Interactions on record — worth a quick check against your medications. Based on 10 of 17 ingredients. Check your meds →
Dietary supplement

Enzyme Probiotic Complex Ingredients & Drug Interactions

by American Health

Enzyme Probiotic Complex label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Enzyme Probiotic Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Enzyme Probiotic Complex is a dietary supplement by American Health with 17 active ingredients. Its ingredients are commonly taken for digestive health and regularity, diarrhea (including antibiotic-related), irritable bowel syndrome (ibs) symptoms.Based on those ingredients, 2,103 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Psyllium, B. bifidum, Lactobacillus acidophilus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Enzyme Probiotic Complex by American Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Enzyme Probiotic Complex by American Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Enzyme Probiotic Complex by American Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 9 of its 17 active ingredients.
  • “Bio-Active Probiotic Complex” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Digestive Enzyme Complex Blend” is a proprietary blend — the label gives one combined amount (40 mg) without saying how much of each component you get.
  • “Fiber Complex” is a proprietary blend — the label gives one combined amount (10 mg) without saying how much of each component you get.

This product contains 17 ingredients: a blend of digestive enzymes, probiotics, and fiber. The active digestive enzymes include bromelain (from pineapple), papain (from papaya), protease enzymes (three types), amylase (breaks down starches), lipase (breaks down fats), lactase (breaks down milk sugar), hemicellulase, and cellulase.

The probiotic strains are Bifidobacterium animalis lactis, B. bifidum, Lactobacillus acidophilus, L. bulgaricus, and L. brevis. It also contains grapefruit pectin and psyllium for fiber, plus oat bran.

The inactive ingredients are vegetable cellulose, silica, rice bran, and vegetable magnesium stearate.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestive health and nutrient absorption.
  • We looked for evidence on: Antibiotic-associated diarrhea, Constipation, Diarrhea, Dyspepsia, Gastroesophageal reflux disease (GERD), Inflammatory bowel disease (IBD) — and 3 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Blond Psyllium is rated "Effective" for Constipation.
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea.

The probiotics show some promise: B. bifidum and L. acidophilus are both possibly effective for irritable bowel syndrome and respiratory tract infections. L. acidophilus is also possibly effective for H. pylori infection, antibiotic-related diarrhea, and bacterial vaginosis.

Psyllium is effective for constipation and likely effective for high cholesterol and heart disease. Lactase is effective for lactose intolerance.

However, for most other uses listed — bromelain for hay fever or burns, papain for muscle soreness or herpes, and the other conditions — there isn't enough reliable evidence to rate their effectiveness.

The evidence, ingredient by ingredient Bifidobacterium Bifidum Lactobacillus Acidophilus Lactobacillus Delbrueckii Bromelain Papain Proteolytic Enzymes (proteases) Lactase Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 10 of the 10 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 10 of 10.
  • General safety write-ups exist for 10 of 10.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bromelain is generally well tolerated short-term, but long-term safety data are limited. Common side effects include diarrhea, flatulence, stomach upset, and headache.

It can trigger allergic reactions in sensitive people, including swelling or difficulty swallowing if inhaled. The probiotics are generally well tolerated in healthy people but should be used cautiously by anyone with a weakened immune system.

Possible side effects include bloating, flatulence, and mild abdominal discomfort. Papain is well tolerated as food but may irritate the digestive tract and cause allergic reactions; high doses carry rare risks of esophageal perforation and severe gastritis.

Psyllium is generally well tolerated when taken with adequate water but may cause abdominal pain, bloating, diarrhea, or constipation; rare serious effects include bowel or esophageal obstruction, and allergic reactions can occur with repeated use. Protease enzymes may cause digestive upset or allergic reactions.

Pectin, lactase, and lipase are generally well tolerated but may cause mild digestive side effects.

Side effects, ingredient by ingredient Bifidobacterium Bifidum Lactobacillus Acidophilus Lactobacillus Delbrueckii Bromelain Papain Proteolytic Enzymes (proteases) Lactase Lipase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 7 of the 10 matched ingredients can interact with medications — Papain, Pectin, Lactobacillus Acidophilus, Blond Psyllium, Bromelain, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; heart-rhythm medications; lithium.
  • For scale: 2,104 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take blood thinners (warfarin, aspirin), diabetes medication (metformin), mood stabilizers (lithium), seizure drugs (carbamazepine), antipsychotics (olanzapine), heart medication (digoxin), cholesterol drugs (lovastatin), antibiotics (especially tetracyclines and others), or birth control pills. Altogether, these interactions span 2,104 individual medications.

No interactions are documented for the ingredients we could not check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with constipation, high cholesterol, and digestive support through its mix of enzymes and probiotics. However, if you take blood thinners, diabetes medications, antibiotics, lithium, seizure drugs, antipsychotics, heart medications, or cholesterol drugs, talk with your doctor or pharmacist before starting — this product has several documented interactions that could affect how your medications work.

People pregnant or breastfeeding should check with their healthcare provider, as safety data are limited for several ingredients.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 11 of 17 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Enzyme Probiotic Complex, straight from the product label.

