Major interaction on record — check this product against your medications before combining. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Advanced With Glucosamine + Chondroitin Ingredients & Drug Interactions

by Schiff Move Free

Advanced With Glucosamine + Chondroitin label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Advanced With Glucosamine + Chondroitin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Advanced With Glucosamine + Chondroitin is a dietary supplement by Schiff Move Free with 4 active ingredients. Its ingredients are commonly taken for osteoarthritis joint pain, joint stiffness, cartilage support.Based on those ingredients, 170 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Glucosamine Hydrochloride, Chondroitin Sulfate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Advanced With Glucosamine + Chondroitin by Schiff Move Free

Ask about any prescription or over-the-counter medication and we check it for interactions with Advanced With Glucosamine + Chondroitin by Schiff Move Free — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Advanced With Glucosamine + Chondroitin by Schiff Move Free

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has four active ingredients. Glucosamine Hydrochloride and Chondroitin Sulfate are the main components — both are naturally occurring compounds found in joint cartilage, and they're combined here to support joint structure and function.

Joint Fluid is hyaluronic acid, which helps cushion and lubricate joints. We couldn't verify the fourth ingredient, Uniflex, because we hold no data for it.

The tablet also contains several inactive ingredients — cellulose, croscarmellose sodium, magnesium stearate, silicon dioxide, and hydroxypropyl cellulose — which are fillers, binders, and coating materials.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: joint health mobility comfort strength flexibility.
  • We looked for evidence on: Joint pain, Knee pain, Osteoarthritis, Exercise-induced muscle soreness, Cartilage support, Joint stiffness — and 1 related terms.
  • The strongest evidence on file: Glucosamine is rated "Likely Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Chondroitin Sulfate is rated "Possibly Effective" for Osteoarthritis.
  • Also on file: Chondroitin Sulfate is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness.

Glucosamine Hydrochloride is rated likely effective for osteoarthritis, the wear-and-tear joint condition. Chondroitin Sulfate is rated possibly effective for both osteoarthritis and cataracts.

Hyaluronic Acid is rated possibly effective for dry eye and venous leg ulcers. For other uses like aging skin, back pain, and various metabolic conditions, the evidence we hold isn't established enough to rate it reliably.

The evidence, ingredient by ingredient Chondroitin Sulfate Glucosamine Hyaluronic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both glucosamine and chondroitin are generally well tolerated when taken by mouth, though quality and benefit vary between products. The most common side effects are digestive — bloating, constipation, cramps, diarrhea, heartburn, and nausea.

Rare serious effects include liver damage (hepatotoxicity) from chondroitin and allergic reactions from glucosamine, ranging from mild itching and hives to severe reactions including anaphylaxis in about 1.5% of reported hypersensitivity cases. Both ingredients have rare reports of asthma flare-ups when combined in products like this one.

Skin reactions — rash, swelling around the eyes and face, hair loss, and photosensitization (sun sensitivity) — have also been reported. The safety data for Uniflex isn't available, and there isn't enough information to know whether these ingredients are safe during pregnancy or breastfeeding; talk with your doctor or pharmacist if you're pregnant or nursing.

Side effects, ingredient by ingredient Chondroitin Sulfate Glucosamine Hyaluronic Acid

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Chondroitin Sulfate, Glucosamine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 170 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting this product, check with your pharmacist if you take warfarin (Coumadin) or any other blood thinner — glucosamine may increase bleeding risk. Also double-check if you're on cancer chemotherapy drugs like etoposide or doxorubicin, diabetes medications, or acetaminophen (Tylenol) regularly.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Schiff Move Free is likely effective for osteoarthritis and possibly helpful for cataracts and dry eye. If you take warfarin or chemotherapy drugs, check with your pharmacist first — these interactions can be serious.

If you're pregnant, breastfeeding, or take diabetes medications or acetaminophen regularly, a conversation with your pharmacist will help you decide if it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Advanced With Glucosamine + Chondroitin, straight from the product label.

