Medication interaction hub

What Supplements Interact with Amoxicillin, Clavulanate Potassium?

Amoxicillin, Clavulanate Potassium brand names: Augmentin, Augmentin XR, Clavulin, Augmentin '125/31 SF', Augmentin '250/62 SF', and others. Every interaction below applies to the brands too.

96 Interactions 6 Major 76 Moderate 14 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Amoxicillin, Clavulanate Potassium? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Amoxicillin, Clavulanate Potassium against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Beer and wine sit among the six major-rated interactions for amoxicillin and clavulanate potassium (Augmentin), and this list deserves real caution. Clavulanate is a well-known antibiotic cause of liver injury, so the 38 ingredients flagged for adding liver stress carry extra weight with this particular drug. The remaining majors either strain the kidneys or keep the antibiotic from absorbing, with activated charcoal the clearest example of the latter.

Most of the 76 moderate entries are milder versions of those same themes. Probiotics are not dangerous here; the antibiotic simply kills the live organisms, so they only help when spaced well apart from each dose. Thickening fibers and gums can lower how much antibiotic reaches your blood, which risks an undertreated infection. Fourteen entries rate minor, but with a liver-sensitive drug and six majors up top, check the full list before starting a supplement mid-course.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 76 Minor 14 No known interaction 1,356

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Amoxicillin, Clavulanate Potassium: Top Interactions at a Glance

The Amoxicillin, Clavulanate Potassium supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 96 interacting ingredients — plus 1,356 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Amoxicillin, Clavulanate Potassium Combinations Today

The Amoxicillin, Clavulanate Potassium + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Bifidobacterium Bifidum + Amoxicillin, Clavulanate Potassiumi

Theoretically, taking Bifidobacterium.

Read the full interaction Moderate Likelihood Probable Lactobacillus Acidophilus + Amoxicillin, Clavulanate Potassiumi

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.

Read the full interaction Moderate Likelihood Probable Bacillus Coagulans + Amoxicillin, Clavulanate Potassiumi

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.

Read the full interaction Moderate Likelihood Probable Bifidobacterium Breve + Amoxicillin, Clavulanate Potassiumi

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.

Read the full interaction Moderate Likelihood Probable Bifidobacterium Longum + Amoxicillin, Clavulanate Potassiumi

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.

Read the full interaction Major Likelihood Probable Activated Charcoal + Amoxicillin, Clavulanate Potassiumi

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Amoxicillin, Clavulanate Potassium

All 1,452 ingredients in our database, ranked by severity — 96 with a Amoxicillin, Clavulanate Potassium interaction on file and 1,356 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Amoxicillin, Clavulanate Potassium?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Bifidobacterium Bifidum with Amoxicillin, Clavulanate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium.

Full Bifidobacterium Bifidum + Amoxicillin, Clavulanate Potassium answer

Can you take Lactobacillus Acidophilus with Amoxicillin, Clavulanate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Acidophilus + Amoxicillin, Clavulanate Potassium answer

Can you take Bacillus Coagulans with Amoxicillin, Clavulanate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.

Full Bacillus Coagulans + Amoxicillin, Clavulanate Potassium answer

Can you take Bifidobacterium Breve with Amoxicillin, Clavulanate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Breve + Amoxicillin, Clavulanate Potassium answer

Can you take Bifidobacterium Longum with Amoxicillin, Clavulanate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Longum + Amoxicillin, Clavulanate Potassium answer

Can you take Rauwolscine with Amoxicillin, Clavulanate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.

Full Rauwolscine + Amoxicillin, Clavulanate Potassium answer

Can you take Red Yeast Rice with Amoxicillin, Clavulanate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of liver damage.

Full Red Yeast Rice + Amoxicillin, Clavulanate Potassium answer

Can you take Rhubarb with Amoxicillin, Clavulanate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.

Full Rhubarb + Amoxicillin, Clavulanate Potassium answer

Can you take Saigon Cinnamon with Amoxicillin, Clavulanate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Saigon cinnamon might cause additive effects when used with hepatotoxic drugs.

