Medication interaction hub

What Supplements Interact with Umeclidinium Bromide, Vilanterol Trifenatate?

Umeclidinium Bromide, Vilanterol Trifenatate brand name: Anoro Ellipta. Every interaction below applies to the brands too.

165 Interactions 9 Major 125 Moderate 31 Minor
Curated & coded by · Clinical Pharmacist · Updated September 29, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Umeclidinium Bromide, Vilanterol Trifenatate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Umeclidinium Bromide, Vilanterol Trifenatate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Anoro Ellipta (umeclidinium and vilanterol), a once-daily COPD inhaler, sits on the wary end of the interaction spectrum, with 165 supplements and herbal ingredients on file and nine rated major. The largest group involves the CYP3A4 enzyme that clears vilanterol; grapefruit can push its levels up, while St. John's wort can pull them down and blunt the breathing benefit. Smaller groups either add to the inhaler's drying anticholinergic side or can stretch the heart's QT interval, the recovery time between beats, raising the odds of a dangerous rhythm.

Caffeine is the one most people will actually meet, since in large amounts it can amplify the push a beta-agonist gives the heart. Even so, most of the 125 moderate entries belong to the CYP3A4 group, and 31 more rate minor. Learn the nine majors first, grapefruit above all because human studies confirm it, then weigh the rest against what you take.

— , Clinical Pharmacist · July 18, 2026

Major 9 Moderate 125 Minor 31 No known interaction 1,287

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Umeclidinium Bromide, Vilanterol Trifenatate: Top Interactions at a Glance

The most significant Umeclidinium Bromide, Vilanterol Trifenatate supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 165 interacting ingredients — plus 1,287 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Umeclidinium Bromide, Vilanterol Trifenatate + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Umeclidinium Bromide, Vilanterol Trifenatatei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable Arsenic + Umeclidinium Bromide, Vilanterol Trifenatatei

Arsenic trioxide can prolong the QT interval.

Read the full interaction Major Likelihood Probable Cesium + Umeclidinium Bromide, Vilanterol Trifenatatei

Theoretically, taking cesium concomitantly with other drugs that prolong the QT interval may increase the risk of ventricular arrhythmias and death.

Read the full interaction Major Likelihood Probable Ephedra + Umeclidinium Bromide, Vilanterol Trifenatatei

Theoretically, ephedra might have an additive effect with drugs that prolong the QT interval.

Read the full interaction Major Likelihood Probable Henbane + Umeclidinium Bromide, Vilanterol Trifenatatei

Concomitant use of henbane can have additive anticholinergic effects and adverse effects with amantadine, antihistamines, atropine, belladonna alkaloids, hyoscy...

Read the full interaction Major Likelihood Probable Scopolia + Umeclidinium Bromide, Vilanterol Trifenatatei

The alkaloid constituents of scopolia, including hyoscyamine, scopolamine, and atropine, could potentiate the effects and adverse effects of anticholinergic dru...

Read the full interaction
The complete list

Every Supplement Checked Against Umeclidinium Bromide, Vilanterol Trifenatate

All 1,452 ingredients in our database, ranked by severity — 165 with a Umeclidinium Bromide, Vilanterol Trifenatate interaction on file and 1,287 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Umeclidinium Bromide, Vilanterol Trifenatate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Fucus Vesiculosus with Umeclidinium Bromide, Vilanterol Trifenatate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.

Full Fucus Vesiculosus + Umeclidinium Bromide, Vilanterol Trifenatate answer

Can you take Hemp with Umeclidinium Bromide, Vilanterol Trifenatate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.

Full Hemp + Umeclidinium Bromide, Vilanterol Trifenatate answer

Can you take Hibiscus Sabdariffa with Umeclidinium Bromide, Vilanterol Trifenatate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP3A4 substrates.

Full Hibiscus Sabdariffa + Umeclidinium Bromide, Vilanterol Trifenatate answer

Can you take Honey with Umeclidinium Bromide, Vilanterol Trifenatate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.

Full Honey + Umeclidinium Bromide, Vilanterol Trifenatate answer

Can you take Hops with Umeclidinium Bromide, Vilanterol Trifenatate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.

Full Hops + Umeclidinium Bromide, Vilanterol Trifenatate answer

Can you take Melatonin with Umeclidinium Bromide, Vilanterol Trifenatate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, melatonin might increase levels of drugs metabolized by CYP3A4.

Full Melatonin + Umeclidinium Bromide, Vilanterol Trifenatate answer

Can you take Passion Flower with Umeclidinium Bromide, Vilanterol Trifenatate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, passion flower might decrease the effects of CYP3A4 substrates.