Brand Schiff Move Free
Barcode (UPC) 020525118738
Net contents 80 Coated Tablet(s)
Market status On market
Date entered into DSLD Aug 24, 2016
DSLD ID 63734
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Advanced With Glucosamine + Chondroitin by Schiff Move Free, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
40
UPC/BARCODE
020525118738
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrates2 Gram(s)1%
Chondroitin Sulfate200 mg--
Glucosamine Hydrochloride1.5 Gram(s)--
Joint Fluid3.3 mg--
Uniflex216 mg--

Other ingredients: Cellulose, Coating, Croscarmellose Sodium, Magnesium Stearate, Silicon Dioxide, Hydroxypropyl Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Easier to swallow tablets2 We know that taking big pills every day can be a challenge. That’s why we have developed easier to swallow, smaller tablets than other leading joint care brands2. Our exclusive state-of-the-art technology allows us to pack the same amount of our powerful ingredients into a smaller tablet, making it easier to take every day for the best possible results. Actual Size

Since 1936

Supports 5 signs of joint health Mobility Comfort Strength Flexibility Lubrication

rb Health \ Hygiene \ Home

1J Aging Res Clin Pract 2014; 3(4): 223-228.

Brand IP Statement(s)

Proud sponsor of the Arthritis Foundation www.arthritis.org Move Free is a Proud Sponsor of the Arthritis Foundation: Move Free is proud to support the Arthritis Foundation’s efforts to help people take control of arthritis. Funds from Move Free are used for cutting-edge scientific research, advocacy and education.

2Move Free Advanced tablets are smaller than other leading joint care products containing the combination of glucosamine and chondroitin

Move Free Joint Health

2015 RB

FruiteX-B Calcium Fructoborate is a registered trademark of VDF FutureCeuticals, Inc. FruiteX-B Calcium Fructoborate is manufactured under US Patent #5,962,049 and pending foreign patents. Used under license from VDF FutureCeuticals, Inc.

HOW DOES MOVE FREE WORK? Move Free Advanced supports 5 signs of joint health: mobility, flexibility, strength, lubrication and comfort so you can do the things you love:

Precautions

JOIN, EARN POINTS & GET REWARDS www.movefreerewards.com See cap sticker for details Valid for U.S. residents only.

CONTAINS SHELLFISH (SHRIMP, CRAB, LOBSTER, AND CRAYFISH)

KEEP OUT OF REACH OF CHILDREN.

Not for use by pregnant or breastfeeding women. If on prescribed medication, consult your physician before use.

Not suitable for use by anyone under the age of 18 years old.

Protected with a tamper evident seal. Do not use if seal under cap is broken or missing.

Formula

With Glucosamine + Chondroitin

CONTAINS SHELLFISH (SHRIMP, CRAB, LOBSTER, AND CRAYFISH)

Chondroitin Sulfate is derived from bovine and porcine sources.

Glucosamine: Glucosamine is key for the formation of cartilage, an essential building block of your joints. Glucosamine also supports the mobility and flexibility you want in everyday life. Chondroitin: Chondroitin is a building block of cartilage that supports joint strength by helping to resist compression in the joint. Chondroitin attracts fluid to your joints to support cushioning and lubrication. Uniflex: Uniflex is a clinically tested mineral complex that supports joint comfort in as little as 2 weeks1. Joint Fluid (or Hyaluronic Acid): Hyaluronic Acid is the same molecule found in healthy joint fluid that supports joint lubrication and smooth movement. As we get older, our levels of HA tend to decrease.

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

2 pills per day

DIRECTIONS: Adults take two (2) tablets once a day with a meal OR one (1) tablet twice daily with meals.

General

062915 8176564

Storage

Store in a cool, dry place with lid tightly closed.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Advanced With Glucosamine + Chondroitin by Schiff Move Free label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Advanced With Glucosamine + Chondroitin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Advanced With Glucosamine + Chondroitin by Schiff Move Free

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container40 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Chondroitin Sulfate

Interacts with
2 drugs
200 mg per serving

Chondroitin sulfate is a naturally occurring building block of cartilage that is widely taken, often with glucosamine, for osteoarthritis joint pain....

Chondroitin Sulfate monograph & interactions

Glucosamine Hydrochloride

Interacts with
170 drugs
1.5 Gram(s) per serving

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of...

Glucosamine Hydrochloride monograph & interactions

Joint Fluid

No known
interactions
3.3 mg per serving Form: Hyaluronic Acid

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin...

