Drug & supplement interaction

Latilactobacillus Sakei + Cefmetazole

Cefmetazole brand name: Zefazone.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Latilactobacillus Sakei has a moderate interaction with Cefmetazole. Theoretically, taking Latilactobacillus sakei with antibiotic drugs might decrease the effectiveness of L.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Latilactobacillus Sakei and Cefmetazole

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIBIOTIC DRUGS

Why this applies to Cefmetazole

Cefmetazole falls under ANTIBIOTIC DRUGS — the group Latilactobacillus Sakei interacts with.

Theoretically, taking Latilactobacillus sakei with antibiotic drugs might decrease the effectiveness of L. sakei.
Latilactobacillus sakei preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. sakei preparations by at least two hours.
Severity Moderate Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: Cefmetazole is an antibiotic, and antibiotics don't tell friendly bacteria apart from harmful ones. Since Latilactobacillus sakei is a live probiotic, taking it at the same time as your Cefmetazole could kill off a good chunk of those organisms before they ever get to work. So the concern here isn't that the probiotic makes your antibiotic dangerous. It's the opposite, really: the antibiotic may just cancel out the probiotic, leaving you paying for something that isn't doing much.

This is a theoretical concern based on how these two work, not strong clinical proof. An easy fix is timing. Try to space the probiotic and your Cefmetazole at least two hours apart. Your Cefmetazole will still treat your infection normally. If you're unsure, check with your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Latilactobacillus Sakei Also Interacts With Other Medications

Latilactobacillus Sakei has 181 moderate known drug interactions in our database — the Cefmetazole one above is one of them. If you take anything else, check it against the full list below.

Moderate 181 No known interaction 2,649 (incl. Cefmetazole)
Taking anything else?

Check Another of Your Medications Against Latilactobacillus Sakei

Covers the 2,830 medications we’ve checked against Latilactobacillus Sakei. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Cefmetazole

This page covers Latilactobacillus Sakei only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cefmetazole page lists 43 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Asarabacca (major), Siberian Cocklebur (major), African Wild Potato (moderate), Aristolochia (moderate) and Bacillus Coagulans (moderate).

By severity: 2 major · 39 moderate · 2 minor.

From our pharmacist’s overview on the Cefmetazole page

“Two entries on this list for cefmetazole (Zefazone) deserve your attention before the other 41, and both threaten the kidneys. Siberian cocklebur and asarabacca (a plant often contaminated with aristolochic acid, a compound the FDA considers unsafe) can each damage kidney function, and combining them with this antibiotic may add to tha…”

Reviewed by 2 · Jul 18, 2026

Open the Cefmetazole interaction page

How much people look this up

Where Latilactobacillus Sakei and Cefmetazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Latilactobacillus Sakei
Top half

#661 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cefmetazole
Steady interest

#1,726 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Latilactobacillus Sakei

What is Latilactobacillus Sakei?

  • Chronic rhinosinusitis and nasal congestion
  • Atopic dermatitis (eczema)
  • Allergies
  • Gut and immune support
  • Skin health

Latilactobacillus sakei is a probiotic bacterium found in fermented foods like kimchi and certain meats, studied mostly for nasal sinus problems and eczema. Early research looks interesting, but evidence is still limited, so it should not replace proven treatments. Talk with a pharmacist or doctor before using it, especially if you have a weakened immune system.

Read the full Latilactobacillus Sakei monograph & all interactions
Keep checking

Other Drugs & Latilactobacillus Sakei

Browse every other medication we’ve checked against Latilactobacillus Sakei — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
181Moderate
0Minor
2,648No known interaction
181 Moderate 2,648 No interaction
Moderate

181 interactions

Showing 60 of 181 moderate interactions — see all 181 on the Latilactobacillus Sakei page.

No interaction 2,648 drugs checked — show the list

We also checked Latilactobacillus Sakei against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,648 medications checked with no known interaction — see the full Latilactobacillus Sakei list.

See the full Latilactobacillus Sakei interactions page
See every supplement checked against Cefmetazole, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Latilactobacillus Sakei monograph › Uses, safety, and every drug interaction in one place Cefmetazole supplement interactions › Every supplement checked against Cefmetazole, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Latilactobacillus Sakei and Cefmetazole Together: Common Questions

Can you take Latilactobacillus Sakei with Cefmetazole?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Latilactobacillus Sakei and Cefmetazole interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.