths can cause itching and skin redness. In rare cases, rash and itching from rice bran has been associated with contact infestation with Pyemotes tritici, an arthropod commonly called straw itch mite.

  1. Fujiwaki T, Furusho K. The effects of rice bran broth bathing in patients with atopic dermatitis. Acta Paediatr Jpn 1992;34:505-10.
  2. Uenotsuchi T, Satoh E, Kiryu H, Yano Y. Pyemotes dermatitis caused by indirect contact with husk rice. Br J Dermatol 2000;143:680-2.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no single official or standardized dose for rice bran supplements. The right amount depends on the product, the form (powder, capsule, or oil), and your reason for using it.

The best approach is to follow the directions on the product label and not exceed the recommended amount. If you are adding rice bran for fiber, start with a small amount and increase slowly while drinking plenty of water. Always check with your pharmacist or doctor before starting a supplement, especially if you have a health condition or take other medicines.

Pregnancy & Breastfeeding

Rice Bran & Pregnancy

Likely Safe

When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of rice bran when used for medicinal purposes during pregnancy and lactation; avoid using.

Rice Bran & Breastfeeding

Likely Safe

When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of rice bran when used for medicinal purposes during pregnancy and lactation; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 7 references that drive our Rice Bran monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  2. Fujiwaki T, Furusho K. The effects of rice bran broth bathing in patients with atopic dermatitis. Acta Paediatr Jpn 1992;34:505-10.
  3. Uenotsuchi T, Satoh E, Kiryu H, Yano Y. Pyemotes dermatitis caused by indirect contact with husk rice. Br J Dermatol 2000;143:680-2. DOI
  4. Satoh R, Tsuge I, Tokuda R, Teshima R. Analysis of the distribution of rice allergens in brown rice grains and of the allergenicity of products containing rice bran. Food Chem. 2019;276:761-767. PubMed
  5. Togashi Y, Inomata N, Suzuki A, Hakuta A, Aihara M. Pediatric case with rice bran allergy induced by epicutaneous sensitization in a family rice shop. Allergol Int. 2019;68(1):117-118. PubMed
  6. So WKW, Chan JYW, Law BMH, et al. Effects of a Rice Bran Dietary Intervention on the Composition of the Intestinal Microbiota of Adults with a High Risk of Colorectal Cancer: A Pilot Randomised-Controlled Trial. Nutrients 2021;13(2):526. PubMed
  7. Haneda Y, Kadowaki S, Furui M, Taketani T. A pediatric case of food-dependent exercise-induced anaphylaxis due to rice bran. Asia Pac Allergy 2021;11(1):e4. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Product directory

Supplement products with Rice Bran

3,347 products in our database contain Rice Bran. Open any to see its full ingredient list and every drug interaction we check.

Astra Garlic by Health Concerns Capsule 90 Capsule(s) View ingredients & interactions Astra Isatis by Health Concerns Capsule 90 Capsule(s) View ingredients & interactions Astra Isatis by Health Concerns Capsule 270 Capsule(s) View ingredients & interactions Astra Isatis by Health Concerns Capsule 90 Capsule(s) View ingredients & interactions Astragalus Root Extract 300 mg by SMNutrition Capsule 200 Capsule(s) View ingredients & interactions ATP Fuel by Researched Nutritionals Capsule 150 Capsule(s) View ingredients & interactions AZO Cranberry Softgels Urinary Tract Health by AZO Softgel 100 Softgels View ingredients & interactions B 100 Complex by Sundown Naturalist Tablet Or Pill 50 Tablet(s) View ingredients & interactions B 100 Complex by Thompson Tablet Or Pill 30 Tablet(s) View ingredients & interactions B 100 Complex by Thompson Tablet Or Pill 60 Tablet(s) View ingredients & interactions B Complex by Thompson Tablet Or Pill 60 Tablet(s) View ingredients & interactions B Complex by VitaCeutical Labs Tablet Or Pill 60 Vegetarian Tablet(s) View ingredients & interactions B Complex by New Sun Tablet Or Pill 120 Tablet(s) View ingredients & interactions B-100 by AN Amazing Nutrition Amazing Formulas Tablet Or Pill 120 Tablet(s) View ingredients & interactions B-100 by Pure Naturals Tablet Or Pill 120 Tablet(s) View ingredients & interactions B-100 B-Complex by Foster Regal Tablet Or Pill 30 Tablet(s) View ingredients & interactions B-100 Ultra B-Complex by Nature's Bounty Tablet Or Pill 50 Coated Tablet(s) View ingredients & interactions B-150 by Wonder Laboratories Tablet Or Pill 100 Tablet(s) View ingredients & interactions B-150 by Wonder Laboratories Tablet Or Pill 250 Tablet(s) View ingredients & interactions B-150 by Wonder Laboratories Tablet Or Pill 100 Tablet(s) View ingredients & interactions B-150 by Wonder Laboratories Tablet Or Pill 250 Tablet(s) View ingredients & interactions B-50 B-Complex by Foster Regal Tablet Or Pill 90 Tablet(s) View ingredients & interactions B-Complex by VitaCeutical Labs Tablet Or Pill 90 Vegetarian Tablet(s) View ingredients & interactions B-Complex by VitaCeutical Labs Capsule 60 Vegetarian Capsule(s) View ingredients & interactions
Pharmacist Counseling Corner

Rice Bran: Common Questions

What is Rice Bran used for, and does it work?
People use Rice Bran for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Rice Bran for Dyslipidemia. For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Rice Bran interact with prescription medications?
We do not currently list any known drug interactions for Rice Bran. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Rice Bran interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Rice Bran with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Rice Bran interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Rice Bran used for?
People most often use Rice Bran for cholesterol and heart health, as well as for added fiber and digestive support. The strongest evidence is for modestly lowering cholesterol, while other uses have weaker support.
Is Rice Bran safe to take?
As a food, Rice Bran is generally safe for most people. Supplements are usually well tolerated but can cause gas or bloating, and high-dose products have less safety data, so it is wise to check with your pharmacist.
Can I take Rice Bran while pregnant or breastfeeding?
Eating Rice Bran as part of normal food is likely fine, but concentrated supplement doses have not been well studied during pregnancy or breastfeeding. Talk to your doctor before using supplements.
Does Rice Bran really lower cholesterol?
It may modestly lower cholesterol in some people thanks to its fiber and plant compounds, but the effect is usually small. It should not replace prescribed cholesterol medicine.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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