Joint Fluid monograph & interactions

Uniflex

216 mg per serving

Other (inactive) ingredients: Cellulose, Coating, Croscarmellose Sodium, Magnesium Stearate, Silicon Dioxide, Hydroxypropyl Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Advanced With Glucosamine + Chondroitin by Schiff Move Free Drug Interactions

Want to check YOUR meds against Advanced With Glucosamine + Chondroitin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
170Drugs
2 Major 13 Moderate 155 Minor

Ingredients driving the most interactions

Glucosamine Hydrochloride 170
Chondroitin Sulfate 2

Individual Drug Interactions

The ingredients in Advanced With Glucosamine + Chondroitin interact with 170 drugs. Click any drug to see the details.

2 of the 4 ingredients in Advanced With Glucosamine + Chondroitin interact with drugs. Each result below shows which ingredient is responsible. Glucosamine Hydrochloride Chondroitin Sulfate

Each ingredient & the kinds of drugs it affects

For each ingredient in Advanced With Glucosamine + Chondroitin with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Glucosamine Hydrochloride4 drug types · 170 drugs

Warfarin (Coumadin)

Glucosamine might increase the anticoagulant effects of warfarin and increase the risk of bruising and bleeding.
In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in international normalized ratio (INR) in patients previously stabilized on warfarin. In one case, the increase in INR occurred only after tripling the dose of a glucosamine/chondroitin supplement from 500 mg/400 mg daily to 1500/1200 mg daily. Additionally, 20 voluntary case reports to the U.S. Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone to increased INR in patients taking warfarin. The mechanism of this interaction is unclear. Glucosamine is a small component of heparin, but is not thought to have anticoagulant activity; however, animal research suggests that it might have antiplatelet activity.

Likelihood Probable Evidence D
Topoisomerase Ii Inhibitors

Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
In vitro research suggests that glucosamine might induce resistance to etoposide (VP16, VePesid) and doxorubicin (Adriamycin) by reducing inhibition of topoisomerase II, an enzyme required for DNA replication in tumor cells. This effect has not been reported in humans.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

Acetaminophen might interfere with the activity of glucosamine sulfate by interacting with the sulfate portion.
Anecdotal reports suggest that adding glucosamine to an acetaminophen regimen might decrease pain control in patients with osteoarthritis. Some research suggests that the sulfate portion of glucosamine sulfate might contribute to its effect in osteoarthritis. Since acetaminophen metabolism requires sulfur and reduces serum sulfate concentrations, acetaminophen could theoretically interfere with the action of glucosamine sulfate. Conversely, the administration of sulfate could theoretically decrease the effectiveness of acetaminophen in sulfate-deficient people by increasing its clearance.

Likelihood Possible Evidence B
Antidiabetes Drugs

Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.
In vitro and animal research has suggested that glucosamine might increase insulin resistance or decrease insulin production. This has raised concerns that taking glucosamine might worsen diabetes and decrease the effectiveness of diabetes drugs. However, clinical research suggests that glucosamine does not have adverse effects on blood glucose or glycated hemoglobin (HbA1C) in healthy, obese, or type 2 diabetes patients.

Likelihood Unlikely Evidence B
Glucosamine Hydrochloride full monograph & interactions

Chondroitin Sulfate1 drug type · 2 drugs

Warfarin (Coumadin)

Taking chondroitin in combination with glucosamine might increase the anticoagulant effects of warfarin. However, the effect of chondroitin alone is unclear.
There have been multiple reports of increased international normalized ratio (INR) in patients taking warfarin with glucosamine, with or without chondroitin. The lack of reports with chondroitin alone seem to suggest that the interactions occurring in these reports may have been due to glucosamine. In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in INR in patients previously stabilized on warfarin. Additionally, 20 voluntary case reports to the US Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone, without chondroitin, to increased INR in patients taking warfarin.

Likelihood Unlikely Evidence D
Chondroitin Sulfate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Advanced With Glucosamine + Chondroitin, from the product label.

