No known drug interactions for the matched ingredients — not a guarantee none exist. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

AFP-Peptizyde with DPP IV Activity Ingredients & Drug Interactions

by Houston Enzymes

Capsule Category: Non-nutrient/non-botanical
No known interaction
The interaction bottom line No known interaction

AFP-Peptizyde with DPP IV Activity is a dietary supplement by Houston Enzymes with 3 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of AFP-Peptizyde with DPP IV Activity by Houston Enzymes

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Peptidase” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Proprietary Enzyme Blend” is a proprietary blend — the label gives one combined amount (320 mg) without saying how much of each component you get.

This product has three active enzyme ingredients designed to support digestion. The two protease enzymes (Protease 4.5 and Protease 6) break down protein, while Dipeptidyl Peptidase-IV is an enzyme that cleaves dipeptides — short protein fragments.

A proprietary peptidase blend is also included to further aid protein digestion. The capsule itself, along with microcrystalline cellulose and medium-chain triglycerides powder, are inactive ingredients that help deliver the enzymes.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: support digestion of food plants including gluten.
  • We looked for evidence on: Gluten sensitivity, Casein intolerance, Protein digestion.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

Effectiveness data for these specific enzyme ingredients is not established in the information we hold. If you're considering this product for a particular digestive concern, your pharmacist or doctor can help you figure out whether enzyme supplementation might fit your situation.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The proteases in this product are generally well tolerated by most adults, though digestive upset or allergic reactions are possible — especially if you have a sensitivity to enzymes (which, rarely, can happen with people exposed to proteolytic enzymes in occupational settings). The data advises against protease use during pregnancy unless prescribed by your doctor, since safety hasn't been established.

During breastfeeding, there's too little safety data, so medical advice is needed before use. If you develop symptoms like allergic rhinitis or asthma after taking this, mention it to your healthcare provider.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases)

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented for the ingredients we could check in this product. Still, if you're on any medications you're unsure about, it's worth a quick conversation with your pharmacist before you start.

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. No medication interactions are currently documented, and safety information is well characterized.

This enzyme product is straightforward — no documented medication interactions. It's generally well tolerated by most adults.

Avoid it during pregnancy unless your doctor says otherwise, and check with your healthcare provider or pharmacist before using it if you're breastfeeding. If you have a known enzyme sensitivity, talk to your pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about AFP-Peptizyde with DPP IV Activity, straight from the product label.

Brand Houston Enzymes
Barcode (UPC) 898631000045
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Nov 21, 2020
DSLD ID 236860
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for AFP-Peptizyde with DPP IV Activity by Houston Enzymes, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
898631000045
IngredientAmount% DV
Protease 4.50 NP--
Protease 60 NP--
Peptidase0 NP--
Dipeptidyl Peptidase-IV0 NP--
Proprietary Enzyme Blend320 mg--

Other ingredients: Capsule, Microcrystalline Cellulose, Medium Chain Triglycerides powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

AFP Peptizyde (Advanced Formula Protease) supports the digestion of food plants, including gluten, casein and soy.

All vegetarian

Digestive support for proteins Aids in breakdown of gluten and casein

Formula

AFP Peptizyde includes DPP IV enzyme activity which aids in the breakdown of casein and gluten.

Enzyme with DPP IV Activity Advanced formula protease

Suggested/Recommended/Usage/Directions

Suggested use: One (1) capsule at the beginning of each meal. Capsules may be opened and contents mixed with food or beverage. Use care not to inhale enzyme powder. Do not use if active ulcers or GI bleeding is present. AFP Peptizyde may be taken with other Houston Enzymes products.

Precautions

Do not use if tamper-proof seal is broken.

To report an adverse event, contact distributor: Houston Nutraceuticals, Inc. (HNI)

Storage

Keep container closed and store at room temperature or in freezer, but do not place in refrigerator due to humid conditions.

General Statements

AFP Peptizyde was developed by Dr. Devin Houston, PhD Enzyme Biochemist

The authority of enzymes

Dr. Houston's Biochemist Formulated Enzymes

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disese.

FDA Statement of Identity

Dietary Supplement

See for yourself

AFP-Peptizyde with DPP IV Activity by Houston Enzymes label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in AFP-Peptizyde with DPP IV Activity by Houston Enzymes

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protease 4.5

No known
interactions
0 NP per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease 4.5 monograph & interactions

Protease 6

No known
interactions
0 NP per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease 6 monograph & interactions

Proprietary Enzyme Blend

320 mg per serving
  • › Peptidase

Other (inactive) ingredients: Capsule, Microcrystalline Cellulose, Medium Chain Triglycerides powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

AFP-Peptizyde with DPP IV Activity by Houston Enzymes Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in AFP-Peptizyde with DPP IV Activity. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for AFP-Peptizyde with DPP IV Activity, from the product label.

Houston Enzymes

See all Houston Enzymes products
Name
Houston Nutraceuticals, Inc. (HNI)
Street Address
116 N. Broadway St.
City
Siloam Springs
State
AR
ZipCode
72761
Phone Number
866-757-8627
Web Address
www.houston-enzymes.com
Pharmacist Counseling Corner

AFP-Peptizyde with DPP IV Activity by Houston Enzymes: Common Questions

Does AFP-Peptizyde with DPP IV Activity by Houston Enzymes interact with any medications?
We do not currently list a known interaction for the mapped ingredients in AFP-Peptizyde with DPP IV Activity. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
AFP-Peptizyde with DPP IV Activity contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant?
The safety data advises against the proteases in this product during pregnancy unless your doctor specifically prescribes it. Talk with your doctor or pharmacist before use if you're pregnant or planning to become pregnant.
Is it safe to use while breastfeeding?
There isn't enough safety data on these enzymes during breastfeeding to recommend use without medical advice. Talk with your healthcare provider or pharmacist for personalized guidance.
What are proteases, and why are they in here?
Proteases are enzymes that break down proteins into smaller pieces your body can absorb. They're included to support protein digestion.
Could I have an allergic reaction to this?
Allergic reactions to proteases are rare but possible, especially digestive upset. In rare cases, people with occupational exposure to airborne proteolytic enzymes have developed allergic reactions like rhinitis or asthma. If you notice any unusual symptoms, talk to your doctor.
What's Dipeptidyl Peptidase-IV supposed to do?
It's an enzyme that cleaves dipeptides — short chains of amino acids — to aid protein breakdown and digestion.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if AFP-Peptizyde with DPP IV Activity is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

AFP-Peptizyde with DPP IV Activity label
Go deeper

The Full Monographs Behind AFP-Peptizyde with DPP IV Activity’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

AFP-Peptizyde with DPP IV Activity's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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