Major interaction on record — check this product against your medications before combining. Based on 5 of 9 ingredients. Check your meds →
Dietary supplement

Adderex XR Ingredients & Drug Interactions

by HTP Hi-Tech Pharmaceuticals

Adderex XR label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Adderex XR against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Adderex XR is a dietary supplement by HTP Hi-Tech Pharmaceuticals with 9 active ingredients. Its ingredients are commonly taken for mental alertness and reducing fatigue, improving athletic performance, headache and migraine relief.Based on those ingredients, 853 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Theobromine, Methyltheobromine, Methylsynephrine HCl. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Adderex XR by HTP Hi-Tech Pharmaceuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with Adderex XR by HTP Hi-Tech Pharmaceuticals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Adderex XR by HTP Hi-Tech Pharmaceuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 9 active ingredients.
  • “Adderex XR Blend” is a proprietary blend — the label gives one combined amount (15 mg) without saying how much of each component you get.
  • “Adderex XR Stimulant & Mood Blend” is a proprietary blend — the label gives one combined amount (470 mg) without saying how much of each component you get.

Adderex XR contains 9 active ingredients designed as central nervous system stimulants. The main ones are methyltheobromine (a caffeine-like compound), theobromine (from cocoa), and a mix of phenethylamine derivatives—Beta-Phenylethylamine HCl and N Methyl Beta Phenylethylamine HCl—along with the stimulants DMHA (1,5-Dimethylhexylamine HCl) and methylsynephrine.

You'll also find Alpha-Phenethylamine Hydrochloride, N,N-Dimethylphenylethylamine Hydrochloride, and N-Methyl-Beta-Methylphenylethylamine HCl. The tablet also contains inactive ingredients like microcrystalline cellulose, starch, magnesium stearate, and colorants (FD&C Red #3 and Yellow #6) that serve as fillers and binders.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: mental focus, concentration and mood elevation.
  • We looked for evidence on: Mental alertness, Cognitive function, Attention deficit-hyperactivity disorder (ADHD), Depression, Fatigue, Chronic fatigue syndrome (CFS) — and 3 related terms.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Mental alertness (Natural Medicines).
  • Also on file: Caffeine is rated "Possibly Ineffective" for Attention deficit-hyperactivity disorder (ADHD).
  • Also on file: Cocoa is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS), Cognitive function, Fatigue.

The evidence for Adderex XR's ingredients is mixed. Methyltheobromine (caffeine) is effective for neonatal apnea and postoperative headache, and likely effective for mental alertness and athletic performance.

Theobromine (cocoa) is possibly effective for cardiovascular disease but insufficient evidence exists for aging skin or asthma. Most of the other active ingredients—DMHA, phenethylamine compounds, and methylsynephrine—have insufficient reliable evidence to rate their effects on athletic performance, depression, or obesity.

No effectiveness data is on file for the product as a whole formulation.

The evidence, ingredient by ingredient Caffeine Cocoa Dimethylhexylamine (dmha) Phenethylamine (pea) Methylsynephrine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Caffeine and cocoa are generally well tolerated in moderate amounts but carry real safety notes. High doses can cause serious side effects.

Caffeine's common adverse effects include anxiety, dependence with chronic use, diarrhea, headache, insomnia, tremors, nausea, and restlessness; rarely, stroke has been reported. Cocoa in food amounts is generally safe but commonly causes constipation, gastrointestinal discomfort, headaches, nausea, and borborygmi (gut rumbling).

DMHA and methylsynephrine are unapproved stimulants with serious safety concerns. Methylsynephrine has been tied to increased blood pressure, palpitations, arrhythmias, and in one product (dexaprine, which contained it) cases of cardiac arrest, chest pain, and nausea within an hour of a single dose.

Phenethylamine compounds may affect heart rate and blood pressure, and a case of anxiety, agitation, and tachycardia was reported in someone taking a multi-ingredient product containing phenethylamine. The safety data for phenethylamine-based compounds in humans is limited.

