Medication interaction hub

What Supplements Interact with Cefmetazole?

Cefmetazole brand name: Zefazone. Every interaction below applies to the brands too.

43 Interactions 2 Major 39 Moderate 2 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Cefmetazole? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Cefmetazole against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Two entries on this list for cefmetazole (Zefazone) deserve your attention before the other 41, and both threaten the kidneys. Siberian cocklebur and asarabacca (a plant often contaminated with aristolochic acid, a compound the FDA considers unsafe) can each damage kidney function, and combining them with this antibiotic may add to that damage. This is a page to read with genuine care rather than a passing glance.

Most of the rest is gentler. Twenty-seven of the 43 ingredients are probiotics, live bacteria that cefmetazole can simply kill off, which weakens the supplement rather than hurting you, and spacing the doses well apart usually solves it. A few herbs may make seizures more likely in people prone to them, and a few compete with cefmetazole for the same kidney transporters that clear it. With 39 moderate and 2 minor entries alongside the 2 major ones, start your reading with the kidney pair.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 39 Minor 2 No known interaction 1,409

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Cefmetazole: Top Interactions at a Glance

The most significant Cefmetazole supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 43 interacting ingredients — plus 1,409 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Cefmetazole + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + Cefmetazolei

Siberian cocklebur can adversely affect the kidney.

Read the full interaction Major Likelihood Possible Asarabacca + Cefmetazolei

Asarabacca, a herbaceous plant, is often contaminated with aristolochic acid, a compound known for its nephrotoxic effects.

Read the full interaction
The complete list

Every Supplement Checked Against Cefmetazole

All 1,452 ingredients in our database, ranked by severity — 43 with a Cefmetazole interaction on file and 1,409 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Cefmetazole?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Bacillus Coagulans with Cefmetazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.

Full Bacillus Coagulans + Cefmetazole answer

Can you take Lactobacillus Jensenii with Cefmetazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus jensenii with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Jensenii + Cefmetazole answer

Can you take Lactobacillus Johnsonii with Cefmetazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus johnsonii with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Johnsonii + Cefmetazole answer

Can you take Latilactobacillus Sakei with Cefmetazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Latilactobacillus sakei with antibiotic drugs might decrease the effectiveness of L.

Full Latilactobacillus Sakei + Cefmetazole answer

Can you take Levilactobacillus Brevis with Cefmetazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Levilactobacillus brevis with antibiotic drugs might decrease the effectiveness of L.

Full Levilactobacillus Brevis + Cefmetazole answer

Can you take Ligilactobacillus Salivarius with Cefmetazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Ligilactobacillus salivarius with antibiotic drugs might decrease the effectiveness of L.

Full Ligilactobacillus Salivarius + Cefmetazole answer

Can you take Limosilactobacillus Fermentum with Cefmetazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Limosilactobacillus fermentum with antibiotic drugs might decrease the effectiveness of L.

Full Limosilactobacillus Fermentum + Cefmetazole answer

Can you take Limosilactobacillus Reuteri with Cefmetazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Limosilactobacillus reuteri with antibiotic drugs might decrease the effectiveness of L.

Full Limosilactobacillus Reuteri + Cefmetazole answer

Can you take Probiotics with Cefmetazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking antibiotic drugs with certain probiotics might decrease the effectiveness of probiotics.

Full Probiotics + Cefmetazole answer

Can you take African Wild Potato with Cefmetazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence shows that African wild potato extract inhibits OAT3.

Full African Wild Potato + Cefmetazole answer

Can you take Aristolochia with Cefmetazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Aristolochia is nephrotoxic.

Full Aristolochia + Cefmetazole answer

Can you take Banderol with Cefmetazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Small lab studies have found that Banderol may also inhibit OATP1B3 (Organic Anion Transporting Polypeptide 1B3), in addition to OATP1B1.

Full Banderol + Cefmetazole answer

Can you take Biofeedback with Cefmetazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that electroencephalogram (EEG) biofeedback might lower the seizure threshold in some patients.

Full Biofeedback + Cefmetazole answer

Can you take Caffeic Acid with Cefmetazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caffeic acid might increase the levels and clinical effects of OAT3 substrates.

Full Caffeic Acid + Cefmetazole answer

Can you take Dendrobium with Cefmetazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The dendrobium constituent dendrobine is reported to have convulsant effects.

Full Dendrobium + Cefmetazole answer

Can you take Flaxseed with Cefmetazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxse...

Full Flaxseed + Cefmetazole answer

Can you take Ginkgo with Cefmetazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.

Full Ginkgo + Cefmetazole answer

Can you take Melatonin with Cefmetazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.

Full Melatonin + Cefmetazole answer

Can you take Mountain Ash with Cefmetazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking large amounts of fresh mountain ash berries may cause kidney damage due to its parasorbic acid constituent.

Full Mountain Ash + Cefmetazole answer

Can you take Quercetin with Cefmetazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the effects and adverse effects of OAT3 substrates.

Full Quercetin + Cefmetazole answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Cefmetazole is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Cefmetazole, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Cefmetazole sits in 5 interaction categories. Open any one to see what the group means:

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Cefmetazole through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Cefmetazole through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Cefmetazole through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Cefmetazole through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Cefmetazole through this category.

Related: does Cefmetazole deplete any nutrients?

Cefmetazole has 7 reported nutrient associations in the research literature — see the Cefmetazole nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Cefmetazole

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Cefmetazole.

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Pharmacist Counseling Corner

Cefmetazole & Supplements: Common Questions

What supplements interact with Cefmetazole?
More than you might expect — 43 in total, though they are far from equal: 2 are rated major, 39 moderate, and 2 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Asarabacca, Bacillus Coagulans.
Which Cefmetazole supplement interactions are the most serious?
The 2 major-rated combinations — led by Siberian Cocklebur and Asarabacca — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Cefmetazole?
Usually yes — most people on Cefmetazole can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Zefazone have the same supplement interactions as Cefmetazole?
Yes — Zefazone all contain Cefmetazole, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Cefmetazole deplete any vitamins or nutrients?
It might — Cefmetazole has 7 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Cefmetazole nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Cefmetazole and my other medications?
This page covers Cefmetazole against supplements and herbal ingredients. Checking Cefmetazole against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.