Herb & supplement monograph

Shilajit Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Shilajit interacts with medications. The heart of this page is the interaction list — every drug Shilajit is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Shilajit is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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On this page

Shilajit Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Shilajit drug interaction appears low for most people. None of the interactions on record are rated major, and the central concern is documented mostly in animal research rather than well-controlled human studies.

Interactions deserving the most attention

The combinations that deserve the most care involve diabetes medications. Shilajit appears to lower fasting blood sugar, and in animal research it strengthened the glucose-lowering effect of both metformin and glibenclamide when the products were taken together for several weeks. Because blood sugar is a closely managed target, this added effect could push levels lower than intended, so closer glucose monitoring is sensible for anyone combining shilajit with these medicines.

What the rest of the list means

Although the list of interacting medications is fairly long, that does not mean every pairing is harmful. Nearly all of it traces back to this one blood sugar concern, which is rated moderate and rests on limited, largely animal-based evidence rather than proven problems in people. Predicted effects like this do not always translate into meaningful changes for everyone.

Check your medications against Shilajit

Based on HelloPharmacist’s Shilajit interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Shilajit

86 medications have a known interaction with Shilajit, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Shilajit using our pharmacist-reviewed interaction data.

AI summaries are generated from our Shilajit interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Shilajit combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Shilajit affects

Every type of medication (drug category) Shilajit is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Shilajit interacts with

Antidiabetes Drugs

Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Most human and animal research shows that shilajit can decrease fasting plasma glucose levels. In an animal model, shilajit 100 mg per kg daily enhanced the glucose-lowering ability of both glibenclamide and metformin when given in combination over a 4 week period. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D

Monograph

Shilajit: Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed July 2026 ·

The bottom line

Shilajit is a sticky, tar-like substance found in rocks of mountain ranges like the Himalayas, used in traditional Ayurvedic medicine for energy and vitality. Human evidence is limited and mostly small or early-stage, so its real benefits are uncertain. Quality and purity vary widely, and contamination with heavy metals is a real concern, so choose tested products and talk to your pharmacist before use.

Part used: Mineral exudate (resin) from rock layers
Common forms: Resin, capsules, powder, tablets

People commonly use it for

Fatigue and low energy
Male fertility and testosterone support
General vitality and aging
Athletic performance
Cognitive support

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallUse caution

Unpurified products may contain heavy metals or other contaminants, so only use purified, tested brands.

PregnancyInsufficient reliable information

There is insufficient reliable information available about the safety of shilajit when used during pregnancy and lactation.

Read the full pregnancy detail

BreastfeedingInsufficient reliable information

There is insufficient reliable information available about the safety of shilajit when used during pregnancy and lactation.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Shilajit is a sticky, blackish-brown substance that oozes from cracks in rocks, mainly in high mountain ranges such as the Himalayas, Altai, and Caucasus. It is thought to form slowly over centuries from the breakdown of plant and microbial material. It is not a single plant but a natural mineral and organic exudate.

Shilajit has a long history in Ayurvedic (traditional Indian) medicine, where it is called a "destroyer of weakness." People take it hoping to boost energy, stamina, and overall vitality. Today it is sold as a purified resin, powder, or in capsules and tablets.

How it works

Shilajit contains a mix of compounds, including fulvic acid and humic substances, along with various minerals and small molecules. Fulvic acid is often described as the main active ingredient and is thought to act as an antioxidant and to help carry minerals in the body.

Researchers have proposed that shilajit may support energy production in cells, reduce oxidative stress, and influence certain hormones. Keep in mind that most of these ideas come from test-tube and animal studies, and it is not clear how well they apply to people.

Effectiveness

Does Shilajit work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by Dr. Brian Staiger, PharmD.

Evidence overview · 13 uses evaluated

13 Insufficient evidence

How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.

2Likely EffectiveGood evidence, though not yet conclusive.

3Possibly EffectiveSome evidence suggests a benefit.

4Possibly IneffectiveSome evidence it may not help.

5Likely IneffectiveFairly strong evidence it doesn’t help.

6IneffectiveStrong evidence it doesn’t work.

7Insufficient Reliable Evidence to RateToo little research to say either way.

For Shilajit, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 13 conditions — evidence insufficient to rate

Insufficient Reliable Evidence To Rate Alzheimer disease