Pregnancy and lactation safety is not well established for most ingredients in this product—caffeine and cocoa are possibly safe in pregnancy but possibly unsafe at higher amounts, and small amounts pass into breast milk. DMHA, methylsynephrine, and the phenethylamines lack sufficient safety data for pregnancy and breastfeeding and should be avoided.

Side effects, ingredient by ingredient Caffeine Cocoa Dimethylhexylamine (dmha) Phenethylamine (pea) Methylsynephrine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Cocoa, Caffeine, Phenethylamine (pea), Dimethylhexylamine (dmha), Methylsynephrine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 853 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Adderex XR, double-check any ephedrine you're taking (Major risk of serious cardiovascular events). Then check stimulant drugs, sedatives, blood pressure medications, serotonergic drugs (antidepressants, migraine meds), MAOIs, antipsychotics, asthma inhalers (beta-agonists), seizure medications, and certain antibiotics or heart drugs (Moderate severity).

The interaction count is large—use the search tool for your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Adderex XR is a multi-stimulant supplement with substantial interaction risk and several unapproved or high-concern ingredients. If you take any prescription medication—especially blood pressure drugs, antidepressants, asthma inhalers, sedatives, or seizure medications—check each one with the tool on this page before considering this product.

Talk to your pharmacist or doctor about your full medication list and whether this supplement is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Adderex XR, straight from the product label.

Brand HTP Hi-Tech Pharmaceuticals
Barcode (UPC) 811836026917
Net contents 30 Tablet(s)
Market status On market
Date entered into DSLD Aug 23, 2023
DSLD ID 299462
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Adderex XR by HTP Hi-Tech Pharmaceuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
30
UPC/BARCODE
811836026917
IngredientAmount% DV
Methyltheobromine0 NP--
Theobromine0 NP--
Adderex XR Blend15 mg--
Alpha-Phenethylamine Hydrochloride0 NP--
Adderex XR Stimulant & Mood Blend470 mg--
1,5-Dimethylhexylamine HCl0 NP--
Beta-Phenylethylamine HCl0 NP--
N Methyl Beta Phenylethylamine HCl0 NP--
N,N-Dimethylphenylethylamine Hydrochloride0 NP--
N-Methyl-Beta-Methylphenylethylamine HCl0 NP--
Methylsynephrine HCl0 NP--

Other ingredients: Dextrose, Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Sodium Starch Glycolate, Starch, Triacetin, Titanium Dioxide, Silica, FD&C Red #3, FD&C Yellow #6

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Warning: Not for use by individuals under the age of 18 years.

Do not use if you are pregnant or nursing.

Individuals who consume caffeine with this product may experience serious adverse health effects. Individuals who are sensitive to the effects of caffeine should consult a licensed health care professional before consuming this product. Do not consume synephrine of caffeine from other sources, included but not limited to: coffee, tea, soda, or other dietary products or medication containing caffeine or phenylephrine. Do not use more than 8 weeks.

Consult your physician prior to use if you are taking medication, including but not limited to MAOI inhibitors, aspirin, antidepressants, nonsteroidal anti-inflammatory drugs or products containing phenylephrine, ephedrine, pseudoephedrine, or other stimulants.

Consult your physician prior to use if you have a medical condition, including but not limited to: heart , liver, kidney, or thyroid disease, psychiatric or seizure disorders, difficulty urinating, diabetes, high blood pressure, cardiac arrhythmia, recurrent headaches, enlarged prostate or glaucoma. Discontinue two weeks prior to surgery or if you experience rapid heart beat, dizziness, severe headache or shortness of breath. In case of accidental overdose, seek professional assistance or contact a poison control center immediately. Avoid alcohol while taking this product. Exceeding recommended serving may cause serious adverse health effects including heart attack and stroke. Improper use of this product may be hazardous to a persons health.

Formulation

Elevates mood & CNS stimulant! Sustained release technology Strongest focusing aid without a prescription! Helps adults maintain concentration & improve productivity!

