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Dietary supplement

AgmaPure Agmatine Unflavored Ingredients & Drug Interactions

by Muscle Feast

AgmaPure Agmatine Unflavored label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking AgmaPure Agmatine Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

AgmaPure Agmatine Unflavored is a dietary supplement by Muscle Feast with 1 active ingredient. Its ingredients are commonly taken for pre- and post-workout support, muscle pumps and exercise performance, cognitive support and mood.Based on those ingredients, 258 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Agmatine Sulfate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against AgmaPure Agmatine Unflavored by Muscle Feast

Ask about any prescription or over-the-counter medication and we check it for interactions with AgmaPure Agmatine Unflavored by Muscle Feast — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of AgmaPure Agmatine Unflavored by Muscle Feast

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: agmatine sulfate, a compound that your body naturally produces. There are no inactive or other ingredients listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Agmatine's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: enhance nitric oxide production and improve nutrient delivery.
  • We looked for evidence on: Athletic performance, Muscle strength, exercise endurance, recovery time, muscle pumps.
  • The closest evidence on file: Agmatine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Agmatine is rated "Insufficient Reliable Evidence To Rate" for Muscle strength.

The evidence for agmatine isn't established yet in the data we hold. The product has been studied for alcohol use disorder, Alzheimer disease, anxiety, athletic performance, autism spectrum disorder, and bipolar disorder, but each of those carries a rating of insufficient reliable evidence.

That doesn't mean it doesn't work — it means the research so far isn't strong enough to say either way.

The evidence, ingredient by ingredient Agmatine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use of agmatine appears generally well tolerated. The most common side effects reported in small studies were diarrhea, indigestion (dyspepsia), and nausea — mild to moderate, and they resolved when people stopped taking it.

However, long-term safety in humans hasn't been well studied yet. If you're pregnant or breastfeeding, there isn't enough safety data, so it's best to avoid use.

Talk with your doctor or pharmacist about whether agmatine is right for you in those situations.

Side effects, ingredient by ingredient Agmatine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Agmatine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 258 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check this product against any blood pressure medications you take — agmatine may increase the risk of low blood pressure (Moderate severity). Also double-check diabetes medications before starting, since agmatine may raise the risk of low blood sugar (Moderate severity).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Agmatine sulfate is a single-ingredient supplement generally well tolerated short-term, but it does interact with blood pressure and diabetes medications, so check with your pharmacist first if you take either. Long-term safety data is limited, and it's not recommended in pregnancy or while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about AgmaPure Agmatine Unflavored, straight from the product label.

Brand Muscle Feast
Net contents 7 Oz(s); 200 Gram(s)
Market status On market
Date entered into DSLD Feb 23, 2022
DSLD ID 261353
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for AgmaPure Agmatine Unflavored by Muscle Feast, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.5 Gram(s)
Maximum serving Sizes:
1.5 Gram(s)
Servings per container
133
IngredientAmount% DV
Agmatine Sulfate1500 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Muscle Feast AgmaPure Agmatine is designed to enhance nitric oxide production and improve nutrient delivery to muscle cells. It can boost endurance, as well as decrease recovery time. We have chosen AgmaPure Agmatine, because it is a unique green, high purity agmatine sulfate. It's produced by a natural biological process and away from the neurohazard impurity Arcaine, which exists in almost all the other brands of Agmatine Sulfate.

The purest form of agmatine sulfate available

AGMAPURE Natural Agmatine Sulfate

Suggested/Recommended/Usage/Directions

Suggested use: As an adult dietary supplement, take one serving (1500 mg) in 6-8 ounces of water, 1-2 times per day or as directed by your doctor. Mix 1 level (1.5g) scoop with 6-8 oz. water or beverage of choice up to 2 times a day.

Formulation

Non-GMO

Certified Vegan AVA American Vegetarian Association

Seals/Symbols

Made in our GMP Compliant Facility Made in an FDA Registered Facility Certified Vegan AVA American Vegetarian Association

General Statements

SDVOSB Service Distributed Veteran Owned Small Business

Ohio family owned business

FDA Statement of Identity

Dietary Supplement

Storage

Keep tightly closed in a cool, dry place away from sunlight.

