Medication interaction hub

What Supplements Interact with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?

Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir brand name: Viekira Pak. Every interaction below applies to the brands too.

185 Interactions 6 Major 144 Moderate 35 Minor
Curated & coded by · Clinical Pharmacist · Updated October 2, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Viekira Pak (ombitasvir, paritaprevir, ritonavir, dasabuvir) treats hepatitis C, and it leaves little room for supplement improvisation, so understand the six major-rated entries here first. The ritonavir component exists specifically to boost the other drugs by blocking a liver enzyme called CYP3A4, and 121 of these ingredients ride that same enzyme, so combinations can push levels too high or drag them low. St. John's wort is the starkest example; it can drop drug levels enough to cause treatment failure and viral resistance, while grapefruit raises them instead.

The liver is the other pressure point. Thirty-eight entries can add strain to an organ already fighting hepatitis C, and ordinary alcohol sits among those major risks. Most of the 144 moderate and 35 minor entries are smaller versions of the same enzyme and absorption stories. A treatment this important deserves a clean supplement slate until your pharmacist has vetted each item.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 144 Minor 35 No known interaction 1,267

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir: Top Interactions at a Glance

The most significant Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 185 interacting ingredients — plus 1,267 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Ombitasvir, Paritaprevir, Ritonavir, Dasabuviri

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Ombitasvir, Paritaprevir, Ritonavir, Dasabuviri

Siberian cocklebur can adversely affect the liver.

Read the full interaction Major Likelihood Likely St. John's Wort + Ombitasvir, Paritaprevir, Ritonavir, Dasabuviri

St.

Read the full interaction Major Likelihood Probable Activated Charcoal + Ombitasvir, Paritaprevir, Ritonavir, Dasabuviri

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Beer + Ombitasvir, Paritaprevir, Ritonavir, Dasabuviri

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Major Likelihood Probable Wine + Ombitasvir, Paritaprevir, Ritonavir, Dasabuviri

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir

All 1,452 ingredients in our database, ranked by severity — 185 with a Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir interaction on file and 1,267 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Echinacea with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.

Full Echinacea + Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir answer

Can you take Cubebs with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Several compounds isolated from cubebs can inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Cubebs + Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir answer

Can you take Danshen with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Danshen might alter the levels and clinical effects of drugs metabolized by CYP3A4.

Full Danshen + Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase the levels and clinical effects of THC.

Full Delta-9-tetrahydrocannabinol (thc) + Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir answer

Can you take Devil's Claw with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Full Devil's Claw + Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir answer

Can you take Dhea with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Full Dhea + Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir answer

Can you take Diosmin with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, diosmin might inhibit the metabolism of CYP3A4 substrates.

Full Diosmin + Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir answer

Can you take Eleuthero with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eleuthero might increase levels of P-glycoprotein substrates.

Full Eleuthero + Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir answer

Can you take English Ivy with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C8.

Full English Ivy + Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir answer

Can you take Ephedra with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Ephedra + Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir answer

Can you take Epistane with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Epistane + Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir answer

Can you take Ergot with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ergotamine, a constituent of ergot, is a substrate of cytochrome P450 3A4 (CYP3A4).

Full Ergot + Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir answer

Can you take Eucalyptus with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.

Full Eucalyptus + Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir answer

Can you take European Barberry with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.

Full European Barberry + Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir answer

Can you take Evening Primrose with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, evening primrose oil might increase the levels and effects of lopinavir.

Full Evening Primrose + Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir answer

Can you take Evodia with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase the levels and clinical effects of evodia.

Full Evodia + Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir answer

Can you take False Unicorn with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, false unicorn extract inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full False Unicorn + Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir answer

Can you take Fennel with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

Full Fennel + Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir answer

Can you take Fever Bark with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase the levels and clinical effects of yohimbine, a constituent of fever bark.

Full Fever Bark + Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir answer

Can you take Feverfew with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.

Full Feverfew + Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir sits in 12 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir through this category.

Cytochrome P450 2C8 (Cyp2C8) Substrates 11 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

11 of the supplement ingredients on this page reach Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir through this category.

Ritonavir (Norvir) 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir through this category.

Lopinavir/Ritonavir (Kaletra) 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir through this category.

Protease Inhibitors (Pis) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir through this category.

Cytochrome P450 1A2 (Cyp1A2) Inducers 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir through this category.

Nirmatrelvir/Ritonavir (Paxlovid) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Pharmacist Counseling Corner

Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir & Supplements: Common Questions

What supplements interact with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?
Our database currently documents 185 ingredients with a known Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir interaction (6 major, 144 moderate, 35 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 185. The highest-ranked right now: Grapefruit, Siberian Cocklebur, St. John's Wort.
Which Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir supplement interactions are the most serious?
The 6 major-rated combinations — led by Grapefruit, Siberian Cocklebur, St. John's Wort, Activated Charcoal and Beer — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?
Plenty of supplements coexist fine with Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Viekira Pak have the same supplement interactions as Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir?
Yes — Viekira Pak all contain Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir and my other medications?
This page covers Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir against supplements and herbal ingredients. Checking Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 2, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.