Schiff Move Free

See all Schiff Move Free products
Name
Reckitt Benckiser
City
Parsippany
State
NJ
ZipCode
07054-0224
Phone Number
1-800-526-6251
Web Address
www.movefree.com
Pharmacist Counseling Corner

Advanced With Glucosamine + Chondroitin by Schiff Move Free: Common Questions

Does Advanced With Glucosamine + Chondroitin by Schiff Move Free interact with any medications?
Yes. Based on its ingredients, Advanced With Glucosamine + Chondroitin has a known interaction with 170 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Advanced With Glucosamine + Chondroitin contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are glucosamine and chondroitin supposed to do?
They're naturally occurring compounds in joint cartilage. Glucosamine is likely effective for osteoarthritis, and chondroitin is possibly effective for both osteoarthritis and cataracts — they work to support joint structure and cushioning.
What's hyaluronic acid doing in here?
It's the active ingredient labeled 'Joint Fluid' in this product. It helps cushion and lubricate joints. It's rated possibly effective for dry eye and venous leg ulcers.
What side effects might I get?
Most commonly, digestive upset — bloating, constipation, diarrhea, heartburn, nausea. Less often, skin reactions like rash, swelling, or itching, and very rarely, allergic reactions or asthma flare-ups. Liver damage is rare but has been reported.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety information to know either way. Talk with your doctor or pharmacist before using it if you're pregnant or nursing — they can give you personalized advice based on your situation.
Is there enough evidence this actually works?
For osteoarthritis, glucosamine is likely effective. Chondroitin is possibly effective for osteoarthritis and cataracts. For other uses listed on the label, the evidence isn't established enough to rate reliably.
What if I'm taking acetaminophen (Tylenol) for pain?
This product may slightly reduce how well acetaminophen works for pain relief, so combining them might be less effective than you'd expect. Your pharmacist can suggest the best approach for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Advanced With Glucosamine + Chondroitin is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Advanced With Glucosamine + Chondroitin label
Go deeper

The Full Monographs Behind Advanced With Glucosamine + Chondroitin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chondroitin Sulfate

Interacts with 2 drugs

Chondroitin sulfate is a naturally occurring building block of cartilage that is widely taken, often with glucosamine, for osteoarthritis joint pain. The evidence is mixed—some people report...

Read the full Chondroitin Sulfate monograph → Herb & supplement monograph

Glucosamine

Interacts with 170 drugs

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of the knee. The evidence is mixed, with so...

Read the full Glucosamine monograph → Herb & supplement monograph

Hyaluronic Acid

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...