Brand American Health
Barcode (UPC) 076630295871
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD May 22, 2015
DSLD ID 44582
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Enzyme Probiotic Complex by American Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
UPC/BARCODE
076630295871
IngredientAmount% DV
Bromelain44.8 GDU--
Bifidobacterium animalis lactis0 NP--
B. bifidum0 NP--
Lactobacillus acidophilus0 NP--
L. bulgaricus0 NP--
Papain393750 FCCPU--
Amylase241.5 DU--
Protease 35.3 SAPU--
Protease 4.5210 HUT--
Lactase12.1 ALU--
Hemicellulase5.3 CU--
Lipase78.8 FIP--
Grapefruit Pectin0 NP--
L. brevis0 NP--
Oat Bran0 NP--
Bio-Active Probiotic Complex0 NP--
Digestive Enzyme Complex Blend40 mg--
Cellulase5.3 CU--
Fiber Complex10 mg--
Psyllium0 NP--

Other ingredients: Vegetable Cellulose, Silica, Rice Bran, Vegetable Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Enzyme Probiotic Complex is an advanced, dual-action formula that delivers multi-level digestive and nutrient absorption benefits from both enzymes and probiotics in one convenient supplement. This exclusive vegetarian complex contains: 9 Active, Naturally-Based Digestive Enzymes 2 Billion Bio-Active Probiotic Microorganisms 5 Beneficial Cultures Enzyme Probiotic Complex supports all dietary plans including specialized low fat, low carbohydrate and protein based diets. It works to maximize nutrient absorption, by delivering a broad spectrum of enzyme activity for more thorough protein, fat and carbohydrate breakdown. Along with the additional benefits from 2 billion bio-active probiotics, Enzyme Probiotic Complex provides the essential foundation you need for efficient digestion and gastric wellness.

Visit www.AmericanHealthUS.com for our complete line of products

Dual-action Advanced support for digestion & nutritional absorption 9 active, naturally-based enzymes 2 billion bio-active probiotic microorganisms Helps with gastro-intestinal health & digestion Digestive health

For digestive health Enzyme probiotic complex contains 9 distinct, naturally-based protein, carbohydrate and fat-digesting enzymes, to help support the body's natural digestive process. Enzymes help break down protein into amino acids, carbohydrates into simple sugars and fats into fatty acids that your body absorbs as nutrients for energy needs and cell growth. If protein, carbohydrates and fats are not properly digested, they may be broken down by the bacteria in the gastro-intestinal tract, which can cause you to feel unsettled and out of balance due to inefficient digestion. For intestinal health Enzyme probiotic complex also contains 2 billion bio-active probiotic microorganisms per capsule. Probiotics not only support microbial balance of healthy intestinal flora, but assist in the body's natural digestive process and contribute to the healthy functioning of the immune system. Intestinal microflora imbalance may lead to inefficient digestion. Additionally, balanced intestinal microflora helps promote a favorable environment for the absorption of nutrients, further supporting digestive health. Enzyme probiotic complex is the ideal choice for those individuals looking for a superior level of dual nutritional benefits to helps maintain and gastro-intestinal wellness.

Broad spectrum enzyme activity for more thorough protein, fat & carbohydrate breakdown

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

General

Prod No. 29587 B54622 04B

Brand IP Statement(s)

2014 American Health, Inc.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) vegetarian capsule twice daily, preferably with your largest meals.

Formula

Contains milk, wheat and soy ingredients.

Precautions

Contains milk, wheat and soy ingredients.

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult you doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Formulation

No egg, no sugar, no artificial color, no artificial flavor, no sodium. Non-GMO.

Suitable for vegetarians.

Storage

Store at room temperature.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Enzyme Probiotic Complex by American Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Enzyme Probiotic Complex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Enzyme Probiotic Complex by American Health

These are the 17 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bio-Active Probiotic Complex

0 NP per serving

Digestive Enzyme Complex Blend

40 mg per serving

Fiber Complex

10 mg per serving

Other (inactive) ingredients: Vegetable Cellulose, Silica, Rice Bran, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Enzyme Probiotic Complex by American Health Drug Interactions

Want to check YOUR meds against Enzyme Probiotic Complex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,103Drugs
332 Moderate 1,771 Minor

Ingredients driving the most interactions

Psyllium 2,025
B. bifidum 182
Lactobacillus acidophilus 182
L. bulgaricus 182
Bromelain 141

Individual Drug Interactions

The ingredients in Enzyme Probiotic Complex interact with 2,103 drugs. Click any drug to see the details.

7 of the 17 ingredients in Enzyme Probiotic Complex interact with drugs. Each result below shows which ingredient is responsible. Psyllium B. bifidum Lactobacillus acidophilus L. bulgaricus Bromelain Grapefruit Pectin Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Enzyme Probiotic Complex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Psyllium7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, blond psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Blond psyllium might reduce carbamazepine absorption and serum levels. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug.

