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Dietary supplement

Androstenedione-25 Ingredients & Drug Interactions

by Douglas Laboratories

Androstenedione-25 label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Androstenedione-25 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Androstenedione-25 is a dietary supplement by Douglas Laboratories with 1 active ingredient. Its ingredients are commonly taken for muscle building, athletic performance, boosting testosterone.Based on those ingredients, 41 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Androstenedione. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Androstenedione-25 by Douglas Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Androstenedione-25 by Douglas Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Androstenedione-25 by Douglas Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: androstenedione, a hormone precursor (a building block your body can convert into other hormones). The tablet also includes inactive ingredients — mannitol, cellulose, vegetable stearate, and silica — which are fillers and binders that help hold the pill together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Androstenedione product and its label doesn't state a use — see Androstenedione's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for androstenedione is limited. It's rated likely ineffective for muscle strength.

For sexual dysfunction, athletic performance, erectile dysfunction, and fatigue, there isn't enough reliable evidence in our data to say whether it works or doesn't. The data we hold doesn't establish that this ingredient delivers meaningful benefits for these uses.

The evidence, ingredient by ingredient Androstenedione

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Androstenedione carries real safety concerns. The facts label it a controlled substance with hormonal risks and little proven benefit.

Serious adverse effects are rare but include liver toxicity, and potential links to breast, endometrial, pancreatic, and prostate cancers. More commonly, it may cause acne, hair loss, unwanted hair growth, and skin changes in both men and women.

It is not safe during pregnancy or while breastfeeding — the safety data advises against use in both.

Side effects, ingredient by ingredient Androstenedione

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Androstenedione.
  • The most serious interaction on file is rated Moderate.
  • For scale: 41 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take estrogen-based medications (birth control, hormone replacement therapy), check with your pharmacist before using this product. The interaction is moderate in severity — androstenedione may amplify estrogen's effects and side effects in your body.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a hormone-altering supplement with significant safety red flags and weak evidence of benefit. If you're considering it for athletic performance or sexual function, the evidence doesn't support those uses.

Anyone with a history of hormone-sensitive cancer, liver disease, or who takes estrogen should avoid it. Talk with your pharmacist or doctor before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Androstenedione-25, straight from the product label.

Brand Douglas Laboratories
Barcode (UPC) 310539002551
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Jun 25, 2012
DSLD ID 10177
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Androstenedione-25 by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
60
UPC/BARCODE
310539002551
IngredientAmount% DV
Androstenedione25 mg--

Other ingredients: Mannitol, Cellulose, Vegetable Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

A Dietary Supplement

Formulation

This product contains NO yeast, wheat gluten, soy protein, milk/dairy, corn, sodium, starch, artificial coloring, preservatives or flavoring.

Suggested/Recommended/Usage/Directions

Suggested Usage: As a dietary supplement, adults take 1 tablet daily or as directed by physician. (May be taken sublingually by allowing tablet to dissolve in mouth or with water or juice.)

Precautions

KEEP OUT OF REACH OF CHILDREN.

Tamper resistant package, do not use if outer seal is missing.

Storage

For optimal storage conditions, store in a cool, dry place. (59(0)-77(0)F/15(0)-25(0)C) (35-65% relative humidity)

General

Formula #83904

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Androstenedione-25 by Douglas Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Androstenedione-25 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Androstenedione-25 by Douglas Laboratories

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Androstenedione

Interacts with
41 drugs
25 mg per serving

Androstenedione is a prohormone that the body can convert into testosterone and estrogen, but studies have not shown that taking it reliably builds mu...

Androstenedione monograph & interactions

Other (inactive) ingredients: Mannitol, Cellulose, Vegetable Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Androstenedione-25 by Douglas Laboratories Drug Interactions

Want to check YOUR meds against Androstenedione-25?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
41Drugs
41 Moderate

Ingredients driving the most interactions

Androstenedione 41

Individual Drug Interactions

The ingredients in Androstenedione-25 interact with 41 drugs. Click any drug to see the details.

1 of the 1 ingredient in Androstenedione-25 interact with drugs. Each result below shows which ingredient is responsible. Androstenedione

Each ingredient & the kinds of drugs it affects

For each ingredient in Androstenedione-25 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Androstenedione1 drug type · 41 drugs

Estrogens

Theoretically, androstenedione might increase the effects and adverse effects of estrogens.
Androstenedione is a precursor to estrogen and seems to increase estrogen levels. However, androstenedione is converted to estrogen only in low estrogen environments. Patients taking estrogen do not have low estrogen levels because of the estrogen treatment. Therefore, androstenedione is unlikely to be converted to estrogen in these patients. However, until more is known, use with caution or avoid using.

Likelihood Possible Evidence D
Androstenedione full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Androstenedione-25, from the product label.

Douglas Laboratories

See all Douglas Laboratories products
Name
Douglas Laboratories
City
Pittsburgh
State
PA
ZipCode
15205
Web Address
www.douglaslabs.com
Pharmacist Counseling Corner

Androstenedione-25 by Douglas Laboratories: Common Questions

Does Androstenedione-25 by Douglas Laboratories interact with any medications?
Yes. Based on its ingredients, Androstenedione-25 has a known interaction with 41 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Androstenedione-25 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Androstenedione-25 if I'm pregnant or breastfeeding?
No. The safety data advises against it during pregnancy — it's rated likely unsafe. It's also unsafe and not recommended while breastfeeding. Talk with your doctor before considering any hormone-altering supplement during these times.
Does androstenedione actually build muscle or boost athletic performance?
For muscle strength, it's rated likely ineffective based on the evidence we hold. For athletic performance, there isn't enough reliable evidence to say either way. The science doesn't clearly support these common reasons people take it.
What are the most common side effects?
In men, acne and skin changes are possible. In women, you might see male-pattern baldness, extra hair growth, acne, and coarsening of the skin. Serious effects like liver toxicity or cancer risk are rare but documented.
Is this safe for long-term use?
The facts label it a controlled substance with hormonal risks and little proven benefit. Serious adverse effects — including cancers and liver damage — are documented, even if rare. This isn't a supplement meant for casual, long-term use.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Androstenedione-25 label
Go deeper

The Full Monographs Behind Androstenedione-25’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Androstenedione

Interacts with 41 drugs

Androstenedione is a prohormone that the body can convert into testosterone and estrogen, but studies have not shown that taking it reliably builds muscle or improves athletic performance. I...

