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Dietary supplement

Alpha GPC 250 mg Ingredients & Drug Interactions

by Pure Nootropics

Alpha GPC 250 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Alpha GPC 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Alpha GPC 250 mg is a dietary supplement by Pure Nootropics with 1 active ingredient. Its ingredients are commonly taken for memory and learning support, age-related cognitive decline, alzheimer's disease and dementia (under study).Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Alpha-Glycerylphosphorylcholine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Alpha GPC 250 mg by Pure Nootropics

Ask about any prescription or over-the-counter medication and we check it for interactions with Alpha GPC 250 mg by Pure Nootropics — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Alpha GPC 250 mg by Pure Nootropics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: alpha-GPC (alpha-glycerylphosphorylcholine), a compound that supplies choline, which your brain uses to make acetylcholine—a neurotransmitter involved in memory and learning. The capsule also includes several inactive ingredients (hypromellose, dicalcium phosphate dihydrate, silicon dioxide, and stearate) that serve as fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: cognitive support and memory function.
  • We looked for evidence on: Cognitive function, Alzheimer disease, Vascular dementia, age-related cognitive decline, learning.
  • The strongest evidence on file: Alpha-gpc is rated "Possibly Effective" for Alzheimer disease (Natural Medicines).
  • Also on file: Alpha-gpc is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Vascular dementia.

Alpha-GPC is possibly effective for Alzheimer disease based on the data we hold. For other uses—brain tumor, general cognitive function, vascular dementia, and stroke—the evidence is insufficient to establish whether it works.

If you're considering it for any of these conditions, talk with your doctor about whether the current evidence supports a trial.

The evidence, ingredient by ingredient Alpha-gpc

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Alpha-GPC is generally well tolerated in studies, though long-term safety hasn't been fully established. A small number of people taking it orally have reported dizziness, headache, insomnia, nausea, and heartburn.

More concerning is that oral use for at least 2 months has been rarely associated with an elevated risk of stroke compared with non-users or shorter-term users. The safety information for pregnancy and lactation isn't on file; if you're pregnant or nursing, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Alpha-gpc

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Alpha-gpc.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take a scopolamine patch (Transderm Scop) for motion sickness, alpha-GPC might reduce its effectiveness—check with your doctor or pharmacist before combining them. Although we could only document one interaction, the ingredient affects 16 individual medications across various categories, so it's important to confirm your exact medications on this page's interaction tool before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Alpha-GPC may be worth considering if you're exploring options for Alzheimer disease, but the evidence for other brain-related uses is weak. Because long-term safety isn't fully known and there's a rare association with stroke risk at higher durations, this isn't a casual supplement—discuss it with your doctor or pharmacist first, especially if you're on a scopolamine patch or other medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Alpha GPC 250 mg, straight from the product label.

Brand Pure Nootropics
Barcode (UPC) X002I2C24V
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 316480
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Alpha GPC 250 mg by Pure Nootropics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
X002I2C24V
IngredientAmount% DV
Alpha-Glycerylphosphorylcholine250 mg--

Other ingredients: Hypromellose, Dicalcium Phosphate Dihydrate, Silicon Dioxide, Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Always Non-GMO Gluten Free Preservative Free

Lab tested

Provides Support for Cognition

General Statements

Unlock Your Potential

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: Consult with a healthcare practitioner before taking this.

Do not take this if you are pregnant, nursing or under the age of 18.

Do not take this if you are pregnant, nursing or under the age of 18.

If you experience adverse reactions from taking this product, discontinue immediately and contact a healthcare practitioner.

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Suggested Use: Take 1 capsule daily, up to two times per day, or as recommended by your healthcare practitioner.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Alpha GPC 250 mg by Pure Nootropics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Alpha GPC 250 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Alpha GPC 250 mg by Pure Nootropics

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Alpha-Glycerylphosphorylcholine

Interacts with
16 drugs
250 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

Alpha-Glycerylphosphorylcholine monograph & interactions

Other (inactive) ingredients: Hypromellose, Dicalcium Phosphate Dihydrate, Silicon Dioxide, Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Alpha GPC 250 mg by Pure Nootropics Drug Interactions

Want to check YOUR meds against Alpha GPC 250 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Alpha-Glycerylphosphorylcholine 16

Individual Drug Interactions

The ingredients in Alpha GPC 250 mg interact with 16 drugs. Click any drug to see the details.

1 of the 1 ingredient in Alpha GPC 250 mg interact with drugs. Each result below shows which ingredient is responsible. Alpha-Glycerylphosphorylcholine

Each ingredient & the kinds of drugs it affects

For each ingredient in Alpha GPC 250 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Alpha-Glycerylphosphorylcholine1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
Alpha-Glycerylphosphorylcholine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Alpha GPC 250 mg, from the product label.

Pure Nootropics

See all Pure Nootropics products
Name
Pure Nootropics, LLC
Street Address
P.O. Box 6827
City
Albuquerque
State
NM
ZipCode
87197
Phone Number
424-738-0385
Web Address
purenootropics.net
Pharmacist Counseling Corner

Alpha GPC 250 mg by Pure Nootropics: Common Questions

Does Alpha GPC 250 mg by Pure Nootropics interact with any medications?
Yes. Based on its ingredients, Alpha GPC 250 mg has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Alpha GPC 250 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is alpha-GPC and what does it do?
Alpha-GPC is a compound that delivers choline to your brain, which your brain converts into acetylcholine, a chemical messenger involved in memory and learning. It's been studied most for age-related memory loss.
Does this really work for memory loss?
For Alzheimer disease, the evidence suggests it may help—that's why it's rated possibly effective. For other uses like general brain fog or cognitive sharpness, the evidence isn't strong enough yet to say either way.
Are there any side effects?
Most people tolerate it well. A small number have reported mild side effects like dizziness, headache, insomnia, nausea, and heartburn. Rarely, especially if you take it for 2 months or longer, there's been an association with elevated stroke risk—something important to discuss with your doctor.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety information on file for pregnancy and lactation. Talk with your doctor or pharmacist before taking it if you're pregnant or nursing.
I take a scopolamine patch for motion sickness. Is this okay to add?
Alpha-GPC might reduce how well the patch works, at least based on a small study. Check with your doctor or pharmacist before combining them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Alpha GPC 250 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Alpha GPC 250 mg label
Go deeper

The Full Monographs Behind Alpha GPC 250 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph →
Sources

Sources & How We Checked

Alpha GPC 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
  4. Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.

See these in context on the Alpha-gpc monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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