Medication interaction hub

What Supplements Interact with Lonapegsomatropin-Tcgd?

Lonapegsomatropin-Tcgd brand name: Skytrofa. Every interaction below applies to the brands too.

20 Interactions 20 Moderate
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Lonapegsomatropin-Tcgd? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Lonapegsomatropin-Tcgd against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Skytrofa (lonapegsomatropin) is a once-weekly growth hormone injection for children who don't make enough of their own, and its interaction list is manageable rather than alarming. All 20 entries sit at moderate, with none rated major, and almost every one traces back to the same mechanism, growth hormone's ability to speed up a liver enzyme called CYP3A4. For herbs containing pyrrolizidine alkaloids, a family that includes comfrey, butterbur, and roughly a dozen relatives, that faster processing may generate more of the liver-damaging byproducts those plants already carry.

The same enzyme effect runs in reverse for cannabidiol and other cannabis-derived products, which may end up at lower levels and simply do less than expected. Nearly all of this evidence is theoretical, from lab or animal studies, so the sensible posture is knowing these pairings and watching for changes rather than fearing them. The pyrrolizidine plants deserve skipping regardless, given their own liver record.

— , Clinical Pharmacist · July 18, 2026

Moderate 20 No known interaction 1,432

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Lonapegsomatropin-Tcgd: Top Interactions at a Glance

The most significant Lonapegsomatropin-Tcgd supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 20 interacting ingredients — plus 1,432 more checked with no known interaction. See the complete ranked list.

Start here

The Moderate Interactions to Know About

The most clinically significant Lonapegsomatropin-Tcgd + supplement combinations in our database, best-documented first. Open any card for the full report.

Moderate Likelihood Possible Alkanna + Lonapegsomatropin-Tcgdi

Hepatotoxic pyrrolizidine alkaloids (PAs) are substrates of cytochrome P450 3A4 (CYP3A4).

Read the full interaction Moderate Likelihood Possible Alpine Ragwort + Lonapegsomatropin-Tcgdi

Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in alpine ragwort.

Read the full interaction Moderate Likelihood Possible Boneset + Lonapegsomatropin-Tcgdi

Boneset belongs to the genus Eupatorium, and many species of this genus contain hepatotoxic pyrrolizidine alkaloids (PAs).

Read the full interaction Moderate Likelihood Possible Borage + Lonapegsomatropin-Tcgdi

Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.

Read the full interaction Moderate Likelihood Possible Butterbur + Lonapegsomatropin-Tcgdi

Theoretically, CYP3A4 inducers might increase the toxicity of butterbur.

Read the full interaction Moderate Likelihood Possible Cannabidiol (cbd) + Lonapegsomatropin-Tcgdi

Theoretically, CYP3A4 inducers might decrease cannabidiol levels.

Read the full interaction
The complete list

Every Supplement Checked Against Lonapegsomatropin-Tcgd

All 1,452 ingredients in our database, ranked by severity — 20 with a Lonapegsomatropin-Tcgd interaction on file and 1,432 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Lonapegsomatropin-Tcgd?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Alkanna with Lonapegsomatropin-Tcgd?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hepatotoxic pyrrolizidine alkaloids (PAs) are substrates of cytochrome P450 3A4 (CYP3A4).

Full Alkanna + Lonapegsomatropin-Tcgd answer

Can you take Alpine Ragwort with Lonapegsomatropin-Tcgd?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in alpine ragwor...

Full Alpine Ragwort + Lonapegsomatropin-Tcgd answer

Can you take Boneset with Lonapegsomatropin-Tcgd?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Boneset belongs to the genus Eupatorium, and many species of this genus contain hepatotoxic pyrrolizidine alkaloids (PAs).

Full Boneset + Lonapegsomatropin-Tcgd answer

Can you take Borage with Lonapegsomatropin-Tcgd?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.

Full Borage + Lonapegsomatropin-Tcgd answer

Can you take Butterbur with Lonapegsomatropin-Tcgd?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the toxicity of butterbur.

Full Butterbur + Lonapegsomatropin-Tcgd answer

Can you take Cannabidiol (cbd) with Lonapegsomatropin-Tcgd?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might decrease cannabidiol levels.

Full Cannabidiol (cbd) + Lonapegsomatropin-Tcgd answer

Can you take Cannabis with Lonapegsomatropin-Tcgd?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might reduce the levels and clinical effects of cannabis.

Full Cannabis + Lonapegsomatropin-Tcgd answer

Can you take Coltsfoot with Lonapegsomatropin-Tcgd?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hepatotoxic pyrrolizidine alkaloids (PA) are substrates of cytochrome P450 3A4 (CYP3A4).

