Medication interaction hub

What Supplements Interact with Hydrochlorothiazide, Irbesartan?

Hydrochlorothiazide, Irbesartan brand name: Avalide. Every interaction below applies to the brands too.

273 Interactions 10 Major 226 Moderate 37 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Hydrochlorothiazide, Irbesartan? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Hydrochlorothiazide, Irbesartan against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

273 supplements and herbal ingredients have interactions with Hydrochlorothiazide, Irbesartan on file in the HelloPharmacist interaction database — 10 rated major, 226 moderate, and 37 minor. The most serious involve American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe.

Our assessment: with 10 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Hydrochlorothiazide, Irbesartan.

Major 10 Moderate 226 Minor 37 No known interaction 1,179

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Hydrochlorothiazide, Irbesartan: Top Interactions at a Glance

The Hydrochlorothiazide, Irbesartan supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 273 interacting ingredients — plus 1,179 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Hydrochlorothiazide, Irbesartan Combinations Today

The Hydrochlorothiazide, Irbesartan + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Pomegranate + Hydrochlorothiazide, Irbesartani

Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible Melatonin + Hydrochlorothiazide, Irbesartani

Theoretically, taking melatonin with antihypertensive drugs might increase the risk of hypotension or hypertension.

Read the full interaction Minor Likelihood Unlikely Grape + Hydrochlorothiazide, Irbesartani

It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.

Read the full interaction Minor Likelihood Possible Birch + Hydrochlorothiazide, Irbesartani

Theoretically, birch might interfere with diuretic therapy.

Read the full interaction Moderate Likelihood Possible Slippery Elm + Hydrochlorothiazide, Irbesartani

Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Read the full interaction Moderate Likelihood Possible Green Tea + Hydrochlorothiazide, Irbesartani

Theoretically, using green tea with diuretic drugs might increase the risk of hypokalemia.

Read the full interaction
The complete list

Every Supplement Checked Against Hydrochlorothiazide, Irbesartan

All 1,452 ingredients in our database, ranked by severity — 273 with a Hydrochlorothiazide, Irbesartan interaction on file and 1,179 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Hydrochlorothiazide, Irbesartan?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Pomegranate with Hydrochlorothiazide, Irbesartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.

Full Pomegranate + Hydrochlorothiazide, Irbesartan answer

Can you take Melatonin with Hydrochlorothiazide, Irbesartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with antihypertensive drugs might increase the risk of hypotension or hypertension.

Full Melatonin + Hydrochlorothiazide, Irbesartan answer

Can you take Grape with Hydrochlorothiazide, Irbesartan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.

Full Grape + Hydrochlorothiazide, Irbesartan answer

Can you take Birch with Hydrochlorothiazide, Irbesartan?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, birch might interfere with diuretic therapy.

Full Birch + Hydrochlorothiazide, Irbesartan answer

Can you take Slippery Elm with Hydrochlorothiazide, Irbesartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Hydrochlorothiazide, Irbesartan answer

Can you take Schisandra with Hydrochlorothiazide, Irbesartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, schisandra might decrease the levels and clinical effects of CYP2C9 substrates.

Full Schisandra + Hydrochlorothiazide, Irbesartan answer

Can you take Sea Buckthorn with Hydrochlorothiazide, Irbesartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking sea buckthorn with antihypertensive drugs might increase the risk of hypotension.

Full Sea Buckthorn + Hydrochlorothiazide, Irbesartan answer

Can you take Senna with Hydrochlorothiazide, Irbesartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.

Full Senna + Hydrochlorothiazide, Irbesartan answer

Can you take Sodium Bicarbonate with Hydrochlorothiazide, Irbesartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sodium bicarbonate may increase the risk of hypokalemia in patients taking thiazide diuretics.

Full Sodium Bicarbonate + Hydrochlorothiazide, Irbesartan answer

Can you take Soy with Hydrochlorothiazide, Irbesartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.

Full Soy + Hydrochlorothiazide, Irbesartan answer

Can you take Squill with Hydrochlorothiazide, Irbesartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Squill contains cardiac glycosides.