Sourced from a GMP Certified Facility Good Manufacturing Practice Quality Assure

Seals/Symbols

Sourced from a GMP Certified Facility Good Manufacturing Practice Quality Assured

Suggested/Recommended/Usage/Directions

Suggested use: Take one (1) tablet in the morning and one (1) tablet after lunch if needed. Do not exceed 2 tablets daily.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Adderex XR by HTP Hi-Tech Pharmaceuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Adderex XR label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Adderex XR by HTP Hi-Tech Pharmaceuticals

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Adderex XR Blend

15 mg per serving
  • › Alpha-Phenethylamine Hydrochloride

Adderex XR Stimulant & Mood Blend

470 mg per serving

Other (inactive) ingredients: Dextrose, Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Sodium Starch Glycolate, Starch, Triacetin, Titanium Dioxide, Silica, FD&C Red #3, FD&C Yellow #6. These complete the product’s ingredient list but are not active constituents.

Interaction report

Adderex XR by HTP Hi-Tech Pharmaceuticals Drug Interactions

Want to check YOUR meds against Adderex XR?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
853Drugs
8 Major 739 Moderate 106 Minor

Ingredients driving the most interactions

Theobromine 661
Methyltheobromine 655
Methylsynephrine HCl 191
Beta-Phenylethylamine HCl 187
1,5-Dimethylhexylamine HCl 172

Individual Drug Interactions

The ingredients in Adderex XR interact with 853 drugs. Click any drug to see the details.

5 of the 9 ingredients in Adderex XR interact with drugs. Each result below shows which ingredient is responsible. Theobromine Methyltheobromine Methylsynephrine HCl Beta-Phenylethylamine HCl 1,5-Dimethylhexylamine HCl

Each ingredient & the kinds of drugs it affects

For each ingredient in Adderex XR with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Theobromine37 drug types · 661 drugs

Ace Inhibitors (Aceis)

Theoretically, taking cocoa with ACEIs might increase the risk of adverse effects.
Human research shows that dark chocolate can inhibit ACE. Additionally, prolonged angioedema in an elderly patient on an ACE inhibitor was precipitated with intake of diabetic chocolate.

Likelihood Possible Evidence D
Adenosine (Adenocard)

Theoretically, cocoa might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Cocoa contains caffeine. Caffeine is a competitive inhibitor of adenosine at the cellular level. However, caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole than adenosine-induced stress testing.

Likelihood Possible Evidence B
Alcohol (Ethanol)

Theoretically, concomitant use might increase levels and adverse effects of caffeine.
Cocoa contains caffeine. Alcohol reduces caffeine metabolism. Concomitant use of alcohol can increase caffeine serum concentrations and the risk of caffeine adverse effects.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, cocoa may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Clinical research shows that intake of cocoa can inhibit platelet adhesion, aggregation, and activity and increase aspirin-induced bleeding time. For patients on dual antiplatelet therapy, cocoa may enhance the inhibitory effect of clopidogrel, but not aspirin, on platelet aggregation.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking cocoa with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that cocoa can modestly decrease blood pressure in hypertensive and normotensive patients.

Likelihood Possible Evidence D
Beta-Adrenergic Agonists

Theoretically, large amounts of cocoa might increase the cardiac inotropic effects of beta-agonists.
Cocoa contains caffeine. Theoretically, large amounts of caffeine might increase cardiac inotropic effects of beta-agonists. A case of atrial fibrillation associated with consumption of large quantities of chocolate in a patient with chronic albuterol inhalation abuse has also been reported.

Likelihood Probable Evidence D
Cytochrome P450 1A2 (Cyp1A2) Inhibitors

Theoretically, concomitant use might increase the levels and adverse effects of caffeine.
Cocoa contains caffeine. Caffeine is metabolized by cytochrome P450 1A2 (CYP1A2),. Theoretically, drugs that inhibit CYP1A2 may decrease the clearance rate of caffeine from cocoa and increase caffeine levels.

Likelihood Possible Evidence D
Dipyridamole (Persantine)

Theoretically, cocoa might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Cocoa contains caffeine. Caffeine may inhibit dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram might increase the risk of adverse effects from caffeine.
Cocoa contains caffeine. In human research, disulfiram decreases the rate of caffeine clearance.

