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Dietary supplement

Align Probiotic Ingredients & Drug Interactions

by Align

Align Probiotic label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Align Probiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Align Probiotic is a dietary supplement by Align with 1 active ingredient. Its ingredients are commonly taken for digestive health and regularity, irritable bowel syndrome (ibs), diarrhea (including antibiotic-related).Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium longum longum 35624. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Align Probiotic by Align

Ask about any prescription or over-the-counter medication and we check it for interactions with Align Probiotic by Align — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Align Probiotic by Align

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Align Probiotic is a single-ingredient supplement containing Bifidobacterium longum longum 35624, a strain of beneficial bacteria (probiotic) that lives naturally in the human gut. The capsule also contains several inactive ingredients — microcrystalline cellulose, hypromellose, sucrose, magnesium stearate, sodium caseinate, titanium dioxide, trisodium citrate dihydrate, propyl gallate, and gellan gum — that serve as fillers, binders, and capsule material.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Bifidobacterium Longum's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Digestive health and gastrointestinal regularity.
  • We looked for evidence on: Antibiotic-associated diarrhea, Diarrhea, Irritable bowel syndrome (IBS), Constipation, Clostridioides difficile infection, digestive wellness — and 1 related terms.
  • The closest evidence on file: Bifidobacterium Longum is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Bifidobacterium Longum is rated "Insufficient Reliable Evidence To Rate" for Constipation, Diarrhea, Irritable bowel syndrome (IBS), Rotaviral diarrhea, and more.

The evidence for Bifidobacterium longum in conditions like age-related cognitive decline, allergic rhinitis (hay fever), antibiotic-associated diarrhea, anxiety, asthma, and athletic performance is insufficient to rate its effectiveness based on the data we hold. That doesn't mean it won't help — it means large, rigorous studies haven't yet established whether it does for these uses.

Talk with your doctor about whether this probiotic might be worth trying for your specific situation.

The evidence, ingredient by ingredient Bifidobacterium Longum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bifidobacterium longum is generally well tolerated in healthy people. Caution is warranted if you're seriously ill or have a weakened immune system, since rare cases of the bacteria entering the bloodstream have been reported in critically ill patients and preterm infants.

Oral side effects are rare but have included abdominal discomfort, bloating, flatulence, constipation, and one reported case of dry cough. Limited safety data exist, so check with your doctor before using while breastfeeding.

Pregnancy data suggest it's possibly safe, but talk it over with your healthcare provider.

Side effects, ingredient by ingredient Bifidobacterium Longum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bifidobacterium Longum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Align, double-check your medications for antibiotic drugs — the live organisms in this probiotic might be killed off if you take them at the same time. Your doctor or pharmacist can help you time the doses apart.

Use the search tool on this page to verify your exact medications, and talk it over with your healthcare provider.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Align is a straightforward single-strain probiotic best suited for generally healthy people. If you're on antibiotics, immunocompromised, critically ill, or pregnant or breastfeeding, talk with your doctor or pharmacist before starting — timing and individual risk matter here.

Check your medications against the tool on this page, and discuss the product with your own healthcare provider if you have questions about whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Align Probiotic, straight from the product label.

Brand Align
Barcode (UPC) 037000939528
Net contents 14 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 278088
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Align Probiotic by Align, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
14
UPC/BARCODE
037000939528
IngredientAmount% DV
Bifidobacterium longum longum 356244 mg--

Other ingredients: Microcrystalline Cellulose, Hypromellose, Sucrose, Magnesium Stearate, Sodium Caseinate, Titanium Dioxide, Trisodium Citrate Dihydrate, Propyl Gallate, Gellan Gum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Gluten free Soy free

Vegetarian

Guaranteed potency

24/7 digestive support With continued daily use. Naturally helps with occasional abdominal discomfort, gas, and bloating Helps promote and support a healthy digestive system

Why use Align? Helps with occasional abdominal discomfort, gas, and bloating

Fortifies the digestive system with healthy bacteria 24/7

Storage

No refrigeration required

For best results, we recommend you store Align below 86 degrees F (30 degrees C) in the original blister unit.

