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Dietary supplement

Freeze Dried Nopal Cactus Prickly Pear 500 mg Ingredients & Drug Interactions

by Natural Home Cures

Freeze Dried Nopal Cactus Prickly Pear 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Freeze Dried Nopal Cactus Prickly Pear 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Freeze Dried Nopal Cactus Prickly Pear 500 mg is a dietary supplement by Natural Home Cures with 1 active ingredient. Its ingredients are commonly taken for blood sugar control, high cholesterol, hangover symptoms.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic freeze dried Nopal Cactus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Freeze Dried Nopal Cactus Prickly Pear 500 mg by Natural Home Cures

Ask about any prescription or over-the-counter medication and we check it for interactions with Freeze Dried Nopal Cactus Prickly Pear 500 mg by Natural Home Cures — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Freeze Dried Nopal Cactus Prickly Pear 500 mg by Natural Home Cures

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: organic freeze dried nopal cactus (prickly pear cactus) at 500 mg per capsule. The capsule itself is made from gelatine, an inactive ingredient.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Prickly Pear Cactus's overall clinical evidence instead.

Moderate

Some clinical evidence supports Prickly Pear Cactus for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Diabetes — rated "Possibly Effective" (Natural Medicines).

Prickly pear cactus is possibly effective for diabetes. The evidence for other conditions—age-related cognitive decline, benign prostatic hyperplasia (enlarged prostate), indigestion (dyspepsia), and high cholesterol—is insufficient to rate, meaning we don't have enough reliable data to know whether it works for those purposes.

The evidence, ingredient by ingredient Prickly Pear Cactus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Prickly pear cactus is generally well tolerated when eaten as food, though supplement safety hasn't been studied as thoroughly. The most common side effects are abdominal fullness, indigestion, mild diarrhea, and nausea.

Rare cases of headache, insomnia, and dizziness have been reported in clinical studies. There isn't enough safety data to know whether it's safe in supplement amounts during pregnancy or while breastfeeding—talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Prickly Pear Cactus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Prickly Pear Cactus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take antidiabetes medications (such as chlorpropamide, glyburide, glipizide, metformin, or any other diabetes drug). These have a Moderate interaction risk with prickly pear cactus, and combining them may increase your risk of low blood sugar.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

If you have type 2 diabetes and are interested in prickly pear cactus for blood sugar support, this supplement may be worth discussing with your doctor—but you'll need to monitor your blood sugar carefully and make sure it doesn't lower it too much when combined with your diabetes medication. If you take any other medications, check them against the interaction tool first.

Talk it over with your own doctor or pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Freeze Dried Nopal Cactus Prickly Pear 500 mg, straight from the product label.

Brand Natural Home Cures
Barcode (UPC) 000309510927
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Dec 18, 2021
DSLD ID 258065
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Freeze Dried Nopal Cactus Prickly Pear 500 mg by Natural Home Cures, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
000309510927
IngredientAmount% DV
organic freeze dried Nopal Cactus1000 mg--

Other ingredients: Gelatine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

The FDA & Health Canada have not evaluated this product. This product is not intended to diagnose, treat, cure, mitigate or prevent disease.

Dietary Supplement

Precautions

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Caution: Do not exceed recommended dose.

Pregnant or nursing mothers, children under 18, and individuals with known medical conditions should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under 18, and individuals with known medical conditions should consult a physician before using this or any dietary supplement.

This product is manufactured and packaged in a facility which may also process milk, soy, wheat, egg, peanuts, tree nuts, fish and crustacean shellfish.

Storage

Store in a cool, dry place.

Formula

(Genuine Opuntia Streptacantha)

Our Nopal Cactus (authentic opuntia streptacantha) provides significant health benefits.

Formulation

Grown without the use of chemicals, pesticides, herbicides, or synthetic fertilizers.

To ensure maximum health benefits, our Nopal is immediately freeze dried after harvesting turning it into pure, rich, Nopal powder capsules.

Supports a healthy immune system Supports healthy glucose levels Supports healthy cholesterol levels Helps balance fluids and electrolytes

Suggested/Recommended/Usage/Directions

Recommended to take with Natural Home Cures Prickly Pear Drops along with Pure Alkaline Water Drops with Bioavailable Coral Calcium. Suggested use: As a dietary supplement, take two (2) capsules, 3 times a day.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Freeze Dried Nopal Cactus Prickly Pear 500 mg by Natural Home Cures label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Freeze Dried Nopal Cactus Prickly Pear 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Freeze Dried Nopal Cactus Prickly Pear 500 mg by Natural Home Cures

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Organic freeze dried Nopal Cactus

Interacts with
86 drugs
1000 mg per serving

Prickly pear cactus is a desert plant whose pads and fruit are eaten as food and taken as a supplement, mainly for blood sugar, cholesterol, and hango...