Read the full Hyaluronic Acid monograph →
Sources

Sources & How We Checked

Advanced With Glucosamine + Chondroitin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 84 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chondroitin Sulfate 22 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Tallia AF, Cardone DA. Asthma exacerbation associated with glucosamine-chondroitin supplement. J Am Board Fam Pract 2002;15:481-4..
  3. Danao-Camara T. Potential side effects of treatment with glucosamine and chondroitin. Arthritis Rheum 2000;43:2853. PubMed
  4. Rozenfeld V, Crain JL, Callahan AK. Possible augmentation of warfarin effect by glucosamine-chondroitin. Am J Health Syst Pharm 2004;61:306-307. PubMed
  5. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;354:795-808. DOI
  6. Knudsen J, Sokol GH. Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: Case report and review of the literature and MedWatch database. Pharmacotherapy 2008;28:540-8. PubMed
  7. Yue QY, Strandell J, Myrberg O. Concomitant use of glucosamine potentiates the effect of warfarin. Jan 2006. Drug Safety 29(10):911-1010. DOI
  8. Nordling, J. and van, Ophoven A. Intravesical glycosaminoglycan replenishment with chondroitin sulphate in chronic forms of cystitis. A multi-national, multi-centre, prospective observational clinical trial. Arzneimittelforschung. 2008;58(7):328-335. PubMed
  9. Nickel, J. C., Egerdie, B., Downey, J., Singh, R., Skehan, A., Carr, L., and Irvine-Bird, K. A real-life multicentre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulphate for the treatment of interstitial cystit
  10. Oliviero, U., Sorrentino, G. P., De Paola, P., Tranfaglia, E., D'Alessandro, A., Carifi, S., Porfido, F. A., Cerio, R., Grasso, A. M., Policicchio, D., and . Effects of the treatment with matrix on elderly people with chronic articular degeneration. Drug
  11. Crowley, D. C., Lau, F. C., Sharma, P., Evans, M., Guthrie, N., Bagchi, M., Bagchi, D., Dey, D. K., and Raychaudhuri, S. P. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int.J.Med.Sc PubMed
  12. Nickel, J. C., Egerdie, R. B., Steinhoff, G., Palmer, B., and Hanno, P. A multicenter, randomized, double-blind, parallel group pilot evaluation of the efficacy and safety of intravesical sodium chondroitin sulfate versus vehicle control in patients with
  13. Sawitzke, A. D., Shi, H., Finco, M. F., Dunlop, D. D., Harris, C. L., Singer, N. G., Bradley, J. D., Silver, D., Jackson, C. G., Lane, N. E., Oddis, C. V., Wolfe, F., Lisse, J., Furst, D. E., Bingham, C. O., Reda, D. J., Moskowitz, R. W., Williams, H. J.
  14. Wildi, L. M., Raynauld, J. P., Martel-Pelletier, J., Beaulieu, A., Bessette, L., Morin, F., Abram, F., Dorais, M., and Pelletier, J. P. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starti
  15. Pavelka and et al. Double-blind, dose effect study of oral cs 4 & 6 1200mg, 800mg, 200mg against placebo in the treatment of femorotibial osteoarthritis. Wular Rheumatol Liter 1998;27(suppl 2):63.
  16. Cerda C, Bruguera M, Parés A. Hepatotoxicity associated with glucosamine and chondroitin sulfate in patients with chronic liver disease. World J Gastroenterol 2013;19(32):5381-4. PubMed
  17. von Felden J, Montani M, Kessebohm K, Stickel F. Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate. Int J Clin Pharmacol Ther 2013;51(3):219-23. PubMed
  18. Provenza JR, Shinjo SK, Silva JM, Peron CR, Rocha FA. Combined glucosamine and chondroitin sulfate, once or three times daily, provides clinically relevant analgesia in knee osteoarthritis. Clin Rheumatol 2015;34:1455-62. PubMed
  19. Ossendza RA, Grandval P, Chinoune F, Rocher F, Chapel F, Bernardini D. [Acute cholestatic hepatitis due to glucosamine forte]. Gastroenterol Clin Biol. 2007 Apr;31(4):449-50.
  20. Greenlee H, Crew KD, Shao T, Kranwinkel G, Kalinsky K, Maurer M, Brafman L, Insel B, Tsai WY, Hershman DL. Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer. Support Care Cancer 201 PubMed
  21. Chu EC, Huang KHK, Cheung G, Ng G, Lin A. Delayed Skin Allergy to Glucosamine Chondroitin Supplement. Cureus 2023;15(3):e36310. PubMed
  22. Lila AM, Alekseeva LI, Baranov AA, et al. Chondroitin sulfate and glucosamine combination in patients with knee and hip osteoarthritis: A long-term observational study in Russia. World J Orthop 2023;14(6):443-457. PubMed

See these in context on the Chondroitin Sulfate monograph →

Glucosamine 58 references
  1. Adams ME. Hype about glucosamine. Lancet 1999;354:353-4. PubMed
  2. Balkan B, Dunning BE. Glucosamine inhibits glucokinase in vitro and produces a glucose-specific impairment of in vivo insulin secretion in rats. Diabetes 1994;43:1173-9. PubMed
  3. Giaccari A, Morviducci L, Zorretta D, et al. In vivo effects of glucosamine on insulin secretion and insulin sensitivity in the rat: possible relevance to the maladaptive responses to chronic hyperglycaemia. Diabetologia 1995;38:518-24. PubMed
  4. Holmang A, Nilsson C, Niklasson M, et al. Induction of insulin resistance by glucosamine reduces blood flow but not interstitial levels of either glucose or insulin. Diabetes 1999;48:106-11. PubMed
  5. Houpt JB, McMillan R, Wein C, Paget-Dellio SD. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. J Rheumatol 1999;26:2423-30.
  6. Barclay TS, Tsourounis C, McCart GM. Glucosamine. Ann Pharmacother 1998;32:574-9.
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See these in context on the Glucosamine monograph →

Hyaluronic Acid 4 references
  1. Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
  2. U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
  3. Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
  4. Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed

See these in context on the Hyaluronic Acid monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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