Full Squill + Hydrochlorothiazide, Irbesartan answer

Can you take St. John's Wort with Hydrochlorothiazide, Irbesartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, St.

Full St. John's Wort + Hydrochlorothiazide, Irbesartan answer

Can you take Star Of Bethlehem with Hydrochlorothiazide, Irbesartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking diuretics with star of Bethlehem might increase the risk of toxicity.

Full Star Of Bethlehem + Hydrochlorothiazide, Irbesartan answer

Can you take Stinging Nettle with Hydrochlorothiazide, Irbesartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining stinging nettle with diuretic drugs may have additive effects.

Full Stinging Nettle + Hydrochlorothiazide, Irbesartan answer

Can you take Strophanthus with Hydrochlorothiazide, Irbesartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and strophanthus can increase the risk of cardiac glycoside toxicity due to...

Full Strophanthus + Hydrochlorothiazide, Irbesartan answer

Can you take Swamp Milkweed with Hydrochlorothiazide, Irbesartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, potassium depleting diuretics might increase the risk of toxicity with swamp milkweed.

Full Swamp Milkweed + Hydrochlorothiazide, Irbesartan answer

Can you take Terminalia with Hydrochlorothiazide, Irbesartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2C9 substrates.

Full Terminalia + Hydrochlorothiazide, Irbesartan answer

Can you take Theanine with Hydrochlorothiazide, Irbesartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.

Full Theanine + Hydrochlorothiazide, Irbesartan answer

Can you take Tinospora Cordifolia with Hydrochlorothiazide, Irbesartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C9.

Full Tinospora Cordifolia + Hydrochlorothiazide, Irbesartan answer

Can you take Tragacanth with Hydrochlorothiazide, Irbesartan?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Hydrochlorothiazide, Irbesartan answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Hydrochlorothiazide, Irbesartan is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Hydrochlorothiazide, Irbesartan, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Hydrochlorothiazide, Irbesartan sits in 10 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Hydrochlorothiazide, Irbesartan through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Hydrochlorothiazide, Irbesartan through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Hydrochlorothiazide, Irbesartan through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Hydrochlorothiazide, Irbesartan through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Hydrochlorothiazide, Irbesartan through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Hydrochlorothiazide, Irbesartan through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Hydrochlorothiazide, Irbesartan through this category.

Angiotensin Receptor Blockers (Arbs) 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide, Irbesartan through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide, Irbesartan through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide, Irbesartan through this category.

Related: does Hydrochlorothiazide, Irbesartan deplete any nutrients?

Hydrochlorothiazide, Irbesartan has 9 reported nutrient associations in the research literature — see the Hydrochlorothiazide, Irbesartan nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Hydrochlorothiazide, Irbesartan

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Hydrochlorothiazide, Irbesartan.

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Type a product name, brand, or UPC — smart search across our full catalog.

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Pharmacist Counseling Corner

Hydrochlorothiazide, Irbesartan & Supplements: Common Questions

What supplements interact with Hydrochlorothiazide, Irbesartan?
More than you might expect — 273 in total, though they are far from equal: 10 are rated major, 226 moderate, and 37 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: American Hellebore, Siberian Cocklebur, Tyramine.
Which Hydrochlorothiazide, Irbesartan supplement interactions are the most serious?
The 10 major-rated combinations — led by American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Hydrochlorothiazide, Irbesartan?
Usually yes — most people on Hydrochlorothiazide, Irbesartan can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Avalide have the same supplement interactions as Hydrochlorothiazide, Irbesartan?
Yes — Avalide all contain Hydrochlorothiazide, Irbesartan, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Hydrochlorothiazide, Irbesartan deplete any vitamins or nutrients?
It might — Hydrochlorothiazide, Irbesartan has 9 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Hydrochlorothiazide, Irbesartan nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Hydrochlorothiazide, Irbesartan and my other medications?
This page covers Hydrochlorothiazide, Irbesartan against supplements and herbal ingredients. Checking Hydrochlorothiazide, Irbesartan against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.