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Dietary supplement

Agmatine Ingredients & Drug Interactions

by AI Sports Nutrition

Agmatine label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Agmatine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Agmatine is a dietary supplement by AI Sports Nutrition with 1 active ingredient. Its ingredients are commonly taken for pre- and post-workout support, muscle pumps and exercise performance, cognitive support and mood.Based on those ingredients, 258 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Agmatine Sulfate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Agmatine by AI Sports Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Agmatine by AI Sports Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Agmatine by AI Sports Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: agmatine sulfate. Agmatine is a compound that naturally occurs in the body and is formed from the amino acid arginine.

The capsule also holds inactive ingredients — gelatin, microcrystalline cellulose, and magnesium stearate — which are standard excipients that help form and deliver the capsule.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: increase endurance and support exercise performance.
  • We looked for evidence on: Athletic performance, Muscle strength, Muscular endurance, Workout capacity, Exercise stamina, Physical performance.
  • The closest evidence on file: Agmatine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Agmatine is rated "Insufficient Reliable Evidence To Rate" for Muscle strength.

The evidence for agmatine isn't yet established in our data. The facts we hold show insufficient reliable evidence to rate its use for alcohol use disorder, Alzheimer disease, anxiety, athletic performance, autism spectrum disorder, and bipolar disorder.

That doesn't mean it doesn't work — it means the research isn't there yet to support those claims. If you're considering agmatine for a specific condition, your pharmacist or doctor can tell you what the current science actually shows.

The evidence, ingredient by ingredient Agmatine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use of agmatine appears generally well tolerated in humans, but long-term safety hasn't been well studied. The most common side effects reported in small clinical trials are diarrhea, indigestion (dyspepsia), and nausea — and they typically showed up within a few days.

These effects resolved once people stopped taking it. Agmatine is not recommended during pregnancy or while breastfeeding because there isn't enough safety data to know either way.

If you're pregnant, planning to become pregnant, or nursing, talk with your doctor or pharmacist before starting this product.

Side effects, ingredient by ingredient Agmatine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Agmatine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 258 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking agmatine, double-check with your pharmacist if you're on blood pressure medication or diabetes medication. Both carry moderate-risk interactions where agmatine could theoretically intensify their effects, lowering your blood pressure or blood sugar too much.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Agmatine may be worth considering if you're interested in its potential uses, but it's not right for everyone. If you take blood pressure or diabetes medication, you'll need to check with your pharmacist first — the interactions are real.

Pregnant or breastfeeding? Skip it until you've talked with your doctor.

Short-term side effects are usually mild, but we don't know much about long-term use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Agmatine, straight from the product label.

Brand AI Sports Nutrition
Barcode (UPC) 804879593102
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 255659
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Agmatine by AI Sports Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
804879593102
IngredientAmount% DV
Agmatine Sulfate500 mg--

Other ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Increase endurance

Supports massive pumps Optimizes insulin levels

Modulates nitric oxide levels

Suggested/Recommended/Usage/Directions

As a dietary supplement, take 2 capsules first thing in the morning with a meal, or take 1 capsule in the morning with a meal, and then another capsule 30 minutes prior to training.

Precautions

Warning: Not for individuals under the age of 18 years.

Do not use if pregnant or nursing. Consult a physician before using this or any product if you have, or have a family history of, including but not limited to high blood pressure, cardiac arrhythmia, heart, liver, kidney, thyroid, or psychiatric disease, pheochromocytoma, diabetes, asthma, recurrent headaches, anemia, nervousness, anxiety, depression or other psychiatric condition, peptic ulcers, Parkinson's disease, glaucoma, difficulty in urinating, prostate enlargement, or seizure disorder, or if you are using a monoamine oxidase inhibitor (MAOI) or any other dietary supplement, prescription drug, or over-the-counter drug containing ephedrine, pseudoephedrine, or phenylpropanolamine (ingredients found in certain allergy, asthma, cough or cold, immunosuppressants, and weight control products).

Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects, including heart attack and stroke. Discontinue use and call a physician or licensed qualified health care professional immediately if you experience rapid heartbeat, dizziness, severe headache, shortness of breath, or other similar symptoms.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Agmatine by AI Sports Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Agmatine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Agmatine by AI Sports Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Agmatine Sulfate

Interacts with
258 drugs
500 mg per serving

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most...

Agmatine Sulfate monograph & interactions

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Agmatine by AI Sports Nutrition Drug Interactions

Want to check YOUR meds against Agmatine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
258Drugs
258 Moderate

Ingredients driving the most interactions

Agmatine Sulfate 258

Individual Drug Interactions

The ingredients in Agmatine interact with 258 drugs. Click any drug to see the details.

1 of the 1 ingredient in Agmatine interact with drugs. Each result below shows which ingredient is responsible. Agmatine Sulfate

Each ingredient & the kinds of drugs it affects

For each ingredient in Agmatine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Agmatine Sulfate2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D
Agmatine Sulfate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Agmatine, from the product label.

AI Sports Nutrition

See all AI Sports Nutrition products
Name
AI Sports Nutrition
Street Address
2578 Enterprise Rd #114
City
Orange City
State
FL
ZipCode
32763
Web Address
www.aisportsnutition.com
Pharmacist Counseling Corner

Agmatine by AI Sports Nutrition: Common Questions

Does Agmatine by AI Sports Nutrition interact with any medications?
Yes. Based on its ingredients, Agmatine has a known interaction with 258 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Agmatine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What side effects might I experience?
The most common ones reported in trials are diarrhea, indigestion, and nausea. These typically appeared within a few days of starting and went away once people stopped taking it. Short-term use appears well tolerated overall, though long-term safety isn't well studied yet.
Can I take this while pregnant or breastfeeding?
The safety data isn't there, so it's best to avoid agmatine during pregnancy and while breastfeeding. Talk with your doctor or pharmacist for personalized advice if you're in either situation.
How much agmatine was used in the studies you mentioned?
In the trial where side effects appeared, participants took 3.56 grams of agmatine sulfate daily. The effects showed up within 2–3 days and resolved when they stopped.
Is agmatine proven to work for [condition]?
We don't have reliable evidence yet to rate agmatine for uses like anxiety, athletic performance, Alzheimer disease, autism spectrum disorder, bipolar disorder, or alcohol use disorder. That means the research either isn't there or isn't conclusive — not that it definitely doesn't work.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Agmatine is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Agmatine label
Go deeper

The Full Monographs Behind Agmatine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Agmatine

Interacts with 258 drugs

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...

Read the full Agmatine monograph →
Sources

Sources & How We Checked

Agmatine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Agmatine 3 references
  1. Piletz JE, Aricioglu F, Cheng JT, et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today 2013;18(17-18):880-93. PubMed
  2. Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial. Pain Med 201 PubMed
  3. Shopsin B. The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study. Acta Neuropsychiatr 2013;25(2):113-8. PubMed

See these in context on the Agmatine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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