Medication interaction hub

What Supplements Interact with Alendronate Sodium, Cholecalciferol?

Alendronate Sodium, Cholecalciferol brand name: Fosamax Plus D. Every interaction below applies to the brands too.

25 Interactions 1 Major 15 Moderate 9 Minor
Curated & coded by · Clinical Pharmacist · Updated October 1, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Alendronate Sodium, Cholecalciferol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Alendronate Sodium, Cholecalciferol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Activated charcoal carries the only major rating against Fosamax Plus D (alendronate with cholecalciferol), and it deserves real respect from anyone taking this bone medicine. Charcoal soaks up drugs in the gut, so less alendronate ever reaches the skeleton it is supposed to strengthen. The other 24 entries, 15 rated moderate and 9 minor, mostly tell the same story in milder form: minerals, fibers, and gums that bind or block the drug before it can be absorbed.

The twist worth knowing is that calcium, the very supplement most people on an osteoporosis drug are told to take, is one of the moderate offenders, and so is ordinary coffee, which cuts alendronate absorption by about 60 percent in human studies. That does not mean giving these things up. It means timing matters here more than with most medicines, so put real hours between your dose and everything else, and let your pharmacist confirm the schedule.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 15 Minor 9 No known interaction 1,427

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Alendronate Sodium, Cholecalciferol: Top Interactions at a Glance

The Alendronate Sodium, Cholecalciferol supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 25 interacting ingredients — plus 1,427 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Alendronate Sodium, Cholecalciferol Combinations Today

The Alendronate Sodium, Cholecalciferol + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Calcium + Alendronate Sodium, Cholecalciferoli

Calcium reduces the absorption of bisphosphonates.

Read the full interaction Moderate Likelihood Probable Iron + Alendronate Sodium, Cholecalciferoli

Iron reduces the absorption of bisphosphonates.

Read the full interaction Moderate Likelihood Probable Magnesium + Alendronate Sodium, Cholecalciferoli

Magnesium can decrease absorption of bisphosphonates.

Read the full interaction Moderate Likelihood Probable Whey Protein + Alendronate Sodium, Cholecalciferoli

Theoretically, whey protein might reduce the absorption of bisphosphonates.

Read the full interaction Major Likelihood Probable Activated Charcoal + Alendronate Sodium, Cholecalciferoli

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Moderate Likelihood Probable Coffee + Alendronate Sodium, Cholecalciferoli

Coffee reduces alendronate bioavailability.

Read the full interaction
The complete list

Every Supplement Checked Against Alendronate Sodium, Cholecalciferol

All 1,452 ingredients in our database, ranked by severity — 25 with a Alendronate Sodium, Cholecalciferol interaction on file and 1,427 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Alendronate Sodium, Cholecalciferol?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Calcium with Alendronate Sodium, Cholecalciferol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Calcium reduces the absorption of bisphosphonates.

Full Calcium + Alendronate Sodium, Cholecalciferol answer

Can you take Iron with Alendronate Sodium, Cholecalciferol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Iron reduces the absorption of bisphosphonates.

Full Iron + Alendronate Sodium, Cholecalciferol answer

Can you take Magnesium with Alendronate Sodium, Cholecalciferol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Magnesium can decrease absorption of bisphosphonates.

Full Magnesium + Alendronate Sodium, Cholecalciferol answer

Can you take Whey Protein with Alendronate Sodium, Cholecalciferol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, whey protein might reduce the absorption of bisphosphonates.

Full Whey Protein + Alendronate Sodium, Cholecalciferol answer

Can you take Activated Charcoal with Alendronate Sodium, Cholecalciferol?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Alendronate Sodium, Cholecalciferol answer

Can you take Coffee with Alendronate Sodium, Cholecalciferol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee reduces alendronate bioavailability.

Full Coffee + Alendronate Sodium, Cholecalciferol answer

Can you take Coffee Charcoal with Alendronate Sodium, Cholecalciferol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Alendronate Sodium, Cholecalciferol answer

Can you take Dolomite with Alendronate Sodium, Cholecalciferol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the calcium and magnesium in dolomite might decrease the absorption of bisphosphonates.

Full Dolomite + Alendronate Sodium, Cholecalciferol answer

Can you take European Mandrake with Alendronate Sodium, Cholecalciferol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Alendronate Sodium, Cholecalciferol answer

Can you take Glucomannan with Alendronate Sodium, Cholecalciferol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Alendronate Sodium, Cholecalciferol answer

Can you take Green Coffee with Alendronate Sodium, Cholecalciferol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, green coffee may decrease the levels and effects of alendronate.

Full Green Coffee + Alendronate Sodium, Cholecalciferol answer

Can you take Guar Gum with Alendronate Sodium, Cholecalciferol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Alendronate Sodium, Cholecalciferol answer

Can you take Gum Arabic with Alendronate Sodium, Cholecalciferol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Alendronate Sodium, Cholecalciferol answer

Can you take Phosphate Salts with Alendronate Sodium, Cholecalciferol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking phosphate salts with bisphosphonates might increase the risk of hypocalcemia.

Full Phosphate Salts + Alendronate Sodium, Cholecalciferol answer

Can you take Slippery Elm with Alendronate Sodium, Cholecalciferol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Alendronate Sodium, Cholecalciferol answer

Can you take Tragacanth with Alendronate Sodium, Cholecalciferol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Alendronate Sodium, Cholecalciferol answer

Can you take Thyroid Extract with Alendronate Sodium, Cholecalciferol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Alendronate Sodium, Cholecalciferol answer

Can you take Agar with Alendronate Sodium, Cholecalciferol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Alendronate Sodium, Cholecalciferol answer

Can you take Algin with Alendronate Sodium, Cholecalciferol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Alendronate Sodium, Cholecalciferol answer

Can you take Black Psyllium with Alendronate Sodium, Cholecalciferol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Alendronate Sodium, Cholecalciferol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Alendronate Sodium, Cholecalciferol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Alendronate Sodium, Cholecalciferol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Alendronate Sodium, Cholecalciferol sits in 3 interaction categories. Open any one to see what the group means:

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Alendronate Sodium, Cholecalciferol through this category.

Bisphosphonates 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Alendronate Sodium, Cholecalciferol through this category.

Alendronate (Fosamax) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Alendronate Sodium, Cholecalciferol through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Alendronate Sodium, Cholecalciferol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Alendronate Sodium, Cholecalciferol.

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Products that contain Alendronate Sodium, Cholecalciferol-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Alendronate Sodium, Cholecalciferol.

ATP Ignite Natural Mixed Berry Flavor by XYMOGEN contains Coffee ATP Ignite Natural Mixed Berry Flavor by XYMOGEN contains Coffee
Pharmacist Counseling Corner

Alendronate Sodium, Cholecalciferol & Supplements: Common Questions

What supplements interact with Alendronate Sodium, Cholecalciferol?
More than you might expect — 25 in total, though they are far from equal: 1 are rated major, 15 moderate, and 9 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Activated Charcoal, Calcium, Coffee.
Which Alendronate Sodium, Cholecalciferol supplement interactions are the most serious?
Focus on the major group: Activated Charcoal. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Alendronate Sodium, Cholecalciferol?
Usually yes — most people on Alendronate Sodium, Cholecalciferol can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Fosamax Plus D have the same supplement interactions as Alendronate Sodium, Cholecalciferol?
Yes — Fosamax Plus D all contain Alendronate Sodium, Cholecalciferol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Alendronate Sodium, Cholecalciferol and my other medications?
This page covers Alendronate Sodium, Cholecalciferol against supplements and herbal ingredients. Checking Alendronate Sodium, Cholecalciferol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 1, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.