Organic freeze dried Nopal Cactus monograph & interactions

Other (inactive) ingredients: Gelatine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Freeze Dried Nopal Cactus Prickly Pear 500 mg by Natural Home Cures Drug Interactions

Want to check YOUR meds against Freeze Dried Nopal Cactus Prickly Pear 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

organic freeze dried Nopal Cactus 86

Individual Drug Interactions

The ingredients in Freeze Dried Nopal Cactus Prickly Pear 500 mg interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Freeze Dried Nopal Cactus Prickly Pear 500 mg interact with drugs. Each result below shows which ingredient is responsible. organic freeze dried Nopal Cactus

Each ingredient & the kinds of drugs it affects

For each ingredient in Freeze Dried Nopal Cactus Prickly Pear 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic freeze dried Nopal Cactus1 drug type · 86 drugs

Antidiabetes Drugs

Combining prickly pear cactus with antidiabetes drugs might increase the risk of hypoglycemia.
Case reports show that combining prickly pear cactus with antidiabetes drugs such as chlorpropamide, glyburide, glipizide, and metformin can increase the risk of hypoglycemia in patients with type 2 diabetes. Advise patients to monitor glucose levels closely. Dose adjustments may be necessary.

Likelihood Probable Evidence D
organic freeze dried Nopal Cactus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Freeze Dried Nopal Cactus Prickly Pear 500 mg, from the product label.

Natural Home Cures

See all Natural Home Cures products
Name
Natural Home Cures
Street Address
#65-55 Mansion Street
City
Poughkeepsie
State
New York
ZipCode
12601
Phone Number
(845) 875-6155
Web Address
www.nopalpowdercapsules.net
Pharmacist Counseling Corner

Freeze Dried Nopal Cactus Prickly Pear 500 mg by Natural Home Cures: Common Questions

Does Freeze Dried Nopal Cactus Prickly Pear 500 mg by Natural Home Cures interact with any medications?
Yes. Based on its ingredients, Freeze Dried Nopal Cactus Prickly Pear 500 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Freeze Dried Nopal Cactus Prickly Pear 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data on supplement amounts of prickly pear cactus during pregnancy or breastfeeding. Talk with your doctor or pharmacist about whether it's right for you in either situation—they can weigh the specific details of your health.
What are the side effects?
Most people tolerate it well. The most common side effects are abdominal fullness, indigestion, mild diarrhea, and nausea. A small number of people in clinical studies reported headache, insomnia, or dizziness. Very rare cases of serious bowel obstruction have been reported, but only with extremely large amounts of the fruit itself.
Does prickly pear cactus really help with diabetes?
The evidence says it's possibly effective for diabetes. That means there's some research backing it, but it's not definitive. If you have diabetes and want to try it, talk with your doctor first—especially since it can lower blood sugar and might interact with your diabetes medications.
What is nopal cactus?
Nopal (prickly pear) cactus is a plant native to Mexico. This product uses the freeze-dried pad of the cactus, which preserves its nutrients in a concentrated form.
Does this supplement contain fillers?
The capsule is made from gelatine. The active ingredient is the freeze-dried cactus itself—no other fillers are listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Freeze Dried Nopal Cactus Prickly Pear 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Freeze Dried Nopal Cactus Prickly Pear 500 mg label
Go deeper

The Full Monographs Behind Freeze Dried Nopal Cactus Prickly Pear 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Prickly Pear Cactus

Interacts with 86 drugs

Prickly pear cactus is a desert plant whose pads and fruit are eaten as food and taken as a supplement, mainly for blood sugar, cholesterol, and hangover symptoms. Some small studies suggest...

Read the full Prickly Pear Cactus monograph →
Sources

Sources & How We Checked

Freeze Dried Nopal Cactus Prickly Pear 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Prickly Pear Cactus 9 references
  1. Meckes-Lozyoa M, Roman-Ramos R. Opuntia streptacantha; a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14:116-8.
  2. Rayburn K, Martinez R, Escobedo M, et al. Glycemic effects of various species of nopal (Opuntia sp.) in type 2 diabetes mellitus. Texas J Rural Health 1998;26:68-76.
  3. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  4. Sobieraj DM, Freyer CW. Probable hypoglycemic adverse drug reaction associated with prickly pear cactus, glipizide, and metformin in a patient with type 2 diabetes mellitus. Ann Pharmacother 2010;44:1334-7. PubMed
  5. Kleiner, O., Cohen, Z., and Mares, A. J. Low colonic obstruction due to Opuntia ficus indica seeds: the aftermath of enjoying delicious cactus fruits. Acta Paediatr. 2002;91(5):606-607.
  6. Steinberg, J. M. and Eitan, A. Prickly pear fruit bezoar presenting as rectal perforation in an elderly patient. Int J Colorectal Dis. 2003;18(4):365-367. PubMed
  7. Meckes-Lozyoa, M. and Roman-Ramos, R. Opuntia streptacantha: a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14(3-4):116-118.
  8. Onakpoya IJ, O'Sullivan J, Heneghan CJ. The effect of cactus pear (Opuntia ficus-indica) on body weight and cardiovascular risk factors: a systematic review and meta-analysis of randomized clinical trials. Nutrition. 2015;31(5):640-6. PubMed
  9. Han EH, Lim MK, Lee S, et al. Efficacy of Ethanolic Extract of Opuntia ficus-indica var. saboten Stems for Improving Cognitive Function in Elderly Subjects 55-85 Years of Age: A Randomized, Double-Blind, Placebo-Controlled Study. J Med Food 2020;23(11):11

See these in context on the Prickly Pear Cactus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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