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Dietary supplement

Align Probiotic Extra Strength Ingredients & Drug Interactions

by Align

Align Probiotic Extra Strength label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Align Probiotic Extra Strength against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Align Probiotic Extra Strength is a dietary supplement by Align with 1 active ingredient. Its ingredients are commonly taken for digestive health and regularity, irritable bowel syndrome (ibs), diarrhea (including antibiotic-related).Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium longum longum 35624. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Align Probiotic Extra Strength by Align

Ask about any prescription or over-the-counter medication and we check it for interactions with Align Probiotic Extra Strength by Align — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Align Probiotic Extra Strength by Align

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Align Probiotic Extra Strength contains one active ingredient: Bifidobacterium longum, a beneficial bacterium that colonizes the gut. The capsule also holds several inactive ingredients — microcrystalline cellulose, hypromellose, sucrose, sodium caseinate, magnesium stearate, titanium dioxide, trisodium citrate dihydrate, gellan gum, and propyl gallate — that serve as binders, fillers, and capsule materials.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Bifidobacterium Longum's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: digestive health and regularity.
  • We looked for evidence on: Abdominal pain, Antibiotic-associated diarrhea, Clostridioides difficile infection, Constipation, Diarrhea, Irritable bowel syndrome (IBS) — and 4 related terms.
  • The closest evidence on file: Bifidobacterium Longum is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Bifidobacterium Longum is rated "Insufficient Reliable Evidence To Rate" for Constipation, Diarrhea, Ulcerative colitis, Irritable bowel syndrome (IBS), and more.

The evidence on Bifidobacterium longum for the conditions listed — age-related cognitive decline, hay fever, antibiotic-associated diarrhea, generalized anxiety, asthma, and athletic performance — is insufficient to rate. That means the current data we hold don't establish whether it works for these uses.

If you're interested in this product for a specific health concern, talk it over with your doctor or pharmacist to see what the broader research landscape shows.

The evidence, ingredient by ingredient Bifidobacterium Longum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bifidobacterium longum is generally well tolerated in healthy people, but caution is warranted if you're seriously ill or have a weakened immune system — rare cases of the bacterium entering the bloodstream have been reported in critically ill infants and adults. Common side effects are uncommon; a small number of people have reported abdominal discomfort, bloating, flatulence, or rarely, constipation.

One person in a clinical trial reported a dry cough. Safety data are limited, so use this product only with your doctor's guidance.

If you're breastfeeding, limited data exist — check with your doctor before starting.

Side effects, ingredient by ingredient Bifidobacterium Longum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bifidobacterium Longum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start this product, check with your doctor or pharmacist if you take antibiotic drugs. Antibiotics can reduce how well this probiotic works by killing the live organisms in the capsule — timing matters.

Use the checker on this page to look up your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Align Probiotic Extra Strength is a single-ingredient probiotic that's generally well tolerated in healthy people, but it does interact with antibiotics. If you're on an antibiotic or have any chronic illness or immune compromise, talk with your own doctor or pharmacist before taking it.

They can help you figure out whether it's right for you and how to time it with your other medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Align Probiotic Extra Strength, straight from the product label.

Brand Align
Barcode (UPC) 037000505051
Net contents 21 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 278089
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Align Probiotic Extra Strength by Align, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
21
UPC/BARCODE
037000505051
IngredientAmount% DV
Bifidobacterium longum longum 3562417.5 mg--

Other ingredients: Microcrystalline Cellulose, Hypromellose, Sucrose, Sodium Caseinate, Magnesium Stearate, Titanium Dioxide, Trisodium Citrate Dihydrate, Gellan Gum, Propyl Gallate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Gluten free Soy free

Vegetarian

Guaranteed potency

24/7 digestive support With continued daily use. Naturally helps promote and support a healthy digestive system

Fortifies the digestive system with healthy bacteria 24/7

Storage

No refrigeration required

For best results, we recommend you store Align Extra Strength below 77 degrees F (25 degrees C) in the original blister unit.

Suggested/Recommended/Usage/Directions

Directions: Take one capsule per day.