Precautions

Keep out of reach of children.

Do not exceed the recommended dose. Consult your physician before using this product.

Do not use this product if you are pregnant or nursing. Do not use this product if you are taking any prescription medication.

Do not use this product if you are under the age of 18.

Warning: This product is manufactured in a GMP compliant plant that processes milk.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

AgmaPure Agmatine Unflavored by Muscle Feast label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

AgmaPure Agmatine Unflavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in AgmaPure Agmatine Unflavored by Muscle Feast

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1.5 Gram(s) Dosage formPowder Servings per container133 Amounts shown are per serving.

Agmatine Sulfate

Interacts with
258 drugs
1500 mg per serving

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most...

Agmatine Sulfate monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

AgmaPure Agmatine Unflavored by Muscle Feast Drug Interactions

Want to check YOUR meds against AgmaPure Agmatine Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
258Drugs
258 Moderate

Ingredients driving the most interactions

Agmatine Sulfate 258

Individual Drug Interactions

The ingredients in AgmaPure Agmatine Unflavored interact with 258 drugs. Click any drug to see the details.

1 of the 1 ingredient in AgmaPure Agmatine Unflavored interact with drugs. Each result below shows which ingredient is responsible. Agmatine Sulfate

Each ingredient & the kinds of drugs it affects

For each ingredient in AgmaPure Agmatine Unflavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Agmatine Sulfate2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D
Agmatine Sulfate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for AgmaPure Agmatine Unflavored, from the product label.

Muscle Feast

See all Muscle Feast products
Name
Muscle Feast
Street Address
1320 Boston Road
City
Nashport
State
OH
ZipCode
43830
Phone Number
(888) 734-3634
Web Address
www.musclefeast.com
Pharmacist Counseling Corner

AgmaPure Agmatine Unflavored by Muscle Feast: Common Questions

Does AgmaPure Agmatine Unflavored by Muscle Feast interact with any medications?
Yes. Based on its ingredients, AgmaPure Agmatine Unflavored has a known interaction with 258 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
AgmaPure Agmatine Unflavored contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is agmatine and what does it do?
Agmatine sulfate is a compound your body produces naturally. It's being studied for several conditions including alcohol use disorder, anxiety, and Alzheimer disease, but the evidence so far isn't strong enough to confirm it works for any of those. Your pharmacist can talk you through what the research shows.
What side effects might I experience?
In small studies, the most common side effects were diarrhea, indigestion, and nausea. They were mild to moderate and went away when people stopped taking it. Short-term use seems generally well tolerated, but long-term effects in humans haven't been well studied.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data to know either way, so it's best to avoid agmatine during pregnancy and while breastfeeding. Talk with your doctor or pharmacist for personalized advice about your situation.
Is this safe to take long-term?
Short-term use appears generally well tolerated, but long-term safety in humans hasn't been well studied. If you're thinking about using it regularly, check in with your pharmacist first.
Why does this product have so many drug interactions?
Agmatine interacts with over 250 medications, but most are within two main drug categories: blood pressure medications and diabetes medications. The number is high because there are many drugs in each category — not because agmatine is unusually risky. That's why checking your exact medications is important.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if AgmaPure Agmatine Unflavored is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

AgmaPure Agmatine Unflavored label
Go deeper

The Full Monographs Behind AgmaPure Agmatine Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Agmatine

Interacts with 258 drugs

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...

Read the full Agmatine monograph →
Sources

Sources & How We Checked

AgmaPure Agmatine Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Agmatine 3 references
  1. Piletz JE, Aricioglu F, Cheng JT, et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today 2013;18(17-18):880-93. PubMed
  2. Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial. Pain Med 201 PubMed
  3. Shopsin B. The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study. Acta Neuropsychiatr 2013;25(2):113-8. PubMed

See these in context on the Agmatine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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