Suggested/Recommended/Usage/Directions

Directions: Take one capsule per day.

Brand IP Statement(s)

Patents: www.pg.com/patents

General Statements

Developed by gastroenterologists #1 doctor recommended brand

Why use probiotics? Common issues such as diet, changes in routine, travel and stress may disrupt your natural balance of good bacteria.

#1 Doctor and #1 Gastroenterologist recommended probiotic brand

Money Back Guarantee Procter & Gamble stands behind our product. If you are not satisfied with Align, simply return the UPC code from this package and your original sales receipt within 60 days of purchase for a full refund in the form of a prepaid card. Visit AlignProbioitics.com/refund for details. Among gastroenterologists who recommend a brand of probiotic in ProVoice 2008-2018 surveys. Among doctors who recommend a brand of probiotic in ProVoice 2018 survey.

Questions? 1-800-208-0112 or AlignProbiotics.com

FDA Statement of Identity

Probiotic Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Contains: Milk

Warnings: Parental supervision is recommended for the use of this product. Keep out of reach of children.

Tamper Evident: Carton sealed for your protection. Do not use if blister unit is open or torn.

Formula

Align Probiotic is the product of more than 10 years of scientific research and contains the pure-strain probiotic, Bifidobacterium 35624

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Align Probiotic by Align label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Align Probiotic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Align Probiotic by Align

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container14 Amounts shown are per serving.

Bifidobacterium longum longum 35624

Interacts with
182 drugs
4 mg per serving

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most...

Bifidobacterium longum longum 35624 monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Sucrose, Magnesium Stearate, Sodium Caseinate, Titanium Dioxide, Trisodium Citrate Dihydrate, Propyl Gallate, Gellan Gum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Align Probiotic by Align Drug Interactions

Want to check YOUR meds against Align Probiotic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bifidobacterium longum longum 35624 182

Individual Drug Interactions

The ingredients in Align Probiotic interact with 182 drugs. Click any drug to see the details.

1 of the 1 ingredient in Align Probiotic interact with drugs. Each result below shows which ingredient is responsible. Bifidobacterium longum longum 35624

Each ingredient & the kinds of drugs it affects

For each ingredient in Align Probiotic with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium longum longum 356241 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum longum 35624 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Align Probiotic, from the product label.

Align

See all Align products
Name
Procter & Gamble
City
Cincinnati
State
OH
ZipCode
45202
Phone Number
1-800-208-0112
Web Address
www.pg.com
Pharmacist Counseling Corner

Align Probiotic by Align: Common Questions

Does Align Probiotic by Align interact with any medications?
Yes. Based on its ingredients, Align Probiotic has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Align Probiotic contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Align while I'm on antibiotics?
Taking antibiotics and this probiotic at the same time might reduce how well the probiotic works, since antibiotics can kill the live organisms. Your doctor or pharmacist can advise you on spacing the doses apart — typically a couple of hours — so they don't interfere with each other.
Is Align safe if I have a weak immune system?
Caution is needed. While rare, cases of the bacteria entering the bloodstream have been reported in seriously ill and immunocompromised patients. Check with your doctor before starting, especially if you're critically ill or have a weakened immune system.
Is it safe to take Align while breastfeeding?
Limited safety data exist for this probiotic during breastfeeding. The available data suggest it's possibly safe, but you should talk with your doctor or pharmacist before using to get personalized advice for your situation.
What side effects might I experience?
Most people tolerate Align well. Rare side effects reported include abdominal discomfort, bloating, flatulence, constipation, and in one case a dry cough. Stop and contact your healthcare provider if you experience anything concerning.
Does Align work for digestive problems or other conditions?
The evidence for this strain of probiotic in conditions like antibiotic-associated diarrhea, allergies, and other common uses is insufficient to rate based on the data we hold. Talk with your doctor about whether it might help for your specific concern.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Align Probiotic is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Align Probiotic label
Go deeper

The Full Monographs Behind Align Probiotic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph →
Sources

Sources & How We Checked

Align Probiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
  12. Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
  15. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
  17. Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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