Medication interaction hub

What Supplements Interact with Cocaine Hydrochloride (prescription drug)?

Cocaine Hydrochloride (prescription drug) brand names: Goprelto, Numbrin. Every interaction below applies to the brands too.

158 Interactions 6 Major 119 Moderate 33 Minor
Curated & coded by · Clinical Pharmacist · Updated September 26, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Cocaine Hydrochloride (prescription drug)? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Cocaine Hydrochloride (prescription drug) against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

158 supplements and herbal ingredients have interactions with Cocaine Hydrochloride (prescription drug) on file in the HelloPharmacist interaction database — 6 rated major, 119 moderate, and 33 minor. The most serious involve Grapefruit, Ephedra, Peyote, Rauvolfia Vomitoria and Sida Cordifolia.

Our assessment: with 6 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Cocaine Hydrochloride (prescription drug).

Major 6 Moderate 119 Minor 33 No known interaction 1,294

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Cocaine Hydrochloride (prescription drug): Top Interactions at a Glance

The Cocaine Hydrochloride (prescription drug) supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 158 interacting ingredients — plus 1,294 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Cocaine Hydrochloride (prescription drug) Combinations Today

The Cocaine Hydrochloride (prescription drug) + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Melatonin + Cocaine Hydrochloride (prescription drug)i

Theoretically, melatonin might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Minor Likelihood Possible Ashwagandha + Cocaine Hydrochloride (prescription drug)i

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.

Read the full interaction Major Likelihood Probable Sida Cordifolia + Cocaine Hydrochloride (prescription drug)i

Theoretically, Sida cordifolia might increase the risk of adverse cardiovascular effects when taken with stimulant drugs.

Read the full interaction Moderate Likelihood Possible Phenpromethamine + Cocaine Hydrochloride (prescription drug)i

Theoretically, taking phenpromethamine with stimulant drugs might have additive effects and increase the risk of adverse cardiovascular effects.

Read the full interaction Minor Likelihood Possible Octopamine + Cocaine Hydrochloride (prescription drug)i

Octopamine is thought to have stimulant effects.

Read the full interaction Moderate Likelihood Possible White Pepper + Cocaine Hydrochloride (prescription drug)i

In vitro evidence suggests that piperine, a constituent of white pepper, inhibits cytochrome P450 3A4 (CYP3A4).

Read the full interaction
The complete list

Every Supplement Checked Against Cocaine Hydrochloride (prescription drug)

All 1,452 ingredients in our database, ranked by severity — 158 with a Cocaine Hydrochloride (prescription drug) interaction on file and 1,294 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Cocaine Hydrochloride (prescription drug)?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Melatonin with Cocaine Hydrochloride (prescription drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, melatonin might increase levels of drugs metabolized by CYP3A4.

Full Melatonin + Cocaine Hydrochloride (prescription drug) answer

Can you take Ashwagandha with Cocaine Hydrochloride (prescription drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.

Full Ashwagandha + Cocaine Hydrochloride (prescription drug) answer

Can you take Sida Cordifolia with Cocaine Hydrochloride (prescription drug)?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, Sida cordifolia might increase the risk of adverse cardiovascular effects when taken with stimulant drugs.

Full Sida Cordifolia + Cocaine Hydrochloride (prescription drug) answer

Can you take Phenpromethamine with Cocaine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking phenpromethamine with stimulant drugs might have additive effects and increase the risk of adverse cardiovascular effe...

Full Phenpromethamine + Cocaine Hydrochloride (prescription drug) answer

Can you take Octopamine with Cocaine Hydrochloride (prescription drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Octopamine is thought to have stimulant effects.

Full Octopamine + Cocaine Hydrochloride (prescription drug) answer

Can you take Calamus with Cocaine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effec...

Full Calamus + Cocaine Hydrochloride (prescription drug) answer

Can you take Cannabis with Cocaine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis may increase the levels and adverse effects of CYP3A4 substrates.

Full Cannabis + Cocaine Hydrochloride (prescription drug) answer

Can you take Cat's Claw with Cocaine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.

Full Cat's Claw + Cocaine Hydrochloride (prescription drug) answer

Can you take Ceylon Leadwort with Cocaine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Ceylon Leadwort + Cocaine Hydrochloride (prescription drug) answer

Can you take Chanca Piedra with Cocaine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.

Full Chanca Piedra + Cocaine Hydrochloride (prescription drug) answer

Can you take Chokeberry with Cocaine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.

Full Chokeberry + Cocaine Hydrochloride (prescription drug) answer

Can you take Clove with Cocaine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.

Full Clove + Cocaine Hydrochloride (prescription drug) answer

Can you take Coleus with Cocaine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.

Full Coleus + Cocaine Hydrochloride (prescription drug) answer

Can you take Corydalis Yanhusuo with Cocaine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might increase serum levels of drugs metabolized by CYP3A4.

Full Corydalis Yanhusuo + Cocaine Hydrochloride (prescription drug) answer

Can you take Cranberry with Cocaine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Full Cranberry + Cocaine Hydrochloride (prescription drug) answer

Can you take Cubebs with Cocaine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Several compounds isolated from cubebs can inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Cubebs + Cocaine Hydrochloride (prescription drug) answer

Can you take Danshen with Cocaine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Danshen might alter the levels and clinical effects of drugs metabolized by CYP3A4.

Full Danshen + Cocaine Hydrochloride (prescription drug) answer

Can you take Devil's Claw with Cocaine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Full Devil's Claw + Cocaine Hydrochloride (prescription drug) answer

Can you take Dhea with Cocaine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Full Dhea + Cocaine Hydrochloride (prescription drug) answer

Can you take Dimethylhexylamine (dmha) with Cocaine Hydrochloride (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining DMHA with stimulant drugs might increase the risk of adverse cardiovascular effects.

Full Dimethylhexylamine (dmha) + Cocaine Hydrochloride (prescription drug) answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Cocaine Hydrochloride (prescription drug) is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Cocaine Hydrochloride (prescription drug), and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Cocaine Hydrochloride (prescription drug) sits in 3 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Cocaine Hydrochloride (prescription drug) through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Cocaine Hydrochloride (prescription drug) through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Cocaine Hydrochloride (prescription drug) through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Cocaine Hydrochloride (prescription drug)

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Cocaine Hydrochloride (prescription drug).

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Pharmacist Counseling Corner

Cocaine Hydrochloride (prescription drug) & Supplements: Common Questions

What supplements interact with Cocaine Hydrochloride (prescription drug)?
Our database currently documents 158 ingredients with a known Cocaine Hydrochloride (prescription drug) interaction (6 major, 119 moderate, 33 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 158. The highest-ranked right now: Grapefruit, Ephedra, Peyote.
Which Cocaine Hydrochloride (prescription drug) supplement interactions are the most serious?
Focus on the major group: Grapefruit, Ephedra, Peyote, Rauvolfia Vomitoria and Sida Cordifolia, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Cocaine Hydrochloride (prescription drug)?
Plenty of supplements coexist fine with Cocaine Hydrochloride (prescription drug); a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Goprelto have the same supplement interactions as Cocaine Hydrochloride (prescription drug)?
Yes — Goprelto, Numbrin all contain Cocaine Hydrochloride (prescription drug), so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Cocaine Hydrochloride (prescription drug) and my other medications?
This page covers Cocaine Hydrochloride (prescription drug) against supplements and herbal ingredients. Checking Cocaine Hydrochloride (prescription drug) against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 26, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.