Medication interaction hub

What Supplements Interact with Lamivudine, Raltegravir?

Lamivudine, Raltegravir brand name: Dutrebis. Every interaction below applies to the brands too.

34 Interactions 1 Major 23 Moderate 10 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Lamivudine, Raltegravir? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Lamivudine, Raltegravir against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

With Dutrebis (lamivudine and raltegravir), the stakes are keeping HIV fully suppressed, so I treat these 34 interactions as ones to get ahead of, not shrug off. The single major-rated entry is activated charcoal, which soaks up medicine in the gut and can strip out enough of the dose to matter. Most of the other 33 do one of two things: they slow or block absorption (fiber products like glucomannan and guar gum, plus calcium and iron, which can bind raltegravir directly), or they speed up or slow down glucuronidation, the pathway your body uses to clear raltegravir, with everything from CBD to cabbage nudging it.

Horsetail deserves a specific mention, since case reports tie it to detectable viral loads in people on regimens containing lamivudine. That is exactly the outcome this drug exists to prevent. Of the rest, 23 rate moderate and 10 minor, and spacing fibers and minerals well apart from your dose handles a good share of them.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 23 Minor 10 No known interaction 1,418

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Lamivudine, Raltegravir: Top Interactions at a Glance

The most significant Lamivudine, Raltegravir supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 34 interacting ingredients — plus 1,418 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Lamivudine, Raltegravir + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Activated Charcoal + Lamivudine, Raltegraviri

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Lamivudine, Raltegravir

All 1,452 ingredients in our database, ranked by severity — 34 with a Lamivudine, Raltegravir interaction on file and 1,418 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Lamivudine, Raltegravir?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Zinc with Lamivudine, Raltegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.

Full Zinc + Lamivudine, Raltegravir answer

Can you take Calcium with Lamivudine, Raltegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Calcium may reduce levels of raltegravir.

Full Calcium + Lamivudine, Raltegravir answer

Can you take Milk Thistle with Lamivudine, Raltegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, milk thistle might affect the clearance of drugs that undergo glucuronidation.

Full Milk Thistle + Lamivudine, Raltegravir answer

Can you take Panax Ginseng with Lamivudine, Raltegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Panax ginseng with raltegravir might increase the risk of liver toxicity.

Full Panax Ginseng + Lamivudine, Raltegravir answer

Can you take Slippery Elm with Lamivudine, Raltegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Lamivudine, Raltegravir answer

Can you take Tragacanth with Lamivudine, Raltegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Lamivudine, Raltegravir answer

Can you take Uva Ursi with Lamivudine, Raltegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.

Full Uva Ursi + Lamivudine, Raltegravir answer

Can you take Valerian with Lamivudine, Raltegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.

Full Valerian + Lamivudine, Raltegravir answer

Can you take Thyroid Extract with Lamivudine, Raltegravir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Lamivudine, Raltegravir answer

Can you take Agar with Lamivudine, Raltegravir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Lamivudine, Raltegravir answer

Can you take Algin with Lamivudine, Raltegravir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Lamivudine, Raltegravir answer

Can you take Black Psyllium with Lamivudine, Raltegravir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Lamivudine, Raltegravir answer

Can you take Blond Psyllium with Lamivudine, Raltegravir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Lamivudine, Raltegravir answer

Can you take Carob with Lamivudine, Raltegravir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Lamivudine, Raltegravir answer

Can you take Karaya Gum with Lamivudine, Raltegravir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Lamivudine, Raltegravir answer

Can you take Marshmallow with Lamivudine, Raltegravir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Lamivudine, Raltegravir answer

Can you take Xanthan Gum with Lamivudine, Raltegravir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Lamivudine, Raltegravir answer

Can you take Chrysin with Lamivudine, Raltegravir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, chrysin might increase the clearance of drugs that are UGT1A1 substrates, thereby reducing their effectiveness.

Full Chrysin + Lamivudine, Raltegravir answer

Can you take Activated Charcoal with Lamivudine, Raltegravir?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Lamivudine, Raltegravir answer

Can you take Brussels Sprout with Lamivudine, Raltegravir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. A cabbage and Brussels sprout-containing diet seems to boost elimination through glucuronide conjugation.

Full Brussels Sprout + Lamivudine, Raltegravir answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Lamivudine, Raltegravir is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Lamivudine, Raltegravir, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Lamivudine, Raltegravir sits in 5 interaction categories. Open any one to see what the group means:

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Lamivudine, Raltegravir through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Lamivudine, Raltegravir through this category.

Integrase Inhibitors 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Lamivudine, Raltegravir through this category.

Raltegravir (Isentress) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Lamivudine, Raltegravir through this category.

Nucleoside Reverse Transcriptase Inhibitors (Nrtis) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Lamivudine, Raltegravir through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Lamivudine, Raltegravir

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Lamivudine, Raltegravir.

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Products that contain Lamivudine, Raltegravir-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Lamivudine, Raltegravir.

Women's 40+ One Daily Multivitamin by MegaFood contains Cabbage Spectro Multivitamin Man by Solaray contains Cabbage Raw Vitamin D3+ by Codeage contains Cabbage Indole-3 Supreme 200 mg by Solaray contains Cabbage
Pharmacist Counseling Corner

Lamivudine, Raltegravir & Supplements: Common Questions

What supplements interact with Lamivudine, Raltegravir?
In our interaction database, 34 supplement and herbal ingredients have an interaction with Lamivudine, Raltegravir on file — 1 rated major, 23 moderate, and 10 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Activated Charcoal, Brussels Sprout, Cabbage.
Which Lamivudine, Raltegravir supplement interactions are the most serious?
Focus on the major group: Activated Charcoal. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Lamivudine, Raltegravir?
That depends entirely on which supplement. The honest answer for Lamivudine, Raltegravir is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Dutrebis have the same supplement interactions as Lamivudine, Raltegravir?
Yes — Dutrebis all contain Lamivudine, Raltegravir, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Lamivudine, Raltegravir and my other medications?
This page covers Lamivudine, Raltegravir against supplements and herbal ingredients. Checking Lamivudine, Raltegravir against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.