Full Passion Flower + Umeclidinium Bromide, Vilanterol Trifenatate answer

Can you take Rhodiola with Umeclidinium Bromide, Vilanterol Trifenatate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.

Full Rhodiola + Umeclidinium Bromide, Vilanterol Trifenatate answer

Can you take Valerian with Umeclidinium Bromide, Vilanterol Trifenatate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.

Full Valerian + Umeclidinium Bromide, Vilanterol Trifenatate answer

Can you take Vitamin D with Umeclidinium Bromide, Vilanterol Trifenatate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Full Vitamin D + Umeclidinium Bromide, Vilanterol Trifenatate answer

Can you take Yohimbe with Umeclidinium Bromide, Vilanterol Trifenatate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.

Full Yohimbe + Umeclidinium Bromide, Vilanterol Trifenatate answer

Can you take Calabar Bean with Umeclidinium Bromide, Vilanterol Trifenatate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.

Full Calabar Bean + Umeclidinium Bromide, Vilanterol Trifenatate answer

Can you take Deanol with Umeclidinium Bromide, Vilanterol Trifenatate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.

Full Deanol + Umeclidinium Bromide, Vilanterol Trifenatate answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Umeclidinium Bromide, Vilanterol Trifenatate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, THC may increase the levels and clinical effects of CYP3A4 substrates.

Full Delta-9-tetrahydrocannabinol (thc) + Umeclidinium Bromide, Vilanterol Trifenatate answer

Can you take Eleuthero with Umeclidinium Bromide, Vilanterol Trifenatate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.

Full Eleuthero + Umeclidinium Bromide, Vilanterol Trifenatate answer

Can you take Gymnema with Umeclidinium Bromide, Vilanterol Trifenatate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.

Full Gymnema + Umeclidinium Bromide, Vilanterol Trifenatate answer

Can you take Humann Superbeets Heart Chews with Umeclidinium Bromide, Vilanterol Trifenatate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Full Humann Superbeets Heart Chews + Umeclidinium Bromide, Vilanterol Trifenatate answer

Can you take Jequirity with Umeclidinium Bromide, Vilanterol Trifenatate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro research shows that jequirity extract inhibits CYP3A4 enzymes.

Full Jequirity + Umeclidinium Bromide, Vilanterol Trifenatate answer

Can you take Kava with Umeclidinium Bromide, Vilanterol Trifenatate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if kava inhibits CYP3AA; research is conflicting.

Full Kava + Umeclidinium Bromide, Vilanterol Trifenatate answer

Can you take Milk Thistle with Umeclidinium Bromide, Vilanterol Trifenatate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if milk thistle inhibits CYP3A4; research is conflicting.

Full Milk Thistle + Umeclidinium Bromide, Vilanterol Trifenatate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Umeclidinium Bromide, Vilanterol Trifenatate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Umeclidinium Bromide, Vilanterol Trifenatate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Umeclidinium Bromide, Vilanterol Trifenatate sits in 4 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Umeclidinium Bromide, Vilanterol Trifenatate through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Umeclidinium Bromide, Vilanterol Trifenatate through this category.

Beta-Adrenergic Agonists 15 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

15 of the supplement ingredients on this page reach Umeclidinium Bromide, Vilanterol Trifenatate through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Umeclidinium Bromide, Vilanterol Trifenatate through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Umeclidinium Bromide, Vilanterol Trifenatate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Umeclidinium Bromide, Vilanterol Trifenatate.

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Pharmacist Counseling Corner

Umeclidinium Bromide, Vilanterol Trifenatate & Supplements: Common Questions

What supplements interact with Umeclidinium Bromide, Vilanterol Trifenatate?
Our database currently documents 165 ingredients with a known Umeclidinium Bromide, Vilanterol Trifenatate interaction (9 major, 125 moderate, 31 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 165. The highest-ranked right now: Grapefruit, Arsenic, Cesium.
Which Umeclidinium Bromide, Vilanterol Trifenatate supplement interactions are the most serious?
The 9 major-rated combinations — led by Grapefruit, Arsenic, Cesium, Ephedra and Henbane — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Umeclidinium Bromide, Vilanterol Trifenatate?
Plenty of supplements coexist fine with Umeclidinium Bromide, Vilanterol Trifenatate; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Anoro Ellipta have the same supplement interactions as Umeclidinium Bromide, Vilanterol Trifenatate?
Yes — Anoro Ellipta all contain Umeclidinium Bromide, Vilanterol Trifenatate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Umeclidinium Bromide, Vilanterol Trifenatate and my other medications?
This page covers Umeclidinium Bromide, Vilanterol Trifenatate against supplements and herbal ingredients. Checking Umeclidinium Bromide, Vilanterol Trifenatate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 29, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.