Read the full Androstenedione monograph →
Sources

Sources & How We Checked

Androstenedione-25's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Androstenedione 21 references
  1. van Weerden WM, van Kreuningen A, Elissen NM, et al. Effects of adrenal androgens on the transplantable human prostate tumor PC-82. Endocrinol 1992;131:2909-13.
  2. Mecenas CA, Giussani DA, Owiny JR, et al. Production of premature delivery in pregnant rhesus monkeys by androstenedione infusion. Nat Med 1996;2:443-8. PubMed
  3. Anon. Creatine and androstenedione, two dietary supplements. Med Lett Drugs Ther 1998;40:105-6.
  4. Broeder CE, Quindry J, Brittingham K, et al. The Andro Project: physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program. Arch Intern Med 2000;160:30
  5. Leder BZ, Longcope C, Catlin DH, et al. Oral androstenedione administration and serum testosterone concentrations in young men. JAMA 2000;283:779-82. PubMed
  6. Kachhi PN, Henderson SO. Priapism after androstenedione intake for athletic performance enhancement. Ann Emerg Med 2000;35:391-3. PubMed
  7. King DS, Sharp RL, Vukovich MD, et al. Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men. A randomized controlled trial. JAMA 1999;281:2020-8. PubMed
  8. Weber B, Lewicka S, Deuschle M, et al. Testosterone, androstenedione and dihydrotestosterone concentrations are elevated in female patients with major depression. Psychoneuroendocrinology 2000;25:765-71. PubMed
  9. Brown GA, Vukovich MD, Martini ER, et al. Endocrine responses to chronic androstenedione intake in 30- to 56-year-old men. J Clin Endocrinol Metab 2000;85:4074-80. DOI
  10. Brown GA, Vukovich MD, Martini ER, et al. Effects of androstenedione-herbal supplementation on serum sex hormone concentrations in 30- to 59-year-old men. Int J Vitam Nutr Res 2001;71:293-301. PubMed
  11. Leder, B. Z., Leblanc, K. M., Longcope, C., Lee, H., Catlin, D. H., and Finkelstein, J. S. Effects of oral androstenedione administration on serum testosterone and estradiol levels in postmenopausal women. J Clin Endocrinol Metab 2002;87(12):5449-5454. PubMed
  12. Brown, G. A., Vukovich, M., and King, D. S. Testosterone prohormone supplements. Med Sci Sports Exerc 2006;38(8):1451-1461. PubMed
  13. Cauley, J. A., Lucas, F. L., Kuller, L. H., Stone, K., Browner, W., and Cummings, S. R. Elevated serum estradiol and testosterone concentrations are associated with a high risk for breast cancer. Study of Osteoporotic Fractures Research Group. Ann Intern PubMed
  14. Kohut, M. L., Thompson, J. R., Campbell, J., Brown, G. A., Vukovich, M. D., Jackson, D. A., and King, D. S. Ingestion of a dietary supplement containing dehydroepiandrosterone (DHEA) and androstenedione has minimal effect on immune function in middle-age
  15. Barrett-Connor, E., Garland, C., McPhillips, J. B., Khaw, K. T., and Wingard, D. L. A prospective, population-based study of androstenedione, estrogens, and prostatic cancer. Cancer Res 1-1-1990;50(1):169-173.
  16. Fyssas, I., Syrigos, K. N., Konstandoulakis, M. M., Papadopoulos, S., Milingos, N., Anapliotou, M., Waxman, J., and Golematis, B. C. Sex hormone levels in the serum of patients with pancreatic adenocarcinoma. Horm Metab Res 1997;29(3):115-118. PubMed
  17. Hoque A, Yao S, Till C, et al. Effect of finasteride on serum androstenedione and risk of prostate cancer within the prostate cancer prevention trial: differential effect on high- and low-grade disease. Urology. 2015;85(3):616-20. PubMed
  18. Ritter RH, Cryar AK, Hermans MR. Oral androstenedione-induced impotence and severe oligospermia. Fertil Steril. 2005;84(1):217. PubMed
  19. Judge LW, Bellar DM, Hoover DL, Biggs D, Leitzelar BN, Craig BW. Effects of acute androstenedione supplementation on testosterone levels in older men. Aging Male. 2016;19(3):161-167. PubMed
  20. Badawy MT, Sobeh M, Xiao J, Farag MA. Androstenedione (a natural steroid and a drug supplement): a comprehensive review of its consumption, metabolism, health effects, and toxicity with sex differences. Molecules 2021;26(20):6210. PubMed
  21. Pang Q, Jia A, Al Masri MK, Varkaneh HK, Abu-Zaid A, Gao X. The effect of androstenedione supplementation on testosterone, estradiol, body composition, and lipid profile: a systematic review and meta-analysis of randomized controlled trials. Hormones (Ath PubMed

See these in context on the Androstenedione monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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