Likelihood Probable Evidence B
Diuretic Drugs

Theoretically, using cocoa with diuretic drugs might increase the risk of hypokalemia.
Cocoa contains caffeine. In excessive amounts, caffeine can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.

Likelihood Possible Evidence D
Ephedrine

Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Cocoa contains caffeine. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Cocoa contains caffeine. Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Flutamide (Eulexin)

Theoretically, cocoa might increase the levels and adverse effects of flutamide.
Cocoa contains caffeine. In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide.

Likelihood Possible Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Cocoa contains caffeine. Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Theoretically, abrupt cocoa withdrawal might increase the levels and adverse effects of lithium.
Cocoa contains caffeine. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Cocoa contains caffeine. Large amounts of caffeine with MAOIs might precipitate a hypertensive crisis.

Likelihood Possible Evidence D
Nicotine

Theoretically, concomitant use might increase the risk of hypertension.
Cocoa contains caffeine. Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence B
Pentobarbital (Nembutal)

Theoretically, cocoa might decrease the effects of pentobarbital.
Cocoa contains caffeine. Caffeine might negate the hypnotic effects of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, cocoa might reduce the effects of phenobarbital and increase the risk for convulsions.
Cocoa contains caffeine. Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. The exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Cocoa contains caffeine. Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, cocoa might reduce the effects of phenytoin and increase the risk for convulsions.
Cocoa contains caffeine. Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Cocoa contains caffeine. Quinolones (also referred to as fluoroquinolones) decrease caffeine clearance.

Likelihood Probable Evidence B
Riluzole (Rilutek)

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Cocoa contains caffeine. Caffeine and riluzole are both metabolized by cytochrome P450 1A2, and concomitant use might reduce metabolism of one or both agents.

Likelihood Possible Evidence D
Stimulant Drugs

Theoretically, concomitant use might increase stimulant adverse effects.
Cocoa contains caffeine. Concomitant use might increase the risk of stimulant adverse effects.

Likelihood Probable Evidence C
Theophylline

Theoretically, cocoa might increase the levels and adverse effects of theophylline.
Cocoa contains caffeine. Large amounts of caffeine might inhibit theophylline metabolism. Caffeine decreases theophylline clearance 23% to 29%.

Likelihood Probable Evidence B
Theobromine full monograph & all 37 interactions

Methyltheobromine41 drug types · 655 drugs

Ephedrine

Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Use of ephedrine with caffeine can increase the risk of stimulatory adverse effects. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.

Likelihood Probable Evidence D
Adenosine (Adenocard)

Theoretically, caffeine might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Some evidence shows that caffeine is a competitive inhibitor of adenosine and can reduce the vasodilatory effects of adenosine in humans. However, other research shows that caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Possible Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Caffeine is reported to have antiplatelet activity. Theoretically, it might increase the risk of bleeding when used concomitantly with these agents; however, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Beta-Adrenergic Agonists

Theoretically, large amounts of caffeine might increase the cardiac inotropic effects of beta-agonists.

Likelihood Probable Evidence D
Carbamazepine (Tegretol)

Theoretically, caffeine might reduce the effects of carbamazepine and increase the risk for convulsions.
Animal research suggests that taking caffeine can lower the anticonvulsant effects of carbamazepine and can induce seizures when taken in doses above 400 mg/kg. Human research has shown that taking caffeine 300 mg in three divided doses along with carbamazepine 200 mg reduces the bioavailability of carbamazepine by 32% and prolongs the plasma half-life of carbamazepine 2-fold in healthy individuals.

Likelihood Possible Evidence D
Cimetidine (Tagamet)

Theoretically, cimetidine might increase the levels and adverse effects of caffeine.
Cimetidine decreases the rate of caffeine clearance by 31% to 42%.

Likelihood Likely Evidence B
Clozapine (Clozaril)

Caffeine might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Caffeine might increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg per day inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Although researchers speculate that caffeine might inhibit CYP1A2, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients more sensitive to an interaction between clozapine and caffeine. In one case report, severe, life-threatening clozapine toxicity and multiorgan system failure occurred in a patient with schizophrenia stabilized on clozapine who consumed caffeine 600 mg daily.