Full Coltsfoot + Lonapegsomatropin-Tcgd answer

Can you take Comfrey with Lonapegsomatropin-Tcgd?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid constituents in comfrey.

Full Comfrey + Lonapegsomatropin-Tcgd answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Lonapegsomatropin-Tcgd?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might reduce the levels and clinical effects of THC.

Full Delta-9-tetrahydrocannabinol (thc) + Lonapegsomatropin-Tcgd answer

Can you take Dusty Miller with Lonapegsomatropin-Tcgd?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in dusty miller.

Full Dusty Miller + Lonapegsomatropin-Tcgd answer

Can you take Evodia with Lonapegsomatropin-Tcgd?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking CYP3A4 inducers might decrease the levels and clinical effects of evodia.

Full Evodia + Lonapegsomatropin-Tcgd answer

Can you take Golden Ragwort with Lonapegsomatropin-Tcgd?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in golden ragwor...

Full Golden Ragwort + Lonapegsomatropin-Tcgd answer

Can you take Gravel Root with Lonapegsomatropin-Tcgd?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hepatotoxic pyrrolizidine alkaloids (PA) are substrates of cytochrome P450 3A4 (CYP3A4).

Full Gravel Root + Lonapegsomatropin-Tcgd answer

Can you take Groundsel with Lonapegsomatropin-Tcgd?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking CYP3A4 inducers with groundsel might increase the risk of pyrrolizidine alkaloid toxicity, such as hepatotoxicity.

Full Groundsel + Lonapegsomatropin-Tcgd answer

Can you take Hemp Agrimony with Lonapegsomatropin-Tcgd?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA) which are substrates of cytochrome P450 3A4 (CYP3A4).

Full Hemp Agrimony + Lonapegsomatropin-Tcgd answer

Can you take Hound's Tongue with Lonapegsomatropin-Tcgd?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers can increase the toxicity of the pyrrolizidine alkaloid (PA) constituents of hound's tongue.

Full Hound's Tongue + Lonapegsomatropin-Tcgd answer

Can you take Ostarine with Lonapegsomatropin-Tcgd?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of ostarine with CYP3A4 inducers could decrease the clinical effects of ostarine.

Full Ostarine + Lonapegsomatropin-Tcgd answer

Can you take Sassafras with Lonapegsomatropin-Tcgd?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that cytochrome P450 1A2 (CYP1A2) inducers might increase the cytotoxicity of safrole.

Full Sassafras + Lonapegsomatropin-Tcgd answer

Can you take Tansy Ragwort with Lonapegsomatropin-Tcgd?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in tansy ragwort...

Full Tansy Ragwort + Lonapegsomatropin-Tcgd answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Lonapegsomatropin-Tcgd is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Lonapegsomatropin-Tcgd, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Lonapegsomatropin-Tcgd sits in 2 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Inducers 19 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

19 of the supplement ingredients on this page reach Lonapegsomatropin-Tcgd through this category.

Cytochrome P450 1A2 (Cyp1A2) Inducers 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Lonapegsomatropin-Tcgd through this category.

About Lonapegsomatropin-Tcgd

Lonapegsomatropin-tcgd is a once-weekly injectable form of human growth hormone used to treat growth failure in children with growth hormone deficiency and to replace growth hormone in adults with growth hormone deficiency.

Generic name: Lonapegsomatropin-Tcgd  ·  Brand name: Skytrofa.

See the full Lonapegsomatropin-tcgd injection drug information
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Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Lonapegsomatropin-Tcgd.

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Pharmacist Counseling Corner

Lonapegsomatropin-Tcgd & Supplements: Common Questions

What supplements interact with Lonapegsomatropin-Tcgd?
In our interaction database, 20 supplement and herbal ingredients have an interaction with Lonapegsomatropin-Tcgd on file — 0 rated major, 20 moderate, and 0 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Alkanna, Alpine Ragwort, Boneset.
Which Lonapegsomatropin-Tcgd supplement interactions are the most serious?
None of the Lonapegsomatropin-Tcgd supplement interactions on file are currently rated major. The most significant are the 20 moderate-rated ones — combinations that may need monitoring, a dose adjustment, or separated timing. Still worth a quick look through the ranked list for anything you take daily. Jump to the ranked list.
Can I take vitamins or supplements while on Lonapegsomatropin-Tcgd?
That depends entirely on which supplement. The honest answer for Lonapegsomatropin-Tcgd is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Skytrofa have the same supplement interactions as Lonapegsomatropin-Tcgd?
Yes — Skytrofa all contain Lonapegsomatropin-Tcgd, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Lonapegsomatropin-Tcgd and my other medications?
This page covers Lonapegsomatropin-Tcgd against supplements and herbal ingredients. Checking Lonapegsomatropin-Tcgd against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Lonapegsomatropin-tcgd injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.