Medication interaction hub

What Supplements Interact with Ciclesonide?

Ciclesonide brand names: Omnaris, Alvesco, Zetonna. Every interaction below applies to the brands too.

166 Interactions 2 Major 134 Moderate 30 Minor
Curated & coded by · Clinical Pharmacist · Updated October 8, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ciclesonide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ciclesonide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Ciclesonide (Alvesco, Omnaris, Zetonna) is a corticosteroid for asthma and nasal allergies, and even though it is inhaled rather than swallowed, its supplement list warrants genuine care. The body clears it through the CYP3A4 enzyme, and 121 of the 166 ingredients on file nudge that pathway one way or the other. Grapefruit and St. John's wort are the two rated major: grapefruit blocks the enzyme and can push drug levels up, while St. John's wort speeds it up and can strip away the medicine's benefit.

Ciclesonide also works by quieting inflammation, so another 53 entries are herbs believed to stimulate the immune system, which could in theory work against the medicine rather than with it. Most of the 134 moderate entries fall into one of these two buckets, and the 30 minor ones carry less weight. Grapefruit and St. John's wort come first, since they pair the highest severity with the best-documented evidence.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 134 Minor 30 No known interaction 1,286

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Ciclesonide: Top Interactions at a Glance

The most significant Ciclesonide supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 166 interacting ingredients — plus 1,286 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Ciclesonide + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Ciclesonidei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable St. John's Wort + Ciclesonidei

St.

Read the full interaction
The complete list

Every Supplement Checked Against Ciclesonide

All 1,452 ingredients in our database, ranked by severity — 166 with a Ciclesonide interaction on file and 1,286 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ciclesonide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Feverfew with Ciclesonide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.

Full Feverfew + Ciclesonide answer

Can you take Fucus Vesiculosus with Ciclesonide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.

Full Fucus Vesiculosus + Ciclesonide answer

Can you take Peony with Ciclesonide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Peony + Ciclesonide answer

Can you take Bulbine Natalensis with Ciclesonide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP3A4 substrates.

Full Bulbine Natalensis + Ciclesonide answer

Can you take Bupleurum with Ciclesonide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bupleurum might decrease the effects of immunosuppressants.

Full Bupleurum + Ciclesonide answer

Can you take Calamus with Ciclesonide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effec...

Full Calamus + Ciclesonide answer

Can you take Cannabis with Ciclesonide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis may increase the levels and adverse effects of CYP3A4 substrates.

Full Cannabis + Ciclesonide answer

Can you take Cat's Claw with Ciclesonide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.

Full Cat's Claw + Ciclesonide answer

Can you take Catechu with Ciclesonide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, catechu might interfere with immunosuppressant therapy.

Full Catechu + Ciclesonide answer

Can you take Ceylon Leadwort with Ciclesonide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Ceylon Leadwort + Ciclesonide answer

Can you take Chaga with Ciclesonide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chaga might interfere with immunosuppressive therapy.

Full Chaga + Ciclesonide answer

Can you take Chanca Piedra with Ciclesonide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.

Full Chanca Piedra + Ciclesonide answer

Can you take Chokeberry with Ciclesonide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.

Full Chokeberry + Ciclesonide answer

Can you take Clove with Ciclesonide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.

Full Clove + Ciclesonide answer

Can you take Coleus with Ciclesonide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.

Full Coleus + Ciclesonide answer

Can you take Cordyceps with Ciclesonide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.

Full Cordyceps + Ciclesonide answer

Can you take Corydalis Yanhusuo with Ciclesonide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might increase serum levels of drugs metabolized by CYP3A4.

Full Corydalis Yanhusuo + Ciclesonide answer

Can you take Cranberry with Ciclesonide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Full Cranberry + Ciclesonide answer

Can you take Cubebs with Ciclesonide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Several compounds isolated from cubebs can inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Cubebs + Ciclesonide answer

Can you take Danshen with Ciclesonide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Danshen might alter the levels and clinical effects of drugs metabolized by CYP3A4.

Full Danshen + Ciclesonide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ciclesonide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ciclesonide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ciclesonide sits in 3 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Ciclesonide through this category.

Immunosuppressants 53 ingredients

Medications that damp down the immune system. Supplements that stimulate immunity can work against them.

53 of the supplement ingredients on this page reach Ciclesonide through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Ciclesonide through this category.

About Ciclesonide

Ciclesonide oral inhalation is an inhaled corticosteroid (steroid) used for the long-term, preventive treatment of asthma in people 12 and older.

Generic name: Ciclesonide  ·  Brand names: Omnaris, Alvesco, Zetonna.

See the full Ciclesonide Oral Inhalation drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Ciclesonide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ciclesonide.

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Pharmacist Counseling Corner

Ciclesonide & Supplements: Common Questions

What supplements interact with Ciclesonide?
In our interaction database, 166 supplement and herbal ingredients have an interaction with Ciclesonide on file — 2 rated major, 134 moderate, and 30 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, St. John's Wort, Cannabidiol (cbd).
Which Ciclesonide supplement interactions are the most serious?
The 2 major-rated combinations — led by Grapefruit and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Ciclesonide?
That depends entirely on which supplement. The honest answer for Ciclesonide is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Omnaris have the same supplement interactions as Ciclesonide?
Yes — Omnaris, Alvesco, Zetonna all contain Ciclesonide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Ciclesonide and my other medications?
This page covers Ciclesonide against supplements and herbal ingredients. Checking Ciclesonide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Ciclesonide Oral Inhalation drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 8, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.