Likelihood Possible Evidence B
Dipyridamole (Persantine)

Theoretically, caffeine might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Caffeine inhibits dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram use might increase the levels and adverse effects of caffeine.
Disulfiram decreases the rate of caffeine clearance.

Likelihood Probable Evidence B
Diuretic Drugs

Theoretically, using caffeine with diuretic drugs might increase the risk of hypokalemia.
Caffeine, especially in excessive amounts, can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Ethosuximide (Zarontin)

Theoretically, caffeine might reduce the effects of ethosuximide and increase the risk for convulsions.
Animal research suggests that caffeine 92.4 mg/kg can decrease the anticonvulsant activity of ethosuximide. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Felbamate (Felbatol)

Theoretically, caffeine might reduce the effects of felbamate and increase the risk for convulsions.
Animal research suggests that a high dose of caffeine 161.7 mg/kg can decreases the anticonvulsant activity of felbamate. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Flutamide (Eulexin)

Theoretically, caffeine might increase the levels and adverse effects of flutamide.
In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide. However, this effect has not been reported in humans.

Likelihood Probable Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Abrupt caffeine withdrawal might increase the levels and adverse effects of lithium.
Caffeine has diuretic activity. When abruptly discontinued, caffeine may alter the clearance of lithium. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal and 6 case reports of elevated serum lithium levels after reducing or eliminating caffeine intake. In one case, a male with schizoaffective disorder stabilized on lithium had an elevated lithium level after reducing his caffeine intake by 87%. At a later date, he increased his caffeine intake by 6-fold, resulting in a subtherapeutic lithium level and a recurrence of psychiatric symptoms.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Caffeine has been shown to inhibit monoamine oxidase (MAO) A and B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis. In a case report, a patient that consumed 10-12 cups of caffeinated coffee and took the MAOI tranylcypromine presented with severe hypertension. Hypertension was resolved after the patient switched to drinking decaffeinated coffee.

Likelihood Possible Evidence D
Nicotine

Theoretically, concomitant use might increase the risk of hypertension.
Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence B
Pentobarbital (Nembutal)

Theoretically, caffeine might decrease the effects of pentobarbital.
Caffeine might negate the hypnotic effects of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, caffeine might reduce the effects of phenobarbital and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, caffeine might reduce the effects of phenytoin and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Pioglitazone (Actos)

Theoretically, caffeine might increase the levels and clinical effects of pioglitazone.
Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Quinolones (also called fluoroquinolones) can decrease caffeine clearance by inhibiting cytochrome P450 1A2 (CYP1A2) enzyme.

Likelihood Probable Evidence B
Riluzole (Rilutek)

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Caffeine and riluzole are both metabolized by cytochrome P450 1A2 (CYP1A2), and concomitant use might reduce the metabolism of one or both agents.

Likelihood Possible Evidence D
Methyltheobromine full monograph & all 41 interactions

Methylsynephrine HCl2 drug types · 191 drugs

Beta-Adrenergic Agonists

Methylsynephrine has beta agonist activity. Theoretically, concomitant use of large amounts of methylsynephrine might increase the cardiac inotropic effects of beta-agonists. Beta-adrenergic agonists include albuterol (Ventolin, Proventil), metaproterenol (Alupent), terbutaline (Brethine, Bricanyl), and isoproterenol (Isuprel).

Likelihood Possible Evidence D
Stimulant Drugs

Methylsynephrine has cardiac stimulant effects. Theoretically, taking methylsynephrine with other stimulant drugs might increase the risk of hypertension and adverse cardiovascular effects.
Some stimulant drugs include amphetamine, caffeine, diethylpropion (Tenuate), methylphenidate, phentermine (Ionamin), pseudoephedrine (Sudafed, others), and many others.