Likelihood Probable Evidence D
Lithium

Theoretically, taking blond psyllium at the same time as lithium might reduce lithium absorption.
The fiber in blond psyllium might decrease the absorption of lithium. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, blond psyllium might increase the therapeutic and adverse effects of metformin.
Concurrent use of blond psyllium with metformin slows and increases metformin absorption. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking blond psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in blond psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was taken concomitantly with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking blond psyllium at the same time as digoxin might reduce digoxin absorption.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking blond psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. However, this is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Conversely, case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin.

Likelihood Possible Evidence B
Psyllium full monograph & interactions

B. bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
B. bifidum full monograph & interactions

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions

L. bulgaricus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L. delbrueckii.
Lactobacillus delbrueckii preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. delbrueckii preparations by at least two hours.

Likelihood Probable Evidence D
L. bulgaricus full monograph & interactions

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions

Grapefruit Pectin3 drug types · 23 drugs

Digoxin (Lanoxin)

Theoretically, pectin might reduce the absorption of digoxin, potentially decreasing its effectiveness.
A small clinical study shows that taking digoxin with a kaolin-pectin suspension reduces the absorption of digoxin by about 62%. It is unclear if these effects are due to pectin, kaolin, or the combination.

Likelihood Possible Evidence B
Lovastatin (Mevacor)

Theoretically, pectin might reduce the absorption of lovastatin, potentially decreasing its effectiveness.
Case reports suggest that concomitant use of pectin and lovastatin might reduce the cholesterol-lowering effect of lovastatin, possibly due to reduced intestinal absorption of lovastatin.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
A small clinical study shows that taking tetracycline with bismuth subsalicylate in a kaolin-pectin suspension reduces the absorption of tetracycline by about 34%. It is unclear if these effects are due to pectin, kaolin, bismuth subsalicylate, or the combination.

Likelihood Possible Evidence B
Grapefruit Pectin full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Enzyme Probiotic Complex, from the product label.

American Health

See all American Health products
Name
American Health, Inc.
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
800-445-7137
Web Address
www.AmericanHealthUS.com
Pharmacist Counseling Corner

Enzyme Probiotic Complex by American Health: Common Questions

Does Enzyme Probiotic Complex by American Health interact with any medications?
Yes. Based on its ingredients, Enzyme Probiotic Complex has a known interaction with 2,103 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Enzyme Probiotic Complex contains 17 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this interfere with my antibiotics?
Yes, potentially. The three live probiotic strains in this product (B. bifidum, L. acidophilus, and L. bulgaricus) can lose their effectiveness if you take them at the same time as antibiotics, because antibiotics kill the live organisms. Take them at least a few hours apart — your doctor or pharmacist can help you time them right.
Is this safe during pregnancy?
Not enough safety data exist for most ingredients. Bromelain and papain are possibly unsafe or best avoided in pregnancy. B. bifidum and L. acidophilus are possibly safe, and psyllium is likely safe, but safety for the others hasn't been well studied. Talk with your doctor before taking this during pregnancy.
Can I take this while breastfeeding?
Safety while breastfeeding hasn't been established for most ingredients in this product. Bromelain, papain, protease enzymes, lipase, and several others lack reliable safety data for breastfeeding. Check with your doctor or pharmacist before use.
What do the enzymes in this do?
They help break down food: bromelain and papain break down proteins, amylase breaks down starches, lipase breaks down fats, lactase breaks down milk sugar, and the others help with fiber and cellulose digestion. Together they support the digestive process.
Is this product effective for IBS?
Two of the probiotics — B. bifidum and L. acidophilus — are possibly effective for irritable bowel syndrome based on available evidence. However, the evidence isn't strong, and this product hasn't been tested as a whole for IBS. Results vary from person to person.
What are the most common side effects?
Digestive upset is most likely: bloating, flatulence, diarrhea, gas, and mild abdominal discomfort. These are usually mild and temporary. Stop and call your doctor if you have severe abdominal pain, signs of an allergic reaction (swelling, difficulty breathing), or bowel obstruction (severe constipation).

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Enzyme Probiotic Complex label
Go deeper

The Full Monographs Behind Enzyme Probiotic Complex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Lactobacillus Delbrueckii

Interacts with 182 drugs

Lactobacillus delbrueckii is a 'friendly' bacterium used in food fermentation and sold as a probiotic, often as part of multi-strain products. It is generally considered safe for healthy peo...

Read the full Lactobacillus Delbrueckii monograph → Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph → Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Pectin

Interacts with 23 drugs

Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly help with cholesterol, blood sugar, and di...

Read the full Pectin monograph → Herb & supplement monograph

Blond Psyllium

Interacts with 2,025 drugs

Blond psyllium is a soluble fiber from the seed husks of Plantago ovata, and it is one of the better-studied fiber supplements. It can help with both constipation and diarrhea and may modest...

Read the full Blond Psyllium monograph →
Sources

Sources & How We Checked

Enzyme Probiotic Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 105 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
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Bifidobacterium Bifidum 7 references
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Lactobacillus Acidophilus 15 references
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Lactobacillus Delbrueckii 9 references
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Papain 11 references
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Proteolytic Enzymes (proteases) 3 references
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Lactase 1 reference
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Lipase 1 reference
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Pectin 11 references
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Blond Psyllium 28 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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