Full Saigon Cinnamon + Amoxicillin, Clavulanate Potassium answer

Can you take Slippery Elm with Amoxicillin, Clavulanate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Amoxicillin, Clavulanate Potassium answer

Can you take Spearmint with Amoxicillin, Clavulanate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Spearmint + Amoxicillin, Clavulanate Potassium answer

Can you take Sweet Annie with Amoxicillin, Clavulanate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Sweet Annie + Amoxicillin, Clavulanate Potassium answer

Can you take Sweet Clover with Amoxicillin, Clavulanate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sweet clover with hepatoxic drugs might increase the risk of hepatotoxicity.

Full Sweet Clover + Amoxicillin, Clavulanate Potassium answer

Can you take Syrian Rue with Amoxicillin, Clavulanate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of Syrian rue might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Syrian Rue + Amoxicillin, Clavulanate Potassium answer

Can you take Testolone with Amoxicillin, Clavulanate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Testolone + Amoxicillin, Clavulanate Potassium answer

Can you take Thuja with Amoxicillin, Clavulanate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Thuja products can contains significant amounts of thujone, a neurotoxin.

Full Thuja + Amoxicillin, Clavulanate Potassium answer

Can you take Tragacanth with Amoxicillin, Clavulanate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Amoxicillin, Clavulanate Potassium answer

Can you take Turmeric with Amoxicillin, Clavulanate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Turmeric + Amoxicillin, Clavulanate Potassium answer

Can you take Vitamin A with Amoxicillin, Clavulanate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disea...

Full Vitamin A + Amoxicillin, Clavulanate Potassium answer

Can you take Green Tea with Amoxicillin, Clavulanate Potassium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Green Tea + Amoxicillin, Clavulanate Potassium answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Amoxicillin, Clavulanate Potassium is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Amoxicillin, Clavulanate Potassium, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Amoxicillin, Clavulanate Potassium sits in 7 interaction categories. Open any one to see what the group means:

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Amoxicillin, Clavulanate Potassium through this category.

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Amoxicillin, Clavulanate Potassium through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Amoxicillin, Clavulanate Potassium through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Amoxicillin, Clavulanate Potassium through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Amoxicillin, Clavulanate Potassium through this category.

Amoxicillin (Amoxil, Trimox) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Amoxicillin, Clavulanate Potassium through this category.

Penicillin 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Amoxicillin, Clavulanate Potassium through this category.

Related: does Amoxicillin, Clavulanate Potassium deplete any nutrients?

Amoxicillin, Clavulanate Potassium has 42 reported nutrient associations in the research literature — see the Amoxicillin, Clavulanate Potassium nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Amoxicillin, Clavulanate Potassium

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Amoxicillin, Clavulanate Potassium.

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Products that contain Amoxicillin, Clavulanate Potassium-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Amoxicillin, Clavulanate Potassium.

Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur
Pharmacist Counseling Corner

Amoxicillin, Clavulanate Potassium & Supplements: Common Questions

What supplements interact with Amoxicillin, Clavulanate Potassium?
More than you might expect — 96 in total, though they are far from equal: 6 are rated major, 76 moderate, and 14 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Khat, Siberian Cocklebur, Activated Charcoal.
Which Amoxicillin, Clavulanate Potassium supplement interactions are the most serious?
The 6 major-rated combinations — led by Khat, Siberian Cocklebur, Activated Charcoal, Beer and Wine — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Amoxicillin, Clavulanate Potassium?
Usually yes — most people on Amoxicillin, Clavulanate Potassium can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Augmentin have the same supplement interactions as Amoxicillin, Clavulanate Potassium?
Yes — Augmentin, Augmentin XR, Clavulin, Augmentin '125/31 SF', Augmentin '250/62 SF' and other brands all contain Amoxicillin, Clavulanate Potassium, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Amoxicillin, Clavulanate Potassium deplete any vitamins or nutrients?
It might — Amoxicillin, Clavulanate Potassium has 42 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Amoxicillin, Clavulanate Potassium nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Amoxicillin, Clavulanate Potassium and my other medications?
This page covers Amoxicillin, Clavulanate Potassium against supplements and herbal ingredients. Checking Amoxicillin, Clavulanate Potassium against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.