Likelihood Possible Evidence D
Methylsynephrine HCl full monograph & interactions

Beta-Phenylethylamine HCl2 drug types · 187 drugs

Monoamine Oxidase Inhibitors (Maois)

Theoretically, taking phenethylamine concomitantly with MAOIs may increase adverse effects.
In humans, phenethylamine is oxidized by MAO-B to form the inactive metabolite phenylacetic acid. Animal research shows that administering an MAOI prior to phenethylamine increases the amphetamine-like effects of phenethylamine. However, low-quality clinical research has used phenethylamine with selegiline, an MAOI, with apparent safety.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, combining serotonergic drugs with phenethylamine might increase the risk of serotonergic adverse effects.
Animal research shows that phenethylamine increases levels of serotonin, norepinephrine, and dopamine. Theoretically, combining serotonergic drugs with phenethylamine might increase the risk of additive serotonergic adverse effects, including serotonin syndrome and cerebral vasoconstrictive disorders. However, low-quality clinical research has used phenethylamine with selegiline, a monoamine oxidase inhibitor (MAOI), with apparent safety.

Likelihood Possible Evidence D
Beta-Phenylethylamine HCl full monograph & interactions

1,5-Dimethylhexylamine HCl1 drug type · 172 drugs

Stimulant Drugs

Theoretically, combining DMHA with stimulant drugs might increase the risk of adverse cardiovascular effects.
DMHA is thought to have stimulant effects.

Likelihood Possible Evidence D
1,5-Dimethylhexylamine HCl full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Adderex XR, from the product label.

HTP Hi-Tech Pharmaceuticals

See all HTP Hi-Tech Pharmaceuticals products
Name
Hi-Tech Pharmaceuticals, Inc.
Street Address
6015-B Unity Dr.
City
Norcross
State
GA
ZipCode
30071
Phone Number
1-888-855-7919
Web Address
www.hitechpharma.com
Pharmacist Counseling Corner

Adderex XR by HTP Hi-Tech Pharmaceuticals: Common Questions

Does Adderex XR by HTP Hi-Tech Pharmaceuticals interact with any medications?
Yes. Based on its ingredients, Adderex XR has a known interaction with 853 medications, including 8 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Adderex XR contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Adderex XR if I'm pregnant or breastfeeding?
The safety data isn't clear enough to know either way for most ingredients in this product. Caffeine and cocoa show mixed signals—possibly safe at lower amounts but possibly unsafe at higher doses. DMHA, methylsynephrine, and phenethylamine compounds lack sufficient safety data and should be avoided. Talk with your doctor or pharmacist before using this product if you're pregnant or breastfeeding.
What's methyltheobromine and why does it interact with so many drugs?
Methyltheobromine is a caffeine-like stimulant that your liver processes through an enzyme called CYP1A2. Many medications use the same enzyme pathway, so caffeine can slow down or speed up how your body clears them, changing their strength or effects.
Does Adderex XR contain any fillers?
Yes. Beyond the 9 active ingredients, the tablet contains inactive ingredients like microcrystalline cellulose, starch, magnesium stearate, silica, and food colorants that act as fillers and binders to hold the tablet together.
What are the most common side effects of caffeine in this product?
The most common are anxiety, dependence with chronic use, diarrhea, headache, insomnia, muscle tremors, nausea, and restlessness. Serious side effects like stroke are rare but have been reported.
Why is DMHA flagged as 'avoid'?
DMHA is an unapproved stimulant with serious safety concerns. It's thought to increase the risk of high blood pressure, fast heart rate, and cardiovascular events—effects similar to dimethylamylamine (DMAA), which was banned. There's no safety data for pregnancy or breastfeeding.
Will Adderex XR help with weight loss or athletic performance?
Caffeine is likely effective for athletic performance, but most of the other active ingredients—DMHA, phenethylamine compounds, and methylsynephrine—have insufficient evidence to say whether they work for weight loss or athletic performance.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Adderex XR label
Go deeper

The Full Monographs Behind Adderex XR’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Caffeine

Interacts with 655 drugs

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredness for most healthy adults, but too muc...

Read the full Caffeine monograph → Herb & supplement monograph

Cocoa

Interacts with 661 drugs

Cocoa is rich in plant compounds called flavanols that may modestly support blood vessel function and blood pressure, but most chocolate products are high in sugar, fat, and calories, which...

