Medication interaction hub

What Supplements Interact with Ledipasvir, Sofosbuvir?

Ledipasvir, Sofosbuvir brand name: Harvoni. Every interaction below applies to the brands too.

55 Interactions 2 Major 37 Moderate 16 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ledipasvir, Sofosbuvir? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ledipasvir, Sofosbuvir against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

55 supplements and herbal ingredients have interactions with Ledipasvir, Sofosbuvir on file in the HelloPharmacist interaction database — 2 rated major, 37 moderate, and 16 minor. The most serious involve Activated Charcoal and St. John's Wort.

Our assessment: with 2 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Ledipasvir, Sofosbuvir.

Major 2 Moderate 37 Minor 16 No known interaction 1,397

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Ledipasvir, Sofosbuvir: Top Interactions at a Glance

The most significant Ledipasvir, Sofosbuvir supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 55 interacting ingredients — plus 1,397 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Ledipasvir, Sofosbuvir + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Activated Charcoal + Ledipasvir, Sofosbuviri

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable St. John's Wort + Ledipasvir, Sofosbuviri

St.

Read the full interaction
The complete list

Every Supplement Checked Against Ledipasvir, Sofosbuvir

All 1,452 ingredients in our database, ranked by severity — 55 with a Ledipasvir, Sofosbuvir interaction on file and 1,397 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ledipasvir, Sofosbuvir?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Grapefruit with Ledipasvir, Sofosbuvir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Grapefruit juice does not seem to affect renal P-glycoprotein (P-gp).

Full Grapefruit + Ledipasvir, Sofosbuvir answer

Can you take Black Pepper with Ledipasvir, Sofosbuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of P-glycoprotein substrates.

Full Black Pepper + Ledipasvir, Sofosbuvir answer

Can you take Bitter Melon with Ledipasvir, Sofosbuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter melon might increase levels of P-glycoprotein substrates.

Full Bitter Melon + Ledipasvir, Sofosbuvir answer

Can you take Guar Gum with Ledipasvir, Sofosbuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Ledipasvir, Sofosbuvir answer

Can you take Gum Arabic with Ledipasvir, Sofosbuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Ledipasvir, Sofosbuvir answer

Can you take Hesperidin with Ledipasvir, Sofosbuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of...

Full Hesperidin + Ledipasvir, Sofosbuvir answer

Can you take Indian Long Pepper with Ledipasvir, Sofosbuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Indian long pepper might increase levels of P-glycoprotein substrates.

Full Indian Long Pepper + Ledipasvir, Sofosbuvir answer

Can you take Kava with Ledipasvir, Sofosbuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. It is unclear if kava inhibits P-glycoprotein (P-gp); research is conflicting.

Full Kava + Ledipasvir, Sofosbuvir answer

Can you take Licorice with Ledipasvir, Sofosbuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.

Full Licorice + Ledipasvir, Sofosbuvir answer

Can you take Methoxylated Flavones with Ledipasvir, Sofosbuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence shows that some methoxylated flavones including tangeretin, nobiletin, and heptamethoxyflavone, inhibit P-glycoprotein.

Full Methoxylated Flavones + Ledipasvir, Sofosbuvir answer

Can you take Milk Thistle with Ledipasvir, Sofosbuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, milk thistle might decrease the levels and clinical effects of sofosbuvir.

Full Milk Thistle + Ledipasvir, Sofosbuvir answer

Can you take Moringa with Ledipasvir, Sofosbuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, moringa leaf extract might increase the levels and clinical effects of P-glycoprotein substrates.

Full Moringa + Ledipasvir, Sofosbuvir answer

Can you take Neem with Ledipasvir, Sofosbuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of P-glycoprotein substrates.

Full Neem + Ledipasvir, Sofosbuvir answer

Can you take Oregon Grape with Ledipasvir, Sofosbuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs that are P-glycoprotein (P-gp) substrates.

Full Oregon Grape + Ledipasvir, Sofosbuvir answer

Can you take Quercetin with Ledipasvir, Sofosbuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might alter the effects and adverse effects of P-glycoprotein substrates.

Full Quercetin + Ledipasvir, Sofosbuvir answer

Can you take Rabdosia Rubescens with Ledipasvir, Sofosbuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Rabdosia rubescens might increase levels of p-glycoprotein substrates.

Full Rabdosia Rubescens + Ledipasvir, Sofosbuvir answer

Can you take Rhodiola with Ledipasvir, Sofosbuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rhodiola might increase levels of P-glycoprotein substrates.

Full Rhodiola + Ledipasvir, Sofosbuvir answer

Can you take Sage with Ledipasvir, Sofosbuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might increase levels of drugs transported by P-glycoprotein.

Full Sage + Ledipasvir, Sofosbuvir answer

Can you take Schisandra with Ledipasvir, Sofosbuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Schisandra might increase the levels and clinical effects of P-glycoprotein substrates.

Full Schisandra + Ledipasvir, Sofosbuvir answer

Can you take Slippery Elm with Ledipasvir, Sofosbuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Ledipasvir, Sofosbuvir answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ledipasvir, Sofosbuvir is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ledipasvir, Sofosbuvir, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ledipasvir, Sofosbuvir sits in 5 interaction categories. Open any one to see what the group means:

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Ledipasvir, Sofosbuvir through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Ledipasvir, Sofosbuvir through this category.

Sofosbuvir (Sovaldi) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Ledipasvir, Sofosbuvir through this category.

Ledipasvir 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Ledipasvir, Sofosbuvir through this category.

Sofosbuvir (Solvaldi) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Ledipasvir, Sofosbuvir through this category.

About Ledipasvir, Sofosbuvir

Ledipasvir and sofosbuvir is a two-drug antiviral combination used to treat chronic hepatitis C virus (HCV) infection in adults and children as young as 3 years old.

Generic name: Ledipasvir, Sofosbuvir  ·  Brand name: Harvoni.

See the full Ledipasvir and Sofosbuvir drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Ledipasvir, Sofosbuvir

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ledipasvir, Sofosbuvir.

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Products that contain Ledipasvir, Sofosbuvir-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Ledipasvir, Sofosbuvir.

Standardized St. John's Wort 600 mg by Nature's Truth contains St. John's Wort St. John's Wort-IMT by SP Standard Process contains St. John's Wort St John's Wort Extract by SuperSmart contains St. John's Wort St John's Wort 400 mg by Signature Supplements contains St. John's Wort
Pharmacist Counseling Corner

Ledipasvir, Sofosbuvir & Supplements: Common Questions

What supplements interact with Ledipasvir, Sofosbuvir?
More than you might expect — 55 in total, though they are far from equal: 2 are rated major, 37 moderate, and 16 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Activated Charcoal, St. John's Wort, Coffee Charcoal.
Which Ledipasvir, Sofosbuvir supplement interactions are the most serious?
Focus on the major group: Activated Charcoal and St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Ledipasvir, Sofosbuvir?
Usually yes — most people on Ledipasvir, Sofosbuvir can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Harvoni have the same supplement interactions as Ledipasvir, Sofosbuvir?
Yes — Harvoni all contain Ledipasvir, Sofosbuvir, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Ledipasvir, Sofosbuvir and my other medications?
This page covers Ledipasvir, Sofosbuvir against supplements and herbal ingredients. Checking Ledipasvir, Sofosbuvir against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Ledipasvir and Sofosbuvir drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.