Medication interaction hub

What Supplements Interact with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?

Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor brand name: Glyxambi. Every interaction below applies to the brands too.

284 Interactions 3 Major 241 Moderate 40 Minor
Curated & coded by · Clinical Pharmacist · Updated September 19, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Glyxambi, a DPP-4 inhibitor paired with empagliflozin for type 2 diabetes, warrants genuine caution, because three of its 284 documented supplement interactions carry a major rating. The dominant pattern is additive blood-sugar lowering. Most entries are herbs or foods that reduce glucose on their own, and stacking them onto a medication built to do the same can push sugar dangerously low. Siberian cocklebur stands out worst, with severe hypoglycemia reported in people soon after eating it.

The other two majors act on the drug itself. St. John's wort can lower the drug's blood levels and blunt its effect, while activated charcoal binds it in the gut so less gets absorbed; keep charcoal well separated from your tablets. The 241 moderate and 40 minor entries mostly echo the glucose theme in milder form. Checking your readings more often whenever you add a supplement is the habit that catches these interactions early.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 241 Minor 40 No known interaction 1,168

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor: Top Interactions at a Glance

The Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 284 interacting ingredients — plus 1,168 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor Combinations Today

The Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Ash + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitori

Theoretically, concomitant use with antidiabetes drugs might affect glucose control and increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Acai + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitori

Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.

Read the full interaction Minor Likelihood Unlikely Black Tea + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitori

Theoretically, taking black tea with antidiabetes drugs might interfere with blood glucose control.

Read the full interaction Minor Likelihood Unlikely Coffee + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitori

Theoretically, concomitant use of coffee and antidiabetes drugs might interfere with blood glucose control.

Read the full interaction Minor Likelihood Unlikely Caffeine + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitori

Theoretically, taking caffeine with antidiabetes drugs might interfere with blood glucose control.

Read the full interaction Moderate Likelihood Probable American Ginseng + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitori

Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction
The complete list

Every Supplement Checked Against Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor

All 1,452 ingredients in our database, ranked by severity — 284 with a Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor interaction on file and 1,168 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Ash with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with antidiabetes drugs might affect glucose control and increase the risk of hypoglycemia.

Full Ash + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor answer

Can you take Acai with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.

Full Acai + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor answer

Can you take Black Tea with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking black tea with antidiabetes drugs might interfere with blood glucose control.

Full Black Tea + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor answer

Can you take Coffee with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of coffee and antidiabetes drugs might interfere with blood glucose control.

Full Coffee + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor answer

Can you take Caffeine with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking caffeine with antidiabetes drugs might interfere with blood glucose control.

Full Caffeine + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor answer

Can you take Coffee Charcoal with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor answer

Can you take Cumin with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cumin might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Cumin + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor answer

Can you take Ephedra with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ephedra with antidiabetes drugs might interfere with blood glucose control.

Full Ephedra + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor answer

Can you take European Mandrake with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor answer

Can you take Fenugreek with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.

Full Fenugreek + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor answer

Can you take Fig with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fig leaf might enhance the blood glucose lowering effects of hypoglycemic drugs.

Full Fig + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor answer

Can you take Flaxseed with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.

Full Flaxseed + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor answer

Can you take Glucomannan with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor answer

Can you take Goldenseal with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goldenseal might increase or decrease serum levels of P-glycoprotein (P-gp) substrates.

Full Goldenseal + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor answer

Can you take Gymnema with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gymnema with antidiabetes drugs might increase the risk of hypoglycemia.

Full Gymnema + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor answer

Can you take Inositol Nicotinate with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, inositol nicotinate might increase blood glucose levels and may diminish the effects of antidiabetes drugs.

Full Inositol Nicotinate + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor answer

Can you take Ivy Gourd with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ivy gourd may lower blood glucose levels and might have additive effects when used with antidiabetes drugs.

Full Ivy Gourd + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor answer

Can you take Niacin with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.

Full Niacin + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor answer

Can you take Panax Ginseng with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Panax ginseng with antidiabetes drugs might increase the risk of hypoglycemia.

Full Panax Ginseng + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor answer

Can you take Papaya with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.

Full Papaya + Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor sits in 5 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor through this category.

Empagliflozin (Jardiance) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor through this category.

Related: does Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor deplete any nutrients?

Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor has 1 reported nutrient association in the research literature — see the Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor.

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Pharmacist Counseling Corner

Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor & Supplements: Common Questions

What supplements interact with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?
In our interaction database, 284 supplement and herbal ingredients have an interaction with Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor on file — 3 rated major, 241 moderate, and 40 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, St. John's Wort.
Which Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor supplement interactions are the most serious?
The 3 major-rated combinations — led by Siberian Cocklebur, Activated Charcoal and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?
That depends entirely on which supplement. The honest answer for Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Glyxambi have the same supplement interactions as Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor?
Yes — Glyxambi all contain Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor deplete any vitamins or nutrients?
It might — Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor and my other medications?
This page covers Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor against supplements and herbal ingredients. Checking Antidiabetes, Dipeptidyl Peptidase-4 (DPP-IV) Inhibitor against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 19, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.