Read the full Cocoa monograph → Herb & supplement monograph

Dimethylhexylamine (dmha)

Interacts with 172 drugs

DMHA (dimethylhexylamine, also called octodrine) is a synthetic stimulant added to some pre-workout and weight-loss supplements, often falsely labeled as a natural plant extract. It has not...

Read the full Dimethylhexylamine (dmha) monograph → Herb & supplement monograph

Phenethylamine (pea)

Interacts with 187 drugs

Phenethylamine (PEA) is a natural compound made in the body and found in foods like chocolate; supplements are marketed for mood, focus, and energy. Reliable human research on the supplement...

Read the full Phenethylamine (pea) monograph → Herb & supplement monograph

Methylsynephrine

Interacts with 191 drugs

Methylsynephrine (also called oxilofrine) is a synthetic stimulant sometimes added to weight-loss and pre-workout products, but it is not a legal or approved dietary ingredient in the United...

Read the full Methylsynephrine monograph →
Sources

Sources & How We Checked

Adderex XR's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 373 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Caffeine 236 references
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See these in context on the Caffeine monograph →

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See these in context on the Cocoa monograph →

Dimethylhexylamine (dmha) 6 references
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  4. Rasmussen N, Keizers PH. History full circle: 'novel' sympathomimetics in supplements. Drug Test Anal 2016;8(3-4):283-6. PubMed
  5. Monroe RR, Drell HJ. Oral use of stimulants obtained from inhalers. J Am Med Assoc 1947; 135(14):909-15. PubMed
  6. Fellows EJ. The pharmacology of 2-amino-6-methylheptane. J Pharmacol Exp Ther 1947;90(4):351-8. DOI

See these in context on the Dimethylhexylamine (dmha) monograph →

Phenethylamine (pea) 9 references
  1. Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
  2. Sabelli H, Fink P, Fawcett J, et al. Sustained antidepressant effect of PEA replacement. J Neuropsychiatry Clin Neurosci. 1996;8(2):168-71.
  3. Xie Z, Miller G. Beta-phenylehtylamine alters monoamine transporter function via trace amine-associated receptor 1: implication for modulatory roles of trace amines in brain. J Pharmacol Exp Ther. 2008;325(2):617-28.
  4. Lukasik-Glebocka M, Sommerfeld K, Tezyk A, et al. [Acute poisoning with weight-loss dietary supplement falsely suggesting the use of amphetamine]. Przegl Lek. 2013;70(10):880-3.
  5. Nakamura M, Ishii A, Nakahara D. Characterization of beta-phenyltheylamine-induced monoamine release in rat nucleus accumbens: a microdialysis study. Eur J Pharmacol. 1998;349(2-3):163-9.
  6. Bailey B, Philips S, Boulton A. In vivo release of endogenous dopamine, 5-hydroxytryptamine and some of their metabolites from rat caudate nucleus by phenylethylamine. Neurochem Res. 1987;12(2):173-8. PubMed
  7. Mantegazza P, Riva M. Amphetamine-like activity of beta-phenethylamine after a monoamine oxidase inhibitor in vivo. Journal of Pharmacy and Pharmacology. 1963;151(1):472-8.
  8. Grimsby J, Toth M, Chen K, et al. Increased stress response and beta-phenylethylamine in MAOB-deficient mice. Nat Genet. 1997;17(2):206-10.
  9. Lindemann L, Hoener MC. A renaissance in trace amines inspired by a novel GPCR family. Trends Pharmacol Sci. 2005;26(5):274-81. PubMed

See these in context on the Phenethylamine (pea) monograph →

Methylsynephrine 3 references
  1. Pawar RS, Grundel E. Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs). Drug Test Anal 2017;9:500-517. PubMed
  2. Cohen PA, Avula B, Venhuis B, Travis JC, Wang YH, Khan IA. Pharmaceutical doses of the banned stimulant oxilofrine found in dietary supplements sold in the USA. Drug Test Anal. 2017;9(1):135-142. PubMed
  3. Venhuis B, Keizers P, van Riel A, de Kaste D. A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events. Drug Test Anal. 2014;6(6):578-81. PubMed

See these in context on the Methylsynephrine monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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