Brand IP Statement(s)

Patents: www.pg.com/patents

General Statements

Developed by gastroenterologists #1 doctor recommended brand

Why use probiotics? Common issues such as diet, changes in routine, travel and stress may disrupt your natural balance of good bacteria

#1 Doctor and #1 Gastroenterologist recommended probiotic brand

Money Back Guarantee Procter & Gamble stands behind our product. If you are not satisfied with Align, simply return the UPC code from this package and your original sales receipt within 60 days of purchase for a full refund in the form of a prepaid card. Visit AlignProbioitics.com/refund for details. Among gastroenterologists who recommend a brand of probiotic in ProVoice 2008-2018 surveys. Among doctors who recommend a brand of probiotic in ProVoice 2018 survey

Questions? 1-800-208-0112 or AlignProbiotics.com

Formula

5X extra strength 5x more good bacteria vs. Align Probiotic Capsules

Why use Align Extra Strength? Contains 5X more good bacteria

Align Probiotic is the product of more than 10 years of scientific research and contains the pure-strain probiotic, Bifidobacterium 35624

FDA Statement of Identity

Probiotic Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Contains: Milk

Warnings: Parental supervision is recommended for the use of this product. Keep out of reach of children.

Tamper evident: Carton sealed for your protection. Do not use if blister unit is open or torn.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Align Probiotic Extra Strength by Align label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Align Probiotic Extra Strength label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Align Probiotic Extra Strength by Align

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container21 Amounts shown are per serving.

Bifidobacterium longum longum 35624

Interacts with
182 drugs
17.5 mg per serving

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most...

Bifidobacterium longum longum 35624 monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Sucrose, Sodium Caseinate, Magnesium Stearate, Titanium Dioxide, Trisodium Citrate Dihydrate, Gellan Gum, Propyl Gallate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Align Probiotic Extra Strength by Align Drug Interactions

Want to check YOUR meds against Align Probiotic Extra Strength?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bifidobacterium longum longum 35624 182

Individual Drug Interactions

The ingredients in Align Probiotic Extra Strength interact with 182 drugs. Click any drug to see the details.

1 of the 1 ingredient in Align Probiotic Extra Strength interact with drugs. Each result below shows which ingredient is responsible. Bifidobacterium longum longum 35624

Each ingredient & the kinds of drugs it affects

For each ingredient in Align Probiotic Extra Strength with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium longum longum 356241 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum longum 35624 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Align Probiotic Extra Strength, from the product label.

Align

See all Align products
Name
Procter & Gamble
City
Cincinnati
State
OH
ZipCode
45202
Phone Number
1-800-208-0112
Web Address
www.pg.com
Pharmacist Counseling Corner

Align Probiotic Extra Strength by Align: Common Questions

Does Align Probiotic Extra Strength by Align interact with any medications?
Yes. Based on its ingredients, Align Probiotic Extra Strength has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Align Probiotic Extra Strength contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this probiotic while I'm on antibiotics?
You can, but timing is important. Because antibiotics kill the live organisms in this probiotic, taking them at the same time may reduce how well the probiotic works. Talk with your doctor or pharmacist about spacing them apart — they can give you a dosing schedule that works.
Is this safe if I have a weak immune system?
Caution is needed. While it's generally well tolerated in healthy people, rare cases of this bacterium entering the bloodstream have been reported in critically ill or immune-compromised patients. Check with your doctor before starting if you have any chronic illness or a weakened immune system.
What side effects might I experience?
Most people tolerate it well. Rarely, some people report abdominal discomfort, bloating, flatulence, or constipation. One person reported a dry cough. If you have unusual or bothersome symptoms, tell your doctor.
Is it safe to take while breastfeeding?
The safety data are limited, so we don't have enough information to say either way. Talk with your doctor or pharmacist before using it while breastfeeding — they can help you weigh the risks and benefits for your situation.
Does this probiotic work for digestive health?
The evidence we hold doesn't establish whether Bifidobacterium longum is effective for any specific condition, including digestive issues. Talk with your doctor or pharmacist about what the current research shows and whether this product makes sense for your goals.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Align Probiotic Extra Strength is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Align Probiotic Extra Strength label
Go deeper

The Full Monographs Behind Align Probiotic Extra Strength’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph →
Sources

Sources & How We Checked

Align Probiotic Extra Strength's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
  12. Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
  15. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
  17. Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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